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All Journal Pendidikan Biologi Prosiding Seminar Biologi Bioedukasi Bio-Pedagogi : Jurnal Pembelajaran Biologi EDUSAINS Prosiding Pendidikan Sains Jurnal Pendidikan Biologi Indonesia Jurnal Inovasi Pendidikan IPA Journal of Tropical Biodiversity and Biotechnology Edu Sains: Jurnal Pendidikan Sains dan Matematika Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Jurnal Pendidikan Biologi AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) INKUIRI : Jurnal Pendidikan IPA Biosfer: Jurnal Pendidikan Biologi Jurnal PAJAR (Pendidikan dan Pengajaran) KONSTAN - JURNAL FISIKA DAN PENDIDIKAN FISIKA Bioedukasi: Jurnal Pendidikan Biologi Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) Nusantara Science and Technology Proceedings Proceeding Biology Education Conference Journal of Research in Instructional Journal of Educational Sciences Molekul: Jurnal Ilmiah Kimia Jurnal Inspirasi Peternakan Habitat: Jurnal Ilmiah Ilmu Hewani dan Peternakan
Meti Indrowati
Biology Education, Faculty Of Teacher Training And Education, Universitas Sebelas Maret, Indonesia
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Journal : Molekul: Jurnal Ilmiah Kimia

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Antioxidant, Anti-Aging and Antibacterial Activity from Dewa Leaves Ethanolic Extract (Gynura japonica (Thunb.) Juel) Fatmawati, Umi; Zienitha, Anggie Meilinda; Anggraini, Meisi; Rosita, Lisa; Indrowati, Meti; Harlita, Harlita; Santosa, Slamet; Permatasari, Vera; Primahana, Gian; Yati, Indri; Prastya, Muhamad Eka
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.13792

