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Irfandi, Rizal
Department Of Chemistry, Faculty Of Mathematics And Natural Science, Universitas Negeri Makassar, Makassar, Jalan Daeng Tata Raya Makassar, 90244, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Potential of Quercetin Compound from Guava Leaves (Psidium guajava L.) as a Inhibitor COVID-19 Sengka, Rani; Rompegading, Andi Badli; Irfandi, Rizal; Nur, Muhammad; Arafah, Muhammad; Yani, Ahmad
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.49666

Abstract

This research is a computer-based experimental study using the molecular docking method of quercetin compounds in the leaves of the guava plant (Psidium guajava L.) against the target protein (receptor), namely Mpro SARS-CoV-2 (PDB ID: 6M2N) using various softwares. consists of Chem Draw Ultra version 7.0, Marvin Sketch, PLANTS, Yasara, Discovery Studio Visualizer 2021, and pkCSM online tool and, protox online tool. This study aims to find out how the potential  of the quercetin compound from the leaves of the guava plant (Psidium guajava L.) has on its ability to inhibit the spread of Covid-19 by molecular docking. Data analysis in this study was carried out based on data obtained from the analysis of pharmacokinetic profiles, physicochemical properties, molecular docking, and predictions of toxicity to compounds that have potential as drug ingredients. Based on the results of molecular docking, it was shown that the quercetin compound has the potential to act as an inhibitor of the Mpro receptor (PDB ID: 6M2N) as evidenced by the docking score obtained which is smaller than the docking score obtained by the original ligand of the target receptor.
Co-Authors Abd Rahman Abd Rahman Abdul Kadir Ade Sucitra Putri Ahmad Fudholi Ahmad Ghazali Samad Ahmad Rinaldy Ahmad Yani Ahmad Yani ahmad yani Ahmad Yani Ahyar Ahmad Ahyar Ahmad Ahyar Ahmad Aisyah Gusfira Ambo Upe Andi Alwa Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompeggading Andi Muh. Fathul Andi Pitung Andi Wilda Resky Angga Andriana Anita Anita Arini Rajab Arisa, Arisa Arman Arifuddin Arman Arifuddin Asriana Asriana Audya Syahra Ayu Lestari Ayu Muliana Badli Rompegading, Andi Basir, Sutrisman Baso Bambang Juni Edi Baso Muhammad Reski Bima Sardina Cindy Agustina Cindy Agustina Darsal Dahlan Darwis Desy Kartina Devi Wulandari Ramli Dewi Sartika Dian Ramadhani Dian Ramadhani Diana Eka Pratiwi Dingse Pandiangan Erna Sulastri P Erwing Erwing Esti Arni Fatimah Fatimah Febriani Danur, Riny Firdaus Zenta Hadarmawandi Hadarmawandi Hadarmawandi, Hadarmawandi Harningsih Karim Harningsih Karim Hasnah Natsir Hasnah Natsir Herlina, Besse ihya, Zahratul Ilyas, Nita Magfirah Indah Raya Indah Raya Indah Raya Jasri Djangi, Muhammad Jayawarsa, A.A. Ketut Lili Suryani Mazaya, Maulida Mirjawanda Mirjawanda Mitha Febriani Muh. Damriansyah Muh. Faqhi S. Muh. Fathir Rahmat Muh. Ilham Muhammad Afdal Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Fadryansah Muhammad Fathir Rahmat Muhammad Kemal Nasser Muhammad Nasir Muhammad Nasir Muhammad Nur Muhammad Nur Muhammad Nur Muhammad Nur Muhammad Resky Muhammad Taufiq Muhlis, Nur Fadhillah Muriyati Murniati Safitri Mutmainnah Gani Nasser P, Muh Kemal Negara, Satria Putra Jaya Netti Herawati Nia Febrianti Nirmawati Hamka Nirmayanti Syamsuddin Nur Aulia Hazzah Nur Fadhillah Muhlis Nur Indah Sari Nur Insani Amir Nur Nur Fisabilianti Nur Rahmi Nurcaya Nurcaya Nurul Hikma Fajar Paulina Taba Putri Dewi Suci Ramadhani Rachmat Triandi Tjahjanto Rahma, Besse Nuramalia Rahmawati Rahmawati Ramadani, Ananda Ramadhani, Andi Amaliyah Rani Sengka Renaldi Reski Aggun Sasmita Reski Hamdiah Riki Rusanda Ririn Eka Riska Febrianti Riska Ramayana Rismawati Rismawati Rizky Arfadilla Rony, Zahara Tussoleha Rosdiana Rosdiana Rugaiyah Arfah Ruslang, Ruslang Sahriah Rahim Santi Santi Sarlan, Sarlan Sengka, Rani Sir, Panessai Siti Fauziah SITI HALIMAH LAREKENG, SITI HALIMAH Sitti Aminah Subakir Salnus Subakir Salnus Sudarmianti, Sudarmianti Sugiarti Sugiarti Suharni Sudirman Sulistiani Jarre Sumarni Sumarni Sumiati Side Suriati Eka Putri Suriati Eka Putri Suriya Satar Susan Marlein Mambu Susilo Sudarman Desa Sutrisman Basir Syah, Uswah Trywulan Syamsu Rijal Syamsu Rijal Syamsu Rijal Syamsu Rijal Syamsu Rijal Syamsu Rijal Tantu, Zakiah Vitrani Vitrani Wahid Wahab Yanti, Reski Yetti Anita Yuliana S Zakiah Tantu Zulfian Armah