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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Tropical and Infectious Disease Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal PAEDAGOGIA Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) AcTion: Aceh Nutrition Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Indonesian Journal of Medicine Journal of Maternal and Child Health Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Community Empowerment for Health Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas Indonesian Journal of Global Health research JURNAL ETIKA KEDOKTERAN INDONESIA Nusantara Science and Technology Proceedings Jurnal Pengabdian Masyarakat Sasambo Proceedings of the International Conference on Nursing and Health Sciences Proceeding Muhammadiyah International Public Health and Medicine Conference The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Smart Society Empowerment Journal Media Dermato-Venereologica Indonesiana Media Penelitian dan Pengembangan Kesehatan Jurnal Epidemiologi Kesehatan Indonesia
Tri Nugraha Susilawati
Department Of Microbiology, Faculty Of Medicine, Sebelas Maret University, Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The Prevalence of T Cells Population in the Liver of Patients with Viral Hepatitis Tri Nugraha Susilawati; Triyanta Yuli Pramana; Brian wasita
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 1 (2020): VOLUME 21, NUMBER 1, April 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.418 KB) | DOI: 10.24871/211202033-37

Abstract

Background: It has been widely known that viral hepatitis is a major cause of liver disease that can cause chronic inflammation and carcinoma. This study aimed to describe the frequencies of CD4+ and CD8+ T cells, as well as regulatory T cells (CD25+ and Foxp3+ T cells) in the liver of patients with viral hepatitis in order to understand the comprehensive role of T lymphocytes in the progression of liver diseases attributed to viral hepatitis.Method: Liver biopsies were performed on adult patients presenting to a tertiary hospital in Surakarta, Indonesia with viral hepatitis from 2017 to 2018. Immunohistochemical staining was performed to identify cells expressing CD4+, CD8+, CD25+and Foxp3+ which represent T helper, T cytotoxic, and T regulatory cells, respectively. Additional data were retrieved from the patients’ medical records, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, viral load, and results of ultrasonography and fibroscan.Results: A total of 25 liver samples were collected from patients with chronic HBV infection (n = 21), chronic HCV infection (n = 2), acute HBV infection (n = 1), and from a with multiple liver nodules. The liver injury is minimum in all patients. The study found that CD8+ and CD4+ T cells were predominant whilst the frequency of T regulatory cells is generally low.Conclusions: The findings indicate the involvement of intrahepatic T helper and T cytotoxic in the pathogenesis of viral hepatitis. These liver infiltrating T cell subsets may be readily differentiated into regulatory T cells expressing CD25+ and Foxp3+ in order to prevent severe inflammation and maintain disease chronicity.
Proinflammatory Cytokines and Its Correlation with Liver Injury Tri Nugraha Susilawati; Winda Rahayuningtyas; Triyanta Yuli Pramana
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 3 (2021): VOLUME 22, NUMBER 3, December 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6094.133 KB) | DOI: 10.24871/2232021210-216

Abstract

Background: A persistent infection of hepatitis B virus (HBV) can cause liver cirrhosis and hepatocarcinoma even though the virus itself is non-cytopathic and does not cause cell injury. It has been asserted that liver injury in chronic HBV infection is attributed to the host immune system responding to HBV infection. Cytokines have a critical role in mediating immune responses to viral infection. This study aimed to determine the correlation between the levels of serum IFN-γ, IL-2, IL-17, and TNF- α with the progress of chronic HBV infection that was determined through provisional diagnosis, patient’s age, and the levels of serum transaminases.Method: Blood samples were collected from patients with chronic hepatitis B and the levels of serum IFN-γ, IL-2, IL-17, and TNF-α were measured by using ELISA. The correlation between each cytokine levels and the provisional diagnosis, patient’s age, and serum transaminases were analyzed by using the Spearman correlation test with a p value of 0.05 is considered as statistically significant.Results: A total of 47 samples were collected from patients with chronic hepatitis B (n=38), chronic hepatitis B with liver cirrhosis (n = 6), and chronic hepatitis B with hepatocellular carcinoma (nc = 3). A significant correlation was found between the levels of serum IFN-γ and aspartate aminotransferase (AST) (p = 0.04).Conclusion: The increase of serum IFN-γ and AST levels may highlight the importance of these particular cytokine and liver transaminase in the immune response to chronic HBV infection since IFN-γ is capable to induce apoptotic cell death which promotes AST release and facilitates liver injury.
PEMBERDAYAAN KLUB PERSATUAN DIABETES INDONESIA (PERSADIA) DALAM UPAYA PENCEGAHAN KOMPLIKASI KARDIOVASKULER PADA PENDERITA DIABETES MELLITUS Setyo Sri Rahardjo; Sinu Andhi Jusup; Dono Indarto; Sri Wulandari; Niniek Purwaningtyas; Tri Nugraha Susilawati
Jurnal Pengabdian Masyarakat Sasambo Vol 4, No 1 (2022): November
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jpms.v4i1.931

