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Aggregate Index of Systemic Inflammation is Correlated with Plasma Leakage Indicator in Dengue Virus Infection Jatmiko, Safari; Puspitasari, Metana; Aisyah, Riandini
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 02 (2025): Qanun Medika Vol 09 No 02 July 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i02.25847

Abstract

Severe dengue virus infection (DVI) is characterized by thrombocytopenia and plasma leakage (PL) due to the release of vasoactive cytokines by immune cells such as monocytes, lymphocytes, neutrophils, and platelets in response to dengue virus (DENV). This immune response triggers systemic inflammation, altering monocyte, lymphocyte, and neutrophil kinetics, which in turn affects leukocyte differentials. PL is indicated by an increase in hematocrit (Hct). This study aims to evaluate the potential use of the Aggregate Index of Systemic Inflammation (AISI) as an indicator of plasma leakage. A correlative analytical study with a cross-sectional approach was conducted on 70 pediatric DVI patients diagnosed according to the 2009 WHO criteria and confirmed by anti-DENV IgM/IgG tests. Patients with a history of malignancy, autoimmune thrombocytopenic purpura, or secondary DVI were excluded. Absolute neutrophil, monocyte, platelet, and lymphocyte counts, AISI, and Hct levels were obtained from complete blood count results using a hematology analyzer. The results showed that AISI and lymphocytes correlated with Hct, with correlation values of (r=0.410, p<0.001) and (r=0.446, p<0.001), respectively. In contrast, monocytes, neutrophils, and platelets did not correlate with Hct, with correlation values of (r=-0.009, p=0.942), (r=-0.059, p=0.628), and (r=-0.175, p=0.147), respectively. In conclusion, AISI levels in DVI were low and negatively correlated with Hct, a known indicator of PL. These findings suggest that AISI has potential as a marker for PL and disease severity in DVI.
Deteksi Dini Risiko Sindrom Metabolik pada Remaja di Daerah Urban dan Rural: Early Detection of Metabolic Syndrome Risk in Adolescents in Urban and Rural Areas Aisyah, Riandini; Jatmiko, Safari Wahyu; Bestari, Rochmadina Suci; Supraba, Intan Pratiwi; Utami, Indari; Wibowo, Haryo Kunto; Mapa, Anna Rochim; Utami, Aurelia Ratna; Anggitaratri, Zakia Novi; Haliza, Sheli Nur; Fitri, Alifah Aulia; Anam, Ilham Hafizha Maulana; Azenta, Moch. Tabriz; Syahida, Safira; Sulistiyo, Azka Hafiy; Brilliantama, Fandy Akbar; Maulida, Amira Hasna; Wafiq, Muhammad Azzim; Kamila, Aulida Azkia; Rohman, Raihan Fadzlur
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 8 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i8.9733

Abstract

Metabolic syndrome is a collection of metabolic disorders that are closely related to an increased risk of developing diabetes mellitus and cardiovascular diseases in obese adolescents. Metabolic syndrome in adolescents is still reversible with varying timeframes. In adolescents with metabolic syndrome, the transition from homeostasis with normal blood sugar levels to type 2 diabetes occurs more rapidly compared to adults. Early diagnosis of metabolic syndrome is essential for prevention through lifestyle changes. Living in urban areas has a higher risk of obesity compared to living in rural areas after controlling for other variables. This activity aims to initially screen metabolic syndrome in middle school adolescents in urban and rural areas. The measurement of metabolic syndrome parameters involved 107 students, consisting of 47 middle school students in urban areas and 60 in rural areas. The measurement and data analysis results showed significant differences in body mass index (p<0,001), waist size (p=0.03), waist circumference (p=0.007), and upper arm circumference (p=0.002) between students in urban and rural areas, while blood sugar levels, blood pressure, and neck circumference did not show significant differences.
PENCEGAHAN, DETEKSI DINI, DIAGNOSIS DAN TATA LAKSANA STUNTING PADA BALITA DAN KADER BALITA DI WILAYAH KERJA PUSKESMAS COLOMADU II, KABUPATEN KARANGANYAR Agustina, Tri; Tolibin, Restu Triwulandani; Aisyah, Riandini; Lestari, Nining; Bestari, Rochmadina; Maylafaiza, Annisa; Nafisa, Balqis; Rahayu, Destri; Arrohma, Farah; Fauzi, Favian; Setiani, Hilda; Ramadhani, Marsyanda; Sukardi, Nadya; Pratama, Nur; Ayyasi, Quanta
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 2, September 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i2.12255

