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The Quantitative and Qualitative Analysis of Antibiotic Use in Bone Fracture Patients in a Public Hospital in Indonesia Atmajani, Wanudya; Hasmono, Didik; Awdisma, Wien Maryati; Isparnadi, Erwien; Ramdani, Dewi
Pharmaceutical Journal of Indonesia Vol. 8 No. 1 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.008.01.8

Abstract

Pendahuluan: Terapi antibiotik profilaksis memiliki peran penting dalam memfasilitasi penyembuhan pasca operasi yang optimal. Penggunaan antibiotik yang tidak tepat di rumah sakit akan meningkatkan biaya terapi dan kejadian infeksi nosokomial mikroorganisme infeksius. Antibiotik profilaksis preoperasi diyakini dapat mengurangi kejadian infeksi tempat pembedahan. Tujuan: Penelitian ini bertujuan untuk mengetahui pola penggunaan antibiotik dan menganalisis penggunaan antibiotik secara kualitatif dengan metode Gyssen dan kuantitatif dengan metode defined daily dose (DDD) pada pasien rawat inap dengan fraktur tulang di Rumah Sakit Umum Haji Surabaya, Indonesia. Metode: Penelitian ini merupakan penelitian observasional deskriptif yang dilakukan terhadap 89 sampel. Data dikumpulkan secara retrospektif melalui rekam medis pada periode Januari-Desember 2019. Data penggunaan antibiotic kemudian dianalisis secara kualitatif dan kuantitatif dengan metode Gyssen dan DDD. Hasil: Pada penelitian ini, antibiotik yang banyak digunakan sebagai antibiotik profilaksis dan terapeutik pada pasien fraktur tulang adalah seftriakson. Analisis kuantitatif menggunakan metode DDD menunjukkan bahwa nilai ceftriaxone adalah 45,6/100 pasien-hari dan cefazoline adalah 3,1/100 pasien-hari. Analisis penggunaan antibiotik pada pasien fraktur tulang dengan menggunakan metode Gyssen menunjukkan bahwa penggunaan antibiotik yang rasional sebanyak 84,3%, penggunaan antibiotik tidak tepat waktu sebanyak 4,5%, dan interval pemberian antibiotik tidak tepat sebanyak 11,2%. Kesimpulan: penggunaan antibiotik pada pasien bedah fraktur sudah tergolong penggunaan antibiotik yang rasional namun penggunaan antibiotik masih melebihi standar WHO. Selanjutnya perlu dilakukan penelitian serupa dengan pengambilan data secara prospektif sehingga dapat mengamati kejadian infeksi luka operasi. Introduction: Prophylactic antibiotic therapy has an important role in facilitating optimal postoperative healing. Inappropriate use of antibiotics in hospitals will increase the cost of therapy and the incidence of nosocomial infections of infectious microorganisms. Preoperative prophylactic antibiotics are believed to reduce the incidence of surgical site infections. Objective: This study aims to determine the pattern of antibiotic use and analyse the use of antibiotics qualitatively by the Gyssen method and quantitatively by the defined daily dose (DDD) method in inpatients with bone fractures at the Haji General Hospital Surabaya, Indonesia. Methods: This study was a descriptive observational study conducted on 89 samples. Data were collected retrospectively through medical records in the period January-December 2019. Antibiotic use data were then analysed qualitatively and quantitatively using the Gyssen and DDD methods. Results: In this study, the antibiotic that was widely used as a prophylactic and therapeutic antibiotic in patients with bone fractures was ceftriaxone. Quantitative analysis using the DDD method showed that the value of ceftriaxone was 45.6/100 patient-days and cefazoline was 3.1/100 patient-days. Analysis of antibiotic use in bone fracture patients using the Gyssen method showed that the rational use of antibiotics was 84.3%, the use of antibiotics was not timely as much as 4.5%, and the interval of antibiotic administration was not appropriate as much as 11.2%. Conclusion: the use of antibiotics in fracture surgery patients is classified as rational use of antibiotics but the use of antibiotics still exceeds WHO standards. Furthermore, it is necessary to conduct a similar study with prospective data collection so that it can observe the incidence of surgical wound infection.
INJECTED CITICOLINE IMPROVES IMPAIRMENT AND DISABILITY DURING ACUTE PHASE TREATMENT IN ISCHEMIC STROKE PATIENTS Wahyudi, Rino; Hasmono, Didik; Fitrina, Ruhaya; Armal, Khairil
Folia Medica Indonesiana Vol. 51 No. 4 (2015): Oktober - December 2015
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.922 KB) | DOI: 10.20473/fmi.v51i4.2854

