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Andriyanto
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Journal : current biomedicine

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Penyembuhan luka sayatan menggunakan krim ekstrak teripang laut dan kunyit Alpayet, Rahmat; Mustika, Aulia Andi; Rahma, Anisa; Andriyanto; Sutardi, Lina Noviyanti
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.54-61

Abstract

Background: Skin is the outermost layer that covers and protects the body and is vulnerable to trauma, such as wounds. Turmeric and sea cucumbers are known to have properties in wound healing. Objective: This study aims to determine the effectiveness of a mixture of sea cucumber and turmeric extracts in the form of a cream to heal incision wounds in rats. Methods: Twenty-five male white rats, Sprague Dawley strain, and body weights of 250–300 g were anesthetized, and their skins were slashed. The rats were divided into five groups, namely negative control (wounds without treatment), positive controls (wounds treated with Bioplacenton® topically), and three treatment groups (wounds treated with sea cucumber and turmeric extract cream with concentrations of 0.5%, 1%, and 2% topically). Wound healing parameters were observed daily, namely accelerated wound closure and inflammation reduction. Data were analysed descriptively and tested using the non-parametric Kruskal-Wallis’s test. Results: The results showed that the wounds closed completely in all treated groups. Healing time in the group receiving treatment (positive control and concentration treatment of 0.5%, 1%, and 2% were 8.3 ± 1.5 days, 10.3 ± 0.6 days, 9.3 ± 0 .6 days, and 8.3 ± 1.5 days, respectively) faster than the healing time of the group that did not receive treatment (negative control was 12.6 ± 0.6 days). Conclusion: This study showed that sea cucumber and turmeric extract cream has the potential and is effective for wound healing and can be used as an alternative for wound treatment.
Co-Authors A Zeze A., Samsul Agung, Rendi Marta Agus Oman Sudrajat Aji, Gilang Gusti Alifian Nugraha Alpayet, Rahmat Amrullah Anang Lukmana Andy Suryadi Anggi Anggarini Anggini Widya Alvianti Anisa Rahma, Anisa Arifin Suryo Nugroho Aulia Andi Mustika Aulia Chairani, Aulia Awaludin Bangun, Dwi Agnes Natalia Bayu Adi Putra Budi Maryoto, Agus Cahyo Budi Utomo Cakrahaya, Agus Chairunnisa, Adelia Christina Clarice Leksono Cica Nurhidayah Deri Wanto Diah Nugrahani Pristihadi Digyo, Oscar Daniel Kusumo Elpita Tarigan Etty Zuliawati Zed Faizal Jefri Pratama Fajrina, Nabila Faris Iqbal H Fauzi Rachman, Fauzi Ferawati Fikri Al-Munawar Hamdika Yendri Hardini, Niniek Heni Purwono, Heni Hoang Ha, Van Kim Huda, Anam Miftahul I Ketut Mudite Ifana, Cindy Anola Indrajayani, Galuh Gita Ipong Jazimah Irawati Azizah Irene Abelianata Joni Haryadi, Joni Kalew, Robby Kardiana, Yaya Ketut Adnyane Mudite Kurnia, Sinarianda latif kusairi Leliana Widi Lina Noviyanti Sutardi Mahardika, Ghana Yoga Mahardika Maheni, MRR. Tiyas Mayasari, Ni Luh Putu Ika Medeline Muhlis Fajar Wicaksana Muslikh Napitupulu, Pesta Asni Nur Nabilla, Cintya Nuralfilail, Zakiah Nada Nuri Herachwati Nuryuana Dwi Wulandari Pramesti, Rachmadita Dwi Pramestia, Vinandhita Anjellya Pramudawardhani, Ira Pritha Maya Savitri Putri, Shafa Adela Putu Ronny Angga Mahendra Reza Irawan Ridi Arif Ridwan Arifin Rindy Fazni Nengsih Rudi Ana Pali Safika S, Safika Sari, Nurratri Kurnia Setianingrum, Vinda Maya Sirajuddin Subangkit, Mawar Sukarno Susilawati Toyib, Muchammad Wasmen Manalu Yuliyanto, Rizky yuri, Nurasmi yuri Yusa Irarang Yustianti, Surti