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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Tropical and Infectious Disease Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal PAEDAGOGIA Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) AcTion: Aceh Nutrition Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Community Empowerment for Health Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas Indonesian Journal of Global Health research JURNAL ETIKA KEDOKTERAN INDONESIA Nusantara Science and Technology Proceedings Jurnal Pengabdian Masyarakat Sasambo Proceedings of the International Conference on Nursing and Health Sciences Jurnal Sehat Indonesia (JUSINDO) Proceeding Muhammadiyah International Public Health and Medicine Conference The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Smart Society Empowerment Journal Media Dermato-Venereologica Indonesiana Media Penelitian dan Pengembangan Kesehatan Journal of Midwifery in Community Jurnal Epidemiologi Kesehatan Indonesia
Tri Nugraha Susilawati
Department Of Microbiology, Faculty Of Medicine, Sebelas Maret University, Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Characteristics of patients with Hepatitis B and C at Dr. Moewardi General Hospital in Surakarta, Indonesia Benedictus Aditya Satya Laksana Adji; Triyanta Yuli Pramana; Tri Nugraha Susilawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 54, No 3 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005403202207

Abstract

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain a significant health burden in the world, which is mainly attributed to patients who develop chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). The epidemiology of hepatitis B and C in Surakarta, Central Java Province, Indonesia has never been reported. This study aimed to investigate the demographic, clinical, and laboratory characteristics of patients with hepatitis B and C who were admitted to Dr. Moewardi General Hospital, Surakarta in 2019. The medical records of patients with hepatitis B (n=94) and hepatitis C (n=75) were examined, and the data were analyzed using the chi-square and Mann-Whitney tests. The patients with hepatitis C were generally older, more likely to develop jaundice and ascites, and had higher levels of serum urea, creatinine, AST, and total bilirubin compared to those with hepatitis B. In conclusion, patients with HCV infection had worse clinical presentation and laboratory profiles than those with HBV infection. However, further research is needed on a wider scale to confirm this result.
The Levels of Inhibitory Cytokines in the Serum of Patients with Hepatitis B and C Ainor Rohmah; Sigit Setyawan; Tri Nugraha Susilawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 3 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i3.1678

Abstract

Hepatitis B and C Viruses (HBV dan HCV) can cause acute or chronic hepatitis that may develop into fibrosis, cirrhosis, and hepatocarcinoma. Previous studies have reported that hepatocyte damage is mainly due to overactive immune responses rather than viral infection. Cytokines are essential mediators in the immune response. This study aimed to determine the correlation between the levels of serum inhibitory cytokines, i.e., IL-4, IL-10, and TGF-β, and the development of liver disease in patients with hepatitis B and C. The levels of serum IL-4, IL-10, and TGF-β from 58 patients with hepatitis B or hepatitis C were determined by ELISA. The progression of liver disease is inferred from the levels of serum transaminases and the degree of liver fibrosis. Data were analyzed using the Spearman correlation test with a p-value of < 0.05 is considered statistically significant. This study showed no correlation between the levels of serum IL-4, IL-10, and TGF-β and the development of liver disease in patients with hepatitis B and C (p > 0.05). Therefore, cytokine testing using ELISA was unable to replace liver biopsy to assess liver disease progression in patients with hepatitis B and C.
Development of the Obesity Nutraceutical from Raja and Kepok Banana Peels Kezia Elian Devina; Dono Indarto; Tri Nugraha Susilawati
Proceedings of the International Conference on Nursing and Health Sciences Vol 4 No 1 (2023): January-June 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v4i1.1817

Abstract

Patients with obesity often fail to control their body weight through diet and physical activity, while the existing anti-obesity drugs have some side effects for long-term use. Banana is Indonesia's tropical fruits with the highest production, and the banana peel has become soil waste. This study aimed to analyze nutrients and active compounds of methanol extracts of raja and kepok banana peels (ERP and EKP respectively). Macro and micro-nutrient compositions of the ERP and EKP were determined using the proximate analysis, while Thin Layer Chromatography (TLC) was used to detect the ERP and EKP active compounds. The ERP contained 0.11% crude fibers, 4.44% fat, and 58.08% carbohydrates, different from the EKP (4.25% protein, 20.95% water, and 14.45% minerals). By contrast, both the ERP and EKP contained flavonoids, phenols, tannins, alkaloids, and saponins. In conclusion, ERP is potentially developed as a nutraceutical for obesity treatment in the future. Further study is needed to measure specific fat levels and to analyze specific active compounds in the ERP which can modulate gene expression and interact with protein targets in lipid metabolism.
Nutritional Analysis of Sweet Orange Peel Extract for Development of Obesity Treatment Winda Rizki Pebrina Batubara; Tri Nugraha Susilawati; Dono Indarto
Proceedings of the International Conference on Nursing and Health Sciences Vol 4 No 1 (2023): January-June 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v4i1.1820

