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Pengaruh Pemberian Aspirin terhadap Gambaran Histopatologi Mukosa Gaster Mencit Moammar Rizky Farhan; Oktora, Meta Zulyati; Dita Hasni
As-Shiha: Jurnal Kesehatan Vol. 2 No. 2 (2022): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

Aspirin is a group of non-steroidal anti-inflammatory drugs (NSAIDs) that are widely used by the public to treat rheumatic diseases. Apart from its anti-inflammatory role, aspirin is also an anti-thrombotic agent used in coronary heart disease (CHD) to prevent platelet aggregation. Aspirin is also a potent anipyretic. To determine the gastric mucosal histopathology of mice after being induced by apirin. The scope of the research is Medical Pathology, Anatomy and Pharmacology. The research was conducted at the Pharmacology Laboratory of the Faculty of Pharmacy, Andalas University and for reading the results at the Anatomical Pathology Laboratory, Faculty of Medicine, Baiturrahmah University. This research was conducted in March 2020 - January 2021. This research is a laboratory experimental. The samples used in this study were mice (Mus Musculus) aged 4-6 weeks with a body weight ranging from 18-20 grams. A sample of 18 mice was divided into 2 treatment groups, namely, positive and negative control samples. Aspirin was administered orally using a sonde for 3 consecutive weeks in positive control samples, and negative control samples were not treated. On the 27th day the termination was performed, the stomach was taken and histopathological preparations were made. The results of this study of 9 samples found 22.2% (2 samples) experienced desquamation, 44.4% (4 samples) experienced erosion, 33.3% (3 samples) experienced ulceration. Desquamation characteristics can be seen from the peeling of the uppermost layer of the gastric mucosa. And erosion can be seen from the loss of some areas of the gastric mucosa. Then for ulceration where the entire thickness of the mucosa is lost. There was a change in the picture in the gastric mucosa histopathology of mice (Mus musculus) after being induced by aspirin.
Subcorneal Pustular Dermatosis Dengan Diabetes Melitus Tipe 2 dan Dislipidemia: Sebuah Laporan Kasus Gustia, Rina; Muchyar, Mutia Sari; Ashar, Miranda; Imaduddin, Ummul Khair; Intan, Shinta Ayu; Oktora, Meta Zulyati
Scientific Journal Vol. 5 No. 1 (2026): SCIENA Volume V No 1, January 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i1.331

Abstract

Pendahuluan: Subcorneal pustular dermatosis (SPD), atau penyakit Sneddon–Wilkinson, merupakan dermatosis neutrofilik kronis yang jarang, ditandai dengan pustul superfisial berulang. SPD semakin banyak dilaporkan berhubungan dengan penyakit sistemik, terutama gangguan metabolik seperti diabetes melitus tipe 2 dan dislipidemia, yang dapat berkontribusi terhadap onset dan kekambuhan penyakit. Laporan kasus: Seorang perempuan berusia 36 tahun yang datang dengan keluhan bercak kemerahan berulang disertai pustul superfisial flaksid berwarna kekuningan yang gatal pada daerah perut dan punggung bawah selama dua bulan terakhir. Lesi awalnya membaik dengan kortikosteroid topikal tetapi kambuh kembali dua minggu kemudian dengan cakupan yang lebih luas. Pasien tidak mengeluhkan demam maupun riwayat konsumsi obat sebelumnya. Pasien memiliki penyakit dasar diabetes melitus tipe 2 dan dislipidemia, keduanya dalam kondisi tidak terkontrol dengan baik. Pemeriksaan klinis menunjukkan plak eritematosa multipel dengan pustul superfisial, krusta, erosi, serta makula hiperpigmentasi pada perut dan punggung bawah. Pemeriksaan dermoskopi menunjukkan multiple yellow-white globule di atas dasar eritematosa yang dikelilingi sisik halus. Evaluasi psikologis menunjukkan tingkat kecemasan sedang dan dampak sedang terhadap kualitas hidup.  Kesimpulan: Kasus ini menekankan pentingnya mengevaluasi dan menangani komorbiditas sistemik, karena disfungsi metabolik dapat berkontribusi terhadap inflamasi persisten, kekambuhan berulang, dan respons terapi yang kurang optimal pada Subcorneal Pustular Dermatosis.
Deteksi Dini Kanker Serviks dan Edukasi Kegunaan Pemeriksaan Pap Smear Nana Liana; Nurwiyeni; Meta Zulyati Oktora; Anandia Putriyuni
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 4 (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Cervical cancer is the second largest malignancy after breast cancer in Indonesia. The incidence is increasing every year. In the United States and several other countries, the incidence of cervical cancer has decreased due to public health services and lifestyle changes as well as early implementation through pap smears. In developing countries, the mortality and incidence of cervical cancer has also decreased by 34-80% in the last 50 years. This is sufficient because the period of occurrence of cervical cancer is long and 90-95% of pathological changes in the epithelium can be determined through the Pap smear test. However, in developing countries, health services are still limited and there are no screening programs, cervical cancer is still the leading cause of death in women. Cervical cancer is often diagnosed at an advanced stage and the survival rate is low. On the other hand, the cure rate for early cervical cancer is very high. Therefore, it is important for women to undergo regular pap smears test so that the health condition of the cervix can be monitored and cervical cancer can be detected early.