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POTENSI TANAMAN SALAM (Syzygium polyanthum (Wight) Walp) SEBAGAI TERAPI KANKER: TINJAUAN LITERATUR Indra Nuroso; EM Sutrisna; Riandini Aisyah; Devi Usdiana Rosyidah
Prosiding University Research Colloquium Proceeding of The 13th University Research Colloquium 2021: Mahasiswa (Student Paper)
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Kanker merupakan salah satu penyebab kematian tertinggi.Pengobatan kanker konvensional masih menimbulkan beragam efeksamping, sehingga pengobatan alternatif mengalami perkembangan.Tanaman salam (Syzygium polyanthum Wight) memiliki kandunganflavonoid dan eugenol yang berpotensi sebagai antikanker.Penelitian ini bertujuan untuk menganalisis adanya efek antikankerpada tanaman salam terhadap sel kanker. Penulisan inimenggunakan desain tinjauan literatur dengan metode naratif daribeberapa penelitian yang sudah diterbitkan sebelumnya denganteknik identifikasi artikel mengikuti flow chart dari PRISMA. Datapenelitian ini diperoleh dari mesin pencarian pada aplikasi Googlechrome secara daring dengan menggunakan beberapa pangkalandata meliputi Google Scholar, Pubmed, Science Direct, CochcraneLibrary, Research Gate, Garuda dan CDC. Artikel penelitian yangsesuai dengan kriteria inklusi (uji in vitro dan in vivo; variabel bebasberupa sediaan langsung, ekstrak, fraksinasi, maupun isolat;menggunakan bahasa Indonesia dan bahasa Inggris), kemudiandikumpulkan dan dibuat ringkasan artikel, dibahas dan dibuatkesimpulan. Hasil pengujian fitokimia ekstrak daun salam memilikikandungan seperti flavonoid, tanin, saponin, alkaloida, dan minyakatsiri. Ekstrak flavonoid daun salam memicu terjadinya apoptosisdan menekan proliferasi dari sel kanker dengan adanya peningkatanlevel ROS, ekspresi kaspase-3 dan nuclear factor-kappa B (NFkB)serta penurunan ekspresi HSP70. Ektrak daun salam juga mampumenurunkan jumlah aktivitas metabolit seluler (mitokondria) selkanker untuk memproduksi ATP. Senyawa aktif ekstrak daun salammemiliki potensi sebagai terapi kanker dalam pengujian in vitro.Perlu diteliti lebih lanjut secara in vivo sehingga pengembanganuntuk terapi kanker dapat tercapai.
HUBUNGAN KADAR VITAMIN D DAN PENURUNAN KADAR GLUKOSA DARAH PENDERITA DIABETES MELLITUS Ratnasari Bondan Wijayanti; Iin Novita; Riandini Aisyah; Erika Diana Risanti
Prosiding University Research Colloquium Proceeding of The 13th University Research Colloquium 2021: Kesehatan dan MIPA
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Diabetes melitus atau disebut Diabetes merupakan penyakit gangguan metabolik akibat pankreas tidak memproduksi cukup insulin atau tubuh tidak dapat menggunakan secara efektif insulin yang diproduksi. Kelebihan sekresi glukagon oleh sel alfa dan insulin yang tidak dapat diproduksi atau tidak berperan secara efektif oleh sel beta menyebabkan peningkatan kadar glukosa dalam darah (hiperglikemia). Pemberian vitamin D meningkatkan transkripsi gen reseptor insulin untuk mengurangi kenaikan hiperglikemik dengan menginduksi sel ? pankreas. Tujuan: Menganalisis peran vitamin D dalam menurunkan kadar glukosa darah penderita Diabetes melitus. Metode: Penelitian ini menggunakan jenis studi literatur review dengan menggunakan sumber artikel terbitan dari tahun 2015 sampai November 2020 pada database PubMed dan Science Direct dengan menggunakan kata kunci "vitamin d" OR "ergocalciferols" OR vitamin D AND "glucose" AND "Diabetes mellitus". Analisis data berupa kalimat naratif yang dimulai dengan pemilihan artikel yang sesuai kriteria inklusi, kriteria eksklusi dan relevansi penelitian, yang selanjutnya dilakukan penarikan kesimpulan. Hasil: Artikel yang direview sebanyak 7 artikel yang berasal dari negara-negara seperti Mesir, Pakistan, Arab Saudi, Iran dan Taiwan. Uji klinis pada beberapa penelitian menunjukkan hasil bahwa vitamin D berperan dalam menurunkan glukosa darah pada pasien dengan penyakit diabetes yang secara signifikan menurunkan HbA1c. Kesimpulan: Vitamin D berperan dalam menurunkan kadar glukosa darah penderita Diabetes melitus.
Comparison of the Effectiveness of Permethrin 1% and Dimeticone 4% as Therapy of Pediculosis Capitis: Literature Review Dwi Advina Herdiyanti; Listiana Masyita Dewi; Riandini Aisyah
Prosiding University Research Colloquium Proceeding of The 15th University Research Colloquium 2022: Mahasiswa (Student Paper Presentation) B
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Background: Pediculosis capitis is a scalp disease caused by the infestation of obligate ectoparasites. Infection is usually found in children aged 6-12 years, girls have a higher risk of infection than boys, especially in rural areas in developing countries. One example of treatment that can be done to treat Pediculosis capitis infection is the use of 1% permethrin or 4% dimeticone. Objective: The aim of this study was to compare the effectiveness of permethrin 1% and dimeticone 4% as a treatment for pediculosis capitis. Methods: The research method uses a literature review research design. The data in this study were obtained from several journal databases, namely PubMed, Google Scholar, and Research Gate with the keywords "Permethrin 1%" AND "dimeticone 4%" AND "pediculosis capitis". The data analysis method in this study uses the critical appraisal method with a search strategy in the form of PICO (Population, Intervention, Comparation, Outcome). Results: The results of this study concluded that the use of 4% dimeticone was more effective when compared to the use of 1% permethrin as a treatment for pediculosis capitis.
PENINGKATAN PENGETAHUAN MASYARAKAT TENTANG PREVALENSI DAN FAKTOR RISIKO DIABETES MELITUS SERTA UPAYA PENCEGAHANNYA MELALUI EDUKASI: Improving Public Knowledge of Prevalence and Risk Factors of Diabetes Mellitus, and Its Prevention through Education Aisyah, Riandini; Rochmadina Suci Bestari
Jurnal Pengabdian Masyarakat Medika Vol 3. No. 1, Maret 2023
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v3i1.1587

