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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Berkala Ilmu Kesehatan Kulit dan Kelamin INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Farmasi Sains dan Komunitas Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) JCRS (Journal of Community Research and Service) Journal of halal product and research (JHPR) Berkala Ilmiah Kimia Farmasi Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Jurnal Masyarakat Madani Indonesia Camellia Journal of Tropical Pharmacy and Chemistry

Esti Hendradi

Departement Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya

Author-ID : 2536238

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Effect of Lipid Ratio of Stearic Acid and Oleic Acid on Characteristics of Nanostructure Lipid Carrier (NLC) System of Diethylammonium Diclofenac Hendradi, Esti; Rosita, Noorma; Rahmadhanniar, Erwinda
Indonesian Journal of Pharmacy Vol 28 No 4, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of this study was to determine the effect of lipid ratio of stearic acid and oleic acid on the physical characteristics as well as the entrapment efficiency of diethylammonium diclofenac with Nanostructure Lipid Carrier (NLC) system. Diethylammonium diclofenac (DETA) is Non-Steroid Anti-Inflamatory Drugs (NSAIDs) that has been widely used in the treatment of osteoarthritis and rheumatoid arthritis. In the formulation of NLC-DETA, three different lipid ratios were used, which the ratio of Â stearic acid:oleic acid were 60:40, 70:30, and 80:20, respectively. In this NLC system, DETA served as the active drug, stearic acid as solid lipid, oleic acid as liquid lipid, and Tween 80 as surfactant components. NLC were characterized for organoleptic characteristics, pH, viscosity, particle morphology, particle size and polydispersity index (PI), profiles of Fourier Transform Infra-Red (FTIR) and Differential Thermal Analysis (DTA), and drug entrapment efficiency. The particle shape and morphology were determined by Transmission Electron Microscopy (TEM). The results Â showed that the different ratios of oleic acid lipids and stearic acid had no significant effects on the viscosity and entrapment efficiency of NLC-DETA. On the other hand, it affected the pH of all formulas, which were significantly different. Increasing the amount of liquid lipid in the formulations reduced the size of NLC-DETA particles.Â

Optimation Ca-Alginate Beads as Drug Reservoir in the Patch System for Model AntiInflammatory Drug Esti Hendradi; Isnaeni Isnaeni; Rifaatul Mahmudah
Health Notions Vol 2, No 9 (2018): September
Publisher : Humanistic Network for Science and Technology (HNST)

The aim of this study was to optimize the use of Ca-Alginates beads as a drug reservoir in the patch system with and without freeze-drying process. Meloxicam, an anti-inflammatory non-steroidal drug, was used as a drug model. Ca-alginate beads were prepared by ionic gelation method using polymer alginate and cross-linker CaCl2. The beads were evaluated for its melting temperature, FTIR spectra, and entrapment efficiency. The FTIR study showed the loss of guluronic peaks of alginate caused by a cross-linking process with Ca2+, characteristics peaks of meloxicam still appeared indicating the compatibility of the drug with the polymers used. The using Ca-alginate beads without freeze-drying process as a drug reservoir resulted in a very wet patch that was difficult to dry, cracked surface, and pharmaceutically not acceptable. Meanwhile, patch using Ca-alginate beads with the freezedrying process as a drug reservoir demonstrated satisfactory characteristics with minimum weight variation among the patches that lead to giving uniformity in the drug content. Keywords: Ca-alginate, Freeze-dry, Patch, Meloxicam, Transdermal delivery

Preparation and characterization of BSA-loaded Chitosan Microspheres Esti Hendradi; Retno Sari; Rifka Anggraini Anggai
Health Notions Vol 2, No 9 (2018): September
Publisher : Humanistic Network for Science and Technology (HNST)

Proteins are unstable molecules because of their complex structure and easily degraded by enzymatic systems. Biodegradable microspheres have been used in protein delivery system. Bovine serum albumin was chosen as a model protein. Chitosan/tripolyphosphate microparticles have already been used to encapsulated BSA. The aim of this work was to microencapsulate these protein-CS/TPP by ionic gelation and freeze-drying. The morphology, particle size, and encapsulation efficiency of the prepared microspheres were investigated. The results revealed that the microspheres exhibited good sphericity with ranged in size from 2.25 to 2.73 µm. The study found that the moisture content of microspheres was 2.8%, the encapsulation efficiency of BSA in CS-TPP microspheres ranged from 88.14 to 96.25%. The results suggested that iontoropic gelation method will be an effective method for fabricating chitosan microspheres for delivery of protein.. Keywords: Microspheres, BSA, Ionic Gelation