Abstract

Diabetes mellitus (DM) merupakan penyakit tidak menular (PTM) dengan prevalensi yang cukup tinggi di Kabupaten Karanganyar, Jawa Tengah. Pengendalian gula darah merupakan faktor utama untuk mencegah berbagai komplikasi penyakit DM. Tujuan dari pengabdian masyarakat ini adalah mengaktifkan gerakan masyarakat hidup sehat (Germas) dalam upaya pencegahan komplikasi kardiovaskuler pada penderita DM. Sasaran kegiatan ini adalah masyarakat yang tergabung dalam klub Persatuan Diabetes Indonesia (Persadia) Perumnas Palur, Kecamatan Jaten, Kabupaten Karanganyar, Jawa Tengah dimana kegiatan senam diabetes yang rutin diselenggarakan oleh klub tersebut sempat vakum dikarenakan pandemi Covid-19. Kegiatan pengabdian masyarakat berlangsung pada tanggal 7 Juni 2022 dan diikuti oleh 32 anggota klub. Metode pengabdian adalah edukasi, pelatihan, serta pemeriksaan tekanan darah dan gula darah sewaktu (GDS). Hasil dari kegiatan tersebut adalah meningkatnya pemahaman peserta mengenai penyakit DM dan keterampilan dalam memantau kesehatan melalui penggunaan tensimeter digital dan alat pengukur gula darah. Dari hasil pencatatan tekanan darah dan GDS didapatkan 1 kasus komorbid DM dan hipertensi, 14 kasus hipertensi, dan 2 kasus DM. Dapat disimpulkan bahwa kegiatan ini bermanfaat bagi klub Persadia dan masyarakat di sekitarnya dalam upaya pencegahan dan deteksi penyakit hipertensi dan DM.
Characteristics of patients with Hepatitis B and C at Dr. Moewardi General Hospital in Surakarta, Indonesia Benedictus Aditya Satya Laksana Adji; Triyanta Yuli Pramana; Tri Nugraha Susilawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 54, No 3 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005403202207

Abstract

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain a significant health burden in the world, which is mainly attributed to patients who develop chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). The epidemiology of hepatitis B and C in Surakarta, Central Java Province, Indonesia has never been reported. This study aimed to investigate the demographic, clinical, and laboratory characteristics of patients with hepatitis B and C who were admitted to Dr. Moewardi General Hospital, Surakarta in 2019. The medical records of patients with hepatitis B (n=94) and hepatitis C (n=75) were examined, and the data were analyzed using the chi-square and Mann-Whitney tests. The patients with hepatitis C were generally older, more likely to develop jaundice and ascites, and had higher levels of serum urea, creatinine, AST, and total bilirubin compared to those with hepatitis B. In conclusion, patients with HCV infection had worse clinical presentation and laboratory profiles than those with HBV infection. However, further research is needed on a wider scale to confirm this result.
Edukasi Pencegahan dan Deteksi Dini Penyakit Kardiovaskular di Masa Pandemi COVID-19 Ratna Kusumawati; Heru Sulastomo; Dono Indarto; Sinu Andhi Jusup; Setyo Sri Rahardjo; Niniek Purwaningtyas; Tri Nugraha Susilawati; Yuliana Heri Suselo; Sri Wulandari
Smart Society Empowerment Journal Vol 3, No 1 (2023): Maret
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i1.70327

