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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Global Medical and Health Communication MNJ (Malang Neurology Journal) Biomedical Journal of Indonesia Window of Health : Jurnal Kesehatan Collaborative Medical Journal (CMJ) Health and Medical Journal Human Care Journal Andalas obstetrics and gynecology journal Jurnal Ners Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Pharmaceutical and Sciences. Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Neurona Jurnal Sains Farmasi dan Kesehatan Jurnal Sains, Teknologi dan Kesehatan
Restu Susanti
Departemen Neurologi, Fakultas Kedokteran, Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Hubungan Kadar Delta Like Ligand 1 (DLL-1) Serum dan Cairan Serebrospinal (CSS) Terhadap Derajat Keparahan Meningitis Tuberkulosis Abdul Razak; Syarif Indra; Restu Susanti; Yuliarni Syafrita; Reno Bestari; Gunawan Septa Dinata
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1514

Abstract

Tuberculous meningitis (TBM) is an infection caused by Mycobacterium tuberculosis (M.tb) affecting the meninges, characterized by high morbidity rates. The prognosis of TBM is partially determined by clinical severity, classified according to the British Medical Research Council (BMRC) scale. Delta Like Ligand 1 (DLL-1) is a transmembrane protein that plays a role in the formation of lipid cells, which are essential for the survival, virulence, and defense of M.tb against the host immune system. DLL-1 expression can be induced by the stimulation of M.tb cell walls in response to the human immune system. This study aims to analyze the correlation between DLL-1 levels in the serum and cerebrospinal fluid (CSF) with the clinical severity of TBM patients. A cross-sectional study was conducted involving 30 TBM patients treated at M. Djamil Central General Hospital, Padang, from October 2025 to January 2026. Serum and CSF DLL-1 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method, while TBM severity was assessed based on the BMRC criteria. Data analysis was performed using SPSS version 26.0 with a significance level of p < 0.05. The results of the analysis showed no significant difference in serum DLL-1 levels (p = 0.129) or CSS DLL-1 levels in relation to the severity of TBM (p = 0.097).
HUBUNGAN KADAR UREUM DAN KREATININ SERUM DENGAN FUNGSI KOGNITIF PENDERITA PENYAKIT GINJAL KRONIK Adzra Fadhila Iswan; Restu Susanti; Dian Pertiwi; Lydia Susanti; Almurdi Almurdi; Miftah Irramah
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 2 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i2.2596

Abstract

Chronic Kidney Disease (CKD) may lead to various complications, including cognitive impairment. The causative factor is the toxic substances accumulation in the body, including serum ureum and creatinine. This study aimed to determine the relationship between serum ureum and creatinine levels with cognitive function in CKD patients. Samples were taken using a consecutive sampling technique on 46 CKD patients who were hemodialyzed at RSUP Dr. M. Djamil Padang. Cognitive function was assessed using the Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Serum ureum and creatinine were measured with a spectrophotometer. Data were analyzed using the Chi-Square test. Results showed that CKD patients with cognitive impairment were more likely to be older than 50 years old (54.2%) and male (58.3%), had at least a high school education and above (70.8%), were accompanied by hypertension (75%), and without diabetes mellitus (91.7%). The median serum ureum and creatinine levels in patients with cognitive impairment were 124 mg/dL and 10.05 mg/dL. The relationship between serum ureum and creatinine levels with cognitive function had a 0.039 and 0.768 p-value. There is no relationship between the characteristics of the sample, including age, gender, education level, hypertension, and diabetes mellitus with cognitive function in CKD patients. There is a significant relationship between serum ureum levels and cognitive function, but a non-significant relationship between serum creatinine with the cognitive function of CKD patients.
ASSOCIATION BETWEEN VITAMIN D LEVELS IN SERUM WITH OUTCOME OF TUBERCULOUS MENINGITIS Susanti, Restu; Putri, Fanny Adhy; Hardianti, Sonia
MNJ (Malang Neurology Journal) Vol. 12 No. 2 (2026): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.02.02

