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In Vitro, In Compost, and In Vivo Assessment of Chitosan-Polyethylene Glycol as an Intravaginal Insert for Progesterone Delivery in Sheep E. Y. Yessa; L. I. T. A. Tumbelaka; I. Wientarsih; M. F. Ulum; B. Purwantara; Amrozi
Tropical Animal Science Journal Vol. 46 No. 3 (2023): Tropical Animal Science Journal
Publisher : Faculty of Animal Science, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5398/tasj.2023.46.3.295

Abstract

In estrous synchronization, the hormone progesterone is an important element. Various hormone preparations currently available have limitations, especially those related to environmental impact issues. Various alternatives are being studied, and using biodegradable polymeric materials (chitosan-polyethylene glycol combination) to develop new devices is considered one of the solutions. This contribution aims to design and evaluate intravaginal implants that can release progesterone and be degraded in the body and the environment. Implants are made by melting and molding techniques. In vitro drug release studies using dyes as drug models. Implant degradation studies tested in compost. Changes in the shape of the implant, while it is in the vagina, are observed by ultrasound. Blood collection was performed three days before and during implantation to obtain a blood progesterone profile. In vitro drug release studies using dye as a drug model showed a chitosan-PEG profile that released the drug faster at first, then slowed down. Implant degradation studies in compost and vagina demonstrated a gradual degradation process. The blood progesterone profile increased during implantation, as high as 15 ng/mL on the third day. In conclusion, the chitosan-PEG intravaginal implant formulation designed using the melting and molding technique proved to be degraded in the compost environment. It released the hormone progesterone for four days according to the degradation period of the implant in the vagina.
Evaluasi Pemberian Produk Elektro Bio Stamino® Terhadap Performa Ayam Broiler Hamdika Yendri; Nugroho Sampurno; Fiqhi Alfiansyah; Akbar Wijaya Putra Purnama; Tukiran; Amrozi
Jurnal Veteriner dan Biomedis Vol. 1 No. 2 (2023): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.1.2.108-114.

Abstract

Ayam broiler adalah jenis ayam yang dipelihara khusus untuk produksi daging yang cepat, sehingga pemeliharaan yang baik sangat penting untuk mencapai performa yang optimal. Kunci pemeliharaan ayam broiler dengan skala produksi adalah pakan, manajemen kandang, manajemen kesehatan, dan faktor eksternal. Perlu dikembangkan cara-cara yang baru dalam pemeliharaan ayam broiler agar menghasilkan kualitas yang baik. Salah satunya adalah dengan mengem-bangkan produk suplemen pendamping pakan. Sebanyak 12.000 ekor ayam DOC dibagi kedalam 2 kelompok yai-tu kelompok kontrol yang diberikan pemeliharaan secara normal. Kelompok berikutnya dalah kelompok EBS yaitu kelompok yang diberikan produk Elektro Bio Stamino® setiap hari didalam air minum dengan dosis 2 mL dalam 1 liter air minum. Pemberian sediaan dilakukan sebanyak 1 kali sehari. Parameter yang diamati meliputi penambahan bobot badan, Feed consumption rate dan Feed intake. Pengambilan data dilakukan selama 31 hari. Hasil penelitian menunjuk-kan kelompok yang diberikan sediaan Elektro Bio Stamino® memiliki performa yang lebih baik dibandingkan dengan kelompok kontrol. Hal ini disebabkan nutrisi dan zat yang terkandung didalam produk mampu melengkapi kebutu-han nutrisi ayam selama masa pemeliharaan. Oleh karena itu pemberian Elektro Bio Stamino® memberikan efek positif terhadap performa ayam broiler.
PENGHAMBATAN ENZIM TIROSINASE dan AKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA TELANG (Clitoria ternatea) MENGGUNAKAN METODE DPPH Bayu Febram Prasetyo; Amrozi; Nur Anisa BS
Jurnal Buana Farma Vol. 4 No. 1 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i1.942