Abstract

Obesity is a complex chronic disease that becomes the main factor of cardiometabolic diseases such as heart diseases, stroke and diabetes mellitus. Oxidative stress is involved in the obesity pathogenesis. Diet and physical exercise are recommended for obesity treatment but many obese people have low compliance to these treatments. Sweet orange (Citrus sinensis L.) is an Indonesian fruit with high production per year. This fruit pulp contains high vitamin C level, which is widely used as a strong anti oxidant to inhibit oxidative stress. However, sweet orange peel is just thrown in the soil and becomes rubbish. Therefore, the aim of this study was to analyze nutritional contents of sweet orange peel extract (OPE). Fresh orange peels were obtained from a local market at the Surakarta city and the dried orange peels were extracted using ethanol solvent. Carbohydrate, protein, and fat levels were determined using the existing method at the Food Technology Laboratory while vitamin C and Magnesium (Mg) levels were determined using the spectrophotometric and SSA-flame methods respectively. 100g OPE contained 68.88% carbohydrate, 3.23% protein, 3.41% fat, 1556.6 mg vitamin C and 239.74 mg Mg. In conclusion, the OPE is a good source of vitamin C and Mg, which can be developed as a nutraceutical for obesity treatment. Further investigation is required to determine active compounds in the OPE, which enhances the beneficial effects of vitamin C and Mg.
Genital Tract Infection during Pregnancy and its Association with Preterm Delivery Susilawati, Tri Nugraha; Satria, Yohanes Aditya Adhi
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.11460

Abstract

Genital tract infection (GTI) remains a significant health concern. It is estimated that in 2016, there were 370 million people who suffer from chlamydia, gonorrhea, and trichomoniasis; and 708 million others suffer from genital herpes and condyloma acuminatum. It has been reported that in pregnant women, GTI is associated with preterm delivery. The mechanisms of GTI-associated preterm delivery need to be further understood to prevent neonatal mortality and morbidity that could be the risk factor for neonates' growth and development disorders. This article aims to describe various types of GTI and the associated pathogenesis causing preterm birth. A literature search was conducted to retrieve recent articles published in English from online databases including Pubmed, ScienceDirect, and Google Scholar. This literature study found that GTI evokes inflammatory responses that trigger several mechanisms leading to preterm delivery. The inflammatory responses in GTI include the production of proinflammatory cytokines and robust activation of neutrophils. The key mechanisms that stimulate preterm delivery in GTI include the events of early uterine contraction, preterm premature rupture of membranes, and induction of cervical ripening; which are under normal circumstances in a full-term pregnancy, those mechanisms are regulated by progesterone and prostaglandin levels along with suppression of the inflammatory responses. In conclusion, this paper has described the underlying mechanisms of preterm delivery in pregnant women with ISG. However, such mechanisms remain unclear in candida and gonococcal infection; thus, prompting the need for further studies. 
EFFECT OF RED BEANS AND BLACK BEANS WITH A DIABETES MELLITUS: A SYSTEMATIC REVIEW Pratiwi; Adi Magna Patriadi Nuhriawangsa; Tri Nugraha Susilawati
Muhammadiyah International Public Health and Medicine Proceeding Vol. 3 No. 1 (2023): PROCEEDING MUHAMMADIYAH INTERNATIONAL PUBLIC HEALTH AND MEDICINE CONFERENCE - T
Publisher : Fakultas Kesehatan Masyarakat Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61811/miphmp.v3i1.411

Abstract

Diabetes mellitus is a chronic metabolic disease that requires dietary management. One of the diet strategies is a high consumption of antioxidants and fiber contained in red beans and black beans. The purpose of this article is to prove that red beans and black beans can treat diabetes mellitus. The method is a systematic review using the PRISMA protocol and JBI's Critical Appraisal Tools. The source of the article is experimental studies published in the last 10 years (2013-2023) in Google Scholar, Pubmed, and Science Direct databases. The results showed that red beans and black beans are rich in antioxidants and fiber. Antioxidants and fiber are known to reduce blood glucose levels and increase insulin levels. The conclusion of this article is red beans and black beans can treat diabetes mellitus. The suggestion of this review is that better to increase the daily dose of red beans and black beans consumption to treat diabetes.
The Relationship Between Education, Occupation, and Nutritional Status with Fasting Blood Glucose Levels in Type II Diabetes Mellitus Patients at Jasa Kartini Hospital Tasikmalaya City in 2023 Nurgajayanti, Cendi; Susilawati, Tri Nugraha; Wiboworini, Budiyanti
Nusantara Science and Technology Proceedings The 1st International Conference of Health Institut Kesehatan Mitra Bunda 2024
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4309