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Treatment strategy of ischemic stroke is to reduce the extent of the damage and rescue neurons from death in the early days of ischemic events. Recombinant Tissue-Plasminogen Activator (r-TPA) is the only recommended therapy, but their use is very limited. Citicoline is a neuroprotectant with a therapeutic effect on several stages of the ischemic cascade. However, its use is still being debated. The purpose of this study was to analyze the use of supplementation citicoline injection in patients with acute ischemic stroke in relations to differences in changes in the level of interference (impairment), rate limitation (disability) and the level of obstruction (handicap) between the group receiving supplementation of citicoline injection 2x500 mg iv and the group without supplementation during acute phase treatment. This study was a prospective cohort study using experimental design in patients with acute ischemic stroke who met the inclusion and exclusion criteria with or without supplementation citicoline between January - April 2015 in the National Stroke Hospital, Bukittinggi. Rate of interference was assessed with NIHSS, level of limitations with Barthel Index, and level of obstruction with modified Rankin Scale. Assessment was done 2 times, before and after the treatment. Statistical methods used in this study were Wilcoxon signed rank test, paired T-test and Mann-Whitney test. This study was conducted on 50 subjects divided into 2 groups, a control group without supplementation and group treated with injected citicoline of 2x500 mg iv. Demographic and baseline characteristics did not differ between groups. There were differences in level of interference changes. Mean decrease in control group was 0.96 ± 1.74 NIHSS, while that in treatment group was 2.84 ± 1.46 NIHSS (p <0.05). There were differences in changes in the level of limitations. Mean increase of Barthel Index in control group 9.60 ± 11.17 and in treatment group 20.40 ± 13.99 (p <0.05). However, changes in the level obstacle showed no difference. In conclusion, citicoline injection supplementation in patients with ischemic stroke during acute phase treatment showed improvement differences in changes in the level of distraction (impairment) and the rate limitations (disability), but showed no difference in changes in the level of obstruction (handycaps).
ANALYSIS OF ANTIBIOTICS USE IN PEDIATRIC PNEUMONIA PATIENTS AGED 3 MONTHS - 5 YEARS Aryani, Dhita Evi; Hasmono, Didik; Zairina, Nun; Setiawan, Landia
Folia Medica Indonesiana Vol. 52 No. 2 (2016): APRIL - JUNE 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (211.198 KB) | DOI: 10.20473/fmi.v52i2.5224

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Pneumonia is an infectious disease that causes acute inflammation of the lung parenchyma and compaction exudate in the lung tissue. In addition to causing significant morbidity and mortality, pneumonia is also difficult to diagnose, treatments are less precise and less taken seriously. Pneumonia caused the death of 14% of children under five in Indonesia, with a mortality rate of 83 children per day. The difficulty of diagnosis, the selection of a less appropriate antibiotics, side effects, differences in pharmacokinetics and pharmacodynamics of the drug in infants and antibiotics resistance is to be a problem in itself. Therefore it is necessary to study the analysis of the use of antibiotics in patients with pneumonia of children aged 3 months till 5 years. The aim of this research to analyze antibiotics therapy in patients with pneumonia of children aged 3 months till 5 years. Method: an observational cohort analysis was carried out in the Pediatrics Respirology Division Dr. Soetomo Hospital Surabaya. Data was collected from February to May 2014. Patients who met the inclusion criteria were observed prospectively and the quantity and quality of antibiotics usage assessed with Gyssens category. Result: from February to May 2014 period, prospectively, the antibiotics usage quantitative evaluation used DDD/patient days shows that ampicillin 34.39DDD/100 patient days. Qualitative evaluation using Gyssens category on 75 antibiotics therapy shows that 32% considered appropriate. So, this study showed that ampicillin is most widely and qualitative analysis, only 32% of rational use of antibiotics.
AMPICILLIN SULBACTAM AND CEFOTAXIME ARE SIMILARLY EFFECTIVE IN PEDIATRIC PNEUMONIA Puspitasari, Diny; Hasmono, Didik; Rahman, Taufiqur
Folia Medica Indonesiana Vol. 52 No. 2 (2016): APRIL - JUNE 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.598 KB) | DOI: 10.20473/fmi.v52i2.5225

