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All Journal HAYATI Journal of Biosciences Torani Journal of Fisheries and Marine Science Media Penelitian dan Pengembangan Kesehatan Jurnal Fitofarmaka Indonesia Emerging Science Journal Indonesian Journal of Chemistry ANNALES BOGORIENSES Dinamisia: Jurnal Pengabdian Kepada Masyarakat Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Riset Kesehatan Poltekkes Depkes Bandung Sainstech Farma: Jurnal Ilmu Kefarmasian Narra J Jurnal Ilmiah Kesehatan (JIKA) Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Journal of Pharmaceuticals and Natural Sciences Jurnal Kefarmasian Indonesia Annales Bogorienses
Berna Elya
Fakultas Farmasi Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Emerging Science Journal

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Antidiabetic Properties of Uncaria sclerophylla Roxb: In Vitro, Metabolite Profiling, and Molecular Docking Triadisti, Nita; Hanafi, Muhammad; Mohd Hashim, Najihah; Berna Elya
Emerging Science Journal Vol. 10 No. 1 (2026): February
Publisher : Ital Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28991/ESJ-2026-010-01-019

Abstract

Uncaria sclerophylla Roxb is a traditional medicinal plant used to treat diabetes mellitus in Kalimantan, Indonesia, and the antidiabetic properties of its stem bark have not been previously investigated. This research will focus on investigating the potential of U. sclerophylla stem bark as an antidiabetic with the mechanism of inhibiting dipeptidyl peptidase-4, α-glucosidase, and antioxidants from extracts to chromatographic fractions, including the exploration of the major compounds contained in the most active chromatographic fraction. Extraction using a four-grade maceration technique, bioassays were carried out using spectrophotometric methods, fractionation using gradient column chromatography, and compound profiling using UHPLC-Q-ToF-MS/MS. The profiled compounds were predicted for their bioactivity in silico. The stem bark of U. sclerophylla demonstrated antidiabetic potential, and the methanol extract showed superior antidiabetic potential compared with the other extracts. From the extract, the most active chromatographic fraction, FUS2, was successfully obtained, which had the best activity with DPP-4 inhibition IC50 of 83.07 ± 6.3393 µg/mL, α-glucosidase inhibition IC50 of 58.06 ± 1.6226 µg/mL, and antioxidant IC50 of 8.47 ± 0.0443 (DPPH method) and 8.47 ± 0.0234 µg/mL (FRAP method). Compound profiling of FUS2 and in silico bioassays revealed potential antidiabetic compounds, including rhynchophyllic acid, arecatannin A2, silydianin, and procyanidin A2.
Co-Authors . Azizahwati . Azizahwati . Farida . Frengki . Katrin . Katrin . Nofiantini Ali Muhammad Shodiq Amarila Malik Anastasia Bangun Anastasia Bangun, Anastasia Ariestanti, Donna Maretta Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifianti, Ayun Erwina Aryo Tedjo Atiek Soemiati Atiek Soemiati Atiek Soemiati Atriyon Julzarika Atriyon Julzarika Azizah, Norma N. Azizahwati Azizahwati Azminah Azminah Basah, Katrin Chairunissa, Ananda Hanny Charissa, Meiliana Daan Khambri Dadang Kusmana Dadang Kusmana Deddi Prima Donna Maretta Ariestanti Effionora Anwar Elis Apriyanti Elis Apriyanti, Elis Emiyanah . Emiyanah, Emiyanah Fadlina Chany Saputri Fajriati, Annisa Fajrin, Ajeng M. Farida Farida Farida Ibrahim Fasya Hadaina Maharani Fatma Sri Wahyuni Febriani, Amelia Febrina Amelia Saputri Forestrania, Roshamur Cahya Forestrania, Roshamur Cahyan Frengki Frengki Fulka Nurzaman Hanita Omar Hashim, Najihah BM. Hayun Hayun Henny Vanda Herman Suryadi Hessy Novita Hindun Wilda Risni Iis Irawatty Dewi Ika Maruya Kusuma Ika Mustika Imam Syafi'i Irianti, Marina Ika Islamudin Ahmad Jamilah Abbas Jamilah Abbas Jantan, Ibrahim Joshita Djajadisastra Joshita Djajadisastra Joshita Djajadisastra, Joshita Juheini Amin Juheini Amin Juheini Amin Julian, Muhamad Iqbal Kamaruzzaman, Mohd Amir Kartika Citra Dewi Permata Sari Katrin Basah Katrin Katrin Krinalawaty, Nevy Kusmardi Kusmardi Ladeska, Vera Liza Ariantina Maharani Maharani, Maharani Maharani, Fasya Hadaina Mahdi Jufri Mahmuda, Nur Amalia Makau, Juliann Nzembi Marcha Putri, Nada MARIA BINTANG Martha, Septiani Media Fitri Isma Nugraha Meiliana Charissa Mia Permawati Mihardja, Laurentia K. Mohd Hashim, Najihah Muh Alias L Rajamuddin Muhamad Iqbal Julian Muhammad Hanafi MUHAMMAD HANAFI Muhammad Hanafi Muhammad Hanafi Muhammad Muhammad Nanang Yunarto Nanang Yunarto Neneng Siti Silfi Ambarwati Nevy Krinalawaty Nisa Maria Nofiantini Nofiantini Nofiantini Nofiantini, Nofiantini Noni Zakiah Novi Fajar Utami Novi Sulistyaningrum Novita, Hessy Nugraha, Media Fitri Isma Nurzaman, Fulka Prasetio, Nisrina Putri Puspitasari, Rara Merinda Rahmadi, Agus Rahmasari, Ratika Rajamuddin, Muh Alias Rajamuddin, Muh Alias L Ramadanti, Nur A. Rani Sauriasari, Rani Ratu Ayu Dewi Sartika Reflinur Reflinur REFLINUR REFLINUR Regita Putri, Jasmine Retnosari Andrajati Rieka Widihasputri Rieka Widihasputri, Rieka Robiatul Adawiyah Rohmat, Siti Saudah Rosmalena, Rosmalena Rossa Yunita ROSSA YUNITA Santy Rahmawati Sari, Atika Mutiara Sari, Rifta Sintiami Ramadhani Siti Khadijah Soleh Kosela Soleh Kosela Syafi'i, Imam Syamsu Nur, Syamsu Taufiq Indra Rukmana Triadisti, Nita Veryanti, Putu Rika Wening Enggarini Wening Enggarini Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yesi Desmiaty, Yesi Yuditya Artha