Abstract

The World Health Organization states that diabetes mellitus is caused by several contributing factors including age, gender, education, lifestyle, physical activity, obesity, and family history. This study aims to investigate the relationship between education, occupation, and nutritional status, with fasting blood glucose levels in type 2 diabetes mellitus patients at the outpatient department of Jasa Kartini Hospital in Tasikmalaya City in 2023. An analytical observational study with a cross-sectional design was conducted using secondary data from medical records of 210 samples of diabetes mellitus patients from January to December 2023. Simultaneous assessments were made for each variable, namely education, occupation, nutritional status, and fasting blood glucose levels. The analysis results indicate that the relationship between education and fasting blood glucose levels yielded a p-value of 0.032, while the relationship between occupation and fasting blood glucose levels yielded a p-value of 0.029. However, the relationship between nutritional status and fasting blood glucose levels resulted in a p-value of 0.450. There is a relationship between education and fasting blood glucose levels, there is a relationship between occupation and fasting blood glucose levels, and there is no relationship between nutritional status and fasting blood glucose levels.
The effects of raja banana (Musa acuminata) peel extract on body weight, body mass index, body fat percentage, and visceral fat mass in male rats with obesity Devina, Kezia Elian; Indarto, Dono; Susilawati, Tri Nugraha; Wiboworini, Budiyanti
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 2, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(2).115-125

Abstract

Background: Obesity is a risk factor for metabolic syndrome which can increase mortality. Obese sufferers often fail to lose body weight (BW) through non-pharmacological therapy. Obesity synthetic drugs can cause side effects, so natural ingredients are needed as alternative therapies.Objectives: This study aims to determine the effect of raja banana peel extract (RBPE) on BW, body mass index (BMI), body fat percentage (BFP), and visceral fat mass in obese male rats.Methods: The research subjects were 30 male Wistar rats weighing 125-200 g, aged eight weeks. Obesity was induced by being given high-fat high fructose (HFHFr) feed for 28 days. Rats were randomized and divided into five groups: the negative control group (C-) was given standard feed and distilled water, the positive control (C+) was given standard feed and orlistat, treatment 1 (T1), treatment 2 (T2), and treatment 3 (T3). Which were given standard feed and RBPE doses of 200 mg/kgBW/day, 400 mg/kgBW/day, and 800 mg/kgBW/day. Data before and after the induction of obesity were analyzed using paired t-tests. BW, BMI, and visceral fat mass were analyzed using the One-Way Analysis of Variance (ANOVA) and Repeated Measure ANOVA tests. BFP was analyzed using the Kruskal-Wallis test and the Friedman test.Results: RBPE can significantly reduce BW (p=0.026), BMI (p<0.001), and BFP (p<0.001). However, all groups had no significant difference in visceral fat mass (p=0.187). T3 was the group with the lowest average BW, BMI, BFP, and visceral fat mass although the highest weight loss during the intervention period occurred in C+.Conclusions: RBPE has the potential as an alternative therapy for obesity because it can reduce BW, BMI, and BFP. Future studies can investigate the effect of RBPE on other obesity parameters such as lipid profiles.
Elevated Growol Flour Reduce Fasting Blood Glucose, HOMA-IR and Increase Insulin Level in Rat Model with Type 2 Diabetes Mellitus Nofia, Yasinta; Wasita, Brian; Susilawati, Tri Nugraha
Media Gizi Indonesia Vol. 17 No. 2 (2022): JURNAL MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v17i2.151-158

Abstract

The rise of glucose levels in the blood of patients with type-2 diabetes mellitus (T2DM) is attributed to the decrease of insulin secretion and the interruption of insulin activity. Growol is a fermented product made from cassava that has the potential to lower blood glucose levels in patients with T2DM. This study was aimed to evaluate the effects of oral administration of growol flour on the levels of blood glucose, insulin, and HOMA-IR. A total of 40 male Wistar rats were divided into 5 groups i.e., negative control group, positive control group taking metformin, and 3 treatment groups taking growol flour of 3.1, 6.2, and 9.3 (g/200gBW), respectively, for 2 weeks. Blood glucose levels were measured using Enzymatic Photometric Method GOD-PAP, insulin using the ELISA kit, and HOMA-IR using the formula. The Shapiro Wilk test was used to determine the normality of the data followed by the One-Way ANOVA test and Posthoc Tukey HSD test. The Paired T-test was used to see the difference of pre- and post-treatment levels of blood glucose, insulin, and HOMA-IR. There was a decrease (p<0.05) in blood glucose levels and HOMA-IR after the administration of low, moderate, and high doses of growol flour. In contrast, the levels of insulin increased (p<0.05) after the administration of low, moderate, and high doses. In conclusion, growol flour contributes to the maintenance of T2DM by lowering the levels of fasting blood glucose levels, as well as HOMA-IR, and increasing the levels of insulin in rats.
KOMBINASI KACANG MERAH DAN KULIT KACANG HITAM PADA TIKUS WISTAR MODEL DIABETES MELITUS TIPE 2 Wulandari, Pratiwi; Nuhriawangsa, Adi Magna Patriadi; Susilawati, Tri Nugraha
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 1 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i1.1846

