Claim Missing Document
Check
Articles

Found 37 Documents
Search

ANALISIS FAKTOR-FAKTOR YANG MENGHAMBAT KAJI ETIK PROTOKOL PENELITIAN: STUDI PADA KOMITE ETIK PENELITIAN FAKULTAS KEDOKTERAN UNIVERSITAS SEBELAS MARET, SURAKARTA Susilawati, Tri Nugraha; Putri, Noviyati Rahardjo; Ardhi, Tunggul
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 3 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i3.2084

Abstract

Ethics review is essential prior to conducting research involving humans and animals. This study aimed to evaluate the effectiveness of ethics review procedures and identify the causes of delayed ethical approval of the protocols submitted to Research Ethics Committee of the Faculty of Medicine, Universitas Sebelas Maret during 2022-2023. Retrospective data collected include protocol identity number, institution and educational level of the proposer, research type, date of protocol submission, completion of initial ethics review, and issuance of the ethical clearance certificate. A total of 458 protocols were received over 2 years period but the processing of 8 protocols were discontinued so that those 8 protocols were excluded from further analysis. Of the 450 protocols analysed, most involved human subjects (331; 73.6%). The majority of proposers were from UNS (309; 68.7%), were students (353; 78.4%), and had undergraduate education (166; 36.9%). The duration of the initial ethics review was generally <2 weeks (90.4%). Most (92.7%) protocols needed revision. The majority (66.4%) of proposers needed <2 weeks to revise the protocol. The total time for the entire ethics review process was 22.9 ± 14 days. Further evaluation found that the average duration needed for protocol revision was longer than that for reviewing (16 vs 9 days). It can be concluded that the ethics review process ran effectively so that almost all protocols submitted could undergo initial reviews in a relatively short time. The delayed ethical approval was due to the slow protocol revision process by the proposers.
DURASI MENDERITA DM MEMENGARUHI KONTROL GLIKEMIK JANGKA PANJANG YANG DIUKUR MELALUI HbA1c PADA PASIEN DIABETES MELITUS TIPE 2 Nurgajayanti, Cendi; Susilawati, Tri Nugraha; Wiboworini, Budiyanti
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 3 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i3.2085

Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to abnormalities in insulin secretion or action. In West Java, the prevalence of DM reached 1.9%, with a significant increase in Tasikmalaya City, which recorded 7,436 cases in 2022. This study aimed to explore the relationship between individual characteristics, nutritional status, comorbidities, and duration of DM with HbA1c levels in type 2 diabetes patients at one of the private hospitals in Tasikmalaya City.This study evaluated medical records of 210 patients with type 2 DM. The Spearman's rank correlation test was used to analyse the relationships between variables and a p<0.05 was considered as statistically significant. The research design used is cross sectional with purposive sampling technique.The result showed there was a statistically significant relationship between the duration of illness and HbA1c levels (p = 0.001 and r = 0,072). However, the relationship  between nutritional status or comorbidities and HbA1c levels were not statistically significant (p = 0.471 and 0.187, respectively), indicating no relationship between nutritional status and HbA1c levels. The study concluded there was no significant relationship between nutritional status and comorbidities with HbA1c levels. Namun, ada hubungan antara durasi penyakit dengan kadar HbA1c
VITILIGO SEGMENTAL PADA ANAK YANG DITERAPI DENGAN REGIMEN MOMETASONE FUROATE 0,1%, SOLANUM LYCOPERSICUM L 3%, DAN CERAMIDE (MSC) Suhartono, Suhartono; Ridha Setiawati; Rahmat Sugianto; Radityastuti; Armita Asri Apsari; Tri Nugraha Susilawati
Media Dermato-Venereologica Indonesiana Vol 52 No 1 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i1.517

