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Journal : Indonesian Journal of Pharmaceutical Education

Formulasi Sediaan Emulgel Ekstrak Daun Kelor (Moringa oleifera Lam) Dan Uji Aktivitas Antioksidan Menggunakan Metode DPPh Nurrohwinta Djuwarno, Endah; Hiola, Faramita; Isa, Ishak
Indonesian Journal of Pharmaceutical Education Vol 1, No 1 (2021): Januari-April 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i1.9947

Abstract

Moringa (Moringa oleifera Lam) is one of the plants that has high antioxidant activity, especially in the leaves. Emulgel is one of the topical dosage which dermatologically has several beneficial properties, namely thixotropic, not oily, easy to spread, easy to clean, soft, easy to wash, long lasting, transparent and comfortable when used. The purpose of this research was to formulate moringa (Moringa oleifera Lam) leaves extract into emulgel dosage forms and determine the antioxidant activity of the dosage using DPPH method.The research began with extraction of moringa leaves and optimization of the base by varying the concentration of carbopol 940 as gelling consisting of F1 0.5%, F2 1%, F3 1.5% and F4 2%. The base that met the requirements of good physical stability was F2.  The F2 base was then made into emulgel dosage with 3 concentration variations of the extract, namely F2a 4%, F2b 5% and F2c 6%. The physical stability test result of each formula met the organoleptic test,the pH test, the dispersion test, the adhesion test, the viscosity test, and the freeze-thaw test. The One way ANOVA statistical test result showed that the p value was greater than 0.05, which meant that the emulgel dosage had good physical stability. The IC50values of each antioxidant activity result were F2a (t0 = 120.464 g/mL; t28 = 144.887 g/mL), F2b (t0 = 113.642 g/mL; t28 = 128.407g/mL), F2c (t0 = 74.745 g/mL; t28 = 90.618 g/mL). The statistical results of the t-test showed thep value = 0,027, (less than 0.05), This indicated that there were significant difference results of the antioxidant activity test between the three formulas on the first day (t0) and on the 28th day (t28).
Co-Authors A Muthi Andi Suryadi A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi Abdulkadir, Widysusanty Adam Mustapa, Muhammad AM Andy Suryadi AM. Andy Suryadi Andi Makkulawu Anggai, Rifka Anggraini Aprianto Paneo, Mohamad Arief Ibnu Haryanto Asriyanti Asriyanti Awalludin Awalludin, Awalludin Aziz, Rezky Nur Balikan, Virginia Defita Zubaidi Dewa Ayu Puspita Divia Handayani Mudjidu Dizky Ramadani Papeo Dr. Apt. Hamsidar Hasan S.Si.,M.Si Faradila Ratu Cindana Febriyaningsi Radjak Fika Nuzul Ramadhani Halada, Ichlasul Oktofandi Hamsidar Hasan Hamzah, Alifiah Ramawaty Harwanto, Yelisnawati Hasan, Muadz Hasrita Samudi Hiola, Faramita Indriyani Ishak Isa Ishak, Siti Magfira Jafar La Kilo Julianty Akuba Kariem, Nazli LATIF, MULTIANI S Madania Madania, Madania Mahdalena Sy Pakaya Makkulawu, Andi Manno, Mohamad Reski Mimi Fauziah Tahir Mohamad Adam Mustapa Mohamad Aprianto Paneo Mo’o, Faradila Ratu Cindana Muhamad Handoyo Sahumena Muhamad Handoyo Sahumena Muhamad Handoyo Sahumena Muhammad Taupik Muhammad Taupik Muhammad Taupik Muhammad Taupik Mustapa  Khamal  Rokan Nabila Husnunnisa Ismail Nabila Novreini Djunaidi Nur Ain Thomas Nur Ain Thomas Nur Aisya Tonde Nur Ayini S Lalu Nur Ayun R Yusuf Nur Rasdianah Papeo, Dizky Ramadani Putri Puce, Faradilla Rahmatia Abdullah Rahmatia Baharuddin Rahmayani, Siti Farah Ratnawati Ratnawati Reski Manno, Mohamad Robert Tungadi Ruslin Ruslin Selvi Marcellia Suryadi, A. Mu'thi Andy Susanti Pakaya Teti Sutriyati Tuloli Teti Sutriyati Tuloli Tirta Cahnia Usuli Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti Abdulkadir Wiwin Rewini Kunusa Yasin, Sulistya Zulkarnain Marhaba Zulkarnain Marhaba Zulkifli B. Pomalango