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POTENSI TANAMAN SALAM (Syzygium polyanthum (Wight) Walp) SEBAGAI TERAPI KANKER: TINJAUAN LITERATUR Nuroso, Indra; Sutrisna, EM; Aisyah, Riandini; Usdiana Rosyidah, Devi
Prosiding University Research Colloquium Proceeding of The 13th University Research Colloquium 2021: Mahasiswa (Student Paper)
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Kanker merupakan salah satu penyebab kematian tertinggi.Pengobatan kanker konvensional masih menimbulkan beragam efeksamping, sehingga pengobatan alternatif mengalami perkembangan.Tanaman salam (Syzygium polyanthum Wight) memiliki kandunganflavonoid dan eugenol yang berpotensi sebagai antikanker.Penelitian ini bertujuan untuk menganalisis adanya efek antikankerpada tanaman salam terhadap sel kanker. Penulisan inimenggunakan desain tinjauan literatur dengan metode naratif daribeberapa penelitian yang sudah diterbitkan sebelumnya denganteknik identifikasi artikel mengikuti flow chart dari PRISMA. Datapenelitian ini diperoleh dari mesin pencarian pada aplikasi Googlechrome secara daring dengan menggunakan beberapa pangkalandata meliputi Google Scholar, Pubmed, Science Direct, CochcraneLibrary, Research Gate, Garuda dan CDC. Artikel penelitian yangsesuai dengan kriteria inklusi (uji in vitro dan in vivo; variabel bebasberupa sediaan langsung, ekstrak, fraksinasi, maupun isolat;menggunakan bahasa Indonesia dan bahasa Inggris), kemudiandikumpulkan dan dibuat ringkasan artikel, dibahas dan dibuatkesimpulan. Hasil pengujian fitokimia ekstrak daun salam memilikikandungan seperti flavonoid, tanin, saponin, alkaloida, dan minyakatsiri. Ekstrak flavonoid daun salam memicu terjadinya apoptosisdan menekan proliferasi dari sel kanker dengan adanya peningkatanlevel ROS, ekspresi kaspase-3 dan nuclear factor-kappa B (NFkB)serta penurunan ekspresi HSP70. Ektrak daun salam juga mampumenurunkan jumlah aktivitas metabolit seluler (mitokondria) selkanker untuk memproduksi ATP. Senyawa aktif ekstrak daun salammemiliki potensi sebagai terapi kanker dalam pengujian in vitro.Perlu diteliti lebih lanjut secara in vivo sehingga pengembanganuntuk terapi kanker dapat tercapai.
HUBUNGAN KADAR VITAMIN D DAN PENURUNAN KADAR GLUKOSA DARAH PENDERITA DIABETES MELLITUS Wijayanti, Ratnasari Bondan; Novita, Iin; Aisyah, Riandini; Risanti, Erika Diana
Prosiding University Research Colloquium Proceeding of The 13th University Research Colloquium 2021: Kesehatan dan MIPA
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Diabetes melitus atau disebut Diabetes merupakan penyakit gangguan metabolik akibat pankreas tidak memproduksi cukup insulin atau tubuh tidak dapat menggunakan secara efektif insulin yang diproduksi. Kelebihan sekresi glukagon oleh sel alfa dan insulin yang tidak dapat diproduksi atau tidak berperan secara efektif oleh sel beta menyebabkan peningkatan kadar glukosa dalam darah (hiperglikemia). Pemberian vitamin D meningkatkan transkripsi gen reseptor insulin untuk mengurangi kenaikan hiperglikemik dengan menginduksi sel ? pankreas. Tujuan: Menganalisis peran vitamin D dalam menurunkan kadar glukosa darah penderita Diabetes melitus. Metode: Penelitian ini menggunakan jenis studi literatur review dengan menggunakan sumber artikel terbitan dari tahun 2015 sampai November 2020 pada database PubMed dan Science Direct dengan menggunakan kata kunci "vitamin d" OR "ergocalciferols" OR vitamin D AND "glucose" AND "Diabetes mellitus". Analisis data berupa kalimat naratif yang dimulai dengan pemilihan artikel yang sesuai kriteria inklusi, kriteria eksklusi dan relevansi penelitian, yang selanjutnya dilakukan penarikan kesimpulan. Hasil: Artikel yang direview sebanyak 7 artikel yang berasal dari negara-negara seperti Mesir, Pakistan, Arab Saudi, Iran dan Taiwan. Uji klinis pada beberapa penelitian menunjukkan hasil bahwa vitamin D berperan dalam menurunkan glukosa darah pada pasien dengan penyakit diabetes yang secara signifikan menurunkan HbA1c. Kesimpulan: Vitamin D berperan dalam menurunkan kadar glukosa darah penderita Diabetes melitus.
Comparison of the Effectiveness of Permethrin 1% and Dimeticone 4% as Therapy of Pediculosis Capitis: Literature Review Herdiyanti, Dwi Advina; Dewi, Listiana Masyita; Aisyah, Riandini
Prosiding University Research Colloquium Proceeding of The 15th University Research Colloquium 2022: Mahasiswa (Student Paper Presentation) B
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Background: Pediculosis capitis is a scalp disease caused by the infestation of obligate ectoparasites. Infection is usually found in children aged 6-12 years, girls have a higher risk of infection than boys, especially in rural areas in developing countries. One example of treatment that can be done to treat Pediculosis capitis infection is the use of 1% permethrin or 4% dimeticone. Objective: The aim of this study was to compare the effectiveness of permethrin 1% and dimeticone 4% as a treatment for pediculosis capitis. Methods: The research method uses a literature review research design. The data in this study were obtained from several journal databases, namely PubMed, Google Scholar, and Research Gate with the keywords "Permethrin 1%" AND "dimeticone 4%" AND "pediculosis capitis". The data analysis method in this study uses the critical appraisal method with a search strategy in the form of PICO (Population, Intervention, Comparation, Outcome). Results: The results of this study concluded that the use of 4% dimeticone was more effective when compared to the use of 1% permethrin as a treatment for pediculosis capitis.
The Effectiveness of Installing Long-lasting Insecticidal Nets as Malaria Prevention Efforts: A Systematic Literature Review Nurhayani; Dyah Farida Inli; Riandini Aisyah; Rochmadina Suci Bestari
Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 5 (2022): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v2i5.231