Abstract

Pendahuluan: Vitiligo adalah penyakit depigmentasi (hipomelanosis) didapat pada kulit, membran mukosa, dan rambut yang berbatas tegas, disebabkan oleh hilangnya melanosit secara progresif. Vitiligo biasanya muncul pertama kali saat masa anak-anak atau dewasa muda. Kasus: Seorang anak perempuan berusia 21 bulan 3 minggu timbul bercak putih di pantat sejak usia 5 bulan. Pemeriksaan fisik ditemukan makula depigmentasi, simetris, berbatas tegas, bentuk menyerupai popok ukuran ± 15 cm x 16 cm. Pemeriksaan dengan lampu Wood didapatkan makula berwarna putih seperti kapur dan berbatas tegas. Terapi yang diberikan adalah regimen MSC selama 5 bulan yang terdiri dari mometasone furoate 0,1%, Solanum lycopersicum L 3 % dan ceramide. Diskusi: Faktor- faktor yang berperan dalam proses terjadinya vitiligo antara lain genetik, autoimun, stress oksidatif dan pajanan bahan kimia. Sel T CD8+ berperan penting dalam proses terjadinya vitiligo dengan cara menyerang melanosit dan menghancurkannya. Peningkatan Reactive Oxygen Species (ROS) dapat menyebabkan kerusakan pada melanosit. Pasien ini diberikan steroid topikal mometason furoate 0,1% sebagai terapi lini pertama, dikombinasikan dengan antioksidan dari Solanum lycopersicum L 3% untuk mengurangi kerusakan melanosit akibat ROS, dan ceramide diberikan untuk memperbaiki sawar kulit sehingga progres perjalanan penyakit tidak menjadi lebih buruk. Kesimpulan: Regimen MSC efektif untuk mengobati vitiligo luas pada kasus ini dan dapat ditoleransi dengan baik tanpa menimbulkan efek samping. 
Aplikasi Antimicrobial Susceptibility Test (AST) dalam Mendeteksi Carbapenem-Resistant Enterobacteriaceae (CRE): Sebuah Tinjauan Sistematis Yasmin, Thania; Mashuri, Yusuf Ari; Maryani, Maryani; Susilawati, Tri Nugraha
Majalah Kedokteran Indonesia Vol 73 No 3 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.3-2023-991

Abstract

Introduction: Indonesia has the highest prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in Asia. This shows the importance of early detection and treatment of CRE cases. This systematic review presents recent studies on the global pravelence of CRE, the use of antimicrobial susceptibility test (AST) for detecting CRE, and detection methods of carbapenemase-producing CRE (CP-CRE). Method: A systematic review was conducted on English scientific articles published in PubMed, Science Direct, and Scopus from January 2018 to February 2022. Inclusion criteria were studies that performed CRE examination on human samples and the keywords were ‘antimicrobial susceptibility test’ OR ‘microbial sensitivity test’ OR ‘antimicrobial susceptibility breakpoint determination’ AND ‘carbapenem-resistant Enterobactericeae’ OR ‘carbapenemase-producing Enterobacteriaceae’. The study selection was carried out according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA). Result: The literature search and study selection method resulted in a total of 11 articles for data extraction and analysis. The prevalence of CRE was 9.6% in the study that aimed for CRE screening. CRE is detected mostly by Vitek-2® in urine and blood samples showing imipenem and meropenem-resistant bacteria. Conclusion: The prevalence of CRE was high in the CRE case screening study. The most common CRE detection method is Vitek-2® that could be replaced with disk diffusion method in limited resources settings. CRE detection can be followed by the detection of carbapenemase-producing CRE (CP-CRE) by using genotypic, phenotypic, and fluorogenic assays.
Identification of nutrients and phytochemicals of raja banana (Musa acuminata) peels extracted with ethanol and acetone solvents and its potential as an anti-obesity agent Susilawati, Eva; Indarto, Dono; Susilawati, Tri Nugraha
AcTion: Aceh Nutrition Journal Vol 10, No 2 (2025): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i2.2483

Abstract

Banana peel is a waste that has the potential as an anti-obesity agent due to its nutritional and phytochemical content. This study aims to analyze and compare the content of macronutrients, micronutrients, and phytochemical compounds in raja banana peel extracts. The maceration method was performed during the preparation of extracts by using ethanol and acetone solvents. The nutritional and phytochemical contents of the extracts were compared to determine which solvent produced the optimum anti-obesity properties. The ethanol extract consists of water (17,68%), minerals (22,76%), protein (3,50%), carbohydrates (47,98%), and vitamin C (0,82%). The phytochemical content includes flavonoids (73,38 mgQE/g), tannins (0,32%), and chrysin (1,16 mg/L). In conclusion, the ethanol extract of Raja banana peel contains higher nutrients and phytochemicals than the acetone extract, showing greater potential as an anti-obesity agent. Further research is needed to test its bioactivity in vivo or in vitro.
Peningkatan Kesadaran dan Deteksi Dini Kanker Serviks dan Kanker Payudara melalui Edukasi dan Skrining bagi Tenaga Kesehatan dan Masyarakat Budihastuti, Uki Retno; Melinawati, Eriana; Priyanto, Heru; Ratnasari, Affi Angelia; Susilawati, Tri Nugraha; Prastyoningsih, Aris; Septiana, Yesika Cahya; Mufidah, Amatullah
Jurnal Abdidas Vol. 6 No. 4 (2025): Agustus 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdidas.v6i4.1171