Abstract

Clitoria ternatea or known as the butterfly pea is widely used in the health sector due to its efficacy as antidiabetic, anti-inflammatory, antimicrobial, anticancer, analgesic, antipyretic, and antioxidants. The purpose of this research is to examine the antioxidants and tyrosinase inhibitor activities of butterfly pea ethanol extract as well as to identify the phytochemical content. Antioxidants activities are determined by the DPPH method. The results of this study indicates that butterfly pea extract has very weak antioxidant activities with an IC50 value more than 200 ppm. The results of the tyrosinase inhibitor activities showed that the butterfly pea extract did not inhibit the tyrosinase enzyme. Based on the screening phytochemical tests, the chemical components contained in butterfly pea extract are flavonoids, tannins, saponins, and steroids. Bunga telang flower extract has very weak antioxidant activity and tyrosinase inhibitor testing showed antioxidant flower extract by DPPH method. Tyrosinase inhibitor assay results showed white Bungatelang extract has no activity to inhibit tyrosinase enzyme.
Ovarian Dinamics of Simmental Crossbreed Diagnosed Prolonged Oestrus Cows Treated With a Intravenous of Human Chorionic Gonadotrophin (hCG) nisfu bayu kurniadi; Ligaya ITA Tumbelaka; Amrozi Amrozi; Langgeng Priyanto
Jurnal Veteriner Vol 24 No 3 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.3.271

Abstract

This study was aimed to identify ovarian dynamics using ultrasonography (USG) in simmental crossbreed cows diagnosed prolonged oestrus treatment with human chorionic gonadotrophin (hCG). A total of four Simmental crossbreed cows diagnosed with prolonged oestrous were used in this study. The first oestrous observations in all four cows were a control group, where as the next oestrous cycle observation to the same four cows treated with 1500 IU hCG in jugular vein refer to treated group. The observation of ovarian dynamics was started from the first oestrous day until ovulation occurs in the second oestrus cycle using ultrasonography (USG) with a linear rectal probe. At the same time, follicle and corpus luteum (CL) images were recorded every day. Data were analyzed using paired data comparison test (pair sample t-test). The observation results ovarian dynamics on prolonged oestrus cows showed that the long of oestrous cycle was 22.5 ± 0.5 days, and there are three follicular wave patterns in oestrous cycle. The first wave of dominant follicle was firstly identified on day 3.3 ± 0.5, reached maximum diameter 12.0 ± 0.3 cm. The second and third dominant follicle appeared on day 10.8 ± 0.5 and 15.8 ± 0.5 cm reached maximum diameter 1.2 ± 0.3 cm dan 1.5 ± 0.3 cm. Therapy with hCG does not significantly affect the dominant follicle’s diameter during oestrous (p>0.05). The conclusion of this study showed that 1500 IU of hCG therapy does not affect the development of dominant follicle, however, it can shorten the duration of oestrous and ovulation time.
Sifat bioavailabilitas implan intravaginal berbahan kitosan-PEG-PCL dalam simulasi cairan vagina dan vagina sapi Yessa, Elma Yuliani; Wientarsih, Ietje; Purwantara, Bambang; Amrozi, Amrozi; Ulum, Mokhamad Fakhrul
ARSHI Veterinary Letters Vol. 7 No. 3 (2023): ARSHI Veterinary Letters - August 2023
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.7.3.57-58

Abstract

Penelitian ini bertujuan untuk merancang dan mengevaluasi bioavailabilitas implan intravaginal yang terbuat dari poli-ymer kitosan-polietilen glikol (PEG)-polikaprolakton (PCL) yang dapat terbiodegradasi dalam cairan simulasi vagina (SVF) dan vagina sapi. Implan dibuat menggunakan teknik peleburan dan pencetakan dengan 26 formulasi berbeda. Selanjutnya implan direndam dalam 40 mL SVF pada suhu 37,8℃ dan diamati perubahan morfologi implan setiap hari hingga hari ke 5. Implan yang bertahan hingga hari kelima diuji ketersediaannya lebih lanjut pada vagina sapi dan diamati setiap hari selama 2 minggu. Uji perendaman pada hasil SVF menunjukkan bahwa implan dengan kandungan PEG 75-85% lebih cepat meleleh dibandingkan implan dengan kandungan PEG 20-72%. Implan yang mengandung 1-10% PCL terkikis lebih cepat di SVF dibandingkan implan yang mengandung 22-80% PCL. Implan yang mengandung kitosan dapat tetap stabil di SVF lebih lama dibandingkan implan tanpa kitosan. Uji bioavailabilitas pada vagina sapi menunjukkan bahwa implan 21-23 bertahan hingga hari ke 10, sedangkan implan 24-26 dikeluarkan dari vagina sapi selama pengujian. Implan 21-23 merupakan formulasi yang menjanjikan untuk pengembangan implan intravaginal yang dapat terbiodegradasi. Dengan menyesuaikan komposisi kitosan (antara 14-18 berat%), PEG (maksimum 72 berat%), dan PCL (minimal 20 berat%), implan intravaginal mampu meningkatkan ketersediaan hayati cairan vagina dan vagina yang disimulasikan. ternak
The potential of biodegradable polymers: Chitosan, polyethylene glycol, and polycaprolactone as materials for progesterone intravaginal devices Elma Yuliani Yessa; Ietje Wientarsih; Mokhamad Fakhrul Ulum; Bambang Purwantara; Amrozi Amrozi
Livestock and Animal Research Vol 22, No 1 (2024): Livestock and Animal Research
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/lar.v22i1.72985