Abstract

Pendahuluan: Jumlah kasus penyakit kardiovaskular (PKV) di dunia menunjukkan kecenderungan meningkat termasuk di Indonesia. Kabupaten Sukoharjo di Jawa Tengah melaporkan adanya peningkatan penyakit hipertensi dan diabetes mellitus (DM) yang menjadi faktor risiko penting PKV. Penyakit hipertensi dan DM merupakan penyakit penyerta utama pada kasus coronavirus disease 2019 (COVID-19) sehingga dapat memperburuk gejala dan menyebabkan kematian. Tujuan dari kegiatan pengabdian ini adalah memberikan edukasi tentang pencegahan dan deteksi dini PKV di wilayah Kecamatan Kartasura, Sukoharjo, Jawa Tengah di masa pandemi COVID-19.Metode: Kegiatan pengabdian dilaksanakan di RT 03 RW 02 desa Gowongan, Pucangan, Kartasura, Sukoharjo, Jawa Tengah. Metode pengabdian yang dilakukan berupa pelatihan pengukuran denyut nadi latihan, talk show  mengenai pencegahan dan deteksi dini PKV serta pemeriksaan kesehatan berupa pemeriksaan tekanan darah dan kadar gula darah.Hasil dan pembahasan: Hasil kegiatan pengabdian ini peserta mendapatkan informasi yang valid mengenai pencegahan dan deteksi dini PKV. Selain itu, kegiatan ini menstimulasi keperdulian peserta untuk melakukan upaya pencegahan dan deteksi dini melalui pemeriksaan tekanan darah dan kadar gula darah. Hasil lain yang didapatkan adalah peserta dapat melakukan pengukuran denyut nadi latihan secara mandiri untuk mengoptimalkan olahraga yang dilakukan.Kesimpulan: Edukasi pencegahan dan deteksi dini PKV kepada masyarakat talkshow, pelatihan dan layanan kesehatan telah terlaksana dengan baik. Kegiatan ini dapat memberikan informasi valid kepada masyarakat dan memacu keperdulian masyarakat untuk melakukan upaya pencegahan dan deteksi dini PKV.
The Levels of Inhibitory Cytokines in the Serum of Patients with Hepatitis B and C Ainor Rohmah; Sigit Setyawan; Tri Nugraha Susilawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 3 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i3.1678

Abstract

Hepatitis B and C Viruses (HBV dan HCV) can cause acute or chronic hepatitis that may develop into fibrosis, cirrhosis, and hepatocarcinoma. Previous studies have reported that hepatocyte damage is mainly due to overactive immune responses rather than viral infection. Cytokines are essential mediators in the immune response. This study aimed to determine the correlation between the levels of serum inhibitory cytokines, i.e., IL-4, IL-10, and TGF-β, and the development of liver disease in patients with hepatitis B and C. The levels of serum IL-4, IL-10, and TGF-β from 58 patients with hepatitis B or hepatitis C were determined by ELISA. The progression of liver disease is inferred from the levels of serum transaminases and the degree of liver fibrosis. Data were analyzed using the Spearman correlation test with a p-value of < 0.05 is considered statistically significant. This study showed no correlation between the levels of serum IL-4, IL-10, and TGF-β and the development of liver disease in patients with hepatitis B and C (p > 0.05). Therefore, cytokine testing using ELISA was unable to replace liver biopsy to assess liver disease progression in patients with hepatitis B and C.
Development of the Obesity Nutraceutical from Raja and Kepok Banana Peels Kezia Elian Devina; Dono Indarto; Tri Nugraha Susilawati
Proceedings of the International Conference on Nursing and Health Sciences Vol 4 No 1 (2023): January-June 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v4i1.1817

