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All Journal Jurnal Sain Veteriner Jurnal Ilmiah Mahasiswa Veteriner Bulletin of Data Science Jurnal Ilmiah Ilmu-Ilmu Peternakan Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research Buletin Pengabdian Heca Journal of Applied Sciences Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Jurnal Medika Veterinaria Peternakan Abdi Masyarakat (PETAMAS)
Muhammad Hanafiah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Investigating Scabies Pathogenesis and Therapeutic Potential of Nutmeg Extract in Experimental Animals Erizal, Erizal; Hanafiah, Muhammad; Mudatsir, Mudatsir; Helmi, Teuku Zahrial
Heca Journal of Applied Sciences Vol. 4 No. 1 (2026): March 2026
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v4i1.333

Abstract

Nutmeg (Myristica fragrans) is one of Indonesia’s agricultural commodities with recognized health benefits as a traditional medicine. In addition, nutmeg has potential as a natural treatment for scabies. This study aimed to evaluate the effectiveness of nutmeg fruit bioactive compounds in scabies treatment. Nutmeg extraction was conducted using three different solvents: ethanol, ethyl acetate, and n-hexane. The extract with the most dominant phytochemical composition was further analyzed for bioactive compounds using GC-MS and antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Subsequently, the extract was tested against Sarcoptes scabiei mites obtained from 15 stray cats. The effectiveness of nutmeg extract was evaluated in a spray formulation by observing mite mortality and lesion reduction. The results demonstrated that the ethanol extract of nutmeg fruit contained the most abundant phytochemicals, with 3-Methyl-2,5-Furandione (21.26%) and Maleic Anhydride (14.21%) as the dominant compounds. The ethanol extract also exhibited strong antioxidant activity with an IC₅₀ value of 21.41 ppm. In vitro testing showed 100% mite mortality at a 25% extract concentration within 24 hours, while in vivo testing on scabies-infected cats treated with the nutmeg spray extract revealed a significant reduction in scab lesions compared to the control group. These findings indicate that nutmeg extract possesses potent acaricidal and antioxidant properties, making it a promising alternative treatment for scabies. Further studies are required to refine the formulation and explore its clinical applications.
The effect of aquous extract of johar leaves (Senna siamea) injection on survival rate and blood profile of snakehead fish (Channa striata) Sutriana, Amalia; Panjaitan, Budianto; Siddik, Tasya Luthfiah; Farida, Farida; Hanafiah, Muhammad; Asmilia, Nuzul; Rosmaidar, Rosmaidar; Rahmad, Rahmad
Depik Vol 11, No 3 (2022): DECEMBER 2022
Publisher : Faculty of Marine and Fisheries, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13170/depik.11.3.26841

Abstract

Aqueous extract of johar leaf contains metabolite compounds such as flavonoids, sponins, tannins, phenols, anthraquinones, anthocyanins, and cardiac glycosides which can be used to substitute commercial antibiotics. The use of aqueous extract of johar leaf has been known to have antibacterial activity in vitro. This study aims to determine the effect of aqueous extract of johar leaves (Senna siamea) injection on survival and blood profile of snakehead fish (Channa striata) in vivo. This research was a laboratory study using a completely randomized design (CRD) with 5 treatments and 3 replications with a total sample of 75 snakehead fish. The fishin KA, KB, KC and KD groups were injected with aqueous extract of johar leaves with concentrations of 10%, 20%, 40%, and 60% respectively, while in KE group the fish was injected with distilled water (control). The parameters of this study were the survival rate and blood profile of snakehead fish. Blood hematology examination included calculation of erythrocyte count, hemoglobin level, and hematocrit percentage, leukocyte count, and thrombocyte count. The research data obtained were analyzed using one-way analysis of variance and followed by Duncan's Multiple Distance test. Injection of aqueous extract of johar leaf did not affect the survival rate of snakehead fish. However, hemoglobin and platelet levels significant decrease in the group given 60% concentration of aqueous extract of johar leaf. It can be concluded that aqueous extract of johar leaf at a concentration of 10%, 20%, 40% is safe to use in snakehead fish.Keywords:Johar leaves extractSnakehead fishBlood profileSurvival rate
Prevalensi, Distribusi, dan Faktor Risiko Parasit Zoonotik Potensial pada Tikus (Rattus norvegicus) di Zona Buffer dan Perimeter Pelabuhan Sabang Humairah, Tasya; Athaillah, Farida; Hanafiah, Muhammad; Ferasyi, Teuku Reza; Hambal, Muhammad
Jurnal Sain Veteriner Vol 44, No 1 (2026): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.116400

