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Correlation between IL-1beta and IL-18 Levels with Dengue Virus Infection Severity Sari, Arabella Vonia; Aryati, Aryati; Budhy, Theresia Indah; Ma`ruf, Anwar; Husada, Dominicus; Palupi, Retno; Sunari, I Gusti Agung Ayu Eka Putri; Indrasari, Yulia Nadar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2682

Abstract

Activated monocytes/macrophages and T lymphocytes that generate a cytokine storm are thought to play a critical role in the development of dengue. Cytokine storms, characterized by the excessive production of proinflammatory cytokines, can result in cellular dysfunction and organ failure, often contributing to the severity of dengue in affected patients. Interleukin-18 (IL-18), like IL-1beta, is a proinflammatory cytokine released during inflammation triggered by inflammasome activation. Increased IL-1beta and IL-18 during dengue virus infection (DVI) are known to worsen the host's vascular permeability, increasing hemostasis disorders and potentially, all of which are important elements in the pathophysiology of dengue fever. This study investigates the association between IL-1beta levels, IL-18 levels, age, dengue virus serotype, and the severity of dengue virus infection, aiming to understand how these factors interact and influence disease outcomes. This study is an observational cross-sectional design from 59 DVI patients in Dr. Soetomo General Hospital, Surabaya with positive dengue PCR results. Both IL-1beta and IL-18 levels reveal no significant relationship with the patient's age, infection status, and dengue virus serotype. A weak negative significant relationship between IL-1beta levels and the severity of DVI, indicating an inverse relationship between IL-1beta levels and the severity. Further studies are required to investigate the function of these cytokines in severe dengue.
FACTORS AFFECTING MATERNAL COMPLIANCE IN GIVING MULTIPLE IMMUNIZATION INJECTIONS TO TODDLERS AT MEDOKAN AYU HEALTH CENTER IN SURABAYA Samson, Kristoforus; Husada, Dominicus; Muthmainnah, Muthmainnah
Jurnal Biometrika dan Kependudukan Vol. 14 No. 1 (2025): JURNAL BIOMETRIKA DAN KEPENDUDUKAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbk.v14i1.2025.1-10

Abstract

Maternal compliance as determining factor in increasing the coverage of double immunization injections for children <2-years-old at the Medokan Ayu Health Center in Surabaya. Based on local monitoring data, the average immunized child is still below the target of 90% which is certainly at high risk of exposure to hepatitis-B, tuberculosis, whooping cough, and diphtheria in children. This study aimed to analyze the factors that affect maternal compliance in administering double immunization injections to children <2-years-old at the Medokan Ayu Surabaya Health Center. This was observational research with a cross-sectional study design. Data was collected using questionnaires distributed directly to respondents. The population in this study was mothers who have children <2-years-old at the Medokan Ayu Health Center in Surabaya. Sample selected using the Multistage Random Sampling technique. There was no influence between demographic factors on maternal compliance in administering double immunization injections to children <2-years-old at the Medokan Ayu Health Center in Surabaya (p=0.855). There were effects of perceived vulnerability, perceived severity, perceived benefits, perceived obstacles, belief in success (self-efficacy), and signals to action on maternal compliance in administering double immunization injections to children <2-years-old at the Medokan Ayu Surabaya Health Center (p< 0.05). Mothers who have perceived obstacles, as well as disbelief in the success of double immunization injections tend to disobey in providing immunization injections to their children. The latest program from the Health Center which is home immunization visits is a to increase the coverage of double immunization injections for children <2-years-old.
Peran Pelatihan Dan Peningkatan Keterampilan Tenaga Kesehatan Dalam Penanganan Difteri Di Jawa Timur Pada Tahun 2024 Mustikasari, Rahma Ira; Husada, Dominicus; Kartina, Leny; Basuki, Parwati Setiono; Puspitasari, Dwiyanti; Ismoedijanto, Ismoedijanto; Hilwana, Lutifta; Haq, Arini
Jurnal Gema Ngabdi Vol. 7 No. 2 (2025): JURNAL GEMA NGABDI
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jgn.v7i2.585