Abstract

ABSTRACT. Due to their phytochemical constituents, Dewa leaves (Gynura japonica (Thunb.) Juel.) are often used in traditional medicinal herbs. However, in vitro and in vivo of antioxidative and anti-aging studies of Dewa leaves on yeast as a eukaryotic cell model have not been widely carried out. This study aims to determine the antioxidant, anti-aging, and antibacterial activities derived from G. japonica leaves extract. Extraction was conducted using 70% and 96% ethanol solvents, total phenolic content (TPC) was assayed using Folin-Ciocalteu method, flavonoid contents (TFC) was assayed using aluminum chloride method, antioxidant activity was tested using DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2-azinobis-3-Ethylbenzothiazoline)-6-sulfonic acid) radicals. Subsequently, an anti-aging activity test was performed on the yeast Saccharomyces cerevisiae as a model organism following antibacterial activity. The antibacterial activity test was carried out using well diffusion agar, and the Minimal Inhibitory Concentration (MIC) was determined using the microplate method. We obtained that G. japonica leaves extracted from 70% and 96% methanol solvents, have TPC of 13.14 and 22.11 mg GAE/gr extract, and TFC of 8.04 and 14.09 mg QE/gr extract, respectively. As for DPPH and ABTS antioxidant activity, D70 showed the best activity with IC50 values of 1411.36±56.35 µg/mL and 2516.10±18.77 µg/mL, respectively. The anti-aging test showed that both 70% and 96% ethanol extracts were able to maintain the yeast cell viability under H2O2 oxidative stress. Further, 70% and 96% ethanol extract also showed antibacterial activity at the best value against Staphylococcus aureus with a MIC value of 390.62 µg/mL, it means that Gynura leaves extract has a potency as antibacterial agent. The results of this study indicate that the ethanol extract of G. japonica leaves can be developed for further investigation as an antioxidant and antibacterial therapeutic agent. Keywords: Anti-aging, antibacterial, antioxidant, Gynura japonica, Saccharomyces cerevisiae
Co-Authors A.A. Ketut Agung Cahyawan W Abrari Nur Aan Ilmi Achrudin Achrudin Adhi Nurcholis Afifah, Muthiah Ali, Lalu Usman Alvi Rosyidi Alvi Rosyidi Amalia Ulfa Andinawati Dwita Karina Anggita Widya Nugroho Anggraini, Meisi Anggun Nopitasari Annisa Nur Khasanah Bariroh, Ummi Baskoro Adi P Baskoro Adi Prayitno Baskoro Adi Prayitno Bowo Sugiharto Bowo Sugiharto Bowo Sugiharto Bowo Sugiharto Budi Hartanto C. J. SOEGIHARDJO C.J. SOEGIHARDJO Cindyana Putri Puspita Hapsari Dedy Setiyawan Dewi Puspita Sari Dewi Puspita Sari Dewi Puspita Sari Dewi Puspita Sari Dewi Puspita Sari Dian Rizki Kusuma Amalia Diska Evi Liana Diska Evi Liana Dwi Oetomo Dwi Oetomo Dwito Purnomo DWITO PURNOMO Eni Rahayu ESTU RETNANINGTYAS N Fatiha, Alifia Ninta Feni Andriani Fitriyana Rachmah G. Bramintha Pakartiar Hantyan Galih Tri Rukmana Harlita Harlita Harlita Harlita Harlita Harlita Harlita Harlita Harlita Heru Nurcahyo Heru Nurcahyo Ihda Nuria Afidah Ika Lailatus Sangadah Irfana Fauziah Irsyadah, Naeli Joko Ariyanto Joko Ariyanto Joko Ariyanto Joko Aryanto KUMAYA AGUSTINA Kusnia Patmawati Kusumawardani, Kusumawardani Laksmi, Monika Lintang Lilis Eka Herdiana Lilis Eka Herdiana Malvin Prima Soyoga Maridi - - Maridi Maridi Maridi Maridi MARIDI MARIDI MASRUROH, ROILA DEWI Muhamad Yutam Soleh Muhammad Zaini Murni Ramli Muslikatin, Siti Muzayyinah Muzayyinah Muzayyinah Muzayyinah Muzayyinah Muzayyinah Muzazzinah, Muzazzinah Muzzazinah Muzzazinah Muzzazinah Nanang Riyadi Nurmiyati - - Nurmiyati Nurmiyati Nurmiyati Nurmiyati Nurul Faiqoh Nurul Qomariyah Nurzahra, Vakha Yulia Pandu Haryo Wibowo PANDU HARYO WIBOWO Permatasari, Vera Pramudita, Ayu Prastya, Muhamad Eka Primahana, Gian PUGUH KARYANTO Puguh Karyanto Puguh Karyanto Rahayu Rahayu Rahayu Rahayu RARAS IKA YULIANTI RARAS IKA YULIANTI Rarastoeti Pratiwi Ratna Dewi Kusumawati Resi, Damasus Nosi RIEZKY MAYA PROBOSARI Riezky Maya Probosari Rika Dian Kurniawati Roro Putri Nur Azmi Saputra Wijaya Rosita, Lisa Rumiyati, Rumiyati Sajidan Sajidan Sajidan Sajidan Sarwanto Sarwanto Septiyanto, Arifin Setyawati Handayani SITI NURJANAH Siti Nurjanah Slamet Santosa Slamet Santosa Slamet Santosa Slamet Santosa Slamet Santosa Slamet Santosa Sri Dwiastuti Sri Lestari Sri Lestari Sri Martina Wiraswati Sri Septianti Suciati Suciati Suciati Sudarisman Suciati Sudarisman Sulastri - - Suranto Suranto Susanto, Mardomo Sutarno Taher, Tamrin Taufik Widhiyantoro Dwi Saputro TJAHJADI PURWOKO TJAHJADI PURWOKO Tuti Rahayu Ulfa, Amalia Umi Fatmawati Umi Fatmawati Umi Fatmawati UMI FATMAWATI Vita Anggun Cahyani Wahyu Kodrat Listianthy Widha Sunarno Widha Sunarno Widyastuti, Anie Yuni yati, indri Yudi Rinanto Yunita Rahmawati Zienitha, Anggie Meilinda