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Pneumonia is an infection of the lungs that occurs and still cause high mortality in young children today. The main cause is bacterial or viral. Antibiotics still recommended though it is difficult to know the cause is bacterial or viral. Ampicillin be the first option some guideline. Increased resistance worldwide become one of them concerns the effectiveness of antibiotics. The main treatment of toddler pneumonia in Muhammadiyah Hospital Lamongan are ampicillin sulbactam and cefotaxime. The study was conducted to analyze the effectiveness of both antibiotics. This study aims to analyze comparison in the use of ampicillin sulbactam and cefotaxime pneumonia patients aged 3-59 months from November 2013 to March 2014. Patients who met the inclusion criteria were prospectively observed for clinical data, laboratory data, the data microbiology. After it is analyzed to know the difference between the effectiveness of antibiotics. In this study of 29 patients included in the inclusion criteria, 17 patients who received antibiotics ampicillin sulbactam and 12 patients receiving cefotaxime. In the comparison of the mean pulse pulse is known there is a significant reduction in both groups of patients on the second day and was not significantly different between the two groups (p = 0.084). Likewise, the average ratio of temperature (p = 0.117), breath rate (p = 0.839), leukocytes of patients (p = 0.429). Length of stay for ampicillin sulbactam group was 4.77 days and 5.17 days for cefotaxime group. Analysis showed no differences between the two groups for lenght (p = 0.275). Of the 22 patients who were sampled for blood culture examination only 1 patient with positive results. Based on these results we can conclude that ampicillin sulbactam and cefotaxime effective in cases of children pneumonia, and there is no distinction based on the parameters in body temperature, breath rate, pulse, leukocytes and long hospitalization of patients. Regimentation dosage is appropriate based on guidelines, and length of stay less than 10 days. Found no side effects of both drugs.
ANTIBIOGRAM STUDY AND ANTIBIOTIC USE EVALUATION USING GYSSEN METHOD IN PATIENTS WITH DIABETIC FOOT Fadlilah, Umul; Hasmono, Didik; Wibisono, Yudi Agung; Melinda, Mia
Folia Medica Indonesiana Vol. 52 No. 3 (2016): JULY - SEPTEMBER 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.327 KB) | DOI: 10.20473/fmi.v52i3.5452

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Foot infection is a common and serious problem in people with diabetes, which require proper management (diagnostic and therapeutic approaches) that can be cured. Empiric antibiotic regimen should be based on clinical data and bacteria pattern that are available, but definitive therapy should be based on the results of the infected tissue culture. The selection of initial antibiotic therapy was difficult and unwise use can lead to antibiotic-resistant. Evaluation is needed for using antibiotics to benefit wisely. The aim of this research is to analyzed the pattern of bacteria in diabetic foot and to its sensitivity test to antibiotics, analyze empiric antibiotics that can be recommended, and analyzed the use of antibiotics by Gyssen method. Data was analyzed with observational studies (descriptive non-experimental), retrospectively and prospectively in patients diabetic foot infection that met inclusion criteria. Retrospective data are used to analyzed bacteria pattern and its sensitivity test, while prospective data are used to evaluated the use of antibiotics based on bacteria pattern, during the period of late March-early August 2015 at Mardi Waluyo Hospital. Evaluation was conducted by Gyssen method. The results, retrospective data samples obtained 30 infection bacteria during August 2014-March 2015. The prevalence of gram-negative bacteria as 53.33% with most types of bacteria E.coli and Klebsiella oxytoca (13.33%), and gram-positive bacteria as 46.67% with the highest bacteria are Staphylococcus spp. and Streptococcus spp. From the prospective data in inclusion criteria, 13 patients with the highest prevalence of gram-negative bacteria are Klebsiella oxytoca (28.57%), and most gram-positive Staphylococcus auerus (35.71%). While the qualitative analysis of antibiotic use was conducted on 50 types of antibiotics. The results of the qualitative analysis using Gyssens method obtained category as 62%, 2%, 14%, 2B category as 26%, 3A category as 10%, 4A category 52%, 4B category as 6%, 4C category as 8% and there are no use of antibiotics in the category V and VI. Conclusions, Gyessen method can show that the use of antibiotics in diabetic foot patients in Mardi Waluyo hospital is dominated by inaccuracy in choice of antibiotic, and inaccuracies in the interval antibiotics.
The Pattern of Antibiotic Prescription and Antimicrobial Resistance of Gut Flora Escherichia coli at Aisyiyah Hospital, Bojonegoro Hidayah, Ana Nurlaili; Hasmono, Didik; Thayyib, Muqoddar; Kuntaman, K
Folia Medica Indonesiana Vol. 56 No. 2 (2020): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.3 KB) | DOI: 10.20473/fmi.v56i2.21227