Abstract

Diphtheria, caused by Corynebacterium diphtheriae, is a significant public health threat, particularly in areas with low immunization coverage. Despite national immunization programs, sporadic outbreaks continue to occur, especially in East Java, which reported the highest number of cases in 2021. The disease is transmitted through respiratory droplets and can lead to severe complications if not diagnosed and treated promptly. Diphtheria mortality can be reduced with appropriate treatment, along with good immunization status. Diagnosis can be made both clinically and through laboratory tests, including culturing the diphtheria bacteria from swabs of affected tissues. This community service program aimed to enhance the capacity of healthcare workers in East Java, specifically in Sampang Regency, to manage diphtheria through training that included both theoretical and practical components. The training methods used included pre- and post-tests to assess knowledge, mini lectures on epidemiology, clinical symptoms, diphtheria vaccination, and management, along with case simulations to improve participants' practical skills. The program was attended by 42 participants from various healthcare professions, including doctors, nurses, health analysts, and surveillance officers The evaluation demonstrated a significant improvement in participants' knowledge after the training. This program contributed meaningfully to enhancing preparedness among local healthcare providers and is expected to support more robust early detection and response systems for diphtheria outbreaks in the future.
Hubungan Berat Badan Lahir dengan Risiko Attention Deficit Hyperactivity Disorder pada Anak di Rumah Sakit Universitas Airlangga Rania, Najwa Miftah; Husada, Dominicus; Ningtyas, Woro Setia; Atika, Atika; Anomsari, Hanna Dyahferi
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 3 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss3.1954

Abstract

Kasus Attention Deficit Hyperactivity Disorder tercatat lebih dari 3-7% terjadi di tingkat sekolah dasar. Berat badan lahir rendah diduga meningkatkan risiko ADHD. Penelitian ini bertujuan untuk menganalisis hubungan berat badan lahir dengan risiko ADHD pada anak. Penelitian ini menggunakan desain analitik observasional dengan pendekatan case control yang dilaksanakan di Rumah Sakit Universitas Airlangga Surabaya pada Februari – Mei 2025. Populasi pada penelitian ini yaitu anak yang melakukan pemeriksaan di poli tumbuh kembang Rumah Sakit Universitas Airlangga Surabaya. Sebanyak 80 anak didapatkan melalui teknik purposive sampling, terdiri atas kelompok kasus (berisiko ADHD) dan kontrol (tidak berisiko ADHD). Pada penelitian ini memiliki 2 variabel yaitu berat badan lahir sebagai variabel independen dan risiko ADHD sebagai variabel dependen. Data diperoleh melalui kuesioner abbreviated conners rating scale dan rekam medis, kemudian dianalisis menggunakan Uji Fisher’s Exact dan koefisien kontingensi.  Hasil penelitian menunjukkan bahwa 57,5% anak yang berisiko ADHD memiliki berat badan lahir rendah. Hasil uji statistik menunjukkan hubungan yang bermakna antara berat badan lahir dengan risiko ADHD (p=0,000 dan C=0,432) dengan arah hubungan positif dan kekuatan sedang. Temuan ini menegaskan pentingnya pencegahan BBLR dan deteksi dini ADHD sebagai upaya mengurangi potensi gangguan perkembangan pada anak.
Efek Message Reminder terhadap Waktu Imunisasi Anak : Systematic Review: The Effect of Message Reminder on Child Immunization Time: Systematic Review Kristoforus Samson; Dominicus Husada; Muthmainnah
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 7 No. 2: FEBRUARY 2024 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v7i2.4499