Abstract

Background: The most dangerous form of tuberculosis outside of the lungs, tuberculous meningitis (TBM) causes a lot of illness and even death. Vitamin D endures an important role, via stimulating antimicrobial peptides in the vitamin D receptor (VDR) signaling pathway, which in turn increases macrophage bactericidal activity against Mycobacterium TB, which are associated with the outcome of TB, including TBM. Objective: This research set intended to determine whether there was a connection between TBM patients' blood vitamin D levels and their subsequent health problems. Methods: Scores 4-5 on the Glasgow Outcome Scale (GOS) were used to classify positive clinical results, whereas scores 1-3 were used to classify negative outcomes. Serum vitamin D concentrations were quantified using the ELISA method. Results: The results of TBM patients were unrelated to their blood vitamin D levels (p = 1.000). Compared to the median blood vitamin D level of 51.97 ng/mL in the patients who did not survive, the median level in the patients who did survive was 71.11 ng/mL. When compared to results from individuals with normal blood vitamin D levels, TBM did not substantially vary (p = 0.454). Conclusion: There is evidence that vitamin D insufficiency increases the likelihood of contracting TB and worsens the disease in people who already have it.
SUNCT, A RARE TRIGEMINAL PAIN Restu Susanti
Collaborative Medical Journal Vol 3 No 2 (2020): Mei
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.351 KB) | DOI: 10.36341/cmj.v3i2.1264

Abstract

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) merupakan salah satu sub bagian dari short-lasting unilateral neuralgiform headache attacks. SUNCT sendiri merupakan suatu kondisi yang jarang ditemui dan ditandai dengan nyeri neuralgia tipikal sedang sampai hebat yang berlokasi pada area divisi pertama dari nervus trigeminus yang dapat dirasakan di bagian kepala mana saja. SUNCT bersifat primer dan sekunder. Gejala khas berupa nyeri kepala hebat unilateral dengan gejala otonom dengan injeksi konjungtiva bilateral dan lakrimasi dengan frekuensi serangan lebih dari 60 kali per hari (range 3 sampai 200), di mana serangan ini dapat terjadi secara spontan atau dipicu oleh stimulus mekanik pada daerah yang dipersarafi oleh nervus trigeminus dan tanpa periode refraktori setelahnya. Tatalaksana yang diberikan saat ini masih beragam yaitu pemberian obat anti epilepsi, terapi intervensional, ataupun prosedur invasif. Dibutuhkan pemahaman lanjut dalam diagnosis dan manajemen terapi yang kompleks dalam mentatalaksana pasien dengan SUNCT.
FAKTOR YANG BERHUBUNGAN DENGAN KELUHAN INSOMNIA PADA MAHASISWA PROGRAM STUDI PENDIDIKAN DOKTER Claudia Novi Wijaya; Restu Susanti; Elly Usman
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 1 No. 4 (2024): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Desember 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/nf07b868

Abstract

Mahasiswa rentan menderita insomnia akibat perubahan pola tidur saat memasuki perguruan tinggi dan meningkatnya stres akibat perubahan tuntutan sosial dan akademik. Oleh karena itu, perlu diketahui faktor-faktor yang berhubungan dengan insomnia untuk mengetahui faktor-faktor yang dapat dimodifikasi dalam pengendalian keluhan insomnia pada mahasiswa. Penelitian ini menggunakan desain penelitian analitik dengan pendekatan cross-sectional dan teknik pengambilan sampel proportional stratified simple random sampling. Penelitian ini dilaksanakan selama bulan Oktober 2021 sampai dengan Juni 2022 di Pendidikan Dokter Fakultas Kedokteran Universitas Andalas dengan jumlah sampel sebanyak 71 orang. Mahasiswa Pendidikan Dokter sebagian besar (63,4% atau 45 orang) mempunyai keluhan insomnia. Hasil uji statistik menunjukkan tidak ada hubungan jenis kelamin (p=1,00), kebiasaan merokok (p=0,398), konsumsi kopi (p=0,127), lama penggunaan gadget (p=0,617), dan sleep hygiene (p=0,183) dengan keluhan insomnia. Masih tingginya frekuensi keluhan insomnia pada mahasiswa Pendidikan Kedokteran. Oleh karena itu, perlu dilakukan penelitian lebih lanjut untuk mengkaji faktor risiko lain yang berhubungan dengan keluhan insomnia
Karakteristik Klinis dan Tatalaksana Pasien Karsinoma Nasofaring di RSUP Dr. M. Djamil Padang Meuthia Yolanda; Sukri Rahman; Restu Susanti
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 3 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v3i1.47