Abstract

ABSTRAK International Diabetes Federation (IDF) memperkirakan prevalensi global penderita diabetes mencapai angka 578 juta pada tahun 2030 dan 700 juta pada tahun 2045. Indonesia menempati peringkat ke-7 negara dengan jumlah penderita diabetes terbanyak dan merupakan satu-satunya negara di Asia Tenggara yang masuk dalam daftar tersebut. Hal tersebut erat kaitannya dengan tingginya faktor risiko diabetes dan kurangnya pengetahuan tentang langkah-langkah pencegahan dan pengendalian diabetes. Oleh karena itu diperlukan upaya secara terus menerus untuk memberikan informasi kepada masyarakat tentang prevalensi diabetes, faktor risiko yang menjadi pemicunya, serta upaya dalam mencegah dan mengendalikannya. Kegiatan ini bertujuan meningkatkan pengetahuan masyarakat tentang faktor risiko diabetes serta upaya untuk mencegah terjadinya diabetes melitus. Metode yang dilakukan berupa pemberian pretest, pemaparan materi, dan posttest dengan sasaran kegiatan adalah kelompok ibu-ibu PKK Griya Sakinah 1 Gedongan Colomadu Karanganyar. Hasil analisis menunjukkan terdapat peningkatan pengetahuan sebelum dan sesudah diberikan edukasi sebesar 72,3% dengan p<0,05. Simpulan kegiatan ini bahwa edukasi meningkatkan pengetahuan masyarakat tentang prevalensi, faktor risiko, dan pencegahan serta pengendalian diabetes melitus. ABSTRACT The International Diabetes Federation (IDF) estimates that the global prevalence of diabetics will reach 578 million in 2030 and 700 million in 2045. Indonesia is ranked 7th for the country with the highest number of diabetics and is the only country in Southeast Asia included in the list. This is closely related to the high risk factors for diabetes and the lack of knowledge about diabetes prevention and control approaches. Therefore, continuous efforts are needed to provide information to the public about the prevalence of diabetes, the risk factors that trigger it, as well as efforts to prevent and control it. This activity aimed to improve public knowledge about diabetes risk factors and efforts to prevent and manage this disease. The method used was in the form of pre-test, material presentation, and post-test with the target of the activity being a group of PKK Griya Sakinah 1 Gedongan Colomadu women. The results of the analysis showed that there was an increase in knowledge before and after being given education of 72.3% with p<0.05. The conclusion of this activity is that education improves public knowledge about the prevalence, risk factors, and prevention and control of diabetes mellitus.
Bio-larvicidal Potential of Betel Leaves (Piper betle L) Ethanolic Extract in Addition of PEG 400 Diluent on Aedes aegypti Larvae Dewi, Listiana Masyita; Ariffah, Hilda Zaniba; Aisyah, Riandini; Nurhayani, Nurhayani
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.451-455