Abstract

Malaria is a parasitic disease that is often the cause of death, especially in tropical and subtropical areas. One way to eradicate malaria is to break the chain of disease transmission in order to control the mosquito vector of malaria. The use of insecticide-treated mosquito nets can be used as an alternative in controlling malaria vectors for people who refuse to use the Indoor Residual Spraying (IRS) method. The review articles were obtained through a search using the Pubmed, Google Scholar, Garuda, and ScienceDirect databases. The keywords used were (LLINs OR "Long Lasting Insecticidal Nets") AND Malaria. 1843 articles were obtained, and extraction was carried out based on the restriction criteria so that 13 articles were obtained. In conclusion, the use of insecticide-treated mosquito nets LLIN is effective in killing mosquito vectors so that it has the potential to prevent malaria.
Toll-Like Receptor Activation and B Cell Maturation Via MyD88-Dependent Pathway Under Hyperglycemia Condition Aisyah, Riandini; Jatmiko, Safari Wahyu
Bioeksperimen: Jurnal Penelitian Biologi Vol 10, No 1: March 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v10i1.23328

Abstract

hyperglycemia causes a degenerative syndrome that involves an inflammatory process with an increase in certain proinflammatory cytokines and chemokines which in the process will activate B cells to produce immunoglobulins through several mechanisms. One of the interesting mechanisms is the mechanism via the MyD88 pathway. Objectives: to explore the role of MyD88 adapter protein in Toll-like receptor activation and B cell maturation under hyperglycemia conditions. Methods: a literature review was done to answer the study objectives. Results: Class switching process under hyperglycemia conditions involves activation of NFkB through the inflammatory MyD88-dependent pathway to trigger the expression of TLR and B cell maturation and proliferation as well as antibody production. The MyD88 adapter protein is a protein formed by stimulation of pro-inflammatory cytokines IL-6 and plays a role in the continuation of signals from the TLR and IL-1 pathways. Mature B cell stimulation induces 2 genetic changes in the Ig gene locus, called somatic hypermutation (SHM) and class switch recombination (CSR) to produce antibodies. Changes in immunoglobulin genes occur related to changes in certain DNA segments at the locus of genes where CSR occurs, this gene change requires the role of AID (activated-induced cytidine deaminase) in DNA cleavage. AID in mature B cells is activated by proinflammatory cytokines via induction of NfKB activation via the inflammatory MyD88-dependent pathway. Conclusion: Toll-like receptor activation plays a crucial role in B cell maturation activated by pro-inflammatory cytokine via MyD88 dependent-NFkB activation. 
Expression and Activation of Toll-Like Receptor 9 in Dengue Virus Infection: A Scoping Review Jatmiko, Safari Wahyu; Aisyah, Riandini
Bioeksperimen: Jurnal Penelitian Biologi Vol 9, No 2: September 2023
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v9i2.23052