Formulation and evaluation of hand sanitizer gel containing infused of binahong leaf (Anredera cordifolia) as antibacterial preparation Dyah Rahmasari; Esti Hendradi; Uswatun Chasanah
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.13008

Hand sanitizer gel is one of the alternative methods for hand hygiene when soap and water are not available. Binahong leaf (Anredera cordifolia) is a natural herb that has phenolic, flavonoids, saponins, and the steroid-terpenoids compound, which is potentially used as the active ingredient in the hand sanitizer gel. The primary purpose of this research was to determine the antibacterial potential and physicochemical properties of a hand-sanitizer gel containing binahong leaves’ infusion against Staphylococcus aureus. The efficacy of this formulation was tested against a bacterial strain using the disc diffusion method and determined by measuring the inhibition zone of each preparation. The testing of physicochemical properties includes the organoleptic test, pH, viscosity, and gel spreadability. The physicochemical characteristics of the gel showed excellent properties for all formulas. The antibacterial test showed that hand sanitizer gel containing an infusion of binahong’s leaves has an inhibition zone (6.02 mm; 6.24 mm; 6.55 mm), almost close to a positive control (9.15 mm). In conclusion, the formulated hand sanitizer gel possesses the antibacterial potential to inhibit S. aureus.

Formulation and evaluation of erythropoietin-alginate microspheres at different amount of drug Dewi Hariyadi; Esti Hendradi; Khoirotul Lailiyah
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This research formulate erythropoietin-alginate microspheres and to evaluate characteristics of erythropoietin-alginate microspheres at different amount of drug using aerosolization. Amount of erythropoietin are 10.000 IU (F1); 20.000 IU (F2); 60.000 IU (F3). The mixture of erythropoietin-alginate was sprayed into CaCl2 and was stirred at 1000 rpm for 30 minutes. Formulas resulted spherical shape of microspheres. The size of microspheres was 2.77 Âµm for F1; 3.89 Âµm for F2; and 4.42 Âµm for F3. The results of swelling index showed that swelling index of microspheres increased by increasing the concentration of erythropoietin. The results were in accordance with the size of the microspheres that increased with increasing concentration of drug. The yields of microspheres obtained were respectively 91.92%; 87.53%; 86.50% for F1, F2 and F3. It can be concluded that the particle size of microspheres, swelling index increased by increasing concentration of erythropoietin. In contrast, yield of microspheres decreased by increasing drug concentration. In conclusion, formula of microspheres were potential in terms of characteristics and may recommend for further in vivo study.Â

EFFECT OF SOLID LIPID NANOPARTICLE (SLN) AND NANO STRUCTURE LIPID CARRIER (NLC) SYSTEM ON ANTIOXIDANT STABILITY OF TOMATO EXTRACT (LIPID: CETYL ALCOHOL AND ISOPROPYL MYRISTATE) Sayyidati Aqilah; Esti Hendradi; Noorma Rosita
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Tomato extract was known contains manyantioxidants (Chauhan et al., 2010), such aslycopene, that are easily degraded by UV-B rays. Themechanism lycopene as an antiaging is to reduceskin regeneration and increase the thickness of theepidermis (Sahasrabuddhe, 2011). As anantioxidant, lycopene easily degraded when exposedto light, heat, and oxygen (Chauhan et al., 2011).Drug delivery system based on nanolipid carriersystem, such as: Solid Lipid Nanoparticles (SLN) wasappropriate to stabilize lycopene, as lipophilicsubstance (Wissing and Muller, 2003; Helgason etal., 2009; and Okonogi dan Riangjanapatee, 2014).One of the limitations of SLN is the drug moleculethat has been trapped expulsed easily duringstorage. It is caused of the orderdness of lattice lipidcrystal. Replacement part of solid lipid using liquidlipid (called as nanostructure lipid carriers or NLC)can reduce the orderdness of lattice lipid crystall andit will repaired it (Kaur et al, 2015).In this research have been tried to be compared theability of SLN and NLC to improve the stability ofantioxidant tomato extract. Using 20% total amountof lipid, extract tomato-SLN made from cetyl alcoholas solid lipid and extract tomato-NLC made fromdifference ratio between cetyl alcohol and isopropylmyristate (IPM) such as: 9:1 and 7:3. Tween 80 andKollipor were used as surfactant and co-surfactant.IPM was choose because of its enhancer andemollient effect so easily to apply to the skin(Vadgama et al, 2015).

