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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Kedokteran Brawijaya Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Kesehatan Jurnal Farmasi Klinik Indonesia Pharmacon MPI (Media Pharmaceutica Indonesiana) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Pharmasipha PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Pharmaceutical Journal of Indonesia JFM (Jurnal Farmasi Malahayati) JURNAL FARMASIMED (JFM) Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa Budapest International Research in Exact Sciences (BirEx Journal) Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi dan Sains Indonesia (JFSI) Indonesian Journal of Pharmaceutical Education Jurnal Riset Farmasi Journal of Global Pharma Technology Journal of Pharmaceutical and Sciences. Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Folia Medica Indonesiana Journal of Pharmascience
Didik Hasmono
Department Of Clinical Pharmacy, Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Transportation Other

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Antibiogram study and antibiotic use evaluation using gyssen method in patients with diabetic foot Fadlilah, Umul; Hasmono, Didik; Wibisono, Yudi Agung; Melinda, Mia
Folia Medica Indonesiana Vol. 52, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Foot infection is a common and serious problem in people with diabetes, which require proper management (diagnostic and therapeutic approaches) that can be cured. Empiric antibiotic regimen should be based on clinical data and bacteria pattern that are available, but definitive therapy should be based on the results of the infected tissue culture. The selection of initial antibiotic therapy was difficult and unwise use can lead to antibiotic-resistant. Evaluation is needed for using antibiotics to benefit wisely. The aim of this research is to analyzed the pattern of bacteria in diabetic foot and to its sensitivity test to antibiotics, analyze empiric antibiotics that can be recommended, and analyzed the use of antibiotics by Gyssen method. Data was analyzed with observational studies (descriptive non-experimental), retrospectively and prospectively in patients diabetic foot infection that met inclusion criteria. Retrospective data are used to analyzed bacteria pattern and its sensitivity test, while prospective data are used to evaluated the use of antibiotics based on bacteria pattern, during the period of late March-early August 2015 at Mardi Waluyo Hospital. Evaluation was conducted by Gyssen method. The results, retrospective data samples obtained 30 infection bacteria during August 2014-March 2015. The prevalence of gram-negative bacteria as 53.33% with most types of bacteria E.coli and Klebsiella oxytoca (13.33%), and gram-positive bacteria as 46.67% with the highest bacteria are Staphylococcus spp. and Streptococcus spp. From the prospective data in inclusion criteria, 13 patients with the highest prevalence of gram-negative bacteria are Klebsiella oxytoca (28.57%), and most gram-positive Staphylococcus auerus (35.71%). While the qualitative analysis of antibiotic use was conducted on 50 types of antibiotics. The results of the qualitative analysis using Gyssens method obtained category as 62%, 2%, 14%, 2B category as 26%, 3A category as 10%, 4A category 52%, 4B category as 6%, 4C category as 8% and there are no use of antibiotics in the category V and VI. Conclusions, Gyessen method can show that the use of antibiotics in diabetic foot patients in Mardi Waluyo hospital is dominated by inaccuracy in choice of antibiotic, and inaccuracies in the interval antibiotics.
Ampicillin sulbactam and cefotaxime are similarly effective in pediatric pneumonia Puspitasari, Diny; Hasmono, Didik; Rahman, Taufiqur
Folia Medica Indonesiana Vol. 52, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Pneumonia is an infection of the lungs that occurs and still cause high mortality in young children today. The main cause is bacterial or viral. Antibiotics still recommended though it is difficult to know the cause is bacterial or viral. Ampicillin be the first option some guideline. Increased resistance worldwide become one of them concerns the effectiveness of antibiotics. The main treatment of toddler pneumonia in Muhammadiyah Hospital Lamongan are ampicillin sulbactam and cefotaxime. The study was conducted to analyze the effectiveness of both antibiotics. This study aims to analyze comparison in the use of ampicillin sulbactam and cefotaxime pneumonia patients aged 3-59 months from November 2013 to March 2014. Patients who met the inclusion criteria were prospectively observed for clinical data, laboratory data, the data microbiology. After it is analyzed to know the difference between the effectiveness of antibiotics. In this study of 29 patients included in the inclusion criteria, 17 patients who received antibiotics ampicillin sulbactam and 12 patients receiving cefotaxime. In the comparison of the mean pulse pulse is known there is a significant reduction in both groups of patients on the second day and was not significantly different between the two groups (p = 0.084). Likewise, the average ratio of temperature (p = 0.117), breath rate (p = 0.839), leukocytes of patients (p = 0.429). Length of stay for ampicillin sulbactam group was 4.77 days and 5.17 days for cefotaxime group. Analysis showed no differences between the two groups for lenght (p = 0.275). Of the 22 patients who were sampled for blood culture examination only 1 patient with positive results. Based on these results we can conclude that ampicillin sulbactam and cefotaxime effective in cases of children pneumonia, and there is no distinction based on the parameters in body temperature, breath rate, pulse, leukocytes and long hospitalization of patients. Regimentation dosage is appropriate based on guidelines, and length of stay less than 10 days. Found no side effects of both drugs.
Studi Pemberian Diuretik Pada Pasien Sirosis Hepatik Dengan Komplikasi Asites di RSUD dr. Iskak Tulungagung. Annastasya P.D. , Agies; Puspitasari, Alvina Arum; Hasmono , Didik; Muzayyanah , Binti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.741