Abstract

Toll-like receptors (TLR) are essential to pathogen recognition to activate innate immunity. TLR2, 3, 4, 6, 7, 8, and 9 are involved in immunity to dengue virus. The involvement of TLR9, known to recognize CpG DNA, in dengue virus (DVI) infection, an RNA virus, is unusual. We hypothesize that there is an elevated expression and activation of TLR9 through specific mechanisms in DVI. A scoping review was carried out to collect articles that have been written regarding this topic. Article searches were carried out on the PubMed (Medline), Proquest, EBSCO, and Google Scholar databases with inclusion criteria: articles in the form of research results using human subjects or human cells, conducted from 2013 to 2023, in English, and can be accessed in full -text. Gray articles, books, and review articles were excluded from the study. The literature search results found 821 articles, with eight articles meeting the criteria. Based on mapping, synthesis, and analysis of the articles obtained, it was found that there was increased expression and activation of TLR9 in the DVI due to the release of mtDNA. 
Larvicidal Activity of Ethanol Extracts of Bidara (Ziziphus mauritiana) Leaves and Fruits Against Aedes aegypti Bestari, Rochmadina Suci; Fikri, Muhammad Ihsanul; Aisyah, Riandini; Puspitasari, Metana; Wahyuni, Sri; Porusia, Mitoriana
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.586

Abstract

Dengue fever vector control uses abate chemicals can harm the ecosystem. One of the plants that can be used as a natural larvicide is bidara. Bidara leaves and fruits easily available and contains flavonoids, saponins, alkaloids, and tannins. The compound have an impact on the mortality of Aedes aegypti mosquito larvae. Contains study design, subject, methods, data collection and data analysis. Research on ethanol extract of bidara leaves and bidara fruit with Poly Ethylene Glycol (PEG) was experimental laboratory design with post-test only controlled group design. The technique of extraction is maseration. The larvae of Aedes aegypti instar III-IV are used, 800 in total, divided into 8 groups. At 6, 12, 18, and 24 hours, the number of dead larvae was counted .Normality and homegenity tests obtained the results of data not normally distributed and not homogeneous, so it is necessary to do the Kruskall-Wallis non-parametric test followed by Mann-Whitney post hoc .The result is bidara leaf extract with a concentration of 1.5% + 3% PEG resulted in 100% larval death in the 24th hour, meanwhile bidara fruit extract with concentration of 1.5% + 3% PEG resulted 70% larval death in 24th hour. Ethanol extract of bidara leaves has better effectiveness than bidara fruit extract in its ability as a larvicide, where bidara leaf extract with a concentration of 1.5% + 3% PEG resulted in 100% larval death in the 24th hour.
In silico analysis of myricetin and fisetin as potential B-cell lymphoma extra-large (Bcl-xL) inhibitors in cancer therapy: Myricetin and fisetin as potential Bcl-xL inhibitors Nordin, Noraziah; Abd Ghani, Mohd Faiz; Roslan, Nuruliza; Riandini Aisyah; Sri Wahyuni; Peni Indrayudha; Em Sutrisna
Journal of Tropical Life Science Vol. 15 No. 3
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.15.03.02