Abstract

Karsinoma nasofaring merupakan salah satu kanker kepala leher yang paling sering ditemukan di Indonesia. Karsinoma nasofaring sering terlambat terdiagnosis karena gejala klinis yang tidak khas. Penelitian ini bertujuan untuk mengetahui karakteristik klinis dan tatalaksana pasien karsinoma nasofaring di RSUP Dr. M. Djamil Padang tahun 2018 – 2022. Penelitian ini merupakan penelitian observasional deskriptif dengan pendekatan retrospektif menggunakan data sekunder rekam medis pasien karsinoma nasofaring tahun 2018 – 2022 dengan teknik pengambilan sampel pengambilan sampel total . Pada periode ini tercatat 285 pasien yang pertama kali terdiagnosis karsinoma nasofaring yang belum mendapatkan tatalaksana dan terdapat 250 data pasien karsinoma nasofaring yang memenuhi kriteria inklusi yang kemudian diolah dan ditampilkan dalam bentuk tabel distribusi frekuensi. Pada penelitian ini diperoleh bahwa kejadian karsinoma nasofaring paling banyak ditemukan pada rentang usia 36 – 45 tahun dan 46 – 55 tahun, dengan kejadian lebih sering ditemukan pada laki – laki (66,4%). Keluhan utama yang paling sering dikeluhkan pasien adalah benjolan di leher (58,4%). Gejala klinis yang paling banyak dikeluhkan pasien diantaranya benjolan di leher (76,4%), sumbatan hidung (60%), dan telinga terasa penuh (53,6%). Kebanyakan pasien baru terdiagnosis pada stadium IVA (70,4%) dengan gambaran histopatologi terbanyak adalah karsinoma tidak berdiferensiasi (76,8%). Pada sebagian besar pasien ditemukan metastasis regional dengan lokasi terbanyak pada KGB leher level II (58%), sedangkan metastasis jauh hanya ditemukan pada 1,6% pasien yaitu metastasis tulang. Tatalaksana yang paling banyak diterima pasien adalah kemoterapi neoadjuvan dan dilanjutkan dengan radioterapi.
Hubungan Kadar Matrix Metalloproteinase-9 pada Cairan Serebrospinal dan Serum terhadap Derajat Keparahan dan Luaran Pasien Meningitis Tuberkulosis Sonia Hardianti; Yuliarni Syafrita; Fanny Adhy Putri; Syarif Indra; Restu Susanti; Reno Bestari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1632

Abstract

Tuberculous meningitis (TBM) is a severe form of tuberculosis associated with high mortality and neurological morbidity. Disease severity strongly influences outcome; however, reliable biological predictors remain limited. Matrix metalloproteinase-9 (MMP-9) is a proteolytic enzyme involved in neuroinflammation and blood-brain barrier disruption, and it has been reported to be elevated in both the cerebrospinal fluid (CSF) and serum of TBM patients. This study aimed to evaluate the relationship between MMP-9 levels and the severity and outcome of TBM patients. This was an analytical observational study with a cross-sectional design involving TBM patients treated at Dr. M. Djamil General Hospital, Padang, from January to December 2024. CSF and serum MMP-9 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Disease severity was assessed using the British Medical Research Council (BMRC) criteria, and outcomes at 14 and 60 days were assessed using the Glasgow Outcome Scale. A total of 41 TBM patients were included in the study. The mean CSF MMP-9 level was 2,034.40 ng/L, while the median serum MMP-9 level was 1,490.14 ng/L. The analysis showed no significant association between CSF MMP-9 levels and disease severity (p = 0.276), 14-day outcome (p = 0.269), or 60-day outcome (p = 0.375). Serum MMP-9 levels were likewise not associated with disease severity (p = 0.248), 14-day outcome (p = 0.224), or 60-day outcome (p = 0.138), but they still showed an increasing pattern in patients with a fatal outcome. CSF and serum MMP-9 levels had no significant association with the severity and outcome of TBM patients. These findings suggest that a single MMP-9 measurement is insufficient as a clinical predictor, so a multibiomarker and longitudinal approach should be considered.
Hubungan Kadar Protein S100B Serum dengan Volume Perdarahan dan Tingkat Keparahan Pasien Perdarahan Intraserebral Spontan Fadrian Herjunio; Syarif Indra; Restu Susanti; Yuliarni Syafrita; Dedi Sutia; Reno Bestari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1662

