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Endang Nurcahyani
1Jurusan Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Lampung
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Journal : JURNAL BIOLOGI INDONESIA

 1 
Efek Ekstrak Metanol Makroalga Cokelat (Sargassum sp.), Merah (Gracillaria sp.) dan Taurin Terhadap Gambaran Histopatologi Hepar Mencit Jantan (Mus musculus) yang Diinduksi Benzo(?)Piren Hervidea, Radella; Widiastuti, Endang Linirin; Nurcahyani, Endang; Sutyarso, Sutyarso; Susanto, G. Nugroho
JURNAL BIOLOGI INDONESIA Vol 14, No 1 (2018): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v14i1.3670

Abstract

ABSTRACTCancer is a disease marked by the existence of abnormal growth of cell continuously and uncontroll in an organism body. Benzo(?)pyrene is one of the substances that can cause a cancer. The methanolic extract of Sargassum sp. and Gracillaria sp. has anticancer and antioxidant activity. Other compounds with antioxidant activity is taurine. The aim of this research is to examine the effect from methanolic extract of Sargassum sp. and Gracillaria sp .and also taurine on hepar histopatology of male mice (Mus musculus) induced by benzo(a)pyrene. This research used Completely Randomized Design. 30 male mice were divided into 6 groups of treatments, those were: K1 = (K-), K2= induced by benzo(?)pyrene for 10 days, K3= after induced by benzo(?)pyrene, were given the Sargassum sp. orally with a dose 8mg/mice during 15 days, K4=after induced by benzo(a)pyrene, were given the combination of Sargassum sp. (8mg/mice) and taurine(15,6mg/mice) orally during 15 days, K5= after induced by benzo (?)pyrene, were given the Gracillaria sp.orally with a dose 8mg/mice during 15 days, and K6=after induced by benzo(a)pyrene, were given the combination of Gracillaria sp. (8mg/mice) and taurine (15,6mg/mice) orally during 15 days. Data were analyzed using ANOVA (? = 5%). The result shows that the combination of Sargassum sp. and Gracillaria sp. and taurine can increase the number of erythrocyte , decrease the number of leucocyte and protect the damage of hepar histopatology of male mice (Mus musculus) induced by benzo (?)pyrene. Combination of extract Gracillaria sp. and taurine is the most effective to protect the damage hepar histopatology of male mice(Mus musculus) induced by benzo(? )pyrene.Keywords: male mice,Sargassum sp., Gracillaria sp., taurine, benzo(a)pyrene, hepar
EFEK EKSTRAK METANOL MAKROALGA COKELAT (SARGASSUM SP.), MERAH (GRACILLARIA SP.) DAN TAURIN TERHADAP GAMBARAN HISTOPATOLOGI HEPAR MENCIT JANTAN (MUS MUSCULUS) YANG DIINDUKSI BENZO(?)PIREN Hervidea, Radella; Widiastuti, Endang Linirin; Nurcahyani, Endang; Sutyarso, Sutyarso; Susanto, G. Nugroho
JURNAL BIOLOGI INDONESIA Vol 14, No 1 (2018): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v14i1.3670