Abstract

B-cell lymphoma extra-large (Bcl-xL) is an anti-apoptotic protein that is crucial for cancer cell survival and resistance to chemotherapy. Flavonoids have shown potential as anticancer agents through various pathways, including apoptosis. However, molecular interactions of flavonoids with Bcl-xL remain unknown. This study aims to evaluate the binding affinity and stability of myricetin and fisetin as Bcl-xL inhibitors using in silico approaches, including molecular docking and molecular dynamics (MD) simulations. Molecular docking was performed by AutoDock Vina software to evaluate the binding affinity of myricetin and fisetin to the Bcl-xL protein. MD simulations were conducted using the AMBER 2022.1 package to analyze the stability and dynamic behavior of the flavonoids-Bcl-xL complexes over a 100 ns trajectory. Docking analysis revealed strong binding affinities for both flavonoids, with fisetin exhibiting a slightly higher affinity (-7.6 kcal/mol) compared to myricetin (-7.2 kcal/mol). MD simulations confirmed the stability of both complexes, with myricetin forming a more extensive hydrogen bonding due to its additional hydroxyl groups, contributing to lower RMSD fluctuations and higher structural stability. Binding free energy calculations further supported the favorable interaction of myricetin with Bcl-xL (-61.542 kJ/mol), suggesting its potential as a potent inhibitor. In silico analysis indicates that both myricetin and fisetin have promising inhibitory potential against Bcl-xL, with myricetin demonstrating better stability and binding efficiency. These findings provide a basis for further experimental validation and the potential development of flavonoid-based Bcl-xL inhibitors for targeted cancer therapy.
RASIO EOSINOFIL-MONOSIT TIDAK BERKORELASI DENGAN MARKER DERAJAT PENYAKIT INFEKSI VIRUS DENGUE PADA ANAK Jatmiko, Safari Wahyu; Puspitasari, Metana; Widyastuti, Noor Hafida; Aisyah, Riandini
Majalah Kesehatan Vol. 0 No. 00 (2026): Article in Press
Publisher : Faculty of Medicine Universitas Brawijaya

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Abstract

Rasio Eosinofil-Monosit (REM) telah digunakan sebagai marker inflamasi yang berhubungan dengan derajat penyakit seperti stroke iskemik akut, gagal jantung, dan Grave’s disease, namun belum pernah dilakukan pada infeksi virus dengue (IVD). Eosinofil dan monosit berperan dalam patogenesis IVD dan terdapat laporan bahwa jumlah monosit berbanding terbalik dengan jumlah eosinofil pada kondisi inflamasi. Di sisi lain, platelet dan hematokrit merupakan bagian dari marker derajat penyakit pada IVD. Semakin berat derajat IVD semakin tinggi hematokrit dan semakin rendah platelet. Maka, penelitian mengenai REM dan penyusun REM yang dikaitkan dengan platelet dan hematokrit perlu dilakukan. Tujuan penelitian untuk mengetahui korelasi antara monosit dengan hematokrit, sel esoinofil dengan hematokrit dan platelet, dan REM dengan hematokrit dan platelet pada IVD anak. Metode penelitian observasional dengan desain cross-sectional. Penelitian dilakukan di RS PKU Muhammadiyah Sampangan Surakarta dari Desember 2023-2024 terhadap populasi pasien IVD di bawah 15 tahun, sesuai kriteria IVD WHO 2009, dan terkonfirmasi melalui tes antibodi anti-dengue. Pasien dengan riwayat gangguan homeostasis, komorbid, riwayat vaksinasi dengue, alergi, malignansi, kecacingan, atau sedang mengalami infeksi lainnya dikecualikan dari penelitian. Berdasarkan rumus besar sampel untuk uji korelasi Pearson  menggunakan transfor-masi Fisher’s Z didapatkan jumlah sampel sebanyak 50. Analisis monosit, eosinofil, REM, hematokrit, dan platelet dilakukan menggunakan Hematology Analyzer. Hasil penelitian ditemukan bahwa terdapat korelasi antara monosit dengan Hct (r = 0,361, p = 0,001), namun tidak ada korelasi yang signifikan secara statistik antara eosinofil dan REM dengan platelet dan hematokrit. Kesimpulan menunjukkan monosit berpotensi sebagai indikator derajat keparahan IVD, namun tidak dengan eosinofil dan REM.  
CORRELATION BETWEEN KNOWLEDGE, LEARNINGACHIEVEMENT AND PERSONAL HYGIENE WITH INCIDENCE OF HELMINTHIASIS ON ELEMENTARY STUDENT BESTARI, ROCHMADINA SUCI; AISYAH, RIANDINI; TOLIBIN, RESTU TRIWULANDANI; NURHAYANI; KUSUMANINGRUM, TANJUNG ANITASARI INDAH; NAJMII, MUHAMMAD FIROOS ‘ALLAM
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol. 9 No. 1 (2026): Al-Iqra Medical Journal: Jurnal Berkala Ilmiah Kedokteran
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/50qweb16