INFLUENCE OF OLEIC ACID ON THE IN VITRO PENETRATION OF DICLOFENAC SODIUM GEL Lidya Ameliana; Esti Hendradi; Mochammad Yuwono
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Diclofenac sodium (DS) is a nonsteroidalantiinflammatory drugs (NSAIDs), that inhibitscyclooxygenase-2 enzyme (COX-2). It has first passmetabolism by 40-50%, because of its shortbiological half-life, the drug has to be givenfrequently (Ganiswara, 2005). Dose of DS in gel is 1%(Sweetman, 2007). In peroral use, it may cause therisk of gastrointestinal bleeding, cardiovascular,hypersensitivity reactions and disorders of thecentral nervous (Katzung, 2002, Chuasuwan, et al.,2008).DS does not penetrate well through skin and cannotreach the effective concentration at the site ofaction after transdermal application (Mohammed,2001; Ozguney, et al., 2006). DS partition coefficientin n-octanol-buffer aqua (log P) was 1.1 (Chuasuwan,2008). Lipophilic nature of the stratum corneum andthe hydrophilic nature of the underlying tissuesshowed that the drug will penetrate the skin shouldhave an optimal balance between the lipophilic andhydrophilic properties. In general, the skin is morepermeable to the material which has a partitioncoefficient (P) in octanol-water between 10-1000(Michniac-Kohn et al., 2005).Oleic acid enhances the penetration of drugs intothe skin by increasing the fluidity of the stratumcorneum lipids through the establishment ofchannels (water channels) (Fang , et al , 2003)This study aimed to know the influence of OleicAcid (OA) in several concentrations (1%, 3% and5%) as penetration enhancer on the in vitropenetration of topical DS gel. Furthermore, thephysical properties of the topical preparation(organoleptic, pH and viscosity), and DS penetrationpercutaneously through rat skin . Then observedthat in spite of DS assay and penetrate through therat skin at certain intervals and observed by meansof HPLC.

MICROBIAL ASSAY OF CYPROFLOXACIN IN A BONE IMPLANT (CHITOSAN –BOVINE HYDROXYAPATITE WITH CROSS-LINKER GLUTARALDEHYDE) TOWARDS Staphylococcus aureus ATCC 25923 Esti Hendradi; Dewi Melani Hariyadi; Muhammad Faris Adrianto
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Bone is one part of the body has an important roleto support the body's physiological functions (Porteret al., 2009). Complications of bone diseases andbone disorders caused by traumatic accidents mayresult in a gap (defect) on the bone. The healingprocess of damage or fracture is determined by thelevel of trauma and soft tissue damage (Strobel etal., 2011). Some cases of damage or injury to thebone can not undergo natural recovery (Porter et al.,2009). Therefore, clinical rehabilitation to overcomethe defect on the bone is expected to increase in linewith population growth (Mourino et al., 2010).Treatment rehabilitation of bone cannot beseparated from the risk of infection complications.Complications of bacterial infections can be treatedwith antibiotics. However, in the case of a crack(defect) occurs devascularity of bone tissue so thatthe delivery of antibiotics to the target tissue to beblocked. This resulted in the concentration of theantibiotic to the target so low that it cannotpenetrate the bacteria. The condition can lead tobacterial resistance to antibiotics (Li et al., 2010). Ahigh dose of antibiotics in the long term experiencedproblems because it can cause systemic toxicity andside effects (Mourino et al., 2010). To overcomethese problems, antibiotics can be done locally usinga certain drug delivery systems. The purpose of suchdelivery systems is to provide drug concentration ina specific location and ensure the drug releaseprofile for a certain time period (Dubnika et al.,2012). Drug delivery locally has several advantages,among others, (a) the systemic effects can beavoided, (b) the amount of drugs used less andsecure, and (c) the efficacy and efficiency of drugdelivery locally can be achieved (Harmankaya et al.,2013). Administration of antibiotics locally also tominimize side effects and risk of toxicity comparedto administration of systemic antibiotics. In addition,antibiotics locally also allows conduction in targettissues with high concentration (Mourino et al.,2010). The release of antibiotics on the targetnetwork is expected to last continuously for a certaintime and achieve a greater concentration than theminimum inhibitory concentration (MIC). Drugdelivery systems in a controlled manner (controlledrelease system) can help increase the bioavailabilityof antibiotics in target tissues. The system isdesigned to release the drug at the expectedlocation at a rate appropriate for a certain timeperiod (Mourino et al., 2010). In a previous studyshowed that a good composite is Ciprofloxacin: BHA:Chitosan = 10:30:60. Cross linker withglutaraldehyde (GA) 0.7% and with 10% activeingredient Ciprofloxacin can release Cyprofloxacinfor 30 days (Hendradi et al, 2015). This research willbe seen potency against Staphilococcus aureusATCC25923 Ciprofloxacin for 30 days.