Abstract

According to the World Health Organization (WHO), cirrhosis is a structural change of the liver from normal to abnormal, characterized by fibrosis. Ascites is the most common complication in liver cirrhosis patients with the primary trigger (75%) is portal hypertension. The treatment focuses on removing the fluid from the peritoneal cavity. This study aim to understanding the pattern of diuretic use as ascites therapy in patients with cirrhosis hepatic. An observational study with a retrospective and descriptive approach using total sampling method in patients diagnosed with cirrhosis and ascites who received diuretics at Dr Iskak Tulungagung general hospital during January-December 2022 were conducted. The tools used in this study include medical records, data collection sheets, clinical data sheets, and laboratory data. Among 62 patients, 16 (26%) received spironolactone monotherapy, 9 (14%) furosemide monotherapy, 21 (34%) combination therapy, and 16 (26%) underwent switching between regimens. Spironolactone, particularly at 100 mg orally once daily, either alone or in combination with furosemide (40 mg intravenously once daily), was the most frequently prescribed diuretic regimen. These findings indicate that the therapeutic approach applied in clinical practice has generally followed the AASLD guideline recommendations.
Kajian Literatur: Tinjauan Remdesivir sebagai Pilihan Terapi pada COVID–19 Wien Maryati Awdisma; Ulfa Syafli Nosa; Didik Hasmono; Nurmainah Nurmainah
Journal of Pharmascience Vol. 8 No. 2 (2021): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.11650

Abstract

Infeksi virus corona baru, pertama kali terdeteksi pada akhir Desember 2019, dengan jumlah kasus terkonfirmasi lebih dari 33 juta kasus dan lebih dari 900.000 kematian dilaporkan. Terdefinisi sebagai pandemi, dan belum ada “obat khusus” yang dianggap dapat mengatasinya. Salah satu pendekatan terapeutik yang sedang dievaluasi dalam berbagai uji klinis adalah saat ini adalah remdesivir,telah disetujui oleh Badan Pengawas Obat dan Makanan (BPOM sebagai obat Emergency Use Authorization (EUA) sebagai opsi  penggunaan darurat Tujuan penulisan ini untuk memberikan gambaran tentang penemuan remdesivir, mekanisme aksi, dan penelitian terkini yang mengeksplorasi efektivitas klinisnya. Metode penelitian dilakukan dengan pencarian sumber data PubMed, Google Scholar, Science Direct dan Cochrane hingga November 2020 dengan kata kombinasi kata kunci Convalescent Plasma”; “SARS-CoV-2”, Virus Corona dan dibatasi pada jurnal berbahasa Inggris. yang mengulas penemuan remdesivir, mekanisme kerja, farmakokinetik, farmakodinamik, dan efikasi uji klinis remdesivir dalam pengobatan pasien COVID-19. Kesimpulan dari penelitian ini bahwa remdesivir memiliki efek klinis yang baik setelah 10 hari pengobatan pada pasien COVID-19.Kata Kunci: COVID-19, EUA, Remdesivir, SARS-CoV-2 The new coronavirus infection identified at the end of December 2019 and is receiving a lot of attention around the world. Globally, the number of confirmed cases has increased to more than 33 million cases and more than 900,000 deaths have been reported. This condition is defined as a pandemic situation, and so far no "special drug" is believed to be able to overcome it. One therapeutic approach currently being evaluated in various clinical studies is remdesivir. This drug is approved by the Food and Drug Administration (BPOM) as Emergency Medicine (EUA). This emergency option for remdesivir is considered a promising option for treating patients with COVID19. The purpose of this paper is to provide an overview of recent studies investigating the discovery of remdesivir, its mechanism of action, and its clinical efficacy. The survey method was conducted by searching the data sources of PubMed, Google Scholar, Science Direct, and Cochrane until November 2020. Researchers limit literary studies to English journals. The results of 1000 articles searched that met the selection criteria were 10 articles examining the results of remdesivir, its mechanism of action, pharmacokinetics, pharmacodynamics, and the efficacy of clinical remdesivir in the treatment of patients with COVID 19. The conclusion of this study is that remdesivir has a good clinical effect 10 days after treatment of patients with COVID19.
Studi Penggunaan Antihipertensi Golongan Calcium Channel Blocker pada Pasien Stroke Iskemik Anita Tria Amanda; Nailis Syifa; Didik Hasmono; Rani Nur Badriyah
Jurnal Riset Farmasi Volume 5, No. 2, Desember 2025, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v5i2.8108