Abstract

Kanker serviks dan kanker payudara merupakan dua jenis kanker yang paling umum menyerang wanita di seluruh dunia. Kanker serviks disebabkan oleh infeksi human papillomavirus (HPV), sedangkan kanker payudara disebabkan oleh pertumbuhan sel abnormal pada jaringan payudara. Deteksi dini dan pengobatan yang tepat dapat meningkatkan kemungkinan kesembuhan dan mengurangi angka kematian. Oleh karena itu, edukasi dan deteksi dini kanker serviks dan kanker payudara sangat penting untuk meningkatkan kesadaran dan kesehatan masyarakat. Dalam pengabdian masyarakat ini, kami melakukan edukasi dan deteksi dini kanker serviks dan kanker payudara pada tenaga kesehatan dan masyarakat wanita yang berdomisili di area Solo Raya. Hasilnya menunjukkan bahwa edukasi dan deteksi dini dapat mengingatkan kembali kesadaran dan pengetahuan masyarakat tentang kanker serviks dan kanker payudara, serta meningkatkan kemungkinan deteksi dini dan pengobatan yang tepat.
Associations of Dietary Intake and Sociodemographic Factors with the Incidence of T2DM among Obese Adults Widiasih, Ghina; Indarto, Dono; Susilawati, Tri Nugraha
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6136

Abstract

Type 2 diabetes mellitus (T2DM) is a major public health concern, particularly among obese individuals. Dietary intake, including energy, protein, and fiber consumption plays a key role in metabolic health, with sociodemographic factors influencing its mechanisms. Objective: This study aimed to analyze the associations of these dietary factors and T2DM incidence in obese adults in Surakarta city. This cross-sectional study included 100 obese adults from Surakarta. T2DM status was determined based on their medical records. Dietary intake data were collected using Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ). Sociodemographic data were collected by interview. Multiple binary logistic regression was performed to analyze the association between dietary intake and T2DM with p<0.05. The most participants were female (75.0%) and Javanese (82.0%). Daily fiber intake was significantly associated with a lower risk of T2DM (OR=0.04, 95%CI=0.01–0.14, p<0.001), while ethnicity, educational history, occupation, and monthly personal expenses were identified as significant risk factors (p<0.05). Further analysis, only daily fiber intake (aOR=0.06, 95%CI=0.01–0.29, p<0.001) and occupation (aOR=16.81, 95%CI=3.98–71.08, p<0.001) remained significantly associated with T2DM. Adequate daily fiber intake was the strongest protective factor, while individuals engaged in work were the strongest predictor of T2DM among obese adults in Surakarta city.
ANALYSIS OF SECONDARY METABOLITE LEVELS AND ANTIOXIDANT ACTIVITY OF THE COMBINED EXTRACT OF RAJA BANANA PEEL AND PONTIANAK SWEET ORANGE PEEL Hasibuan, Wahyu Aulia; Wiboworini, Budiyanti; Susilawati, Tri Nugraha
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 2 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i2.2684

