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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Berkala Ilmu Kesehatan Kulit dan Kelamin INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) JCRS (Journal of Community Research and Service) Journal of halal product and research (JHPR) Berkala Ilmiah Kimia Farmasi Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Jurnal Masyarakat Madani Indonesia Camellia Journal of Tropical Pharmacy and Chemistry
Esti Hendradi
Departement Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Nanospanlastics For Transdermal and Topical Drug Delivery: Formulation, Characterization, and Therapeutic Applications: Nanospanlastik untuk Penghantaran Obat Transdermal dan Topikal: Formulasi, Karakterisasi, dan Aplikasi Terapeutik Fitria Rahmadiani; Esti Hendradi; Tutiek Purwanti
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 12 No. 1 (2026): (March 2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2026.v12.i1.17933

Abstract

Nanospanlastic is an elastic nanovesicular drug delivery system developed to enhance skin penetration, retention, and therapeutic efficacy in topical and transdermal applications. However, variations in formulation methods, characterization parameters, and evaluation approaches across studies have limited the standardization of its performance. This review was conducted systematically in accordance with the PRISMA guidelines. A comprehensive literature search was performed using international electronic databases, including ScienceDirect, Springer, PubMed, SAGE, and Taylor & Francis online, covering publications from 2015 to 2025. The keywords used were "nanospanlastic,” “spanlastic,” “nanovesicles,” “transdermal,” “topical,” “characterization,” and “application.” Articles were screened based on predefined inclusion and exclusion criteria, and 32 eligible studies were selected for qualitative meta-synthesis analysis. This article presents a cross-study comparative analysis focusing on formulation factors, physicochemical characteristics, deformability, stability, and dermatological applications. The synthesis results indicate that surfactant–edge activator composition, manufacturing methods, and component ratios significantly influence particle size, polydispersity index (PDI), entrapment efficiency, and deformability index, which, in turn, determine skin penetration and retention performance. Although nanospanlastic demonstrates improved permeation and promising pharmacological effects, challenges remain regarding long-term stability, chronic safety, and scalability for GMP-based industrial production. This review highlights critical research gaps and proposes future development directions, including formulation optimization, harmonization of characterization methods, and broader clinical validation. Therefore, nanospanlastic represents a promising innovative platform for dermatological drug delivery but requires further systematic and translational development
Nanostructured Lipid Carrier (NLC) as a Topical Drug Delivery System : A Review Luluk Latifah; Esti Hendradi; Dewi Isadiartuti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006789

Abstract

Nanostructured Lipid Carrier (NLC) appears as the next generation of lipid nanoparticles which overcomes the weaknesses of Solid Lipid Nanoparticles (SLN). NLC is a delivery system that offers several advantages, such as significantly improved entrapment efficiency, reduced drug expulsion during long-term storage, and increased contact between the drug and the stratum corneum, thereby enhancing drug penetration. The methods used to manufacture NLC have high energy-required such as high-pressure homogenization and high shear homogenization, low energy-required such as microemulsification and phase inversion, and very low or no energy-required such as solvent evaporation and solvent injection. The basic components of an NLC are solid lipids, liquid lipids, and surfactants or mixtures of surfactants. This narrative review refers to several previously published databases on the types, preparation methods, and physical properties of NLC. This review focuses on descriptions related to the NLC as a topical drug delivery system.
PERAN STRATEGIS PKK DALAM MENUNJANG PENINGKATKAN PEMAHAMAN MASYARAKAT TENTANG OBAT DAN SUPLEMEN MAKANAN Esti Hendradi; Retno Sari; Tutiek Purwanti; Tristiana Erawati; Andang Miatmoko; Sugiyartono Sugiyartono
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 2 (2025): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i2.28739

