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All Journal Medula JURNAL PENDIDIKAN TAMBUSAI Jurnal Ilmu Kedokteran dan Kesehatan Media Pendidikan Matematika JK Unila (Jurnal Kedokteran Universitas Lampung) E-JRM Organisms: Journal of Biosciences AMMA : Jurnal Pengabdian Masyarakat JOURNAL OF Qualitative Health Research & Case Studies Reports JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Media Pendidikan Matematika
Septiani, Linda
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Medula

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Potensi Ekstrak Kulit Nanas (Ananas comosus) Sebagai Antimikroba Sinaga, Herman Fransiskus; Apriliana, Ety; Septiani, Linda; Kurniati, Intanri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1427

Abstract

Pineapple is one of the traditional plants that may be used as an alternative treatment to reduce pathogenic microbes. Its content is rich in chlorine, iodine, phenol and the enzyme bromelain which functions to stop microbial growth. This research aims to determine the potential of pineapple peel extract (Ananas comosus) as antimicrobe agents. This research uses a literature review study method, namely by using research articles obtained through a literature search process related to the potential use of pineapple peel extract on microbe from 2015 to 2025. Pineapple peel extract contains the main compounds, namely flavonoids, polyphenols, bromelain and saponins. This content causes pineapple skin extract (Ananas comosus) to have an effect on microbes.
INFEKSI SALURAN KEMIH AKIBAT PENGGUNAAN KATETER PADA PASIEN RAWAT INAP DI RUMAH SAKIT Ananta, Yoga; Mustofa, Syazili; Septiani, Linda; Busman, Hendri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1436

Abstract

Urinary tract infection (UTI) is a disorder caused by microorganisms that multiply in the urinary tract, which is normally sterile from bacteria. Risk factors for UTI include age, gender, medical procedures such as catheterization, hygiene, and duration of catheter use. Catheter-related UTI is the most common type of nosocomial infection, with a prevalence of up to 80% in patients who use catheters. The main cause of UTI is gram-negative bacteria, such as Escherichia coli (48.44%) and Klebsiella pneumoniae. In women, the risk is higher because the urethra is shorter and closer to the anus. UTI is divided into lower and upper urinary tract infections, where symptoms vary from pain during urination to serious complications such as pyelonephritis and urosepsis. The pathophysiology of UTI often involves the colonization of microorganisms on the catheter or urinary tract. The risk of infection increases with the duration of catheter placement, reaching 5–10% per day. Diagnosis of UTI involves history taking, physical examination, and urine culture, although modern methods such as flow cytometry are increasingly used for efficiency. Prevention involves personal hygiene, aseptic technique during catheter insertion, and prophylactic antibiotic use in selected cases. Treatment of UTI includes empiric antibiotics such as trimethoprim-sulfamethoxazole, fluoroquinolones, or nitrofurantoin, depending on the severity and causal pathogen. Appropriate preventive and treatment approaches can reduce the incidence of UTI, improve patient quality of life, and decrease the rate of complications. Keywords: Trigger Factors, Urinary Tract Infection (UTI), Catheter
PEMANFAATAN POTENSI ALAMI SEBAGAI ANTIOKSIDAN Happy, Terza Aflika; Septiani, Linda; Graharti, Risti; Andrifianie, Femmy
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1825

Abstract

Indonesia is one of the world’s most biodiverse countries and possesses a vast potential of medicinal plants as natural therapeutic resources. Many medicinal plants traditionally used by local communities are known to contain secondary metabolites with antioxidant properties. Antioxidants play an essential role in preventing oxidative stress associated with degenerative and infectious diseases. This article aims to review the potential of secondary metabolite compounds from Indonesian medicinal plants as antioxidant agents based on previous studies. This study was conducted using a literature review method by analyzing relevant national and international scientific publications. The results indicate that various medicinal plants, including sweet potato leaves, green tea, roselle, celery, and Peperomia pellucida, contain polyphenolic compounds such as flavonoids, tannins, and phenols, as well as other secondary metabolites including alkaloids, saponins, terpenoids, quinones, coumarins, and anthocyanins. These compounds exhibit antioxidant activity through free radical scavenging, hydrogen atom donation, and inhibition of lipid peroxidation processes. In conclusion, Indonesian medicinal plants demonstrate significant potential as natural sources of antioxidants and offer promising prospects for further development in pharmaceutical and health applications, particularly as raw materials for phytopharmaceutical products and supportive therapies.
Efektivitas Beberapa Ekstrak Tanaman sebagai Ovisida terhadap Aedes aegypti dalam Pencegahan Demam Berdarah Dengue Septiani, Linda; aflika happy, terza; Graharti, Risti; Andrifianie, Femmy; Setyaningrum, Endah
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1827