Abstract

Background: Helminthiasis is a health problem in Indonesia that affects many elementary school children. The effects of worms in children can be malnutrition, anemia and decreased academic achievement. The government has carried out control of worm diseases by providing deworming drugs every 6 months. However, the effectiveness of this program has not been widely studied, the incidence of worms in each region is not widely known, including the risk factors that influence it. Objective: This study aims to determine the correlation between knowledge, learning achievement and personal hygiene with the incidence of helminthiasis in students at Selokaton Karanganyar Elementary School II. Method: The method used is a cross-sectional study, with total sampling. Students were asked to fill out a knowledge and personal hygiene questionnaire, then collect feces. Learning achievement were obtained from final mark of the semester. Feces examination using direct smear and 2% eosin staining. Analysis used binary logistic regression test and Mann-Whitney U test. Result: The results of this study were that students who were positive for helminthiasis were 16%, hookworm infections were the highest burden (10/16), followed by ascariasis an enterobiasis. There was no significant correlation between knowledge, learning achievement and personal hygiene with the incidence of helminthiasis (p>0.05). Conclusion: The conclusion of this study is that there is no significant correlation between knowledge, learning achievement and personal hygiene with the incidence of the incidence of helminthiasis (p>0.05).
Co-Authors Abd Ghani, Mohd Faiz Ahmad Alrizaldi Alfajri, Asri Anam, Ilham Hafizha Maulana Angesti Atiqah Ranasatri Anggitaratri, Zakia Novi Anggreheni, Putri Dwi Anika Candrasari Anindita Putri Handayani Ariffah, Hilda Zaniba Arrohma, Farah Aryanto Asfarina, Fatin Ayyasi, Quanta Azenta, Moch. Tabriz Bestari, Rochmadina Brilliantama, Fandy Akbar Devi Usdiana Rosyidah Dwi Advina Herdiyanti Dyah Farida Inli Em Sutrisna Erika Diana Risanti Estu Puguh Prabancono Faatiha, Arsyal Wanda Fauzi, Favian Fauzi, Favian Arriella Shabri Ikmal Fikri, Muhammad Ihsanul Fitri, Alifah Aulia Graffico Eryza Oldiara Gunawan, Ryan Budi Haliza, Sheli Nur Handayani, Anindita Putri Herdiyanti, Dwi Advina Hidayah Karuniawati Hidayatullah, Muhammad Alim Abdul Majid Iin Novita Nurhidayati Mahmuda Indra Nuroso Jatmiko, Safari Kamila, Aulida Azkia Kumala, Aswa Arsa Kurniati, Yuni Prestyo Kusumaningrum, Tanjung Anitasari Indah Lestari, Nining Listiana Masyita Dewi Mapa, Anna Rochim Maulida Rahmah, Maulida Maulida, Amira Hasna Maylafaiza, Annisa Mitoriana Porusia Muhamad Irfan Hidayatullah Muhammad Adha Muhammad Alim Abdul Majid Hidayatullah Nafisa, Balqis Najmii, Muhammad Firoos Allaam NAJMII, MUHAMMAD FIROOS ‘ALLAM Noor Hafida Widyastuti Nordin, Noraziah Novita, Iin Nur Mahmudah Nur Mahmudah Nurhaliza, Sheli Nurhayani Nurhayani nurhayani Nurhayani, N Nuroso, Indra Pambudi, Nasrurrofiq Risvana Bayu Peni Indrayudha Prabancono, Estu Puguh Prabowo, Nurhasan Agung Pratama, Nur Puspitasari, Metana Rahayu, Destri Ramadhani, Marsyanda Ratnasari Bondan Wijayanti Reisya Tiara Kandita Reisya Tiara Kandita, Reisya Tiara Retno Sintowati - Rif'aini, Fidhia Nur Rochmadina Suci Bestari Rohman, Raihan Fadzlur Rohmaniar, Delianti Roslan, Nuruliza Ryan Budi Gunawan Ryanuranti , Rahma Ghaida Safari Wahyu Jatmiko Salsabila, Nabila Mutia Sella Felina Setiani, Hilda Sholeh, Muhammad Dzikru Irfan Sri Wahyuni Sri Wahyuni Sukardi, Nadya Sulistiyo, Azka Hafiy Sulistyo, Ayu Indah Supraba, Intan Pratiwi Suryani, Latifah Syahida, Safira Tara , Irmanawati Audhina Nirmala Tolibin, Restu Triwulandani Tri Agustina, Tri tri wahyuni Usdiana Rosyidah, Devi Utami, Aurelia Ratna Utami, Indari Wafiq, Muhammad Azzim Wahyu Jatmiko, Safari Wibowo, Haryo Kunto Wijayanti, Ratnasari Bondan Wulandari Berliani Putri Wulandari Berliani Putri, Wulandari Berliani