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Antimicrobial resistance (AMR) is the failure of antibiotic to kill bacteria and becomes ineffective in therapeutic purpose. The AMR bacteria is a major health problem worldwide and Indonesia is not exception. AMR is increased by two factors, higher antibiotic use and low compliance in infection control and prevention.  WHO has recommended 7 bacterial indicators as point of view in surveillance, one of these bacteria is Escherichia coli. This study aimed to analyze the correlation between antibiotic use and resistance pattern of gut flora Escherichia coli. The study was conducted at Aisyiyah Hospital, Bojonegoro from June to October 2017. Total 101 patients from internal medicine and surgery department in this hospital were included in this study. Bacterial gut flora were tested against 12 antibiotics by disk diffusion test at the Department of Clinical Microbiology, Universitas Airlangga.. The results showed that the highest quantity of antibiotic use in internal medicine service was cefepime (40,50 DDD) and the highest resistance rate was ciprofloxacin, whereas in the surgical service it was ceftriaxone (132,75 DDD) with the highest E. coli resistance to amoxicillin-clavulanic acid. The antibiotics use has significant correlation against E. coli resistance on cefotaxime (p=0.046), ceftazidime (p=0.046), ceftriaxone (p=0.017), aztreonam (p=0.024), and cefepime (p=0.010).
Effect of Simvastatin in Serum Interleukin-6 Level in Patients with Acute Ischemic Stroke Meo, Maria Lettisia; Machin, Abdulloh; Hasmono, Didik
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.293 KB) | DOI: 10.20473/fmi.v56i3.24508

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Acute ischemic stroke is the leading cause of death and causing permanent disability in adults worldwide. In acute ischemic stroke, IL-6 levels positively correlated to more severe neurological deficits, more extensive brain damage and worse prognoses. The use of statin was associated with milder initial stroke severity, better functional outcome and lower mortality. This clinically randomized controlled trial study was aimed to analyze the serum levels of IL 6 in acute ischemic stroke patients who treated with Simvastatin 20 mg compare to placebo. Samples were taken using consecutive sampling method from hospitalized acute ischemic stroke patients in Neurology Department of Dr. Soetomo Teaching Hospital Surabaya and Airlangga University Hospital Surabayafrom August to November 2017. Total of 44 patients met the inclusion criteria, consisting of 22 patients in treatment group and 22 patients in control group.There were no significant difference in the characteristic of the patients in both groups (p>0.05). Averages of serum IL-6 in the control and the treatment group are 38.594±74.313 and 17.760±25.253(p=0,438) while averages of serum IL-6 post in the control group and the treatment are 46.586±103.484 and 15.275±17.183 (p=0,589). There were no significant level escalation in pre and post of control group (p = 0.205) and also no significant level reduction in pre and post of treatment group (p = 0.411), while the average difference in the control group (-7.992 + 78.912 pg/ml) and in the treatment group (2.485 + 23.738 pg/ml).
Studi Penggunaan Natrium Bikarbonat pada Pasien Penyakit Ginjal Kronik dengan Asidosis Metabolik Andilusia, Sindy; Hasmono, Didik; Kusumaningtyas, Atika Putri; Syifa', Nailis
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p100-105