Abstract

Abstrak: Pemahaman masyarakat tentang obat termasuk cara mendapatkan, menggunakan, menyimpan dan membuang serta penggunaan suplemen makanan masih perlu mendapat perhatian khusus, terutama untuk masyarakat perifer. Peran apoteker dibutuhkan dalam mengedukasi masyarakat dengan melibatkan gerakan Pemberdayaan dan Kesejahteraan Keluarga (PKK). Tujuan PKM ini adalah meningkatkan pengetahuan tentang obat dan suplemen makanan kepada masyarakat dengan memberdayakan PKK. Tim pengabdian kepada masyarakat Fakultas Farmasi Universitas Airlangga telah menyelenggarakan kegiatan bakti sosial bersama-sama IAI dan kader PKK di Kota Madya Tuban dalam bentuk penyuluhan atau sosialisasi terkait obat dan suplemen makanan. Sosialisasi dilakukan melalui Webinar via Zoom Meeting dalam bentuk seminar dan diskusi interaktif, karena aktivitas pengabdian dilaksanakan saat pandemi Covid-19. Sebagai mitra pada pengabdian masyarakat ini adalah Kader PKK dan Ketua Ikatan Apoteker Indonesia (IAI) Cabang Tuban dengan jumlah peserta yang hadir sejumlah 71 orang. Hasil evaluasi melalui pre-test dan post-test menunjukkan bahwa setelah mengikuti kegiatan rerata pemahaman peserta meningkat 7,04% dan 12,7% masing-masing untuk materi DAGUSIBU dan Probiotik. Diharapkan PKK secara aktif menyebar-luaskan kegiatan sosialisasi kepada masyarakat di seluruh desa.Abstract: Public understanding of medicines, including how to obtain, use, store and dispose of them as well as the use of food supplements, still needs special attention, especially for peripheral communities. The role of pharmacists is needed in educating the public by involving the Family Empowerment and Welfare (PKK) movement. The aim of this PKM is to increase knowledge about medicines and food supplements among the community by empowering PKK. The community service team at the Faculty of Pharmacy, Airlangga University has held social service activities together with IAI and PKK cadres in Tuban in the form of counseling or outreach regarding medicines and food supplements. Socialization was carried out through Webinar via Zoom Meeting in the form of seminars and interactive discussions, because service activities were carried out during the Covid-19 pandemic. As partners in this community service were PKK cadres and the Chair of the Indonesian Pharmacists Association (IAI) in Tuban city with a total of 71 participants attending. The evaluation results via pre-test and post-test showed that after participating in the activity the participants' average understanding increased by 7.04% and 12.7% for DAGUSIBU and Probiotic material, respectively. It is hoped that the PKK will actively spread outreach activities to communities throughout the village.
Co-Authors Abdulloh Suyuti Achmad Toto Poernomo Adeltrudis Adelsa Danimayostu Aditya Fridayanti Aditya Fridayanti Afif Nurul Hidayati, Afif Nurul Ameliana, Lidya Anang Setyo Wiyono Andang Miatmoko Anggai, Rifka Anggraini Ardhani Dwi Lestari1 Arya Putra Damari Aty Widyawaruyanti Bambang Tri Purwanto Budiatin, Aniek Setiya Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Damayanti Dewi Isadiartuti Dewi Melani Hariyadi Diah Mira Indramaya Dini Retnowati Dioni fadia Zatalini Diyah, Nuzul Wahyuning Diyah, Nuzul Wahyuning Djoko Agus Purwanto Dwi Murtiastutik Dwi Setiawan Dyah Rahmasari Esti Rahayuningtyas Evy Ervianti Firdausiah Fania Dwi Putri Putri Firmansyah Ardian Ramadhani Fitria Rahmadiani Frida Magdalena Fridayanti, Aditya Hadi Poerwono Hadi Purwono Hariyadi, Dewi Hariyadi, Dewi Melany Hasan, Wafiqah Latuapo Ida Kristianingsih Idha Kusumawati Irawan, Mukhlis Bayu Irawan, Mukhlis Bayu Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Juni Ekowati Khoirotul Lailiyah Lailiyah, Khoirotul Lailiyah, Khoirotul Linda Astari, Linda Luluk Latifah M. Yulianto Listiawan Mahmudah, Rifaatul Mangestuti Agil Maulia, Arwinda Melanny Ika Sulistyowaty Mochammad Yuwono Mohammad Agus Sjamsur Rijal Mufariha, Mufariha Muhammad Al Rizqi Dharma Fauzi Muhammad Faris Adrianto Namira, Desya Shafa Ninis Yuliati, Ninis Noorma Rosita Nurul Fitriani Nurul Fitriani Paramanandana, Abhimata Paramita, Diajeng Putri Pepy Dwi Endraswari, Pepy Dwi Philip Drake Pratiwi Pudjiastuti Pratiwi, Karina Dyahtantri Pujianti, Efrin Pujianti, Efrin Purnomo, Ahmad Toto Purwitasari, Neny Qurrotu A'yunin Rahmadewi Rahmadewi Rahmadhanniar, Erwinda Rahman, Ave Rahmi Annisa Raudatul Patimah Retno Sari Retno Sari Retno Sari Retno Sari Rifaatul Mahmudah Rifka Anggraini Anggai Rijal, Agus Syamsur Riyana Noor Oktaviyanti Riyanto Teguh Widodo Rubianti, Marissa Astari Safarini Marwah Savitri, Orchidea Meidy Nurintan Sawitri Sawitri Sawitri Sawitri Sayyidati Aqilah Siswandono, Siswandono Siti Wafiroh Sudjarwo Sugiyartono Sugiyartono Sugiyartono, Sugiyartono Sugiyartono1 Sukardiman Sulistyowati, Melanny Ika SUZANA, SUZANA Tengku Riza Zarzani N Tri Susanti Tri Widiandani Tristiana Erawati Munandar Tutiek Purwanti Uswatun Chasanah Uswatun Chasanah Wiwied Ekasari Yusniasari, Putri Antika Yusuf Wibisono Yusuf, Helmy Yusuf, Helmy