Abstract

  ABSTRAK Stunting merupakan gangguan pertumbuhan linier yang ditandai dengan panjang atau tinggi badan menurut umur di bawah -2 SD. Kondisi ini mencerminkan masalah gizi kronik dan masih menjadi tantangan besar di Indonesia. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman dan keterampilan kader serta orang tua balita dalam pencegahan stunting melalui edukasi, pelatihan antropometri, promosi pemberian ASI eksklusif, MPASI bergizi seimbang, dan pemahaman tentang pangan olahan untuk keperluan medis khusus (PKMK). Metode pelaksanaan mencakup survei awal, koordinasi dengan Puskesmas Colomadu II, pelatihan kader, edukasi kepada orang tua, serta evaluasi menggunakan pretest dan posttest. Hasil analisis dengan uji Wilcoxon Signed-Rank menunjukkan tidak terdapat perbedaan signifikan secara statistik, namun terdapat peningkatan nilai deskriptif yang menunjukkan adanya dampak positif terhadap peningkatan pengetahuan. Hasil ini mengindikasikan bahwa pendekatan edukatif berbasis komunitas berpotensi efektif untuk pencegahan stunting bila dilaksanakan secara berkelanjutan dan adaptif.   ABSTRACT Stunting is a linear growth disorder characterized by height or length below -2 SD for age. This condition reflects chronic malnutrition and remains a major challenge in Indonesia. This community service activity aims to improve the understanding and skills of cadres and parents of toddlers in preventing stunting through education, anthropometry training, promotion of exclusive breastfeeding, nutritionally balanced complementary foods, and understanding of processed foods for special medical purposes (PKMK). The implementation methods included an initial survey, coordination with the Colomadu II Community Health Center, cadre training, education for parents, and evaluation using pre-tests and post-tests. The results of the analysis using the Wilcoxon Signed-Rank test showed no statistically significant differences, but there was an increase in descriptive values, indicating a positive impact on knowledge improvement. These results indicate that a community-based educational approach has the potential to be effective in preventing stunting when implemented in a sustainable and adaptive manner.  
PENINGKATAN PENGETAHUAN TENTANG DUKUNGAN KELUARGA TERHADAP GAYA HIDUP SEHAT REMAJA PADA SISWA SMP MUHAMMADIYAH DI SURAKARTA Bestari, Rochmadina Suci; Aisyah, Riandini; Jatmiko, Safari Wahyu; Utami, Aurelia Ratna; Syahida, Safira; Nurhaliza, Sheli; Aryanto; Suryani, Latifah; Sholeh, Muhammad Dzikru Irfan
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 2, September 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i2.12590