Abstract

ABSTRACTCancer is a disease marked by the existence of abnormal growth of cell continuously and uncontroll in an organism body. Benzo(?)pyrene is one of the substances that can cause a cancer. The methanolic extract of Sargassum sp. and Gracillaria sp. has anticancer and antioxidant activity. Other compounds with antioxidant activity is taurine. The aim of this research is to examine the effect from methanolic extract of Sargassum sp. and Gracillaria sp .and also taurine on hepar histopatology of male mice (Mus musculus) induced by benzo(a)pyrene. This research used Completely Randomized Design. 30 male mice were divided into 6 groups of treatments, those were: K1 = (K-), K2= induced by benzo(?)pyrene for 10 days, K3= after induced by benzo(?)pyrene, were given the Sargassum sp. orally with a dose 8mg/mice during 15 days, K4=after induced by benzo(a)pyrene, were given the combination of Sargassum sp. (8mg/mice) and taurine(15,6mg/mice) orally during 15 days, K5= after induced by benzo (?)pyrene, were given the Gracillaria sp.orally with a dose 8mg/mice during 15 days, and K6=after induced by benzo(a)pyrene, were given the combination of Gracillaria sp. (8mg/mice) and taurine (15,6mg/mice) orally during 15 days. Data were analyzed using ANOVA (? = 5%). The result shows that the combination of Sargassum sp. and Gracillaria sp. and taurine can increase the number of erythrocyte , decrease the number of leucocyte and protect the damage of hepar histopatology of male mice (Mus musculus) induced by benzo (?)pyrene. Combination of extract Gracillaria sp. and taurine is the most effective to protect the damage hepar histopatology of male mice(Mus musculus) induced by benzo(? )pyrene.Keywords: male mice,Sargassum sp., Gracillaria sp., taurine, benzo(a)pyrene, hepar
Co-Authors Adrianus Adrianus Agung Kurniawan Agung Kurniawan Agustin, Resya Tamara Agustrina, Rochmah Alfian Bagus Setiawan Amini, Nur Aisyah Amirah Afifah Melta Anis Ashari Annindya Rahma Apherta, Nurshella Apriyanti, Della Ashari, Anis Asrini Puspitasari Ayu Wulan Septitasari Ayu Azahra Putri Najla Azizah, Enur Baehaqi Bambang Hadisutrisno Bambang Irawan Bambang Irawan Bambang Irawan Bayu Putra Danan Jaya Damayanti, Elok Della Apriyanti Desti Deria Rahmadani Desti Syahfitri Dewiyatno, Rezza Kusumma Dian Alfiah Dian Alfiah Dian Pratiwi Dian Pratiwi Dwi Septiani Dwi Septiani E. Suharyanto Eko Nastiti Eko Pramono Elsi Diana Emantis Rosa Emantis Rosa Endang L Widiastuti Endang Linirin Ernawiati, Eti Eti Ernawiati Eti Ernawiati Fachry Abda El Rahman Farisi, Salman Fesya Salma Putri Fithria Mumtazah, Dzul Gardis Andari Hardoko Insan Qudus Hardoko Insan Qudus Harfiani, Nabela H.N. Hendri Busman Hendri Busman Heni Pujiastuti Herlanda, Kishy Dhea Herlina Putri Prastiwi Holizah, Dewi Nure Ika Listiana Imamah Muslimah Imamah Muslimah, Imamah Indah Stellawati Indradewa, Rhian Indriani, Syavira Insan Qudus, Hardoko Intan Okta Nabilla Intan Okta Nabilla Issirep Sumardi Khairunnisa Rizqika A.P Kinasih Cahyono Lili Chrisnawati Lili Chrisnawati Lili Chrisnawati, Lili Linda Kurnia Dewi Linda Septiani Lindawati Lindawati Lucy Adi Tama M Kanedi M. Yogi Riyantama Isjoni Maemonah, Maemonah Mahfut MARIA SUSANTI Martha L. Lande Martha L. Lande Martha Lulus Lande Martha Lulus Lande Martha Lulus Lande Martha Lulus Lande, Martha Lulus Maryani, Rina Ma’ania Zalzabila Meilyana Santa Maria Meilyana Santa Maria Moza Fierda Atiek Muhamad Rizkci Sazilly Mutmainah, Nurul Aniqotun Nadia Fakhriyati Arfa Nadya Rosyalina Nalindri Impitasari Ni Made Nada Elsika Nuning Nurcahyani Nur Aisyah Amini Nurul Aniqotun Mutmainah Oktaviani, Ratna Pertiwi, Prima Sari Purnama Agustin, Kharisma Puspita Dewi, Yulia Putri Wardanis Putri, Feriza Yolanda Qudus, Hardoko Insan R. Fadly Bayu Dwiyoga Radella Hervidea, Radella Raden Mohamad Herdian Bhakti Rahayu Amaliya Rahmadani, Desti Deria Ratna Oktaviani Ratna Oktaviani Resta Tania Ria Aulia Noviantia Ria Aulia Noviantia, Ria Aulia Rina Maryani Risa Suryani Wilyasari Risma Rasmani Rochma Agustrina Rochmah Agustrina Rochmah Agustrina Rochmah Agustrina Rosa, Emantis Rosyalina, Nadya RR. Ella Evrita Hestiandari Sally Khoirunisa Sally Khoirunisa Salman Farisi Sarah Sarah Sazilly, Muhamad Rizkci Selvi Marcelia Sembiring, Rinawati Setiawan, Alfian Bagus Setiawati, Primasari Linda Sri Wahyuningsih Sri Wahyuningsih Sri Wahyuningsih Stellawati, Indah Sukamto, Ika Sumiyarsi Sumardi Sumardi . Sumardi Sumardi Sumardi, Sumardi Suratman Suratman Suratman Suratman Suratman Umar Susanto, G. Nugroho Susanto, G. Nugroho Sutyarso Sutyarso Sutyarso Sutyarso Syahfitri, Desti Syamsiar, Syamsiar T. Indah Setia Ningsih Tara Sesafia Paletri Tarisa Livia Hr Tundjung Tripeni Handayani Tundjung Tripeni Handayani Tundjung Tripeni Handayani Tundjung Tripeni Handayani Tundjung Tripeni Handayani Tundjung Tripeni Handayani, Tundjung Tripeni Wanda Amelia Wardanis, Putri Widiastuti, Endang Linirin Widiastuti, Endang Linirin Yulianti Yulianty Yulianty Soeradji Yulianty Yulianty Yulianty Yulianty Yulianty Yulianty Yulianty Yulianty Yuniar, Lutfiah Zelfi Julita Dwi Putri Zulkifli Zulkifli Zulkifli Zulkifli Zulkifli Zulkifli Zulkifli Zulkifli Zulkifli zulkifli zulkifli Zulkifli Zulkifli