Abstract

Patients with obesity often fail to control their body weight through diet and physical activity, while the existing anti-obesity drugs have some side effects for long-term use. Banana is Indonesia's tropical fruits with the highest production, and the banana peel has become soil waste. This study aimed to analyze nutrients and active compounds of methanol extracts of raja and kepok banana peels (ERP and EKP respectively). Macro and micro-nutrient compositions of the ERP and EKP were determined using the proximate analysis, while Thin Layer Chromatography (TLC) was used to detect the ERP and EKP active compounds. The ERP contained 0.11% crude fibers, 4.44% fat, and 58.08% carbohydrates, different from the EKP (4.25% protein, 20.95% water, and 14.45% minerals). By contrast, both the ERP and EKP contained flavonoids, phenols, tannins, alkaloids, and saponins. In conclusion, ERP is potentially developed as a nutraceutical for obesity treatment in the future. Further study is needed to measure specific fat levels and to analyze specific active compounds in the ERP which can modulate gene expression and interact with protein targets in lipid metabolism.
Nutritional Analysis of Sweet Orange Peel Extract for Development of Obesity Treatment Winda Rizki Pebrina Batubara; Tri Nugraha Susilawati; Dono Indarto
Proceedings of the International Conference on Nursing and Health Sciences Vol 4 No 1 (2023): January-June 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v4i1.1820

Abstract

Obesity is a complex chronic disease that becomes the main factor of cardiometabolic diseases such as heart diseases, stroke and diabetes mellitus. Oxidative stress is involved in the obesity pathogenesis. Diet and physical exercise are recommended for obesity treatment but many obese people have low compliance to these treatments. Sweet orange (Citrus sinensis L.) is an Indonesian fruit with high production per year. This fruit pulp contains high vitamin C level, which is widely used as a strong anti oxidant to inhibit oxidative stress. However, sweet orange peel is just thrown in the soil and becomes rubbish. Therefore, the aim of this study was to analyze nutritional contents of sweet orange peel extract (OPE). Fresh orange peels were obtained from a local market at the Surakarta city and the dried orange peels were extracted using ethanol solvent. Carbohydrate, protein, and fat levels were determined using the existing method at the Food Technology Laboratory while vitamin C and Magnesium (Mg) levels were determined using the spectrophotometric and SSA-flame methods respectively. 100g OPE contained 68.88% carbohydrate, 3.23% protein, 3.41% fat, 1556.6 mg vitamin C and 239.74 mg Mg. In conclusion, the OPE is a good source of vitamin C and Mg, which can be developed as a nutraceutical for obesity treatment. Further investigation is required to determine active compounds in the OPE, which enhances the beneficial effects of vitamin C and Mg.
Reforming Procedures for Assessing Research Protocols During Covid-19 Pandemic Tri Nugraha Susilawati; Erindra Budi Cahyanto; Usman Sudarmaji
PAEDAGOGIA Vol 26, No 2 (2023): PAEDAGOGIA Jilid 26 No 2 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/paedagogia.v26i2.71809

Abstract

: Covid-19 pandemic has caused dramatic changes in daily activities. In particular, human interactions were limited, and most daily duties were directed into an online environment. This study aimed to describe the characteristics of research protocols submitted to the Research Ethics Committee (REC), Faculty of Medicine, Universitas Sebelas Maret (UNS), and evaluate the effectiveness of ethical review procedures implemented during the pandemic era. The following data were retrieved: protocol identity, researcher's institution, researcher's educational background, type of study, the date of protocol submission, and the date when the ethical clearance (EC) certificate was issued. Two hundred seventeen research protocols were submitted to the REC from 1 January 2021 until 30 June 2022. Most researchers were university students, lecturers, physicians, and service providers. Observational studies were more prevalent than interventional studies. The ethical reviews were usually completed within 2-3 weeks unless a few protocols required major revisions. Most applicants and reviewers were satisfied with the process of online review. The REC secretariat played a crucial role in keeping everyone working on schedule. In conclusion, restricting direct human interactions during the COVID-19 pandemic does not affect the ethical review process. With familiar tools, online review becomes more effective than face-to-face meetings.
Genital Tract Infection during Pregnancy and its Association with Preterm Delivery Susilawati, Tri Nugraha; Satria, Yohanes Aditya Adhi
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.11460