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern, with Aedes aegypti serving as the primary vector. The continuous use of synthetic insecticides has led to resistance development and environmental concerns, highlighting the need for safer and sustainable alternatives. This review aims to evaluate the ovicidal potential of selected plant extracts against Aedes aegypti as an early-stage vector control strategy. A literature review was conducted using relevant national and international publications focusing on plant-based ovicides. The findings indicate that extracts from Piper nigrum L., Ocimum basilicum, Syzygium myrtifolium Walp., Tithonia diversifolia, Acorus calamus L., Solanum lycopersicum, and Euphorbia hirta L. effectively reduce egg hatchability of Aedes aegypti. The ovicidal activity is associated with secondary metabolites such as flavonoids, alkaloids, saponins, tannins, terpenoids, polyphenols, and essential oils, which disrupt egg membranes and inhibit embryonic development in a concentration-dependent manner. These findings suggest that plant extracts possess promising potential as natural ovicides and may serve as a basis for further pharmaceutical development and formulation in sustainable dengue vector control.
Tinjauan Literatur Sistematis: Protokol Kriptografi untuk Menjamin Keamanan dan Privasi Data Genomik Wijaya, Angga; Idris, Mohamad; Septiani, Linda; Pestalozi, George
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1840

Abstract

precision medicine. However, the static and hereditary nature of genomic data poses significant privacy risks for individuals and their families. This article aims to conduct a systematic literature review of various modern cryptographic protocols designed to protect genomic data. The research method utilizes a Systematic Literature Review (SLR) approach, analyzing relevant literature from 2018 to 2026. The findings indicate that protocols such as Homomorphic Encryption (HE) and Secure Multi-party Computation (SMPC) offer robust protection but face challenges regarding computational efficiency and bandwidth. Differential Privacy (DP) provides an efficient alternative but carries risks of reduced data accuracy. In conclusion, securing genomic data requires hybrid models that integrate algorithmic efficiency with long-term resilience, particularly against quantum computing threats. Aligning these technologies with Indonesia's Personal Data Protection Law (UU PDP) is crucial for building a secure and credible national health data ecosystem.
Co-Authors Adisa, Mutiara Putri aflika happy, terza aflika, terza Afriyani, Afriyani Akbar, Muhammad Adzan Nur Alghani, Sulthan Rafi Amalia, Usnida Khoiru Ambarwati, Yuli Ananta, Yoga Andrifianie, Femmy Angga Wijaya, Angga Annasya, Benazhir Saninah Aquila Graham Ari Wahyuni Aslina, Enna Cahyani, Faradhila Azqiah Damayanti, Ervina Dwi Budi Santoso Dyah Wulan Sumekar Rengganis Wardani Endah Setyaningrum, Endah Ety Apriliana Fatahillah, Fatahillah Fitria Saftarina George Pestalozi Ghaitsa Lulua Ginting, Bisart Hanna Mutiara, Hanna Happy, Terza Aflika Hendri Busman Heni Pujiastuti Idris, Mohamad Indri Windarti Intan Kusumaningtyas Intanri Kurniati Jhons Fatriyadi Suwandi Kanedi, M. Kanedi, Muhammad Khairun Nisa Khansa, Moh Chandra Lusina, Septia Eva Marcelia, Selvi Marcellia, Selvi Masherni, Erniza Muhammad Ricky Ramadhian Mulya, Ireniza Pradevi Mumtazah, Dzul Fithria Nuning Nurcahyani Nur Diana Oktavia Ningtias, Nabila Primasari Pertiwi Qanita Arindia, Naifa Hana Qurani, Istiqomatul Rahel, Clara Arta Uli Rahmah, Nisrina Nur Rahmawati, Rahmawati Ramadhana Komala Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratna, Maya Ganda Rika Lisiswanti Risti Graharti Rizki Hanriko Roro Rukmi Windi Perdani, Roro Rukmi Rosa, Emantis Satrio, Oktavianus Indra Septia Eva Lusina Septian, Astried Setiawan, Gigih Setiorini, Anggi Shinta Dewi, Brigitta Sinaga, Herman Fransiskus Sofyan Musyabiq Wijaya Suryadi Islami Susianti, Susianti Sutarto . SYAIFUL BAHRI Syazili Mustofa TA Larasati Tri Umiana Soleha Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani Yulianti Zefanya, Ezekial