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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Berkala Epidemiologi Jurnal NERS Indonesian Journal of Tropical and Infectious Disease Jurnal Biometrika dan Kependudukan (Journal of Biometrics and Population) Sari Pediatri Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Gizi Klinik Indonesia Jurnal Keperawatan Muhammadiyah Journal of Maternal and Child Health INTERNATIONAL JOURNAL OF NURSING AND MIDWIFERY SCIENCE (IJNMS) Jurnal Respirasi (JR) Jurnal Gema Ngabdi Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat Majalah Biomorfologi (Biomorphology Journal) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL PROFESSIONAL HEALTH JOURNAL Journal of Multidisciplinary Applied Natural Science KESANS : International Journal of Health and Science Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Jurnal Indonesia Sosial Sains Jurnal Keperawatan JUKEJ: Jurnal Kesehatan Jompa Jurnal Vokasi Keperawatan (JVK) Jurnal Widya Medika Folia Medica Indonesiana
Dominicus Husada
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Distribution of Voltage Gated Sodium Channel (VGSC) Gene Mutational Variation And Acetylcholinesterase-1 (ACE-1) as A Marker For Insecticide Resistance In Culex spp. Mosquitoes In Surabaya Akbar Panjinegara, Muhammad; Basuki, Sukmawati; Husada, Dominicus; Pusarawati, Suhintam
Jurnal Indonesia Sosial Sains Vol. 5 No. 02 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i02.963

Abstract

Culex spp. is a vector for Japanese Encephalitis (JE) and filariasis in Indonesia. JE is caused by Japanese Encephalitis Virus (JEV). JEV attacks the central nervous system and causes inflammation of the brain, lifelong disability, and even death. Filariasis is a chronic infectious disease that can cause permanent disability. Transmission of JE and filariasis can increase due to the density of Culex spp mosquitoes. The purpose of this study was to identify the distribution of mutation variations in the Voltage Gated Sodium Channel (VGSC) and acetylcholinesterase-1 (ace-1) genes in Culex spp. mosquitoes in Surabaya. Mutation variations of the VGSC Culex spp. gene show that there are three genotypes, namely wildtype (LL), heterozygous (LS, FS), and homozygous (FF, SS). Heterozygous (FS) and homozygous (FF, FS) genotypes caused by point mutations in codon 1014 of the VGSC gene are found in the Culex spp. mosquito population in Surabaya. Heterozygous (LF) genotype was not detected in the Culex spp. mosquito population in Surabaya. Another study in Nigeria showed that homozygous/FF genotypes (45.1%) were more prevalent than heterozygotes/LF (36.3%) and wildtypes/LL (18.6%).
HUBUNGAN TINGKAT KECEMASAN IBU DAN KUNJUNGAN IMUNISASI ANAK DI AKHIR PANDEMI COVID-19 DI WONOKUSUMO SURABAYA Salma Asri, Hanifa Irfani; Husada, Dominicus; Djuari, Lilik
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 1 (2024): Volume 5 No 1 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i1.24167