Abstract

Genital tract infection (GTI) remains a significant health concern. It is estimated that in 2016, there were 370 million people who suffer from chlamydia, gonorrhea, and trichomoniasis; and 708 million others suffer from genital herpes and condyloma acuminatum. It has been reported that in pregnant women, GTI is associated with preterm delivery. The mechanisms of GTI-associated preterm delivery need to be further understood to prevent neonatal mortality and morbidity that could be the risk factor for neonates' growth and development disorders. This article aims to describe various types of GTI and the associated pathogenesis causing preterm birth. A literature search was conducted to retrieve recent articles published in English from online databases including Pubmed, ScienceDirect, and Google Scholar. This literature study found that GTI evokes inflammatory responses that trigger several mechanisms leading to preterm delivery. The inflammatory responses in GTI include the production of proinflammatory cytokines and robust activation of neutrophils. The key mechanisms that stimulate preterm delivery in GTI include the events of early uterine contraction, preterm premature rupture of membranes, and induction of cervical ripening; which are under normal circumstances in a full-term pregnancy, those mechanisms are regulated by progesterone and prostaglandin levels along with suppression of the inflammatory responses. In conclusion, this paper has described the underlying mechanisms of preterm delivery in pregnant women with ISG. However, such mechanisms remain unclear in candida and gonococcal infection; thus, prompting the need for further studies. 
Co-Authors 'Ulwiyah, Nuuriyah Adi Magna Patriadi Nuhriawangsa Adiby, Zulfi Azam Adisetya Wicaksono Ainor Rohmah Ardhi, Tunggul Armita Asri Apsari Atik Susianto Basaria, Kevyn Benedictus Aditya Satya Laksana Adji Bernarda, Clarisca Calcafiorentina Bhisma Murti Billah, Muhammad Muayyad Brian wasita Brian Wasita Brian Wasita Buamona, Nur Sitra Budiyanti Wiboworini Cahyaningrum, Nabilla Fitria Cahyanto, Erindra Budi Darmayanti, Aquartuti Tri Defitaria Permatasari Dewi Pratiwi Diana Nurrohima Dono Indarto Dono Indarto Dono Indarto Eriana Melinawati Erindra Budi Cahyanto Erindra Budi Cahyanto Fahmi, Muhammad Izzul Widad Grhasta Dian Perestroika Hasibuan, Wahyu Aulia Heru Priyanto HERU SULASTOMO Heru Sulastomo Hilmy, Farhan Indallah, Nabila Wajihan Ismanta, Anestasia Darmastuti Jusup, Sinu Andhi Kezia Elian Devina Kusmadewi Eka Damayanti Kusmadewi Eka Damayanti Kusumastuti, Wijayanti Larasati, Riska Leli Saptawati Leli Saptawati Lutfinayati, Sofia Marisa Rizqiana Maryani Maryani Mashuri, Yusuf Ari Mufidah, Amatullah Nandyantami, Farah Fauziah Nazili, Muhammad Haqin Niniek Purwaningtyas Niniek Purwaningtyas Nofia, Yasinta Nugraha, Yanika Tiara Nurgajayanti, Cendi Prastyoningsih, Aris Pratiwi Pratiwi Wulandari Puspitasari, Reni Nur Putra, Wahyu Pratama Putri, Noviyati Rahardjo Radityastuti Rahmat Sugianto Ratna Dwi Restuti Ratna Kusumawati Ratna Kusumawati Ratnasari, Affi Angelia Rauf, Muhammad Abdul Ridha Setiawati Riska Larasati Saputri, Nurul Aini Suria Satria, Yohanes Aditya Adhi Satria, Yohanes Aditya Adhi Septiana, Yesika Cahya Setyo Sri Rahardjo Setyo Sri Rahardjo Sigit Setyawan Sri Wulandari Sri Wulandari Suhartono Susianto, Atik Susilawati, Eva Sutarno Sutarno Syaputri, Dwi Triyanta Yuli Pramana Triyanta Yuli Pramana Uki Retno Budihastuti Usman Sudarmaji Usman Sudarmaji Vitri Widyaningsih Widiasih, Ghina Widyaningrum, Sherly Asri Wijiwinarsih, Amallia Winda Rahayuningtyas Winda Rizki Pebrina Batubara Yasmin, Thania Yuliana Heri Suselo Zahida, Sarah