Abstract

Dengue hemorrhagic fever (DHF) is a kind of vector transmitted disease, by Aedes aegypti. It is one of major public health problem around the world, including Indonesia, because it may lead to epidemics and death in a short time. The use of plant extracts as bio-larvicidal is thought to be a promising solution, and one of them is the betel leaves (Piper betle L). The addition of polyethylene glycol (PEG) as a diluent is thought may increase the dispersity of plant extract in the water which is larval medium of growth. Objectives: To determine the bio-larvicidal potential of 95% ethanolic extract of betel leaves (EEBL) in addition of PEG 400 diluent on the Aedes aegypti larval mortality. Material and Method: Betel leaves were extracted by maceration using 95% of ethanol. There are two kinds of EEBL concentration used, 0.2% dan 0.4%. PEG 400 was also added as diluent. The samples in this study were Aedes aegypti larvae at instar III-IV, with a total of 400 larvae. Evaluation was performed at 6, 12, 18, and 24 hours. The data obtained was then analyzed by Kruskall Wallis test and post-hoc Mann Whitney test. Result: In all of treatment groups, larval mortality was reached 100% at 24 hours. From the Kruskall Wallis test, p-value obtained was <0.05. From post-hoc Mann Whitney test, the p-value obtained in the comparation between treatment groups and positive control group was >0.05, and the p-value obtained in the comparation between treatment groups and negative control group was <0.05. Conclusion: EEBL in addition of PEG 400 diluent is potential as bio-larvicidal on Aedes aegypti larvae. It is also known that EEBL at concentration of 0.2% and 0.4% in addition of PEG 400 are as effective as temephos as larvicides on Aedes aegypti larvae.
Influence of Income and Knowledge about Mosquito Nest Eradication (PSN DBD) to The Presence of Aedes aegypti Larvae Bestari, Rochmadina Suci; Prabancono, Estu Puguh; Dewi, Listiana Masyita; Aisyah, Riandini
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 7, No 1 (2020): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (42.548 KB) | DOI: 10.26714/magnamed.7.1.2020.32-41

Abstract

Background: DHF still become health problem in Indonesia. In Central Java, especially Sukoharjo district, Angka Bebas Jentik (ABJ) is still under national standard. Some factors that influence the existence of larvae are the level of income and knowledge about PSN. Consumerism triggered escalation amount of  mosquito breeding sites due to ownership of non-degradable goods like plastic containers, paper cups, and so on. Consumerism is related to income.Objective: To determine corelation between income levels and knowledge about PSN with existence of Aedes aegypti larvae in Karangtengah Village.Method: Designed with cross-sectional approach. The population were residences that has Family Card in Karangtengah Village with a total of 1660 households taken 65 households. The independent variable is the level of income and knowledge about PSN. Dependent variable is existence of larvae. Data analysis used Chi-Square test and contingency coefficient (C).Results: This study showed income with the existence of larvae (container index) (p = 0.009, C = 0.308) and PSN knowledge in the presence of larvae (container index) (p = 0.005, C = 0.332). The results of data analysis show that there is a correlation between income and knowledge about PSN with the existence of larvae.Conclusion: This study showed there is a relationship between income and knowledge about PSN with the existence of larvae.
The Effectiveness of Installing Long-lasting Insecticidal Nets as Malaria Prevention Efforts: A Systematic Literature Review Nurhayani; Dyah Farida Inli; Riandini Aisyah; Rochmadina Suci Bestari
Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 5 (2022): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v2i5.231