Abstract

Ekstrak kulit pisang raja dan ekstrak kulit jeruk manis Pontianak mengandung senyawa bioaktif, seperti flavonoid dan antosianin, yang berpotensi sebagai sumber senyawa bioaktif dengan aktivitas antioksidan. Kombinasi ekstrak kedua bahan ini belum pernah dianalisis sebelumnya. Penelitian ini bertujuan untuk menganalisis kadar total flavonoid, antosianin, aktivitas antioksidan, fenol dan tanin pada ekstrak kombinasi kulit pisang raja dan kulit jeruk manis. Metode penelitian ini menggunakan pendekatan eksperimen, yang dilakukan di Laboratorium Setia Budi pada bulan Juli tahun 2024, dengan menggunakan pelarut etanol 80 % dengan perbandingan 1:10 melalui remaserasi sebanyak lima kali untuk meningkatkan rendemen dan kualitas senyawa yang dihasilkan. Formulasi ekstrak yang digunakan terdiri dari F1 (15:85%), F2 (25:75%), F3 (50:50%), F4 (75:25%). Kadar flavonoid dan tanin dianalisis dengan spektrofotometri, antosianin dengan metode pH diferensial, serta aktivitas antioksidan dan fenol dengan metode DPPH. Hasil penelitian menunjukkan bahwa formula F1 memiliki kadar flavonoid tertinggi (59,53 mgQE/g), F4 menunjukkan aktivitas antioksidan terbaik (91,47% inhibisi), dan F1 mengandung antosianin (361,45 ppm), fenol (1,80%), dan tanin (0,84%) tertinggi. Penambahan kulit jeruk manis meningkatkan kadar antosianin, fenol, dan tanin dalam ekstrak, sedangkan penambahan ekstrak kulit pisang raja meningkatkan aktivitas antioksidan. Penelitian lebih lanjut diperlukan untuk mengeksplorasi senyawa fitokimia lainnya dan potensi kesehatan dari kombinasi ekstrak ini.
Initiation of Gerai Tensi for screening and prevention of non-communicable diseases in the community Susilawati, Tri Nugraha; Billah, Muhammad Muayyad; Syaputri, Dwi; Widyaningrum, Sherly Asri; Kusumastuti, Wijayanti; Buamona, Nur Sitra; Fahmi, Muhammad Izzul Widad; Rauf, Muhammad Abdul; Lutfinayati, Sofia; Cahyaningrum, Nabilla Fitria; Indallah, Nabila Wajihan; Puspitasari, Reni Nur
Journal of Community Empowerment for Health Vol 7, No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.86010

Abstract

Background: The increased incidence of non-communicable diseases (NCDs) necessitates continuous promotional and preventive activities to reduce morbidity and mortality. Since NCDs cannot spread like infectious diseases, they are frequently neglected. In addition, NCDs represent a significant health burden as they can develop chronic consequences and lead to fatalities. The growing burden of NCDs is attributed to increased risk factors, including elevated blood pressure, obesity, body mass index, and blood sugar levels. Furthermore, NCDs can be the primary factor in long-term decreased productivity, leading to detrimental effects on social and economic resources. Some NCDs that are receiving the most attention and have the highest prevalence are hypertension and obesity. This paper aimed to present the prevalence of hypertension and obesity in a village community. Methods: We hosted a Gerai Tensi program as one of the community-based attempts to identify and screen for NCDs. This program was conducted in Dukuh Gowongan RT 003/ RW 002, Pucangan Village, Kartasura District, Sukoharjo Regency, Central Java Province, Indonesia. All the residents aged ≥15 years old were invited to attend Gerai Tensi. The participant's blood pressure, height, weight, and waist circumference were measured. Results: A total of 75 residents of Dukuh Gowongan attended Gerai Tensi. Most participants were female (53.3%), aged 46–55 (24.0%). There were 54.7% (41/75) of participants with hypertension, mainly classified as stage I hypertension (31/75; 41.3%), and 58.7% (44/75) of participants who were obese, mostly grade I obesity (28/75; 37.3%). Conclusion: Hypertension and obesity are prevalent in the community, reaching more than half of the study participants. Coordination with the community health centre and village representatives is required to optimize the promotion and prevention activities, the treatment of diseases, and the sustainability of the Gerai Tensi program.
Integrated assisted post (Posbindu) to lowering high prevalence of hypertension and diabetes mellitus Susilawati, Tri Nugraha; Ismanta, Anestasia Darmastuti; Bernarda, Clarisca Calcafiorentina; Nandyantami, Farah Fauziah; Hilmy, Farhan; Basaria, Kevyn; Nazili, Muhammad Haqin; 'Ulwiyah, Nuuriyah; Zahida, Sarah; Nugraha, Yanika Tiara; Adiby, Zulfi Azam
Journal of Community Empowerment for Health Vol 7, No 3 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.93233