Abstract

Message Reminder teridentifikasi sebagai salah satu strategi dalam meningkatkan cakupan imunisasi dasar lengkap pada anak dan membantu Ibu dalam mengetahui jadwal yang tepat dalam pemberian imunisasi pada anaknya, hal ini berdampak pada ketepatan waktu pemberian imunisasi secara berkala yang dapat mendukung meningkatkan capaian imunisasi dasar lengkap. Studi ini meninjau penelitian sebelumnya yang menggambarkan efek dari Message Reminder terhadap ketepatan waktu pemberian Imunisasi pada anak. Pencarian literature secara sistematis dilakukan pada bulan Juli – Agustus 2023 menggunakan database yaitu Science Direct, ProQuest, dan Pubmed dari populasi sebanyak 48 artikel selama 5 tahun terakhir (2018 – 2023), kemudian diseleksi menjadi 4 artikel sesuai dengan kriteria. 48 artikel yang selanjutnya masuk dalam tahap eliminasi hingga hasil akhir 4 artikel memenuhi syarat untuk full text review. Studi kualitas dinilai dengan menggunakan Skala Newcastle-Ottawa (NOS). Kami mengidentifikasi 4 studi. Upaya untuk meningkatkan cakupan imunisasi dasar lengkap pada anak dilakukan dengan memberikan Message Reminder pada pengasuh atau orangtua anak, sehingga mampu meningkatkan kepatuhan Ibu dalam memberikan Imunisasi Dasar Legkap pada anak sesuai jadwal yang ditentukan. Dari 4 jurnal yang di review terdapat beberapa Ibu yang menjadi patuh serta rutin mengikuti jadwal imunisasi pada anaknya setelah diberikan Message Reminder oleh petugas kesehatan.
Jadwal Imunisasi Anak Usia 0-18 Tahun Rekomendasi Ikatan Dokter Anak Indonesia Tahun 2024 Kaswandani, Nastiti; Gunardi, Hartono; Prayitno, Ari; Kartasasmita, Cissy B.; Prasetyo, Dwi; Husada, Dominicus; Sarosa, Gatot Irawan; Oswari, Hanifah; Ismoedijanto, Ismoedijanto; Rusmil, Kusnandi; Maddepunggeng, Martira; Sitaresmi, Mei Neni; Raihan, Raihan; Handryastuti, Setyo; Soedjatmiko, Soedjatmiko; Hadinegoro, Sri Rezeki S.; Munasir, Zakiudin
Sari Pediatri Vol 26, No 5 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.5.2025.328-36

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Satuan Tugas Imunisasi Ikatan Dokter Anak Indonesia secara periodik melakukan kaji ulang jadwal imunisasi dengan menyelaraskan dengan buku pedoman imunisasi di Indonesia edisi ke 7 tahun 2024, dan sumber-sumber lainnya. Jadwal imunisasi selalu dievaluasi ulang karena beredarnya vaksin baru yang telah disetujui oleh BPOM dan vaksin yang tidak tersedia lagi di Indonesia. Terdapat beberapa perubahan dalam jadwal imunisasi rekomendasi IDAI tahun 2024 yaitu ketersediaan jenis vaksin, seperti pada pneumococcal conjugate vaccine (PCV), vaksin rotavirus, vaksin varisela, vaksin dengue, dan vaksin human papillomavirus (HPV). Agar dalam pelaksanaan lebih mudah, disertakan juga tabel jadwal imunisasi tahun 2024 di akhir.
Profil Isolat Corynebacterium diphtheriae Toksigenik di Jawa Timur Tahun 2012-2017 Soegianto, Sugi Deny Pranoto; Hendrata, Adi Pramono; Irawan, Eveline; Ismoedijanto; Husada, Dominicus
Majalah Kedokteran Indonesia Vol 69 No 2 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.2-2019-75

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Introduction: Diphtheria has been reported as an outbreak in some regions inIndonesia, most of the cases are from East Java.Objective: To describe the profile of toxigenic Corynebacterium diphtheriaeisolates in East Java. Methods. An descriptive study from August 20th -November 30th, 2018. Isolates was selected by cluster random sampling. The viability and toxigenicity testwere done in BBLK Surabaya. Viable and toxigenic isolates were done forcharacteristic analysis. Result: A total of 114 isolates, 6 were non-viable, 108 were viable and toxi-genic. The majority of the hosts were male (58,3%), median age 6,5-year-old(minimum 1, maximum 14-year-old), 50% from the 1-5-year-old age group. Highest origin of isolates from patients (78,7%) rather than carriers (21,3%).The most isolates from Madura (47,2%) and horseshoe area (20,4%). Most ofthem (74.1%) were taken from a pharyngeal swab rather than a nasal swab(25,4%). Mitis was 76,9% and gravis was 23,1%. Conclusion: In this study, the majority of toxigenic Corynebacterium diphtheriae were found in the 1-5-year-old age group and most of them domi-cile in Madura and horseshoe area. Most of the isolates were taken from apharyngeal swab of patients. Mitis was the major variant.
Faktor Risiko Kelahiran Prematur di RSUD Dr. M. Soewandhi Surabaya pada Tahun 2017 Sakinah, Bulqis Inas; Husada, Dominicus; Sulistiawati, Sulistiawati
Majalah Kedokteran Indonesia Vol 69 No 12 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.12-2019-165

