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Journal : Journal of Multidisciplinary Applied Natural Science

Genetic Diversity and Multiplicity of Plasmodium falciparum Infection in Southeast Asia: New Insights from a Systematic Review Praswitasari, Rengganis; Husada, Dominicus; Hasan, Nur Aini; Adnyana, I Made Dwi Mertha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.357

Abstract

Plasmodium falciparum caused four million new malaria cases in Southeast Asia in 2023, with heterogeneous transmission patterns and the development of artemisinin resistance. The merozoite surface protein genes (msp-1 and msp-2) serve as genetic markers for analyzing the parasite population structure and multiplicity of infection (MOI). However, a comprehensive synthesis of regional data is limited. This study aimed to determine the genetic diversity and MOI of P. falciparum in Southeast Asia. This systematic review was guided by PRISMA guidelines with searches in the Scopus, PubMed, ProQuest, and Google Scholar databases (2014–2024). The inclusion criterion was observational studies, analyzing the genetic diversity of P. falciparum via msp-1 and msp-2 markers in Southeast Asia. The extracted data included the frequency of msp-1 and msp-2 family alleles, the prevalence of polyclonal infections, and the mean MOI value. Quality assessment was performed via the joanna briggs institute critical appraisal tools with narrative synthesis following the synthesis without meta-analysis (SWiM) guidelines. Fifteen studies; Indonesia (40%), Thailand (26.67%), Myanmar (20%), Vietnam and Malaysia (6.66%) with 1,830 samples successfully genotyped from 2,130 collected samples. The MAD20 (msp-1) allele dominated most locations, with frequencies of up to 100% in Lampung. The distribution of msp-2 alleles showed geographical variation, with FC27 dominating in Papua (96.2%) and 3D7/IC in Vietnam (97.0%). The prevalence of polyclonal infection ranged from 0-84.6%, with MOI values ranging from 1.0-2.93. The hyperendemic areas presented high MOIs (>2.0), whereas the hypoendemic areas presented MOIs close to 1.0, confirming a positive correlation with malaria transmission intensity. The P. falciparum population in Southeast Asia shows high genetic diversity, with geographically variable allele distribution patterns, and MOI values are correlated with malaria endemicity levels. These findings support the need for regional molecular surveillance and a polyvalent approach to the development of msp-based vaccines.
Co-Authors A’yuni, Zera Qurrota Adnyana , I Made Dwi Mertha Aflahudin, M. Ahda Naufal Agung Dwi Wahyu Widodo Ahmad Suryawan Akbar Panjinegara, Muhammad Alfi Layali Muntaza Anang Endaryanto Andi Airina Binti A Agus Annisa Fira Salsabila anomsari, hanna dyahferi Arguni, Egi Ari Prayitno Ari Prayitno, Ari Arien Dwi Ajeng Adhe Safitri Arina Setyaningtyas Aris Wiji Utami Aryati Aryati Aryati Aryati Atika Atika Atika Atika Atika Bangkit Putrawan Bastiana Bermawi Basuki, Setio Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Bulqis Inas Sakinah Candra Maulana Catarina Rani Cissy B Kartasasmita Cissy B. Kartasasmita Cita Rosita Sigit Prakoeswa Darto Saharso Dessy Putri Pratiwi Destasari Tri Hartanti Desy Primayani Djoko Marsudi Dwi Prasetyo Dwi Prasetyo Dwiyanti Puspitasari, Dwiyanti Edward Adijaya Rusli Egi Arguni Endyka Erye Frety Erna Supatmini Erni Rosita Dewi Esti Yunitasari Estin Puspaningrum Eveline Irawan Fadilla, Aulia Nur Febtarini Rahmawati Fitri Ramadhani Fitriah Fitriah Fitriah, Muhammad Yasin Flora Ramona Sigit Prakoeswa Gatot Irawan Sarosa Gatot Irawan Sarosa, Gatot Irawan Gunadi Ranu, I Gusti Made Reza Hanifah Oswari Hanifah Oswari Haq, Arini Hardyanto Soebono Hari Basuki Notobroto Hartono Gunardi Hartono Gunardi Hasan, Nur Aini Hendrata, Adi Pramono Hilwana, Lutifta I Dewa Gede Ugrasena I Gusti Ngurah Twi Adnyana Ida Safitri Laksanawati Ilya Krisnana, Ilya Irawan, Eveline Irawan, Eveline Irene Ratridewi Irwanto Irwanto, Irwanto Ismoedijanto Isnin Anang Marhana Jihan Kalishah Johanis Johanis Juniastuti Juniastuti Juniastuti Juniastuti Jusak Nugraha Kartina, Leny Kevin Sastra Dhinata Khen Mikhael Kristina Marbun Kristoforus Samson Kusnandi Rusmil Kusnandi Rusmil Laili Primasari Laksmi Wulandari Lilik Djuari Linda Dewanti M. Y. Probohoesodo M. Yulianto Listiawan M.Y. Probohoesodo Maddepunggeng, Martira Martira Maddepunggeng Ma`ruf, Anwar Mei Neni Sitaremi Mei Neni Sitaresmi Mufidah Binti Eka Muhammad Akbar Panjinegara Muhammad Miftahussurur Muhammad Vitanata Arfijanto, Muhammad Vitanata Muntia Rizki Alzahra Mustikasari, Rahma Ira MUTHMAINNAH Muthmainnah Muthmainnah Muziburrahman Muziburrahman Nastiti Kaswandani Natalia Yuwono Nihar, Mahdiyyah Husna Nike Aprilidia Parwati S. Basuki Parwati Setiono Basuki Pasulu, Soraya Salle Polanunu, Masayu Ramadhani Praswitasari, Rengganis Prodjosoewojo, Susantina Pudji Lestari Raihan Raihan Raihan Raihan, Raihan Rania, Najwa Miftah Ratni Indrawanti Reka Elvia Dirda Prasasta Renaldy, Raden Bagus Yanuar Retno Asih Setyoningrum Retno Palupi Retnosari Widowati Risa Etika, Risa Rossyanti, Lynda Rusli, Musofa Sabrina, Haifa Rafiqa Sakinah, Bulqis Inas Salma Asri, Hanifa Irfani Salma, Zukhaila Samson, Kristoforus Santi Martini Sari, Arabella Vonia Sari, Marlita Mustika Sarjana, IWayan Savitri Laksmi Winaputri Sesilia Serly Kebo Setiawati, Yunias Setyo Handryastuti Soedjatmiko Soedjatmiko Soedjatmiko Soegianto, Sugi Deny Pranoto Soegianto, Sugi Deny Pranoto Sofia Alfarizi Sopha, May Ira Sri Rejeki H Hadinegoro. Sri Rezeki S. Hadinegoro, Sri Rezeki S. Sri Umijati Sri Utami Sriwijayanti Sulistyawati Suhintam Pusarawati Sukmawati Basuki Sulistiawati Sulistiawati Sulistiawati Sumaryono Sumaryono Sunari, I Gusti Agung Ayu Eka Putri Supiatun.M, Lilis Sri Susanti Susanti Susanto Nugroho Sutjonong, Tioky Theresia Indah Budhy Sulisetyawati Thiono, Marischa Tita Wafirotul Rizqi Hasanah Widodo Darmowandowo Woro Setia Ningtyas Yuli Astika Yulia Nadar Indrasari Yulida Mufidah Zakiudin Munasir Zakiudin Munasir