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Malaria is a parasitic disease that is often the cause of death, especially in tropical and subtropical areas. One way to eradicate malaria is to break the chain of disease transmission in order to control the mosquito vector of malaria. The use of insecticide-treated mosquito nets can be used as an alternative in controlling malaria vectors for people who refuse to use the Indoor Residual Spraying (IRS) method. The review articles were obtained through a search using the Pubmed, Google Scholar, Garuda, and ScienceDirect databases. The keywords used were (LLINs OR "Long Lasting Insecticidal Nets") AND Malaria. 1843 articles were obtained, and extraction was carried out based on the restriction criteria so that 13 articles were obtained. In conclusion, the use of insecticide-treated mosquito nets LLIN is effective in killing mosquito vectors so that it has the potential to prevent malaria.
Improving Health Profiles and Type 2 Diabetes Mellitus Knowledge of Community Groups in Karanglo Village, Grogol, Sukoharjo, Central Java, Indonesia Through the SEE Method Aisyah, Riandini; Mahmudah, Nur; Candrasari, Anika; Sintowati, Retno; Bestari, Rochmadina Suci; Rosyidah, Devi Usdiana; Supraba, Intan Pratiwi; Utami, Indari
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 10, No 4 (2024): December
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.95765

Abstract

Central Java ranks fourth among regions for the highest number of diabetes melitus (DM) cases, following Jakarta, Yogyakarta, and East Kalimantan. Grogol District in Sukoharjo Regency had the greatest prevalence of DM cases in 2019, accounting for 18.41% of the total. Diabetes melitus significantly impairs the overall well-being of individuals as it affects individuals across all age groups, including those who can work and those who cannot. If left unmanaged, it can lead to a range of outcomes. The Karanglo Village community is considered at high risk for diabetes melitus (DM) due to a history of health ailments and elevated blood glucose levels. Furthermore, this region is still lacking any health education interventions. This activity aimed to do earlier screening and monitoring of blood sugar levels, as well as providing health education, using the SEE approach (Screening, Health Education, and Exercise) to monitor diabetes melitus. The program was implemented in the period from November 2023 to January 2024, which includes a total of 27 participants, all of whom are female. The implementation of the programs involves the following methods: conducting blood sugar level screenings, engaging in diabetes exercises twice a week, providing health education in six meetings that cover topics such as the epidemiology and etiology, risk factors and prevention, symptoms and diagnosis, complications and management of DM, as well as blood glucose monitoring. Apart from using tools in the form of presentation slides, health education also utilized educational posters. At the end of the program, there was an increase in knowledge by 21.5% (p=0.024) based on pretest and posttest scores, improvements in blood sugar levels, total cholesterol levels, and body mass index. To follow up on the program, a group of independent blood sugar observers has been formed who is responsible for further monitoring blood sugar in program participants.
Association of Family History, Body Mass Index, and Exercise Regularity with HbA1c Status in Type 2 Diabetes Melitus Patients Aisyah, Riandini; Prabowo, Nurhasan Agung
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 1 (2025): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.1.2025.1-8

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Background:  Urban life, especially in Surakarta, is easy to access and full of high-carbohydrate food and drink. This has increased unhealthy behavior and diets. The prevalence of diabetes Mellitus (DM) in Surakarta is growing, reaching 24% in 2021. Physical exercise and poor diet are important risk factors for DM, coupled with genetics, causing obesity. HbA1c levels periodically assess DM patients' glycemic management.Objective: This study aims to determine the association between family history, body mass index, and regular exercise with HbA1c status in type 2 DM patients at UNS Surakarta Hospital.Methods: The research was an observational study; 24 patients diagnosed with type 2 DM were recruited from the outpatient clinic of Universitas Sebelas Maret Hospital, Surakarta, Indonesia, in October 2021. Measurements were conducted to determine their HbA1c level by enzymatic methods and body mass index by measuring body weight and height, and they were questioned regarding their physical exercise and family history of diabetes. The data collected were analyzed using multiple logistic regression to ascertain the association between family history, body mass index, and exercise regularity with HbA1c status.Results: The findings indicated no statistically significant association between genetic background, body mass index, and exercise frequency with HbA1c status (p>0.05).Conclusion: This research shows that genetic history, body mass index, and exercise regularity are not associated with HbA1c status in type 2 DM in included subjects.
Optimalisasi Jumantik dan Pemberantasan Sarang Nyamuk dalam Mencegah Penularan Infeksi Virus Dengue pada Kader di Desa Karangbangun: Optimizing Human Resources and the Environment in Preventing the Transmission of Dengue Virus Infection to Cadres in Karangbangun Village Bestari, Rochmadina Suci; Jatmiko, Safari Wahyu; Aisyah, Riandini; Wahyuni, Sri; Mahmudah, Nur; Agustina, Tri; Salsabila, Nabila Mutia; Adha, Muhammad; Kumala, Aswa Arsa; Fauzi, Favian Arriella Shabri Ikmal
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 3 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i3.8528