Abstract

Pandemi Covid-19 berdampak pada berbagai aspek, terutama pelayanan imunisasi. Pelayanan imunisasi terganggu karena banyak orang tua yang khawatir membawa anaknya untuk imunisasi ke puskesmas. Saat ini, di akhir pandemi Covid-19, aktivitas dan layanan kesehatan seharusnya mulai beroperasi kembali secara normal dan kecemasan ibu akan mulai berkurang karena kasus Covid-19 menurun dan protokol kesehatan mulai longgar. Penelitian ini bertujuan untuk menganalisis korelasi antara tingkat kecemasan ibu dan kunjungan imunisasi anak pada akhir pandemi Covid-19. Metode yang digunakan adalah observational analytics dengan pendekatan cross sectional. Total sampel adalah 100 ibu di Wonokusumo Surabaya yang memiliki anak usia 0-2 tahun dengan teknik sampling menggunakan purposive sampling. Analisis data dilakukan dengan menggunakan uji korelasi Rank Spearman. Hasil penelitian menunjukkan bahwa mayoritas ibu tidak memiliki kecemasan, yaitu 86 (86%) ibu. Sementara itu, mayoritas anak rutin berkunjung untuk imunisasi, yaitu 52 (52%) anak. Hasil analisis uji Korelasi Rank Spearman menunjukkan p = 0,903. Dapat disimpulkan bahwa tidak ada hubungan antara tingkat kecemasan ibu dan kunjungan imunisasi anak pada akhir pandemi Covid-19.
PATTERNS OF RIFAMPICIN AND ISONIAZID RESISTANCE IN PULMONARY RR/MDR-TB WITH OR WITHOUT T2DM Sopha, May Ira; Wulandari, Laksmi; Rusli, Musofa; Husada, Dominicus; Prodjosoewojo, Susantina
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tuberculosis (TB) causes approximately[-12pc]AU: Please provide ORCID ID for all authors. 1.6 million deaths each year. The incidence of drug-resistant TB has continued to rise, primarily due to multidrug-resistant tuberculosis (MDR-TB). Drug-resistant TB remains a primary concern in various parts of the world, especially in Eastern Europe, Russia, Asia, and sub-Saharan Africa. This study aimed to analyze the correlation between first-line anti-tuberculosis drug resistance and the presence or absence of T2DM comorbidity in patients with pulmonary RR/MDR TB. This research employed a cross-sectional design, which used secondary data from 2023, obtained from medical records, the Tuberculosis Information System (SITB), and the results of first-line DST tests. The subjects included the RR-TB or MDR-TB patients with or without T2DM, treated at the MDR-TB outpatient clinic of Dr. Soetomo General Hospital, Surabaya. Of 131 patients, a portion had T2DM comorbidity. Statistical analysis showed no significant association between T2DM status and individual resistance to rifampicin (p = 0.247) or isoniazid (p = 0.312). However, clinically, patients with T2DM tended to exhibit more severe and complex resistance patterns. Although there was no statistically significant relationship between T2DM and first-line drug resistance, the presence of T2DM clinically indicated a tendency toward more severe resistance profiles.
The Association Between Maternal Knowledge of Immunization and Acceptance of Multiple Injection Immunization at Community Health Posts in an Urban Primary Healthcare Setting Sabrina, Haifa Rafiqa; Husada, Dominicus; Ningtyas, Woro Setia; Lestari, Pudji
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 4 (2026): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i4.544

Abstract

Introduction: Multiple injection immunization is a service strategy that administers more than one vaccine in a single visit to improve immunization efficiency and coverage. Despite evidence of safety, parental concerns regarding adverse effects remain a major barrier to its acceptance. Maternal knowledge plays a critical role in decision-making related to childhood immunization. Objective: This study aimed to analyze the association between maternal knowledge of immunization and acceptance of multiple injection immunization at community health posts in an urban primary healthcare setting. Method: An analytical observational study with a cross-sectional design was conducted among 82 mothers with children aged 2–24 months, selected using purposive sampling. Data were collected using structured questionnaires and analyzed using the Chi-square test. Result and Discussion: More than half of respondents demonstrated a high level of immunization knowledge (57.3%), and the majority accepted multiple injection immunization (68.3%). Among mothers who accepted multiple injections, 67.9% had a high knowledge level. Statistical analysis showed a significant association between maternal knowledge level and acceptance of multiple injection immunization (p = 0.001). Conclusions: Maternal knowledge of immunization is significantly associated with acceptance of multiple injection immunization. Strengthening educational interventions targeting mothers and families is essential to improve acceptance and sustain optimal immunization coverage.
Genetic Diversity and Multiplicity of Plasmodium falciparum Infection in Southeast Asia: New Insights from a Systematic Review Praswitasari, Rengganis; Husada, Dominicus; Hasan, Nur Aini; Adnyana, I Made Dwi Mertha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.357