Abstract

Abstract. Ischemic stroke is a leading cause of disability and death in Indonesia, with hypertension as the biggest risk factor. Blood pressure control is key to therapy, one of which is through the use of Calcium Channel Blockers (CCBs) that work by arterial vasodilation. This study aims to determine the pattern of CCB use in ischemic stroke patients at Dr. Saiful Anwar Regional Hospital, including drug type, dose, route, frequency, duration of therapy (>3 days), and length of hospitalization (>7 days). The study used a retrospective descriptive design based on medical records data from 2024. The results showed Amlodipine (1 × 10 mg) po as the most common single therapy (71 patients; 40%). Combinations of two drugs, such as Amlodipine and Valsartan, were used in 23 patients (15%), while combinations of three and four drugs were used in 6 (3%) and 2 patients (1%), respectively. In addition, there were 73 cases (41%) of regimen changes during treatment. These findings emphasize the importance of adjusting antihypertensive therapy based on clinical conditions and evaluating the rationality of drug use to improve therapeutic outcomes. Abstrak. Stroke iskemik merupakan penyebab utama kecacatan dan kematian di Indonesia, dengan hipertensi sebagai faktor risiko terbesar. Pengendalian tekanan darah menjadi kunci terapi, salah satunya melalui penggunaan Calcium Channel Blocker (CCB) yang bekerja dengan vasodilatasi arteri. Penelitian ini bertujuan mengetahui pola penggunaan CCB pada pasien stroke iskemik di RSUD Dr. Saiful Anwar, meliputi jenis obat, dosis, rute, frekuensi, durasi terapi (>3 hari), serta lama rawat inap (>7 hari). Penelitian menggunakan desain deskriptif retrospektif berdasarkan data rekam medis tahun 2024. Hasil menunjukkan Amlodipin (1 × 10 mg) po sebagai terapi tunggal terbanyak (71 pasien; 40%). Kombinasi dua obat, seperti Amlodipin dan Valsartan, digunakan pada 23 pasien (15%), sedangkan kombinasi tiga dan empat obat pada 6 (3%) dan 2 pasien (1%). Selain itu, terdapat 73 kasus (41%) perubahan regimen selama perawatan. Temuan ini menegaskan pentingnya penyesuaian terapi antihipertensi berdasarkan kondisi klinis serta evaluasi rasionalitas penggunaan obat untuk meningkatkan luaran terapi.