Abstract

Introduction: Preterm labor is one of the biggest direct cause of neonatal death and determined by various risk factors. Objective: To determine the effect of mother’s age, parity, preterm labor history, multiple pregnancy and pregnancy complications on the incidence of preterm labor. Method: Retrospective case-control method was conducted. Data were obtained from medical records of mothers who did labor in RSUD Dr. M. Soewandhi in 2017. Result: The analysis showed significant relationship between mother’s age (p=0,004), preterm labor history (p=0,006) and pregnancy complications (p less than 0,001) with the incidence of preterm labor. Based on multivariate analysis, mothers aged less than sign 20 and greater than sign dari 35 years old and those who had pregnancy complications were at risk of 3,510 (95% CI 1,481-8,230) and 5,203 (95% CI 2,248-12,040) times of having preterm labor.Conclusion: Maternal age and pregnancy complications were two contributing factors that increase the risk of preterm labor. These factors should be given special attention while assessing pregnancy to prevent preterm labor.
Gambaran Epidemiologi Anak dengan Infeksi Dengue Berat di RSUD Dr. Soetomo Fadilla, Aulia Nur; Husada, Dominicus; Utomo, Budi
Majalah Kedokteran Indonesia Vol 70 No 4 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.4-2020-220

Abstract

Introduction: Dengue infection is endemic to Indonesia and remains a public health problem. Severe dengue infection can cause rapid death, especially in children. Aim: To determine the epidemiology of children with severe dengue infection in Dr. Soetomo Hospital. A cross-sectional study was conducted at the pediatric ward of Dr. Soetomo Hospital. Data were derived from medical records of children aged ≤18 years which hospitalized with severe dengue from March to April 2019. Of 135 children admitted with DHF, obtained 48 samples with characteristics greater than 5–12 years old (72.9%), male (58.3%), residence Surabaya (89.6%), elementary school (60.3%), referral (81.3%), hospitalized ≤5 days (66.7%), day of illness ≥4 days (89.6%), moderate malnutrition (35.4%), had severe plasma leakage consisting of DHF grade III (73%) and IV (27%). Two patients died (4.2%). No patient with congenital disease and malignancy. This study is not in line with the tendency of shifted dengue incidence to older age groups (greater than15 years old) in Indonesia. All patients had severe plasma leakage. No severe dengue patient with severe hemorrhage and organ impairment. Most patients were male, had moderate malnutrition, from referral, day of illness ≥4 days, hospitalized ≤5 days.
Vaksin SARS-CoV-2: Tinjauan Kepustakaan Husada, Dominicus
Majalah Kedokteran Indonesia Vol 70 No 10 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.10-2020-254