Abstract

Introduction: Non-communicable diseases (NCDs) contribute to 74% of global mortality and are responsible for 73% of national casualties. It had been predicted that in 2024, the number of patients with NCDs in Indonesia will be around 92 million people, and among others, hypertension and diabetes mellitus (DM) are significant health burdens in this country. This paper presents a community service activity aimed at screening for NCDs in Sana Village, Sragen Regency, Central Java Province, Indonesia. Methods: An integrated assisted post (Posbindu)was held for early detection and to monitor the main risk factors of NCDs, particularly hypertension and DM. Fifty working-age adults from the Sana village were targeted to attend the Posbindu. Blood pressure and blood glucose levels were measured, followed by treatment and health counseling by the medical students, Mondokan health center officers, and local midwives. Results: The activity was well appreciated by the local community, with a participation rate of 226% (113 attendees out of 50 people targeted), consisting of 22 men and 91 women aged 22–93 years old. Hypertension and DM were detected in 61.9% (70/113) and 5.3% (6/113) participants. Conclusion: The high prevalence of NCDs, particularly hypertension, highlights the importance of maintaining physical fitness and carrying out health checks regularly. Thus, NCD screening through Posbindu is expected to be sustainable.
Co-Authors 'Ulwiyah, Nuuriyah Adi Magna Patriadi Nuhriawangsa Adiby, Zulfi Azam Adisetya Wicaksono Ainor Rohmah Ardhi, Tunggul Armita Asri Apsari Atik Susianto Basaria, Kevyn Benedictus Aditya Satya Laksana Adji Bernarda, Clarisca Calcafiorentina Bhisma Murti Billah, Muhammad Muayyad Brian wasita Brian Wasita Brian Wasita Buamona, Nur Sitra Budiyanti Wiboworini Cahyaningrum, Nabilla Fitria Cahyanto, Erindra Budi Darmayanti, Aquartuti Tri Defitaria Permatasari Dewi Pratiwi Diana Nurrohima Dono Indarto Eriana Melinawati Erindra Budi Cahyanto Fahmi, Muhammad Izzul Widad Grhasta Dian Perestroika Harioputro, Dhani Redhono Hasibuan, Wahyu Aulia Heru Priyanto Heru Sulastomo Hilmy, Farhan Indallah, Nabila Wajihan Ismanta, Anestasia Darmastuti Jusup, Sinu Andhi Kezia Elian Devina Kusmadewi Eka Damayanti Kusmadewi Eka Damayanti Kusumastuti, Wijayanti Larasati, Riska Leli Saptawati Leli Saptawati Lutfinayati, Sofia Marisa Rizqiana Maryani Maryani Mashuri, Yusuf Ari Mufidah, Amatullah Nandyantami, Farah Fauziah Nazili, Muhammad Haqin Niamuzisilawati, Eva Niniek Purwaningtyas Nofia, Yasinta Nugraha, Yanika Tiara Nurgajayanti, Cendi Prastyoningsih, Aris Pratiwi Pratiwi Wulandari Purwaningtyas, Niniek Puspitasari, Reni Nur Putra, Wahyu Pratama Putri, Noviyati Rahardjo Radityastuti Rahardjo, Setyo Sri Rahmat Sugianto Ramadhan, Ahmad Rizqi Ratna Dwi Restuti Ratna Kusumawati Ratna Kusumawati Ratnasari, Affi Angelia Rauf, Muhammad Abdul Ridha Setiawati Riska Larasati Saputri, Nurul Aini Suria Satria, Yohanes Aditya Adhi Satria, Yohanes Aditya Adhi Septiana, Yesika Cahya Setyo Sri Rahardjo Sigit Setyawan Sinu Andhi Jusup, Sinu Andhi Sri Wulandari Sri Wulandari Sudarmaji, Usman Suhartono Sulastomo, Heru Suselo, Yuliana Heri Susianto, Atik Susilawati, Eva Sutarno Sutarno Syaputri, Dwi Triyanta Yuli Pramana Triyanta Yuli Pramana Uki Retno Budihastuti Usman Sudarmaji Vitri Widyaningsih Widiasih, Ghina Widyaningrum, Sherly Asri Wijiwinarsih, Amallia Winda Rahayuningtyas Winda Rizki Pebrina Batubara Yasmin, Thania Zahida, Sarah