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All Journal Jurnal Penelitian Saintek Jurnal Ilmiah Farmasi JBIO: jurnal biosains (the journal of biosciences) Best Journal (Biology Education, Sains and Technology) GANDRUNG: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Nusantara FORTE JOURNAL Jurnal Farmanesia Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Jurnal Farmasi SYIFA Jurnal ABDIMAS MUTIARA Jurnal Medika STIKes Kesehatan Baru JURNAL TEKNOLOGI, KESEHATAN DAN ILMU SOSIAL
Marbun, Eva Diansari
Universitas Sari Mutiara Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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FORMULASI SEDIAAN KRIM TABIR SURYA EKSTRAK ETANOL DAUN PECUT KUDA (Stachytarpheta jamaicensis L) DAN UJI Surya Protection Factor (SPF) SECARA IN VITRO Marbun, Eva Diansari; Sapitri, Alfi; Sianipar, Artha Yuliana; Asfianti, Vivi
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.10697

Abstract

Tabir surya merupakan suatu bahan topikal yang berfungsi untuk mengurangi dampak radiasi yang di sebabkan oleh sinar UV. Daun pecut kuda (Stachytarpetha jamaicensis L) merupakan tanaman yang banyak di manfaatkan untuk menjaga kesehatan dan sebagai obat tradisisonal. Tujuan dari penelitian ini Untuk mengetahui ekstrak etanol daun pecut kuda (Stachytarpheta jamaicensis L) dapat di formulasikan menjadi sediaan krim tabir surya, dan Untuk mengetahui nilai SPF (Sun Protector Factor) dari ekstrak daun pecut kuda (Stachytarpheta jamaicensis L). Metode peneleitian ini menggunakan metode eksperimental atau percobaan yang di mulai dari pengambilan sampel, sortasi basah, pengeringan, sortasi kering, penimbangan, penghalusan simplisia, perkolasi, dan rotary hingga menjadi ekstrak. Hasil penelitian uji mutu fisik krim tabir surya ekstrak etanol daun pecut kuda dengan konsetrasi 1%,2%,3% berbentuk setengah padat, warna cokelat, dan berbau khas rossae. Homogenitas pada sediaan yaitu homogen, Uji pH pada ketiga konsentrasi yaitu 5,9, 6,3, 6,5. Uji tipe krim menunjukkan ketiga konsentrasi yang termasuk tipe m/a. Uji daya lekat pada ketiga konsentrasi memenuhi syarat uji yaitu lebih dari 1 detik. Uji daya sebar pada ketiga konsentrasi memenuhi syarat uji yaitu 5-7cm. Uji iritasi pada ketiga konsentrasi tidak memberikan efek iritasi pada kulit. Uji Viskositas pada ketiga konsentrasi rata-rata 14300. Uji hiodonik dapat di simpulkan bahwa sedian yang paling di sukai panelis adalah konsentrasi 2%. Dan uji nili SPF di dapat hasil F1:1,97(minimal, F2:3,25(minimal), F3:6,41(Ekstra). Kesimpulan pana penelitian ini adalah formulasi ekstrak etanol daun pecut kuda(Stachytarpetha jamaicenis L) dapat di formulasikan sebagai sediaan tabir surya, dan ekstrak etanol daun pecut kuda (Stachytarpetha jamaicensis L) mempunyai nilai SPF(Surya Protection Factor).
Artikel Review: Uji Keamanan dan Toksisitas Obat Herbal dalam Pengembangan Jamu, OHT, dan Fitofarmaka Monica Suryani; Alfi Safitri; Eva Diansari Marbun; Ade Irma Suryani; Cut Alvida Zura
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1393