Abstract

For several decades, a protocol based on the use of progestagens has been used to manage livestock reproduction with minimal alterations. Recently, researchers have gained insight into the short-term use of progestagen protocols lasting 5-7 days, which has been found to reduce the incidence of vaginitis and obviate the use of antibiotics. Additionally, this approach enables the reutilization of silicone-based devices such as CIDRs after a thorough biosecurity assessment. However, these devices have certain limitations. At the end of the treatment, they must be disposed of and cannot be reused, necessitating a re-evaluation of their use for technical and societal reasons, including animal health and welfare, food safety, and environmental impact.A chitosan-PEG intravaginal implant formulation released progesterone for a period of four days, corresponding to the degradation time of the implant in the vagina. The use of a simple melting and molding process for the combination of PCL-PEG-chitosan implants has been observed to result in degradation of both simulated vaginal fluid and vaginal tissue of cows. The development of intravaginal devices made from biodegradable polymers is considered a potential solution because these materials would degrade within the body, eliminating the need for removal and leaving no residue. These devices are safe for animals and the environment.
Peningkatan Kemampuan Siswa Pada Pemahaman Bidang Studi Al Islam Dengan Pembelajaran Berbasis Konstruktivistik Kontekstual di SMP Muhammadiyah 10 Surabaya Amrozi, Amrozi; Asrori, Asrori
TADARUS Vol 9 No 1 (2020)
Publisher : Prodi Pendidikan Agama Islam - Fakultas Agama Islam ( FAI )

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/td.v9i1.5450

Abstract

Masih banyak guru yang menggunakan pembelajaran konvensional untuk bidang studi al-Islam, tentu saja tidak relevan. Mereka beralasan metode ini lebih mudah dilaksanakan. Pemecahan masalah pendidikan dengan kondisi di lapangan saat ini seperti tersebut di atas,  sebenarnya telah dilakukan oleh pemerintah dengan berbagai pembaharuan, antara lain dengan pelatihan dan peningkatan kompetensi guru.Metode yang di gunakan dalam penelitian adalah penelitian tindakan kelas. Penelitian yang dilakukan dengan menekankan adanya niat yang tinggi untuk bertindak memecahkan masalah dan menyempurnakan situasi. Ini merupakan pencermatan terhadap kegiatan yang sengaja dimunculkan, dan terjadi dalam sebuah kelas.Berdasarkan penelitian pada siklus 1, 2 dan 3 diperoleh simpulan sebagai berikut: Kemampuan guru dalam mengelola pembelajaran kontruktivistik yang kontekstual selama tiga siklus mengalami peningkatan. Padasiklus I yaitu dengan nilai rata-rata sebesar 2,41 dengan kategori baik, siklus II : 2,93 dengan kategori baik, dan siklus III sebesar 3,00 dengan kategori baik; 2. Aktivitas guru selama pembelajaran selama tiga siklus, 2. Ketuntasan belajar siswa secara klasikal pada siklus I yaitu 60%, kemudian pada siklus II meningkat menjadi 88,89% danpadasiklus III menurun menjadi 86,67%, 3. Respon siswa pada penerapan model pembelajaran kontruktivistik yang kontekstual dengan media patung manusia, air dan debu padamateri wudhu, tayamum dan mandi wajib yaitu dengan banyaknya siswa yang menjawab setuju sebesar  82,86 %.
Humas Sebagai Stakeholder Sekolah Dalam Keterserapan Lulusan Siswa Smk Kesehatan Yannas Husada Kamiliyah, Kamiliyah; Widodo, Bambang Sigit; Amrozi, Amrozi
Jurnal Ilmiah Mandala Education (JIME) Vol 7, No 2 (2021): Jurnal Ilmiah Mandala Education
Publisher : Lembaga Penelitian dan Pendidikan Mandala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58258/jime.v7i2.2036