Karakter Solid Lipid Nano Particle (SLN) – Ubiquinon (Q10) dengan Beda Jenis Kosurfaktan: Poloxamer 188, Lesitin, Propilen Glikol Noorma Rosita; Qurrotu A'yunin; Esti Hendradi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 6 No. 1 (2019): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Pendahuluan: Ubiquinon atau Coenzyme Q10 (CoQ10) merupakan senyawa kimia yang tidak stabil terhadap cahaya, sehingga mudah terdegradasi. Oleh karena itu, sistem penghantaran yang bisa meningkatkan kestabilan dari CoQ10 sangat dibutuhkan. Solid lipid nanoparticles (SLN) diketahui mampu meningkatan stabilitas molekul, dan memiliki karakteristik pelepasan terkontrol. Karakteristik SLN (ukuran partikel dan efisiensi penjebakan obat), sangat dipengaruhi kompoen penyusun SLN. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui pengaruh perbedaan jenis kosurfaktan terhadap karakteristik SLN-CoQ10. SLN-CoQ10 dibuat dengan metode high shear homogenization pada kecepatan 24000 rpm selama 2 menit, 4 siklus. Metode: Pada penelitian ini dibuat empat formula SLN-CoQ10 dengan propilen glikol (A1), poloxamer 188 (B1), lesitin (C1) sebagai kosurfaktan dan pembanding tanpa kosurfaktan (D1). Hasil: Ukuran diameter partikel SLN-CoQ10 yang dihasilkan dari kosurfaktan propilen glikol, poloxamer 188, lesitin dan yang tanpa menggunakan surfaktan berturut-turut adalah: 556,1 ± 4,89; 174,1 ± 6,69; 220,4 ± 12,01 dan 556,8 ± 17,96 nm sementara itu persen efisiensi penjebakan yang dihasilkan berturut-turut adalah 32,47 ± 6,88; 77,38 ± 8,63; 19,77 ± 5,69; dan 16,09 ± 3,70 %. Kesimpulan: Berdasarkan hasil evaluasi karakteristik, disimpulkan bahwa SLN-CoQ10 yang dibuat dengan ko-surfaktan poloxamer 188 memiliki karakteristik yang paling baik karena memiliki ukuran partikel kecil dan persen efisiensi penjebakan yang paling besar dibandingkan dengan SLN-CoQ10 dengan formula yang menggunakan ko-surfaktan propilen glikol, lesitin atau yang tanpa kosurfaktan.

The Effect of Niosomal System (Span 60-Cholesterol) on Diclofenac Sodium Preparation Characteristics and Diclofenac Sodium Preparation of Hydroxypropyl Cellulose Gel Base (HPC) Adeltrudis Adelsa Danimayostu; Esti Hendradi; Tutiek Purwanti
Research Journal of Life Science Vol 4, No 1 (2017)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Diclofenac sodium is a lipophilic drug. That characteristic makes it difficult to disperse well in hydrophilic gel base. The niosome with its vesicle system could overcome that low dispersibility. It affects penetration by reducing water loss in trans-epidermal layer and change lipid bilayer conformation. The present study was designed to investigate the effect of niosomal system (Span 60–Cholesterol) on preparation characteristics and diclofenac sodium penetration of hydroxypropyl cellulose (HPC) gel base. We examined three different formulas in HPC gel base. Formula III was made in niosomal system. Preparation characteristics were evaluated with organoleptic and acidity tests. Drug penetration was checked using apparatus 5-paddle over disk and 0.45 μm Milipore membrane impregnated with isopropyl myristate. The solution is phosphate buffer saline pH 7.4±0.05 in temperature 37±0.5°C. All of the data were evaluated based on one way ANOVA and continued with HSD test. It was concluded that niosomal system (span 60-cholesterol) has an influence in increasing pH value and penetration (based on flux value and permeability) of diclofenac sodium in HPC gel base.