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Chronic Kidney Disease (CKD) is defined as a condition in which there are abnormalities in kidney performance, and occurs for at least 3 months. Metabolic acidosis is a disturbance of acid-base balance resulting in a decrease in plasma sodium bicarbonate concentration with a decrease in blood pH. Metabolic acidosis patients are characterized by (arterial pH <7.35, PCO2 <35 mmHg, and HCO3- <22 mEq/L [mmol/L]). Sodium bicarbonate increases plasma bicarbonate, and increases blood pH. This study aims to identify the pattern of sodium bicarbonate use in CKD patients who experience metabolic acidosis including type, dose, route, interval, and duration of drug administration at Universitas Muhammadiyah Malang Hospital. This study was conducted in the form of observational research by analyzing descriptively and retrospectively collecting data using Health Record data of patients who underwent hospitalization in the period 01 January 2022 – 31 December 2022. Based on the research that has been carried out, it is concluded that patients who meet the therapeutic targets are 23 patients (96%), indicated by the pattern of sodium bicarbonate use only used singly in all CKD patients with metabolic acidosis as many as 24 patients (100%), the most dose is (3x500mg) po as many as 20 patients (83%), with a duration of administration ≤ 5 days as many as 19 patients (79%). The suggestions that researchers convey are research that has been carried out, can be used as a reference and further guidance.
Evaluation of Pioglitazone Vildagliptin Combination on Lipid Profiles for Outpatients with Type II Diabetes Mellitus Kusumaningrum, Yunita Dyah; Firandi, Adelia; Hasmono, Didik; Aryani, Dhita; Wardhani, Firdha Aprillia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2645

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Pioglitazone and vildagliptin combination is one of the recommended alternatives as antidiabetic therapy to achieve the therapeutic target. This combination with complementary mechanisms of action can improve lipid profiles. This study aims to evaluate lipid profile achievement for outpatients with Type II DM on administering pioglitazone/vildagliptin combination therapy. Methods of the study were an observational prospective study in outpatients with Type II DM who use pioglitazone/vildagliptin combination at RS. Bhayangkara Surabaya during November 2021 – April 2022. Patients were included if aged between 18-80 y.o, used this combination ? 3 months before the study, HbA1C >7%, and were voluntarily involved by signing the informed consent. Laboratory examination of HbA1c, HDL-C, and triglycerides was done initially when patients were voluntarily involved as baseline data and after 3 months as post-data. The final sample in this study consisted of 25 patients who met the inclusion and exclusion criteria. The results of the study show mean value of HDL-C significantly increases from baseline to endpoint (p < 0.05). At the end of 3 months, the lipid profile of HDL-C and triglyceride increases by 30% and 4%, respectively, in patients who achieve the target compared to baseline conditions. The combination therapy of pioglitazone and vildagliptin improved lipid profile control in patients with type 2 diabetes mellitus after 3 months of treatment.
Evaluation of Fondaparinux Use on Kidney Function in Hospitalized COVID-19 Patients with Decreased eGFR Putri Nurhidayah, Eka; Didik Hasmono; Ruddy Hartono
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2731