Co-Authors Adinugraha Amarullah Aghnia Fuadatul Inayah Agriawan Sudirman Agus Sunarko Agus Sunarko Alfa Frista Arta Alfin Giovani Amarullah, Adinugraha Andilusia, Sindy Anita Tria Amanda Annastasya P.D. , Agies Ardianty, Nonie Arina Dery Puspitasari Aryani, Dhita Aryani, Dhita Evi Astutik, Widi Atika Putri Kusumaningtyas Awdisma, Wien Maryati Ayumuyas, Nur Palestin Ayumuyas, Nur Palestin Ayunda Nur Hidayatiningsih Bambang Sidharta Binti Muzayyanah Budi Suprapti Budiatin, Aniek Setiya Bura, Ursula Dua Klowe Chrysnanda Maryska Claudia Tiffany Dea Ayu Nabilah Dinda Monika Nusantara Ratri Dini Setiya Praja Dini Setiya Praja, Dini Setiya Donsu, Yosefien Christania Elisabeth Kasih Fadlilah, Umul Firandi, Adelia Ganesha T Trengginas Giovani, Alfin Hadiyanti, Nur Hanum, Putri Safitri Hariyati, Fera Hariyati, Fera Hartono, Ruddy Hasbi As-Shiddiq Hendra Yadi Heni Pujiastuti Hidajah Rachmawati Hidajah Rachmawati Hidayah Karuniawati Hidayah, Ana Nurlaili IGD Ugrasena Ilfi Hanna, Az Zahra Insyirah Idris, Anissah Irianto, Jimmy Setiawan Irsan Fahmi Almuhtarihan Irsan Fahmi Almuhtarihan Ismawati Isparnadi, Erwien Issaura, Issaura Jenggo Suwarko Joko Semedi Junaidi Khotib Khairil Armal Kuntaman Kuntaman Kusumaningrum , Yunita Dyah Kusumaningtyas, Atika Putri Lilik Yusetyani Lilik Yusetyani Ma'rifah, Nurul Machin, Abdulloh Mahardian Rahmadi Mareta Rindang Andarsari Maria Angelia Yoshida Meiliana, Made Laksmi Meo, Maria Lettisia Mia Melinda Mohammad Saiful Islam Mohammad Saiful Islam, Mohammad Saiful Mohammad Subhan Mohammad Subhan Mohammad Subhan Mohammad Subkhan Muhammad Nashrullah Muktamiroh Muktamiroh Muzayyanah , Binti Muzayyanah, Binti Nadriatul Utami Nadriatul Utami Nailis Syifa Nailis Syifa Ni Made Eravikania Putri Darmawan Nun Zairina, Nun Nur Hadiyanti Nuraida Wisudani Nurfausiah, Nurfausiah Nurmainah Nurmainah Nurul Ma'rifah Paulus Sugianto Pharmasinta Putri Hapsari Pramadani, Yana Puri Safitri Hanum Puspitasari, Alvina Arum Puspitasari, Diny Putri Nurhidayah, Eka Ramdani, Dewi Rani Nur Badriyah Retna Dwi Puspitarini Rino Wahyudi, Rino Risa Septinia Rizki Lisya Nugraha Roni Subagyo RR. Ella Evrita Hestiandari Ruddy Hartono Ruddy Hartono Ruddy Hartono Ruddy Hartono Ruhaya Fitrina, Ruhaya Samirah Samirah, Samirah Sandra J. Parambang Sandra, Pipit Semedi, Joko Sendi Lia Yunita Setiawan, Landia Siti Surdijati Siti Surdijati, Siti Sofiati Diah Baisuni Subagyo, Roni Suharjono Suharjono Sumarno Sumarno Syifa', Nailis Syifa, Nailis' Tanasy, Marledy Taufiqur Rahman, Taufiqur Thayyib, Muqoddar Tista Ayu Fortuna Trengginas, Ganesha T Ugrasena, IGD Ulfa Syafli Nosa Usman Hadi Utami, Nadriatul Wanudya Atmajani Wardhani, Firdha Aprillia Wardhani, Hety Setya Widi Astutik Widi Astutik Wien Maryati Awdisma Wiranata, I Made Wisudani, Nuraida Worotikan, Natania Imanuella Yosefien Christania Donsu Yudi Agung Wibisono Yudistira Nurrizky Grahitaning Putra Rohmaana Yulistiani Yulistiani Yulistiani Yulistiani, Yulistiani Yulistiani, . Yuni, Santi Eka Yuni, Santi Eka