Abstract

ABSTRAK Kesehatan remaja, baik secara fisik maupun mental, telah menjadi isu kesehatan masyarakat yang semakin signifikan dan menjadi perhatian serius secara global, termasuk di Indonesia. Faktor-faktor yang berkontribusi terhadap masalah kesehatan ini meliputi kebiasaan gaya hidup dan kurangnya pengetahuan kesehatan. Keluarga memegang peran yang sangat krusial dan mendasar dalam membentuk perilaku kesehatan remaja. Siswa SMP Muhammadiyah perlu mengetahui pentingnya dukungan keluarga untuk gaya hidup sehat mereka. Tujuan kegiatan ini adalah untuk mengetahui adanya peningkatan pengetahuan tentang dukungan keluarga dalam penarapan gaya hidup sehat remaja pada siswa SMP Muhammadiyah PK Surakarta. Metode pelaksanaannya adalah pretes, penyampaian materi oleh dokter menggunakan presentasi slide, kemudian postes. Hasil yang didapatkan adalah rata-rata nilai pretes adalah 63,36, rata-rata nilai postes adalah 97,59, rata-rata kenaikan skor sebesar 34,54. Dari analisis t-test, didapatkan p<0,001 pada siswa 9A dan siswa 9B yang menunjukkan bahwa terdapat perbedaan yang signifikan pada pengetahuan siswa sebelum dan sesudah edukasi. Simpulan kegiatan ini adalah terdapat peningkatan pengetahuan siswa-siswi SMP tentang peran dukungan keluarga pada gaya hidup sehat mereka.   ABSTRACT Adolescent health, both physically and mentally, has become a significant public health issue and a serious concern globally, including in Indonesia. Factors contributing to this health problem include lifestyle habits and lack of health knowledge. Families play a crucial and fundamental role in shaping adolescent health behaviors. Muhammadiyah junior high school students need to know the importance of family support for their healthy lifestyles. The objective of this study was to determine whether there was an increase in knowledge about family support for healthy lifestyles among junior high school students at Muhammadiyah PK Surakarta. The study was conducted using a pretest, presentation of material by a doctor using slides, and a posttest. The results obtained were an average pretest score of 63.36, an average posttest score of 97.59, and an average score increase of 34.54. From the t-test analysis, p<0.001 was obtained for students in class 9A and class 9B, indicating a significant difference in students' knowledge before and after the education program. The conclusion of this activity is that there was an increase in the knowledge of junior high school students about the role of family support in their healthy lifestyle.
Co-Authors Ahmad Alrizaldi Alfajri, Asri Anam, Ilham Hafizha Maulana Angesti Atiqah Ranasatri Anggitaratri, Zakia Novi Anggreheni, Putri Dwi Anika Candrasari Anindita Putri Handayani Ariffah, Hilda Zaniba Arrohma, Farah Aryanto Asfarina, Fatin Ayyasi, Quanta Azenta, Moch. Tabriz Bestari, Rochmadina Brilliantama, Fandy Akbar Devi Usdiana Rosyidah Dwi Advina Herdiyanti Dyah Farida Inli Em Sutrisna Erika Diana Risanti Estu Puguh Prabancono Faatiha, Arsyal Wanda Fauzi, Favian Fauzi, Favian Arriella Shabri Ikmal Fitri, Alifah Aulia Graffico Eryza Oldiara Gunawan, Ryan Budi Haliza, Sheli Nur Handayani, Anindita Putri Hidayatullah, Muhammad Alim Abdul Majid Iin Novita Nurhidayati Mahmuda Indra Nuroso Jatmiko, Safari Kamila, Aulida Azkia Kumala, Aswa Arsa Kurniati, Yuni Prestyo Lestari, Nining Listiana Masyita Dewi Mapa, Anna Rochim Maulida Rahmah, Maulida Maulida, Amira Hasna Maylafaiza, Annisa Muhamad Irfan Hidayatullah Muhammad Adha Muhammad Alim Abdul Majid Hidayatullah N Nurhayani Nafisa, Balqis Najmii, Muhammad Firoos Allaam Nur Mahmudah Nur Mahmudah Nurhaliza, Sheli Nurhayani nurhayani Nurhayani, N Pambudi, Nasrurrofiq Risvana Bayu Prabancono, Estu Puguh Prabowo, Nurhasan Agung Pratama, Nur Puspitasari, Metana Rahayu, Destri Ramadhani, Marsyanda Ratnasari Bondan Wijayanti Reisya Tiara Kandita Reisya Tiara Kandita, Reisya Tiara Retno Sintowati - Rochmadina Suci Bestari Rohman, Raihan Fadzlur Rohmaniar, Delianti Ryan Budi Gunawan Ryanuranti , Rahma Ghaida Safari Wahyu Jatmiko Salsabila, Nabila Mutia Sella Felina Setiani, Hilda Sholeh, Muhammad Dzikru Irfan Sri Wahyuni Sukardi, Nadya Sulistiyo, Azka Hafiy Sulistyo, Ayu Indah Supraba, Intan Pratiwi Suryani, Latifah Syahida, Safira Tara , Irmanawati Audhina Nirmala Tolibin, Restu Triwulandani Tri Agustina, Tri tri wahyuni Utami, Aurelia Ratna Utami, Indari Wafiq, Muhammad Azzim Wahyu Jatmiko, Safari Wibowo, Haryo Kunto Wulandari Berliani Putri Wulandari Berliani Putri, Wulandari Berliani