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Background: The COVID-19 pandemic has resulted in increased hospitalization rates among patients with multisystem complications, including coagulation disorders and decreased renal function. Fondaparinux, a synthetic anticoagulant with a lower risk of thrombocytopenia, is often used as an alternative to heparin. However, its use in patients with reduced glomerular filtration rate (eGFR) remains debatable, as its elimination is dependent on renal function. Objective: This study aims to evaluate the impact of fondaparinux on renal function, specifically examining changes in eGFR and serum creatinine levels in COVID-19 patients with impaired renal function during treatment at Bhayangkara South Surabaya Hospital. Methods: This research employed a retrospective observational quantitative approach, involving COVID-19 patients who received fondaparinux at the inpatient facility of Bhayangkara Hospital from June 2020 to October 2021. Data were collected from the medical records of patients during their hospitalization, including fondaparinux dosage and eGFR and serum creatinine values, as well as other relevant clinical parameters. Statistical analysis using the Wilcoxon test was conducted to assess significant differences in serum creatinine and eGFR values following fondaparinux administration. Results: Of the 535 patients analyzed, 56 medical records met the inclusion criteria. The results of the Wilcoxon test analysis showed that there was a significant increase in eGFR (p-value 0.012, CI 95%; p-value 0.043, CI 95%; p-value 0.000, CI 95%), a substantial decrease in SCr (p-value 0.035, CI 95%; p-value 0.043, CI 95%; p-value 0.000, CI 95%) based on each degree of COVID-19 severity. Conclusion: The use of fondaparinux may improve kidney function, as indicated by significant decrease in serum creatinine and an increase in eGFR. Furthermore, no bleeding incidents were observed during the use of fondaparinux.
Co-Authors Adinugraha Amarullah Aghnia Fuadatul Inayah Agriawan Sudirman Agriawan Sudirman Agus Sunarko Agus Sunarko Alfa Frista Arta Alfin Giovani Andilusia, Sindy Ardianty, Nonie Arina Dery Puspitasari Aryani, Dhita Aryani, Dhita Evi Astutik, Widi Atika Putri Kusumaningtyas Atmajani, Wanudya Awdisma, Wien Maryati Ayumuyas, Nur Palestin Ayumuyas, Nur Palestin Ayunda Nur Hidayatiningsih Bambang Sidharta Binti Muzayyanah Budi Suprapti Budiatin, Aniek Setiya Bura, Ursula Dua Klowe Chrysnanda Maryska Claudia Tiffany Dea Ayu Nabilah Dinda Monika Nusantara Ratri Dini Setiya Praja Dini Setiya Praja, Dini Setiya Donsu, Yosefien Christania Elisabeth Kasih Fadlilah, Umul Firandi, Adelia Ganesha T Trengginas Giovani, Alfin Hanum, Putri Safitri Hariyati, Fera Hariyati, Fera Hartono, Ruddy Hasbi As-Shiddiq Hendra Yadi Heni Pujiastuti Hidajah Rachmawati Hidajah Rachmawati Hidayah Karuniawati Hidayah, Ana Nurlaili IGD Ugrasena Ilfi Hanna, Az Zahra Insyirah Idris, Anissah Irianto, Jimmy Setiawan Irsan Fahmi Almuhtarihan Irsan Fahmi Almuhtarihan Ismawati Isparnadi, Erwien Issaura, Issaura Jenggo Suwarko Joko Semedi Junaidi Khotib Khairil Armal Kuntaman Kuntaman Kusumaningtyas, Atika Putri Lilik Yusetyani Lilik Yusetyani Machin, Abdulloh Mahardian Rahmadi Mareta Rindang Andarsari Maria Angelia Yoshida Meiliana, Made Laksmi Meo, Maria Lettisia Mia Melinda Mohammad Saiful Islam Mohammad Subhan Mohammad Subhan Mohammad Subhan Mohammad Subkhan Muhammad Nashrullah Muktamiroh Muktamiroh Nadriatul Utami Nailis Syifa Ni Made Eravikania Putri Darmawan Nun Zairina, Nun Nur Hadiyanti Nuraida Wisudani Nurfausiah, Nurfausiah Nurmainah Nurmainah Nurul Ma'rifah Paulus Sugianto Pharmasinta Putri Hapsari Pramadani, Yana Puri Safitri Hanum Puspitasari, Diny Putri Nurhidayah, Eka Ramdani, Dewi Retna Dwi Puspitarini Rino Wahyudi, Rino Risa Septinia Rizki Lisya Nugraha Roni Subagyo RR. Ella Evrita Hestiandari Ruddy Hartono Ruddy Hartono Ruddy Hartono Ruddy Hartono Ruhaya Fitrina, Ruhaya Samirah Samirah Sandra J. Parambang Sandra, Pipit Semedi, Joko Sendi Lia Yunita Setiawan, Landia Siti Surdijati Siti Surdijati, Siti Sofiati Diah Baisuni Suharjono Suharjono, Suharjono Sumarno Sumarno Syifa', Nailis Syifa, Nailis' Tanasy, Marledy Taufiqur Rahman, Taufiqur Thayyib, Muqoddar Tista Ayu Fortuna Ulfa Syafli Nosa Usman Hadi Utami, Nadriatul Wardhani, Firdha Aprillia Wardhani, Hety Setya Widi Astutik Widi Astutik Wien Maryati Awdisma Wiranata, I Made Worotikan, Natania Imanuella Yosefien Christania Donsu Yudi Agung Wibisono Yudistira Nurrizky Grahitaning Putra Rohmaana Yulistiani Yulistiani Yulistiani, . Yuni, Santi Eka Yuni, Santi Eka