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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Berkala Ilmu Kesehatan Kulit dan Kelamin INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Farmasi Sains dan Komunitas Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) JCRS (Journal of Community Research and Service) Journal of halal product and research (JHPR) Berkala Ilmiah Kimia Farmasi Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Jurnal Masyarakat Madani Indonesia Camellia Journal of Tropical Pharmacy and Chemistry
Esti Hendradi
Departement Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : UNEJ e-Proceeding

 1 
EFFECT OF SOLID LIPID NANOPARTICLE (SLN) AND NANO STRUCTURE LIPID CARRIER (NLC) SYSTEM ON ANTIOXIDANT STABILITY OF TOMATO EXTRACT (LIPID: CETYL ALCOHOL AND ISOPROPYL MYRISTATE) Sayyidati Aqilah; Esti Hendradi; Noorma Rosita
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Tomato extract was known contains manyantioxidants (Chauhan et al., 2010), such aslycopene, that are easily degraded by UV-B rays. Themechanism lycopene as an antiaging is to reduceskin regeneration and increase the thickness of theepidermis (Sahasrabuddhe, 2011). As anantioxidant, lycopene easily degraded when exposedto light, heat, and oxygen (Chauhan et al., 2011).Drug delivery system based on nanolipid carriersystem, such as: Solid Lipid Nanoparticles (SLN) wasappropriate to stabilize lycopene, as lipophilicsubstance (Wissing and Muller, 2003; Helgason etal., 2009; and Okonogi dan Riangjanapatee, 2014).One of the limitations of SLN is the drug moleculethat has been trapped expulsed easily duringstorage. It is caused of the orderdness of lattice lipidcrystal. Replacement part of solid lipid using liquidlipid (called as nanostructure lipid carriers or NLC)can reduce the orderdness of lattice lipid crystall andit will repaired it (Kaur et al, 2015).In this research have been tried to be compared theability of SLN and NLC to improve the stability ofantioxidant tomato extract. Using 20% total amountof lipid, extract tomato-SLN made from cetyl alcoholas solid lipid and extract tomato-NLC made fromdifference ratio between cetyl alcohol and isopropylmyristate (IPM) such as: 9:1 and 7:3. Tween 80 andKollipor were used as surfactant and co-surfactant.IPM was choose because of its enhancer andemollient effect so easily to apply to the skin(Vadgama et al, 2015).
INFLUENCE OF OLEIC ACID ON THE IN VITRO PENETRATION OF DICLOFENAC SODIUM GEL Lidya Ameliana; Esti Hendradi; Mochammad Yuwono
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Diclofenac sodium (DS) is a nonsteroidalantiinflammatory drugs (NSAIDs), that inhibitscyclooxygenase-2 enzyme (COX-2). It has first passmetabolism by 40-50%, because of its shortbiological half-life, the drug has to be givenfrequently (Ganiswara, 2005). Dose of DS in gel is 1%(Sweetman, 2007). In peroral use, it may cause therisk of gastrointestinal bleeding, cardiovascular,hypersensitivity reactions and disorders of thecentral nervous (Katzung, 2002, Chuasuwan, et al.,2008).DS does not penetrate well through skin and cannotreach the effective concentration at the site ofaction after transdermal application (Mohammed,2001; Ozguney, et al., 2006). DS partition coefficientin n-octanol-buffer aqua (log P) was 1.1 (Chuasuwan,2008). Lipophilic nature of the stratum corneum andthe hydrophilic nature of the underlying tissuesshowed that the drug will penetrate the skin shouldhave an optimal balance between the lipophilic andhydrophilic properties. In general, the skin is morepermeable to the material which has a partitioncoefficient (P) in octanol-water between 10-1000(Michniac-Kohn et al., 2005).Oleic acid enhances the penetration of drugs intothe skin by increasing the fluidity of the stratumcorneum lipids through the establishment ofchannels (water channels) (Fang , et al , 2003)This study aimed to know the influence of OleicAcid (OA) in several concentrations (1%, 3% and5%) as penetration enhancer on the in vitropenetration of topical DS gel. Furthermore, thephysical properties of the topical preparation(organoleptic, pH and viscosity), and DS penetrationpercutaneously through rat skin . Then observedthat in spite of DS assay and penetrate through therat skin at certain intervals and observed by meansof HPLC.
