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Jason Merari Peranginangin
Department Of Pharmacy Sciences, Faculty Of Pharmacy, Universitas Setia Budi Surakarta, Surakarta, Indonesia
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Journal : Natural Sciences Engineering and Technology Journal

 1 
Fenofibrate Characterization of Solid Lipid Nanoparticles Using the High Shear Homogenization Method Muhimmatul Khoiriyah; Jason Merari Perangirangin; Ilham Kuncahyo
Natural Sciences Engineering and Technology Journal Vol. 2 No. 2 (2022): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v2i2.21

Abstract

Fenofibrate is a drug that can be used to treat hyperlipidemia where the drug is included in the category of Biopharmaceutical classification system II with poor solubility and high permeability. This causes the need to improve the drug delivery system (DDS) made using the solid lipid nanoparticle (SLN) method. SLN fenofibrate can be made using the high shear homogenization method by determining the formula using Factorial 22 Design Expert 12. The formula is made with a concentration of 0.31-1.25% GMS and 1.25-2% Tween-40, then SLN fenofibrate is made by mixing all ingredients until an emulsion is formed and continued with the SLN critical parameter test. From the test results, the critical parameters of SLN fenofibrate for the particle size of 8 formulas 490; 561; 601; 697; 916; 1040; 1818, and 2410 nm. The results obtained for the polydispersity index, respectively, were 0.02; 0.04; 0.08; 0.30; 0.35; 0.48; 0.51, and 0.65. The zeta potential value of the 8 formulas obtained successive values of 2.8; 3.5; 4.2; 4.8; 5.5; 5.8; 8.1, and 8.8 mV. Calculation of the efficiency of the SLN fenofibrate drug obtained successive values of 77.23; 78.53; 79.51; 80.47; 81.17; 87.38; 87.39, and 87.82%. The SLN method can improve drugs that are included in the Biopharmaceutical classification system class II category with the distribution of test results in the particle size range, and the adsorbed drug is more than 70%.
Co-Authors Ahmad Nuzulul Abid Aljufri Mahmud Aminudin Ana Indrayati Andre Kurniawan Antoro, Sutopo Edy Argo Widianto arikha ayu susilowati Aryani, Norsarida Astuty, Meilinda Windy Atalia Tamo Ina Bulu Boedirahardja, Partana Chairun Darmawan, Nopandi Wisnu Desi Alviona Dewi Ekowati Dewi, Lucia Vita Inandha Dewi, Lucia VIta Inandha Dewi, Lutfiana Aswindra Diah Kartika Putri Dian Marlina Dwiannur, Febriandi Ramadhan Endang Diyah Ikasari Felix Imanuel Rachman Fitriarahmah, Giyan Gede Trima Yasa Gede Trima Yasa Gunawan Pamudji Widodo Harsono, Samuel Budi Ika Purwidyaningrum Ilham Kuncahyo Ismi Rahmawati Isna Jati Asiya Iswandi -, Iswandi Iswandi Iswandi Iyem Shahira Julia Megawati Djamal Keswara, Yane Dila Khofifah Maharani Krisdita Sundari Putri Prayitno Lutfi Nofitasari Magdalena Retnoningsih Mardiyono Marlina, Dian Melviani Mohammad Fauzy R. Syahruddin Muhamad Aulia Putra Tawakal Muhimmatul Khoiriyah Munawarah Munawarah Muslihatin, Muslihatin Mustika Endah Pratiwi Najmah Salsabila Narimo Nia Azzahra Nofika Dwi Anitasari Novitarini Nur Anggreini Dwi Sasangka Oentari, Octaviana Dyah Onny Ziasti Fricilia Opstaria saptarini Prasojo Pribadi Pudiastuti RSP R.F.X Premihadi Putra Rahmawati, Ismi Reslely Harjanti Riskayanti Rizal Maarif Rukmana, Rizal Maarif Sabda Wahab Sarimanah, Jamilah Sawal, Rizky Ardian Hartanto Sholehah, Faza Putri Farihatus Sisca Latue Sofia, Anna Sri Rejeki Handayani Sudarwati, Vivid Latri Suhailah, Dhia Sulaiman, Teuku Nanda Saifullah Susanti, Kharisma Dewi Fadia Syamsul Ma'arif Titik Sunarni Titik Sunarni Tri Murti Andayani Tri Wijayanti Tri Wijayanti Widhoretno Puspandari Windi Antika Wiratantri, Fitra Indah Wiwin Herdwiani Wiwin Herdwiani Yaya Sulthon Aziz Yunartika Puspitasari Yurita Werdiningsih Hutami