Abstract

Background: Safety and toxicity testing are essential stages in the development of herbal medicines to ensure therapeutic efficacy without causing adverse effects. In Indonesia, herbal products are classified into traditional herbal medicines (jamu), Standardized Herbal Medicines, and phytopharmaceuticals, each requiring different levels of scientific evidence for safety and efficacy. Objective: This study aims to review the results of safety and toxicity testing of herbal medicines in the development of jamu, Standardized Herbal Medicines, and phytopharmaceuticals in Indonesia over the last five years (2020–2025). Methods: This study employed a descriptive, qualitative literature review. Scientific articles were systematically retrieved from the Garuda, Neliti, Sinta, and Google Scholar databases using relevant keywords related to herbal medicine safety and toxicity testing. A total of twelve peer-reviewed research articles published between 2020 and 2025 met the inclusion criteria. The reviewed studies involved in vivo, in vitro, and in silico testing methods, with toxicity parameters including LD₅₀, LC₅₀, biochemical markers, and histopathological changes. Results: The findings indicate that in vivo testing is the most frequently applied method and generally demonstrates a high safety profile for most herbal preparations. Jamu products are considered safe based on empirical use and standardized raw materials. Standardized Herbal Medicines demonstrate safety through acute and subchronic toxicity evaluations. At the same time, phytopharmaceuticals exhibit the highest level of safety through comprehensive testing using combined in vivo, in vitro, and in silico approaches. Most herbal ingredients fall into the non-toxic to mildly toxic category at high doses. Conclusion: Overall, the reviewed evidence suggests that Indonesian herbal medicines, including jamu, Standardized Herbal Medicines, and phytopharmaceuticals, are generally safe when used appropriately. Strengthening multidisciplinary toxicological approaches and implementing pharmacovigilance principles are essential to ensure long-term safety and support the development of evidence-based national herbal medicines.
Co-Authors Ade Irma Suryani Alfi Safitri Alfi Safitri Alfi Sapitri Alfi Sapitri Amanda Putri, Amelia Ana, Mauli Andre Prayoga Anggraini, Rania Ultah Artha Yuliana Sianipar Artha Yuliana Sianipar Asfianti, Vivi Bemby, Arman Berkat, Syukur br Ginting, Grace Anastasia Chandra, Devina Cut Alvida Zura Darwita Juniwati Barus Darwita Juniwati Barus Denny Satria Dian Arisetya, Dian Erni Erni Fikri, Naufal Noli Fitri, Nadiatul Fitri, Widya Fridelly Mairani Apt Ghifran, Muhammad Al Ginting, Grace Anastasia br. Ginting, Mandike Grace Anastasia br Ginting Grace Anastasia Ginitng Haliza, Aipak Harianja, Ester Saripati Hariman, Hariman Helmi Helmi Herlinawati, Eria Nita Hutasoit , Audi T.A. Hutasoit, Audi T.A. Komsary, Pauline Mainal Furqan Manik, Maria Partiwi Manuppak Tampubolon Marpaung, Jon Kenedy Modesta Tarigan Monica Suryani Napitupulu, Muhammad irianto Natanael Prilitius Ningtia, Ayu Cahya Panggabean, Indah Elsayanti Panjaitan, Grace Emmas Sondang Pebriyandi, Fajar Prayoga, Andre Purba, Elizabet Kristina Purba, Sri Dearmaita Putri, Ananda Dwi Raissa Fitri Realita Lifiani Retnita Ernayani Lubis Rezza Fikrih Utama Rizki Ndraha, Alva Hagaini Rosina Sitohang Safitri, Alfi Sahputri, Cut Juliana Santy Simamora Sapitri*, Alfi Sapitri, Alfi Sianipar, Artha Yuliana Sihombing, Johas Silitonga, Desni Rinanda Silitonga, Evawani M Sinaga, Dianty Secilia Siti Maimunah Sitinjak, Joan Mervin Situmorang, Imelda Stefani Overia Suharyanisa Supartiningsih - - Surbakti, Christica Ilsana SURBAKTI, CHRISTICA ILSANNA Susanti, Julia Syahfitri, Novita Syukur Berkat Waruwu Tampubolon, Manuppak Irianto Thaib, Cut Masyitah Thaib, Cut Masyithah Turrahmi, Alvia Ulfata, Zikri Ulfayani Mayasari Utama, Rezza Fikrih Vivi Asfianti Yosy Cinthya Eriwaty Silalahi Zuhairiah Nasution, Zuhairiah