MICROBIAL ASSAY OF CYPROFLOXACIN IN A BONE IMPLANT (CHITOSAN –BOVINE HYDROXYAPATITE WITH CROSS-LINKER GLUTARALDEHYDE) TOWARDS Staphylococcus aureus ATCC 25923 Esti Hendradi; Dewi Melani Hariyadi; Muhammad Faris Adrianto
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Bone is one part of the body has an important roleto support the body's physiological functions (Porteret al., 2009). Complications of bone diseases andbone disorders caused by traumatic accidents mayresult in a gap (defect) on the bone. The healingprocess of damage or fracture is determined by thelevel of trauma and soft tissue damage (Strobel etal., 2011). Some cases of damage or injury to thebone can not undergo natural recovery (Porter et al.,2009). Therefore, clinical rehabilitation to overcomethe defect on the bone is expected to increase in linewith population growth (Mourino et al., 2010).Treatment rehabilitation of bone cannot beseparated from the risk of infection complications.Complications of bacterial infections can be treatedwith antibiotics. However, in the case of a crack(defect) occurs devascularity of bone tissue so thatthe delivery of antibiotics to the target tissue to beblocked. This resulted in the concentration of theantibiotic to the target so low that it cannotpenetrate the bacteria. The condition can lead tobacterial resistance to antibiotics (Li et al., 2010). Ahigh dose of antibiotics in the long term experiencedproblems because it can cause systemic toxicity andside effects (Mourino et al., 2010). To overcomethese problems, antibiotics can be done locally usinga certain drug delivery systems. The purpose of suchdelivery systems is to provide drug concentration ina specific location and ensure the drug releaseprofile for a certain time period (Dubnika et al.,2012). Drug delivery locally has several advantages,among others, (a) the systemic effects can beavoided, (b) the amount of drugs used less andsecure, and (c) the efficacy and efficiency of drugdelivery locally can be achieved (Harmankaya et al.,2013). Administration of antibiotics locally also tominimize side effects and risk of toxicity comparedto administration of systemic antibiotics. In addition,antibiotics locally also allows conduction in targettissues with high concentration (Mourino et al.,2010). The release of antibiotics on the targetnetwork is expected to last continuously for a certaintime and achieve a greater concentration than theminimum inhibitory concentration (MIC). Drugdelivery systems in a controlled manner (controlledrelease system) can help increase the bioavailabilityof antibiotics in target tissues. The system isdesigned to release the drug at the expectedlocation at a rate appropriate for a certain timeperiod (Mourino et al., 2010). In a previous studyshowed that a good composite is Ciprofloxacin: BHA:Chitosan = 10:30:60. Cross linker withglutaraldehyde (GA) 0.7% and with 10% activeingredient Ciprofloxacin can release Cyprofloxacinfor 30 days (Hendradi et al, 2015). This research willbe seen potency against Staphilococcus aureusATCC25923 Ciprofloxacin for 30 days.
Co-Authors Abdulloh Suyuti Abhimata Paramanandana Achmad Toto Poernomo Adeltrudis Adelsa Danimayostu Aditya Fridayanti Aditya Fridayanti Afif Nurul Hidayati, Afif Nurul Ameliana, Lidya Anang Setyo Wiyono Andang Miatmoko Anggai, Rifka Anggraini Ardhani Dwi Lestari1 Arya Putra Damari Aty Widyawaruyanti Bambang Tri Purwanto Budiatin, Aniek Setiya Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Damayanti Dewi Hariyadi Dewi Isadiartuti Dewi Isadiartuti Dewi Melani Hariyadi Diah Mira Indramaya Dini Retnowati Dini Retnowati Dioni fadia Zatalini Diyah, Nuzul Wahyuning Diyah, Nuzul Wahyuning Djoko Agus Purwanto Dwi Murtiastutik Dwi Setiawan Dyah Rahmasari Esti Rahayuningtyas Evy Ervianti Firdausiah Fania Dwi Putri Putri Frida Magdalena Fridayanti, Aditya Hadi Poerwono Hadi Purwono Hariyadi, Dewi Hariyadi, Dewi Hariyadi, Dewi Melany Hasan, Wafiqah Latuapo Ida Kristianingsih Idha Kusumawati Irawan, Mukhlis Bayu Irawan, Mukhlis Bayu Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Juni Ekowati Khoirotul Lailiyah Lailiyah, Khoirotul Lailiyah, Khoirotul Latifah, Luluk Linda Astari, Linda M. Agus Syamsur Rijal M. Yulianto Listiawan Mahmudah, Rifaatul Mangestuti Agil Maulia, Arwinda Melanny Ika Sulistyowaty Miatmoko, Andang Mochammad Yuwono Mohammad Agus Sjamsur Rijal Mufariha, Mufariha Muhammad Al Rizqi Dharma Fauzi Muhammad Faris Adrianto Nahdhia, Nadhifatun Namira, Desya Shafa Ninis Yuliati, Ninis Noorma Rosita Nurul Fitriani Nurul Fitriani Paramita, Diajeng Putri Pepy Dwi Endraswari, Pepy Dwi Philip Drake Pratiwi Pudjiastuti Pratiwi, Karina Dyahtantri Pujianti, Efrin Pujianti, Efrin Purnomo, Ahmad Toto Purwitasari, Neny Qurrotu A'yunin Rahmadewi Rahmadewi Rahmadhanniar, Erwinda Rahman, Ave Rahmi Annisa Ramadhani, Firmansyah Ardian Raudatul Patimah Retno Sari Retno Sari Retno Sari Rifaatul Mahmudah Rifka Anggraini Anggai Rijal, Agus Syamsur Riyana Noor Oktaviyanti Riyanto Teguh Widodo Riyanto Teguh Widodo Rubianti, Marissa Astari Safarini Marwah Savitri, Orchidea Meidy Nurintan Sawitri Sawitri Sawitri Sawitri Sayyidati Aqilah Siswandono, Siswandono Siti Wafiroh Sudjarwo Sugiyartono, Sugiyartono Sugiyartono1 Sukardiman Sulistyowati, Melanny Ika SUZANA, SUZANA Tengku Riza Zarzani N Tri Susanti Tri Widiandani Tristiana Erawati Tristiana Erawati Tutiek Purwanti Uswatun Chasanah Uswatun Chasanah Wiwied Ekasari Yusniasari, Putri Antika Yusuf Wibisono Yusuf, Helmy Yusuf, Helmy