Abstract

Spontaneous intracerebral hemorrhage is a hemorrhagic stroke with high mortality and morbidity rates. Hemorrhage volume and the degree of neurological severity are important factors influencing prognosis. Brain tissue damage due to hemorrhage triggers the release of biomarkers such as S100B protein, which is secreted by astrocytes. This study aims to determine the relationship between serum S100B protein levels and the volume of bleeding and severity in patients with spontaneous intracerebral hemorrhage. This observational, analytical, cross-sectional study was conducted on 47 patients with primary spontaneous intracerebral hemorrhage aged ≥18 years with onset within 0–24 hours, admitted to Dr. M. Djamil Padang General Hospital between August 2025 and February 2026 and confirmed by head CT scan. Serum S100B protein levels were measured using an enzyme-linked immunosorbent assay (ELISA), hemorrhage volume was assessed using the Broderick method, and severity was assessed using the NIHSS score. Statistical analysis used the Mann-Whitney and Kruskal-Wallis tests. A total of 30 patients (63.8%) had a bleeding volume <30 cc and 27 patients (57.4%) had moderate neurological deficits. The median serum S100B protein level was 0.049 µg/L. There was a significant median difference between serum S100B protein levels and hemorrhage volume (p=0.047), but not with clinical severity based on the NIHSS (p=0.173). Serum S100B protein levels differed significantly between the small and large hemorrhage volume groups, but not across clinical severity groups based on the NIHSS.
Co-Authors Abdi, Tri Jaya Abdillah, Tegar Abdul Razak Adzra Fadhila Iswan Afriani, Nita Afriwardi Afriwardi Afriyeni Sri Rahmi Akmal Irsyadi Iswan Almurdi Almurdi Anggrainy, Fenty Arina Widya Murni ATTIYA ISTARINI Aulia Noza Claudia Novi Wijaya Darwin Amir, Darwin Dea Rika Putri Purba Dedi Sutia Dhani Arief Prandana Dian Pertiwi Dian Pertiwi Alty Dicky Lesmana Eldi Sauma Eryati Darwin Eva Decroli Fadrian Herjunio Fanny Adhy Putri Fanny Adhy Putri Fanny Adhy Putri Gunawan Septa Dinata Gunawan Septa Dinata Gusti Revilla Hanny Vidya Sari Hardianti, Sonia Harun Harnavi Hasmiwati Hendra Permana Hendra Permana Hirowati Ali Hirowati Ali, Hirowati Husna Yetti Husni Minanda Fikri Ida Rahmah Burhan Ilahi, Fitratul Indra, Syarif Isnindiah Koerniati Isnu Lucky Riandini Isnu Lucky Riandini, Isnu Lucky Istiqomah Kurniawan, Yoga Setia Lenny Arinda Lesti Marliana Lydia Susanti, Lydia Melda Yelmaiza Meuthia Yolanda Miftah Irramah Musrizal Adli Nabila Priscilla Putri Nada Utami Prahastiwi Nita Afriani Novia Riza Lestari Nur Indrawaty Lipoeto Priyanka Prima Putri Putra, Syandrea Prima Putri, Azhara Dhiya Yosse Putri, Fanny Adhy Putri, Nabila Priscilla Rachmat Saleh Eka Putra Reno Bestari Reno Bestari Reno Bestari Reno Bestari Ridho Ahmad Jabbar Rifki Irsyad Rika Susanti Rizki Muhammad Rananda Rudy Afriant Salsabilah Firdausiah Saptino Miro Selfi Renita Rusjdi Sonia Hardianti Sukri Rahman Sutia, Dedi Syamel Muhammad Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Tiara Mardalifa Tofrizal Tofrizal Tofrizal Ulya Uti Fasrini Umul Khair Yoga Setia Kurniawan Yulia Trisna Yuliarni Syafrita Yuliarni Syafrita Yulistini, Yulistini Yuniar Lestari Yusri, Elfira Zakiya Ifana Putri