Abstract

AbstractA Public Relations as a Stakeholder in the Availability of Graduates of SMK Kesehatan Yannas Husada Bangkalan.The purpose of this research is to find out the efforts made by public relations as a stakeholder in schools in the availability of vocational school graduates. This research used qualitative method with descriptive qualitative approach. Data collection techniques through (1) Observations, (2) Interviews, and (3) Documentation Studies. The results showed that (1) Public Relations made several special programs that had been prepared at the beginning and implemented in accordance with the planning, (2) The percentage of graduates of SMK Kesehatan Yannas Husada in the last three years was 20% of students working, 55% of students continued their studies, and 25% of students did not or had not worked. Keywords: Public relation, stakeholder, availability  of graduates, vocational school.AbstrakTujuan penelitian ini adalah untuk mengetahui upaya yang dilakukan hubungan masyarakat sebagai stakeholder di sekolah dalam keterserapan lulusan siswa SMK. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif kualitatif. Teknik pengumpulan data melalui (1) Observasi, (2) Wawancara, dan (3) Studi dokumentasi. Hasil penelitian menunjukkan bahwa (1) Humas membuat beberapa program khusus yang di telah disusun di awal dan dilaksanakan sesuai dengan perencanaannya, (2) Persentase  keterserapan lulusan siswa SMK Kesehatan Yannas Husada dalam periode tiga tahun terakhir adalah 20% siswa yang bekerja, 55% siswa yang melanjutkan pendidikan, dan 25% siswa yang tidak atau belum bekerja. Kata Kunci: Humas, stakeholder, keterserapan lulusan, SMK.
THE PRODUCTION OF FREEZE-DRIED EGG YOLK POWDER AND ITS EFFECT ON THE QUALITY OF GARUT RAM LIQUID SEMEN Ariantie, Oriza Savitri; Amrozi, Amrozi; Yusuf, Tuty Laswardi; Rochman, Nurul Taufiqu; Purwantara, Bambang
Jurnal Kedokteran Hewan Vol 15, No 2 (2021): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i2.19669

Abstract

This research aims to evaluate the protective potency of freeze-dried egg yolk powder on Garut ram sperm during the liquid semen preservation process. Semen with good sperm quality was divided into three groups and diluted using the following Tris diluents: fresh egg yolk-Tris (FEY-Tris), commercial egg yolk powder-Tris (CEY-Tris), and freeze-dried egg yolk powder-Tris (DEY-Tris). Semen that had been diluted was observed every 12 hours until sperm progressive motility was 50%. Sperm quality was tested for progressive motility percentages, viability, intact plasma membrane (IPM), and intact acrosome (IA). Fresh egg yolk had a particle size of 14460.00330.76 nm, with polydispersity index value (PI) and zeta potential (ZP) being 1.000.11 and -9.220.30 mV, respectively. The particle size of commercial egg yolk powder was 877.90168.86 nm with PI value 0.340.04 and ZP-28.71.24 mV. The particle size of freeze-dried egg yolk powder was 1296.0086.73 nm, with PI value 0.700.04 and ZP-34.50.64 mV. Progressive motility percentage showed that DEY-Tris diluent managed to survive to 51.116.06% for 168 hours, compared to FEY-Tris (51.256.74%) which survived for 156 hours, although no longer than CEY-Tris diluent (53.476.33%) which survive for 180 hours (P0.05). Higher sperm motility was also supported by viability percentage, IPM, and IA, which were all higher (P0.05). In conclusion, freeze dried egg yolk powder mixed with Tris buffer was able to maintain sperm quality during the liquid semen preservation process.
PREVALENCE OF MARES GRANULOSA THECA CELL TUMOR (GTCT) IN INDONESIA Amrozi, Amrozi; Melia, Juli; Parwati, Luci; Tumbelaka, Ligaya I.T.A.
Jurnal Kedokteran Hewan Vol 13, No 4 (2019): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v13i4.12797