Abstract

Type 2 Diabetes Mellitus (T2DM) is a metabolic disease that require pharmacological and non-pharmacological therapies. Comsuming functional foods that are high in antioxidants and fiber such as red beans and black beans beneficial to patients with T2DM. The study aimed to examine the effect of the combination of red beans (Phaseolus vulgaris L.) flour and black beans (Phaseolus vulgaris) coat extract on body weight, blood glucose, insulin level and pancreatic tissue of T2DM model rats. This randomized controlled trial involved 36 male Wistar rats divided into 6 groups consisted of non-diabetic rats (Group I) and nicotinamide-streptozotocin induced diabetic rats (Group II-VI). Group II was negative control; Group III-V were given a combination with the proportion of flavonoid/ fiber in each kgBW as follows: 22.5 mg/0.25 g; 45 mg/0.5 g; and 90 mg/1 g. Group VI was the positive control. Data on body weight, fasting blood glucose levels and insulin levels were analyzed using Two-Way Anova, while pancreatic histopathology scoring data used Kruskal-Wallis.There was a significant difference between the dose and duration of intervention on body weight, fasting blood glucose and insulin levels (p=0.001). The intervention groups showed there were no pancreatic histopathology change as good as the positive control (p>0.05). The combination of flavonoids and fiber at a dose of 45 mg/0.5 g per kgBW was proven to gain weight, reduce fasting blood glucose levels, increase insulin levels and no pancreatic histopathology change in T2DM rats models as well as the postive control group.
Co-Authors 'Ulwiyah, Nuuriyah Adi Magna Patriadi Nuhriawangsa Adiby, Zulfi Azam Adisetya Wicaksono Ainor Rohmah Ardhi, Tunggul Armita Asri Apsari Atik Susianto Basaria, Kevyn Benedictus Aditya Satya Laksana Adji Bernarda, Clarisca Calcafiorentina Bhisma Murti Billah, Muhammad Muayyad Brian wasita Brian Wasita Brian Wasita Buamona, Nur Sitra Budiyanti Wiboworini Cahyaningrum, Nabilla Fitria Cahyanto, Erindra Budi Darmayanti, Aquartuti Tri Defitaria Permatasari Dewi Pratiwi Diana Nurrohima Dono Indarto Eriana Melinawati Erindra Budi Cahyanto Fahmi, Muhammad Izzul Widad Grhasta Dian Perestroika Harioputro, Dhani Redhono Hasibuan, Wahyu Aulia Heru Priyanto Heru Sulastomo Hilmy, Farhan Indallah, Nabila Wajihan Ismanta, Anestasia Darmastuti Jusup, Sinu Andhi Kezia Elian Devina Kusmadewi Eka Damayanti Kusmadewi Eka Damayanti Kusumastuti, Wijayanti Larasati, Riska Leli Saptawati Leli Saptawati Lutfinayati, Sofia Marisa Rizqiana Maryani Maryani Mashuri, Yusuf Ari Mufidah, Amatullah Nandyantami, Farah Fauziah Nazili, Muhammad Haqin Niamuzisilawati, Eva Niniek Purwaningtyas Nofia, Yasinta Nugraha, Yanika Tiara Nurgajayanti, Cendi Prastyoningsih, Aris Pratiwi Pratiwi Wulandari Purwaningtyas, Niniek Puspitasari, Reni Nur Putra, Wahyu Pratama Putri, Noviyati Rahardjo Radityastuti Rahardjo, Setyo Sri Rahmat Sugianto Ramadhan, Ahmad Rizqi Ratna Dwi Restuti Ratna Kusumawati Ratna Kusumawati Ratnasari, Affi Angelia Rauf, Muhammad Abdul Ridha Setiawati Riska Larasati Saputri, Nurul Aini Suria Satria, Yohanes Aditya Adhi Satria, Yohanes Aditya Adhi Septiana, Yesika Cahya Setyo Sri Rahardjo Sigit Setyawan Sinu Andhi Jusup, Sinu Andhi Sri Wulandari Sri Wulandari Sudarmaji, Usman Suhartono Sulastomo, Heru Suselo, Yuliana Heri Susianto, Atik Susilawati, Eva Sutarno Sutarno Syaputri, Dwi Triyanta Yuli Pramana Triyanta Yuli Pramana Uki Retno Budihastuti Usman Sudarmaji Vitri Widyaningsih Widiasih, Ghina Widyaningrum, Sherly Asri Wijiwinarsih, Amallia Winda Rahayuningtyas Winda Rizki Pebrina Batubara Yasmin, Thania Zahida, Sarah