Abstract

Tikus ( Rattus norvegicus ) berperan sebagai hewan reservoir parasit zoonotik terutama di kawasan pelabuhan dengan aktivitas manusia dan operasional logistik yang tinggi. Penelitian ini bertujuan untuk mengidentifikasi jenis parasit zoonotik yang berpotensi menginfeksi tikus, mengetahui kepadatan tikus di zona penyangga dan perimeter Pelabuhan Sabang, serta menganalisis hubungan antara faktor lingkungan dengan keberadaan tikus. Penelitian ini menggunakan desain cross sectional dengan metode purposive sampling . Sebanyak 64 ekor tikus berhasil ditangkap menggunakan perangkap hidup. Pemeriksaan parasit dilakukan melalui metode sentrifugasi, modifikasi Ziehl–Neelsen , gerusan organ, dan identifikasi ektoparasit, sedangkan analisis statistik dilakukan menggunakan uji Chi-square , uji Fisher, serta perhitungan Relative Risk (RR). Hasil penelitian menunjukkan bahwa kepadatan relatif tikus di Pelabuhan Sabang tergolong tinggi dengan kepadatan tertinggi pada CT2 (27,14%), diikuti Kawasan Penyangga 1 (22,86%), Kawasan Penyangga 2 (14,29%), CT1 (14,29%), dan CT3 (12,86%). Parasit yang teridentifikasi meliputi Hymenolepis nana (18,8%), Hymenolepis diminuta (14,1%), Strongyloides spp. (28,1%), Capillaria hepatica (10,9%), ooista Isospora sp. (4,7%), serta ektoparasit Xenopsylla cheopis (9,4%) dan Ornithonyssus sp. (35,9%). Faktor lingkungan yang berhubungan signifikan dengan keberadaan tikus adalah kondisi drainase, keberadaan sisa pangan, kondisi Tempat Pembuangan Sampah (TPS), dan celah akses ( ρ < 0,05). Dalam pendekatan One Health , temuan ini menunjukkan bahwa faktor sanitasi dan kondisi fisik lingkungan berperan penting dalam menentukan kepadatan tikus serta potensi risiko parasit zoonotik di Kawasan Pelabuhan Sabang. 
Co-Authors Abd. Rasyid Syamsuri Adam S, Koji Al Amalia Sutriana arif gumilar Arman Sayuti Armia, Yasser Athaillah, Farida Aulia Malik Fajar Aza Annisa Utami Baehaqi Basri A. Gani, Basri A. budianto panjaitan Dwinna Aliza Dwinna Aliza Emi Minarni Erdiansyah Rahmi Erdiansyah Rahmi Erizal Erizal Fadrial Karmil Farid Wajidi Farida Athaillah Farida Farida Farida Farida Hamdani Budiman Hamdani Budiman Humairah, Tasya Ilham Ilham Indra Wahyudi, Indra Ismail Ismail Joko Prastowo Juli Melia M. Hasan Maulida, Sri Mudatsir Mudatsir Mufti Kamaruddin Mufti Kamaruddin Muhammad Bahi Muhammad Hambal Muhammad Hambal Muhammad Jalalluddin N. Nazaruddin Nur Afriyanti Nuraini Latif Nurdianti - NURLIANA NURLIANA Nurul Hidayati Nuzul Asmilia Nuzul Asmilia Pratama, Said Mirza R. Rusli Rahmad Rahmad Rastina Rastina Rosmaidar Rosmaidar, Rosmaidar Rusli . Rusli Rusli Rusli Sulaiman Salim, Muhammad Nur Sembiring, Rinawati Siddik, Tasya Luthfiah Sri Hartati Sri Hartati Subhaini Jakfar Sugito Sugito Sugito Sugito Sukarni Sukarni Sulastri, S t fadrial karmil Teuku Armansyah Teuku Reza Ferasyi Teuku Reza Ferasyi Teuku Zahrial Helmi Widya Nanda Winaruddin Winaruddin Wisnu Nurcahyo Wisnu Nurcahyo Yudha Fahrimal Yundari, Yundari