Abstract

Dengue virus infection (IVD) is still a health problem in Indonesia. In Karangbangun Matesih Karanganyar Village, there were 13 cases of IVD in April 2024. The government program to eradicate IVD vectors has not been implemented optimally. Karangbangun Village has potential healthcare resources to be used as agents for eradicating IVD vectors. So far there has been no education about the function of jumantik as larva monitors and mosquito nest eradication (PSN). Therefore, it is necessary to provide education about the function of jumantik and PSN to health cadres in Karangbangun Village. The aim and benefit of this community service activity is that the health cadres of Karangbangun Matesih Karanganyar Village understand the function of jumantik and PSN. The extension activity was preceded by a pretest, and speaker presentation and ended with a posttest. The results of the education showed an increase in health cadres' knowledge after the education based on a comparison of pre-test and post-test scores (p<0.001; Effect Size (Cohen's d) = -1.993). Education about the function of jumantik and eradicating mosquito nests to health cadres in Karangbangun Village increased knowledge significantly and the average post-test score showed an increase.
Co-Authors Ahmad Alrizaldi Alfajri, Asri Anam, Ilham Hafizha Maulana Angesti Atiqah Ranasatri Anggitaratri, Zakia Novi Anggreheni, Putri Dwi Anika Candrasari Anindita Putri Handayani Ariffah, Hilda Zaniba Arrohma, Farah Aryanto Asfarina, Fatin Ayyasi, Quanta Azenta, Moch. Tabriz Bestari, Rochmadina Brilliantama, Fandy Akbar Devi Usdiana Rosyidah Dwi Advina Herdiyanti Dyah Farida Inli Em Sutrisna Erika Diana Risanti Estu Puguh Prabancono Faatiha, Arsyal Wanda Fauzi, Favian Fauzi, Favian Arriella Shabri Ikmal Fitri, Alifah Aulia Graffico Eryza Oldiara Gunawan, Ryan Budi Haliza, Sheli Nur Handayani, Anindita Putri Hidayatullah, Muhammad Alim Abdul Majid Iin Novita Nurhidayati Mahmuda Indra Nuroso Jatmiko, Safari Kamila, Aulida Azkia Kumala, Aswa Arsa Kurniati, Yuni Prestyo Lestari, Nining Listiana Masyita Dewi Mapa, Anna Rochim Maulida Rahmah, Maulida Maulida, Amira Hasna Maylafaiza, Annisa Muhamad Irfan Hidayatullah Muhammad Adha Muhammad Alim Abdul Majid Hidayatullah N Nurhayani Nafisa, Balqis Najmii, Muhammad Firoos Allaam Nur Mahmudah Nur Mahmudah Nurhaliza, Sheli Nurhayani nurhayani Nurhayani, N Pambudi, Nasrurrofiq Risvana Bayu Prabancono, Estu Puguh Prabowo, Nurhasan Agung Pratama, Nur Puspitasari, Metana Rahayu, Destri Ramadhani, Marsyanda Ratnasari Bondan Wijayanti Reisya Tiara Kandita Reisya Tiara Kandita, Reisya Tiara Retno Sintowati - Rochmadina Suci Bestari Rohman, Raihan Fadzlur Rohmaniar, Delianti Ryan Budi Gunawan Ryanuranti , Rahma Ghaida Safari Wahyu Jatmiko Salsabila, Nabila Mutia Sella Felina Setiani, Hilda Sholeh, Muhammad Dzikru Irfan Sri Wahyuni Sukardi, Nadya Sulistiyo, Azka Hafiy Sulistyo, Ayu Indah Supraba, Intan Pratiwi Suryani, Latifah Syahida, Safira Tara , Irmanawati Audhina Nirmala Tolibin, Restu Triwulandani Tri Agustina, Tri tri wahyuni Utami, Aurelia Ratna Utami, Indari Wafiq, Muhammad Azzim Wahyu Jatmiko, Safari Wibowo, Haryo Kunto Wulandari Berliani Putri Wulandari Berliani Putri, Wulandari Berliani