Abstract

Plasmodium falciparum caused four million new malaria cases in Southeast Asia in 2023, with heterogeneous transmission patterns and the development of artemisinin resistance. The merozoite surface protein genes (msp-1 and msp-2) serve as genetic markers for analyzing the parasite population structure and multiplicity of infection (MOI). However, a comprehensive synthesis of regional data is limited. This study aimed to determine the genetic diversity and MOI of P. falciparum in Southeast Asia. This systematic review was guided by PRISMA guidelines with searches in the Scopus, PubMed, ProQuest, and Google Scholar databases (2014–2024). The inclusion criterion was observational studies, analyzing the genetic diversity of P. falciparum via msp-1 and msp-2 markers in Southeast Asia. The extracted data included the frequency of msp-1 and msp-2 family alleles, the prevalence of polyclonal infections, and the mean MOI value. Quality assessment was performed via the joanna briggs institute critical appraisal tools with narrative synthesis following the synthesis without meta-analysis (SWiM) guidelines. Fifteen studies; Indonesia (40%), Thailand (26.67%), Myanmar (20%), Vietnam and Malaysia (6.66%) with 1,830 samples successfully genotyped from 2,130 collected samples. The MAD20 (msp-1) allele dominated most locations, with frequencies of up to 100% in Lampung. The distribution of msp-2 alleles showed geographical variation, with FC27 dominating in Papua (96.2%) and 3D7/IC in Vietnam (97.0%). The prevalence of polyclonal infection ranged from 0-84.6%, with MOI values ranging from 1.0-2.93. The hyperendemic areas presented high MOIs (>2.0), whereas the hypoendemic areas presented MOIs close to 1.0, confirming a positive correlation with malaria transmission intensity. The P. falciparum population in Southeast Asia shows high genetic diversity, with geographically variable allele distribution patterns, and MOI values are correlated with malaria endemicity levels. These findings support the need for regional molecular surveillance and a polyvalent approach to the development of msp-based vaccines.
Hubungan Imunisasi Dasar Lengkap dengan Kejadian Pneumonia pada Balita di Indonesia Tahun 2020-2025: Studi Literatur Nugraheny, Risca Ayu; Ferdinandus, Euvanggelia Dwilda; Husada, Dominicus; Sulistiawati, Sulistiawati
JUKEJ : Jurnal Kesehatan Jompa Vol 5 No 1 (2026): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol5.Iss1.2447

