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Darto Darto
FISIP Universitas Padjadjaran
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Journal : Universa Medicina

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Topiramate sprinkle is effective in the treatment of childhood epilepsy Gunawan, Prastiya Indra; Suharso, Darto
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.34-42

Abstract

BackgroundEpilepsy remains one of the most frequently occurring pediatric problems. Approximately 10-15% patients do not respond to conventional therapy. Topiramate as a novel antiepileptic drug has a broad spectrum activity, presumably indicative of multiple anti-seizure mechanisms. Previous studies of topiramate as adjunctive and monotherapy in adults have shown beneficial effects. The objective of this research was to evaluate the efficacy and tolerability of topiramate sprinkle monotherapy in pediatric epilepsy.MethodsThis experimental research was conducted in the Pediatric Neurology outpatient clinic department, Soetomo hospital, Surabaya, involving 18 consecutive subjects. Subjects meeting the inclusion criteria were treated with topiramate sprinkle adjusted dose. Seizure frequency and side effects were observed in weeks 1, 4, 8, 12, 16, 20 and 24, respectively. Electro encephalogram (EEG) and laboratory examinations were performed prior to and after 6 months of treatment. The t-test for related samples and McNemar test were utilized for statistical analysis. ResultsA total of 15 subjects completed the study. Topiramate-treated patients showed a statistically significant difference of seizure frequency reduction from 2.7 ± 1.16 to 0.13 ± 0.51 (p=0.000) with 93.7% patients being seizure free in 20 weeks. EEG recordings did not differ statistically in decrement of epileptiform activity in 20% subjects. About 7% subjects developed drowsiness and 33.3% subjects suffered from appetite suppression in the initial treatment. Laboratory results showed no abnormalities. ConclusionsThere was reduction of seizure frequency and no EEG recording alterations after topiramate sprinkle monotherapy. Topiramate as a monotherapy is highly effcicacious in childhood epilepsy.
Co-Authors Abas, Azlan Abdullah, Muhammad Solihin Abdur Rabi' Adi Novianto Agung Purnomoadi Agus Iswantoko Agus Suprapto Aiyub, Kadaruddin Ali Murtadho, Mohammad Alifa, Rosita Angelia Ratnasari, Affi Anggraeni, Asih Anindya, Galuh Rajni Annaufal, Ubbayu Ashari, Ari Bagiasna, Komang Beni K. Elyoza Rimporokok Bilal Syahrul Istiqlal, Ahmad Budiman Rusli C.M. Sri Lestari, C.M. Sri Dhuhitta, Aryya Mulya Dian Nur Aini, Dian Nur Edo Muhamad Hadad Gibran, Edo Muhamad Eko Prasetyo Widyanto Eko Retnowati, Eko Elisa Susanti Eriana Melinawati Farras Wahdan, Arib Fauzi, Muhammad Rifqi Firman Nusa, Rafi Handoyo Saputro, Handoyo Hasan, Saiful Heris Pamuntjar Hermawan Udiyanto Hermawan, Susong Heru Priyanto Heru Priyanto I Made Sunada I Wayan Sukarya Dilaga Iman Santoso Irma Mardhianna, Irma Jalif Jalif Ksatriya, Yudhistya Ngudi Insan Kurnia Irawati, Raden Roro Astrid Kurniawan, Pradhana Laqif, Abdurahman Laqif, Abdurrahman Miftah, Ahmad Zaini Mudasir Mudasir Muhammad, Bayu Muharam, Riki Satia Muhtady, Dedi Muhtar, Entang Adhy Natalia, Deska Ngudi Insan Ksyatria, Yudhistira Nina Karlina Nuraeni, Annisa Suci Nurlaily Rafikalia Iskandar, Winda Nursanti, Erma Nuur, Aliffudin Pertiwi, Shyntia Jashmin Prasojo, Imam Hakim Prastiya Indra Gunawan Prisasanti, Dympna Prameilita Puji Hariati Winingsih, Puji Hariati Rahmad Mulyadi Rantasari, Affi Angelia Ratnasari, Affi Angelia Rd. Ahmad Buchari, Rd. Ahmad Rohmah, Fadillah Nur Rudi Hariyanto Rusdijanto Rusdijanto, Rusdijanto Rusdijianto Rusdijianto Savitri Aditiany Sebastian, Rio Sholihah, Sitta Hasanatin Sudjatmiko Sudjatmiko, Sudjatmiko Sudjatmiko, Sudjatmiko Sufiyanto Sufiyanto, Sufiyanto Suhanto, Laura Novelia Sulaiman Zuhdi Suprapto Suprapto Suryasari, Gadis Tazid, Abu Teguh Prakosa, Teguh Thahir, Musa Ucu Koswara, Ucu Uki Retno Budihastuti Utomo, Gadhang Satryo Wahyu Dirgantara Wardatul Mufidah Wasyanto, Trisulo Wibowo, Sandi Yusuf Heri Widya Dwiyanti Wijayanti, Agung Sari Wisnuwati, Wisnuwati