Abstract

The pandemic of Systemic Acute Respiratory Syndrome-coronavirus-2 (SARS-CoV-2) could not be stopped until mid-June 2020. The difficulty in finding a panacea for this disease made the vaccine very valuable. At present there are more than 100 vaccine candidates worldwide, with at least 10 have begun undergoing clinical trials in humans. The vaccine at its farthest stage is from the University of Oxford, which has entered phase 3. There are multiple approaches in vaccine research, and some methods have never been used before. Some of the vaccines in the study were originally intended for the previous SARS-CoV and Middle East Respiratory Syndrome-coronavirus (MERS-CoV). The main target in general is the protein spike S. Several obstacles need to be considered, such as the absence of a vaccine for the corona virus, the antibody-dependent enhancement (ADE) mechanism, and the possibility of immunopotentiation. In Indonesia there are 4 teams with vaccine research, and 3 other companies that work with international institutions abroad to directly enter the clinical trial phase 2 or 3. After the vaccine has been found, it is necessary to guarantee equality in gaining access among various countries.
Co-Authors A’yuni, Zera Qurrota Aflahudin, M. Ahda Naufal Agung Dwi Wahyu Widodo Ahmad Suryawan Akbar Panjinegara, Muhammad Alfi Layali Muntaza Anang Endaryanto Andi Airina Binti A Agus Annisa Fira Salsabila anomsari, hanna dyahferi Arguni, Egi Ari Prayitno Ari Prayitno, Ari Arien Dwi Ajeng Adhe Safitri Arina Setyaningtyas Aris Wiji Utami Aryati Aryati Aryati Aryati Atika Atika Atika Atika Atika Bangkit Putrawan Bastiana Bermawi Basuki, Setio Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Bulqis Inas Sakinah Candra Maulana Catarina Rani Cissy B Kartasasmita Cissy B. Kartasasmita Cita Rosita Sigit Prakoeswa Darto Saharso Dessy Putri Pratiwi Destasari Tri Hartanti Desy Primayani Djoko Marsudi Dwi Prasetyo Dwi Prasetyo Dwiyanti Puspitasari, Dwiyanti Edward Adijaya Rusli Egi Arguni Endyka Erye Frety Erna Supatmini Erni Rosita Dewi Esti Yunitasari Estin Puspaningrum Eveline Irawan Fadilla, Aulia Nur Febtarini Rahmawati Fitri Ramadhani Fitriah Fitriah Fitriah, Muhammad Yasin Flora Ramona Sigit Prakoeswa Gatot Irawan Sarosa Gatot Irawan Sarosa, Gatot Irawan Gunadi Ranu, I Gusti Made Reza Hanifah Oswari Hanifah Oswari Haq, Arini Hardyanto Soebono Hari Basuki Notobroto Hartono Gunardi Hartono Gunardi Hendrata, Adi Pramono Hilwana, Lutifta I Dewa Gede Ugrasena I Gusti Ngurah Twi Adnyana Ida Safitri Laksanawati Ilya Krisnana, Ilya Indrasari, Yulia Nadar Irawan, Eveline Irawan, Eveline Irene Ratridewi Irwanto Irwanto, Irwanto Ismoedijanto Isnin Anang Marhana Jihan Kalishah Johanis Johanis Juniastuti Juniastuti Juniastuti Juniastuti Jusak Nugraha Kartina, Leny Kevin Sastra Dhinata Khen Mikhael Kristina Marbun Kristoforus Samson Kusnandi Rusmil Kusnandi Rusmil Laili Primasari Lilik Djuari Linda Dewanti M. Y. Probohoesodo M. Yulianto Listiawan M.Y. Probohoesodo Maddepunggeng, Martira Martira Maddepunggeng Ma`ruf, Anwar Mei Neni Sitaremi Mei Neni Sitaresmi Mufidah Binti Eka Muhammad Akbar Panjinegara Muhammad Miftahussurur Muhammad Vitanata Arfijanto, Muhammad Vitanata Muntia Rizki Alzahra Mustikasari, Rahma Ira MUTHMAINNAH Muthmainnah Muthmainnah Muziburrahman Muziburrahman Nastiti Kaswandani Natalia Yuwono Nihar, Mahdiyyah Husna Nike Aprilidia Parwati S. Basuki Parwati Setiono Basuki Pasulu, Soraya Salle Polanunu, Masayu Ramadhani Pudji Lestari Raihan Raihan Raihan Raihan, Raihan Rania, Najwa Miftah Ratni Indrawanti Reka Elvia Dirda Prasasta Renaldy, Raden Bagus Yanuar Retno Asih Setyoningrum Retno Palupi Retnosari Widowati Risa Etika, Risa Rossyanti, Lynda Sakinah, Bulqis Inas Salma Asri, Hanifa Irfani Salma, Zukhaila Samson, Kristoforus Santi Martini Sari, Arabella Vonia Sari, Marlita Mustika Sarjana, IWayan Savitri Laksmi Winaputri Sesilia Serly Kebo Setiawati, Yunias Setyo Handryastuti Setyo Handryastuti, Setyo Soedjatmiko Soedjatmiko Soedjatmiko Soegianto, Sugi Deny Pranoto Soegianto, Sugi Deny Pranoto Sofia Alfarizi Sri Rejeki H Hadinegoro. Sri Rezeki S. Hadinegoro, Sri Rezeki S. Sri Umijati Sri Utami Sriwijayanti Sulistyawati Suhintam Pusarawati Sukmawati Basuki Sulistiawati Sulistiawati Sulistiawati Sumaryono Sumaryono Sunari, I Gusti Agung Ayu Eka Putri Supiatun.M, Lilis Sri Susanti Susanti Susanto Nugroho Sutjonong, Tioky Theresia Indah Budhy Sulisetyawati Thiono, Marischa Tita Wafirotul Rizqi Hasanah Widodo Darmowandowo Woro Setia Ningtyas Yuli Astika Yulida Mufidah Zakiudin Munasir Zakiudin Munasir