Abstract

Pneumonia merupakan salah satu penyebab utama morbiditas dan mortalitas pada balita di Indonesia, dengan angka kematian mencapai 19.000 kasus pada tahun 2018. Penelitian ini bertujuan untuk menganalisis hubungan antara kelengkapan imunisasi dasar dengan kejadian pneumonia pada balita melalui studi literatur. Penelusuran dilakukan pada Google Scholar, DOAJ, dan ResearchGate, dengan kriteria artikel yang diterbitkan tahun 2020-2025. Sebanyak 10 artikel yang memenuhi kriteria dianalisis secara deskriptif naratif untuk mengidentifikasi pola hubungan antara imunisasi dasar lengkap dan risiko pneumonia. Hasil kajian menunjukkan bahwa balita dengan imunisasi dasar tidak lengkap memiliki risiko lebih tinggi mengalami pneumonia dibandingkan balita yang telah menerima imunisasi lengkap, khususnya melalui vaksin DPT, Hib, dan Campak. Efektivitas imunisasi dipengaruhi oleh faktor tambahan seperti status gizi, pemberian vitamin A, pemberian ASI eksklusif, dan kondisi lingkungan rumah. Temuan ini menegaskan pentingnya strategi pencegahan pneumonia yang bersifat komprehensif, mengintegrasikan pemberian imunisasi lengkap, perbaikan gizi, promosi ASI eksklusif, serta peningkatan kualitas lingkungan. Secara praktis, hasil penelitian dapat menjadi acuan dalam pengembangan program intervensi yang melibatkan keluarga, tenaga kesehatan, dan masyarakat untuk menurunkan kejadian pneumonia pada balita secara efektif..
Co-Authors A’yuni, Zera Qurrota Adnyana , I Made Dwi Mertha Aflahudin, M. Ahda Naufal Agung Dwi Wahyu Widodo Ahmad Suryawan Akbar Panjinegara, Muhammad Alfi Layali Muntaza Anang Endaryanto Andi Airina Binti A Agus Annisa Fira Salsabila Arguni, Egi Ari Prayitno Ari Prayitno, Ari Arien Dwi Ajeng Adhe Safitri Arina Setyaningtyas Aris Wiji Utami Aryati Aryati Aryati Aryati Atika Atika Atika Atika Atika Bangkit Putrawan Bastiana Bermawi Basuki, Setio Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Bulqis Inas Sakinah Candra Maulana Catarina Rani Cissy B Kartasasmita Cissy B. Kartasasmita Cita Rosita Sigit Prakoeswa Darto Saharso Dessy Putri Pratiwi Destasari Tri Hartanti Desy Primayani Djoko Marsudi Dwi Prasetyo Dwi Prasetyo Dwiyanti Puspitasari, Dwiyanti Edward Adijaya Rusli Egi Arguni Endyka Erye Frety Erna Supatmini Erni Rosita Dewi Esti Yunitasari Estin Puspaningrum Eveline Irawan Fadilla, Aulia Nur Febtarini Rahmawati Ferdinandus, Euvanggelia Dwilda Fitri Ramadhani Fitriah Fitriah Fitriah, Muhammad Yasin Flora Ramona Sigit Prakoeswa Gatot Irawan Sarosa Gatot Irawan Sarosa, Gatot Irawan Gunadi Ranu, I Gusti Made Reza Hanifah Oswari Hanifah Oswari Hanna Dyahferi Anomsari Haq, Arini Hardyanto Soebono Hari Basuki Notobroto Hartono Gunardi Hartono Gunardi Hasan, Nur Aini Hendrata, Adi Pramono Hilwana, Lutifta I Dewa Gede Ugrasena I Gusti Ngurah Twi Adnyana Ida Safitri Laksanawati Ilya Krisnana, Ilya Irawan, Eveline Irawan, Eveline Irene Ratridewi Irwanto Irwanto, Irwanto Ismoedijanto Isnin Anang Marhana Jihan Kalishah Johanis Johanis Juniastuti Juniastuti Juniastuti Juniastuti Jusak Nugraha Kartina, Leny Kevin Sastra Dhinata Khen Mikhael Kristina Marbun Kristoforus Samson Kusnandi Rusmil Kusnandi Rusmil Laili Primasari Laksmi Wulandari Lilik Djuari Linda Dewanti M. Y. Probohoesodo M. Yulianto Listiawan M.Y. Probohoesodo Maddepunggeng, Martira Martira Maddepunggeng Ma`ruf, Anwar Mei Neni Sitaremi Mei Neni Sitaresmi Mufidah Binti Eka Muhammad Akbar Panjinegara Muhammad Miftahussurur Muhammad Vitanata Arfijanto, Muhammad Vitanata Muntia Rizki Alzahra Mustikasari, Rahma Ira MUTHMAINNAH Muthmainnah Muthmainnah Muziburrahman Muziburrahman Nastiti Kaswandani Natalia Yuwono Nihar, Mahdiyyah Husna Nike Aprilidia Nugraheny, Risca Ayu Parwati S. Basuki Parwati Setiono Basuki Pasulu, Soraya Salle Polanunu, Masayu Ramadhani Praswitasari, Rengganis Prodjosoewojo, Susantina Pudji Lestari Raihan Raihan Raihan Raihan, Raihan Rania, Najwa Miftah Ratni Indrawanti Reka Elvia Dirda Prasasta Renaldy, Raden Bagus Yanuar Retno Asih Setyoningrum Retno Palupi Retnosari Widowati Risa Etika, Risa Rossyanti, Lynda Rusli, Musofa Sabrina, Haifa Rafiqa Sakinah, Bulqis Inas Salma Asri, Hanifa Irfani Salma, Zukhaila Samson, Kristoforus Santi Martini Sari, Arabella Vonia Sari, Marlita Mustika Sarjana, IWayan Savitri Laksmi Winaputri Sesilia Serly Kebo Setiawati, Yunias Setyo Handryastuti Soedjatmiko Soedjatmiko Soedjatmiko Soegianto, Sugi Deny Pranoto Soegianto, Sugi Deny Pranoto Sofia Alfarizi Sopha, May Ira Sri Rejeki H Hadinegoro. Sri Rezeki S. Hadinegoro, Sri Rezeki S. Sri Umijati Sri Utami Sriwijayanti Sulistyawati Suhintam Pusarawati Sukmawati Basuki Sulistiawati Sulistiawati Sulistiawati Sumaryono Sumaryono Sunari, I Gusti Agung Ayu Eka Putri Supiatun.M, Lilis Sri Susanti Susanti Susanto Nugroho Sutjonong, Tioky Theresia Indah Budhy Sulisetyawati Thiono, Marischa Tita Wafirotul Rizqi Hasanah Widodo Darmowandowo Woro Setia Ningtyas Yuli Astika Yulia Nadar Indrasari Yulida Mufidah Zakiudin Munasir Zakiudin Munasir