Abstract

This study was conducted to determine the prevalence rate of mares GTCT in Indonesia. Ultrasound examination of ovaries were performed on mares in Java and Madura Island of Indonesia. Thirteen mares had been affected by GTCT from 2913 number of examinations. The prevalence rate of GTCT during year 2006 and 2007 were 4.71% and 5.56%, respectively followed by a decrease in prevalence rate of GTCT during 2008-2014. The reproductive cycle in a mare with GTCT had returned to normal 6 months after ovariectomy.
Co-Authors . Aryogi A. Boediono A. Winarto Ade Ocktaviani Ade Ocktaviani, Ade Adi Winarto Afiqah binti Abd Latif Agik Suprayogi Agus Setiyono Akbar Wijaya Putra Purnama Andriani Andriani Andriyanto . Andriyanto A Andriyanto Andriyanto Anita Esfandiari Arief Boediono Arifianto, Dinar Arman Sayuti Arman Sayuti Asrori Asrori Aulia Andi Mustika Azery bin Kamiring B Purwantara B Purwantara B. Purwantara Bagus Setiawan Bagus Setiawan Bambang Purwantara Bambang Purwatara Bambang Purwatara, Bambang Bambang Sigit Widodo Bayu Febram Prasetyo Bondan Achmadi Bondan Achmadi Bondan Achmadi Bondan Achmadi, Bondan Budianto Panjaitan D Sajuthi Darsono Darsono Dedi Rahmat Setiadi Diah Nugrahani Pristihadi Dian Masyitha E. Y. Yessa Edelina Sinaga Elma Yuliani Yessa Erly R Adistya Erly Rizka Adistya Erly Rizka Adistya Fiqhi Alfiansyah Hamdika Yendri Hazar Sukareksi Hazar Sukareksi, Hazar Herdis . Herdis H Herdis H Herdis Herdis Hidayati Mukarromah Hidayati Mukarromah Ho Kin Wai I Supriatna I wayan Teguh Wibawan I. Wientarsih Ietje Wientarsih IETJE WIENTARSIH Iga Mahardi Iga Mahardi Iman Supriatna Juli Melia Juli Melia K. B. Putro Kamiliyah, Kamiliyah Kiki Amalia Rama koekoeh santoso Krido Brahmo Putro Kudang Boro Seminar Langgeng Priyanto Leo Sapelani Soinbala Ligaya I. T. A. Tumbelaka Ligaya ITA Tumbelaka Luci Parwati M Agus Setiadi M Ibnu Satria M. F. Ulum M. Ibnu Satria Maharani Maharani, Maharani Mokhamad Fakhrul Ulum, Mokhamad Muchidin Noordin MUHAMMAD AGIL Muhammad Danang Eko Yulianto Muhammad Imron Muhammad Imron Muhammad Imron Mutmainnah Mutmainnah Mutmainnah Mutmainnah Ni Wayan Kurniani Karja nisfu bayu kurniadi Nugroho Sampurno Nur Anisa BS Nurul Taufiqu Rochman Nurul Taufiqu Rochman Oriza Savitri Ariantie Oriza Savitri Ariantie P Situmorang Parwati, Luci R I Afiriantini Rachmat Herman Rahminiwati, Min Rastina Rastina Riasari Gail Sianturi Ridi Arif Rivangga Yuda Hendika Roslizawaty r Roslizawaty r Roslizawaty Roslizawaty Rusdin - Santoso . Santoso S Santoso S Santoso Santoso Sari Yanti Hayanti Satya Gunawan Setiadi, Hirawan Siti Dwi Rahmah Ayumi Solly Aryza Srihadi Agungpriyono Sriyanto - Sugganya a/p Ravi Syafruddin S Syafruddin s T L Yusuf Tukiran Tuty Laswardi Yusuf Tuty Laswardi Yusuf TUTY LASWARDI YUSUF W. Manalu Wasmen Manalu Yessa, Elma Yuliani Yudha Fahrimal Yudha Fahrimal Yudi Eka Satria