Co-Authors Abdulloh Suyuti Abhimata Paramanandana Achmad Toto Poernomo Adeltrudis Adelsa Danimayostu Aditya Fridayanti Aditya Fridayanti Afif Nurul Hidayati, Afif Nurul Ameliana, Lidya Anang Setyo Wiyono Andang Miatmoko Anggai, Rifka Anggraini Ardhani Dwi Lestari1 Arya Putra Damari Aty Widyawaruyanti Bambang Tri Purwanto Budiatin, Aniek Setiya Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Damayanti Dewi Hariyadi Dewi Isadiartuti Dewi Isadiartuti Dewi Melani Hariyadi Diah Mira Indramaya Dini Retnowati Dini Retnowati Dioni fadia Zatalini Diyah, Nuzul Wahyuning Diyah, Nuzul Wahyuning Djoko Agus Purwanto Dwi Murtiastutik Dwi Setiawan Dyah Rahmasari Esti Rahayuningtyas Evy Ervianti Firdausiah Fania Dwi Putri Putri Frida Magdalena Fridayanti, Aditya Hadi Poerwono Hadi Purwono Hariyadi, Dewi Hariyadi, Dewi Hariyadi, Dewi Melany Hasan, Wafiqah Latuapo Ida Kristianingsih Idha Kusumawati Irawan, Mukhlis Bayu Irawan, Mukhlis Bayu Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Juni Ekowati Khoirotul Lailiyah Lailiyah, Khoirotul Lailiyah, Khoirotul Latifah, Luluk Linda Astari, Linda M. Agus Syamsur Rijal M. Yulianto Listiawan Mahmudah, Rifaatul Mangestuti Agil Maulia, Arwinda Melanny Ika Sulistyowaty Miatmoko, Andang Mochammad Yuwono Mohammad Agus Sjamsur Rijal Mufariha, Mufariha Muhammad Al Rizqi Dharma Fauzi Muhammad Faris Adrianto Nahdhia, Nadhifatun Namira, Desya Shafa Ninis Yuliati, Ninis Noorma Rosita Nurul Fitriani Nurul Fitriani Paramita, Diajeng Putri Pepy Dwi Endraswari, Pepy Dwi Philip Drake Pratiwi Pudjiastuti Pratiwi, Karina Dyahtantri Pujianti, Efrin Pujianti, Efrin Purnomo, Ahmad Toto Purwitasari, Neny Qurrotu A'yunin Rahmadewi Rahmadewi Rahmadhanniar, Erwinda Rahman, Ave Rahmi Annisa Ramadhani, Firmansyah Ardian Raudatul Patimah Retno Sari Retno Sari Retno Sari Rifaatul Mahmudah Rifka Anggraini Anggai Rijal, Agus Syamsur Riyana Noor Oktaviyanti Riyanto Teguh Widodo Riyanto Teguh Widodo Rubianti, Marissa Astari Safarini Marwah Savitri, Orchidea Meidy Nurintan Sawitri Sawitri Sawitri Sawitri Sayyidati Aqilah Siswandono, Siswandono Siti Wafiroh Sudjarwo Sugiyartono, Sugiyartono Sugiyartono1 Sukardiman Sulistyowati, Melanny Ika SUZANA, SUZANA Tengku Riza Zarzani N Tri Susanti Tri Widiandani Tristiana Erawati Tristiana Erawati Tutiek Purwanti Uswatun Chasanah Uswatun Chasanah Wiwied Ekasari Yusniasari, Putri Antika Yusuf Wibisono Yusuf, Helmy Yusuf, Helmy

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