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All Journal Jurnal Penyuluhan Cakrawala Pendidikan INOTEKS : Jurnal Inovasi Ilmu Pengetahuan, Teknologi, dan Seni JRAK: Jurnal Riset Akuntansi dan Komputerisasi Akuntansi Jurnal Pendidikan Indonesia KOMUNITAS: INTERNATIONAL JOURNAL OF INDONESIAN SOCIETY AND CULTURE Media Ilmu Keolahragaan Indonesia Jurnal Keolahragaan Journal of Physical Education Health and Sport Jurnal Ekonomi Pembangunan: Kajian Masalah Ekonomi dan Pembangunan Jurnal Terapan Ilmu Keolahragaan Journal of ICSAR The Journal of Educational Development Journal of Government and Civil Society JOURNAL SPORT AREA Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Promotion and Behavior Journal of Maternal and Child Health Jurnal SPORTIF : Jurnal Penelitian Pembelajaran ACTIVE: Journal of Physical Education, Sport, Health and Recreation Narra J Jurnal Pengabdian Olahraga Masyarakat Indonesian Journal of Physical Education and Sport Science (IJPESS) Prosiding University Research Colloquium Physical Therapy Journal of Indonesia FISIO MU: Physiotherapy Evidences Media Penelitian dan Pengembangan Kesehatan
Agus Kristiyanto
Jurusan POK FKIP Universitas Sebelas Maret Surakarta Jalan Menteri Supeno 13 Manahan Surakarta
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Aerobic exercise improves spatial memory in a rat model of meningitis Zaidah, Lailatuz; Soetrisno, Soetrisno; Purwanto, Bambang; Kristiyanto, Agus; Wasita, Brian; Widyaningsih, Vitri
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.977

Abstract

Infections of the nervous system, such as acute bacterial meningitis, pose serious health problems that require immediate intervention. In experimental animals, exposure to lipopolysaccharide (LPS) is used to induce meningitis. Aside from drug intervention to reduce inflammation in meningitis, aerobic exercise helps to maintain the regulatory mechanisms of brain homeostasis through anti-inflammatory mechanisms. The aim of this study was to evaluate the effect of aerobic exercise on malondialdehyde (MDA), nuclear factor-kappa B (NF-κB), insulin-like growth factor 1 (IGF-1), endothelial nitric oxide synthase (eNOS), brain-derived neurotrophic factor (BDNF), apoptosis, and spatial memory. A four-week experimental study was conducted using 18 rats, which were randomly divided into three different groups (six rats per group): healthy rats as negative controls (non-meningitis), a treatment group treated with antibiotic treatment (meningitis group), and a third group (aerobic exercise group) treated with antibiotics and aerobic exercise following LPS-induced meningitis. Data were analyzed using a one-way analysis of variance (ANOVA) test, and the comparison between groups used the Bonferroni post-hoc test. The results showed that aerobic exercise significantly reduced MDA (p<0.001), NF-κB (p=0.035), and apoptosis (p=0.020) while increasing the serum levels of IGF-1 (p<0.001), eNOS (p=0.011), and BDNF (p=0.001) levels. Improvement in spatial memory was significant in the aerobic exercise group (p<0.001). This study suggested that aerobic exercise could be a promising adjunct therapy in meningitis management strategies, particularly due to its effect on improving spatial memory. Further clinical trials are needed to confirm these findings for clinical use.
Effect of clove flower extract (Syzygium aromaticum) administration timing on skeletal muscle damage induced by eccentric exercise: An in vivo study Ningrum, Tyas Sari Ratna; Doewes, Muchsin; Indarto, Dono; Cilmiaty, Risya; Kristiyanto, Agus; Widyaningsih, Vitri
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1680

Abstract

Eccentric exercise often leads to oxidative stress, inflammation, and muscle damage that impair athletic performance. To counter these adverse effects, clove flower extract (Syzygium aromaticum) offers promising potential as a natural remedy to promote muscle repair with its potent antioxidant and anti-inflammatory properties. The aim of this study was to assess the effects of clove flower extract administration timing on oxidative stress and inflammatory responses in skeletal muscle damage induced by acute eccentric exercise in mice. This study used a post-test-only control group design, involving 35 male mice (Mus musculus, Balb/c) randomly divided into five groups: a healthy control group (HC) with no exercise and no treatment, a negative control group (NC) with exercise but no treatment, and three treatment groups: T1, T2, and T3 (clove flower extract 24 hours before exercise, immediately after exercise, and 24 hours after exercise, respectively). The treatment groups received a single dose of clove flower extract (500 mg/kg body weight). The skeletal muscle damage of mice was collected for the NADPH oxidase (NOX) and superoxide dismutase (SOD) activities using spectrophotometry, and toll-like receptor 4 (TLR4) and interleukin-8 (IL-8) measurements using enzyme-linked immunosorbent assay (ELISA). Moreover, the skeletal muscle damage was analyzed through the histopathological method. Data were analyzed using one-way analysis of variance (ANOVA) followed by Fisher's least significant difference (LSD) tests as a post hoc test. The result showed that clove flower extract significantly reduced NOX activity (p=0.049) and IL-8 levels (p=0.032), and increased SOD activity (p=0.001) while not significantly affecting the TLR4 levels (p=0.532). Moreover, the results showed a significant reduction in muscle damage (p=0.001). The study highlights that the administration of clove flower extract (500mg/kg bw) can be given 24 hours before, immediately after exercise, or 24 hours after exercise to prevent muscle damage.
Co-Authors Agus Margono Alfira fitriana Anggriani, Atika Febri Aprilia, Khalida Nawa Apriliyani, Florida Betty Arif, Akbarudin Ayuningtiyas, Citra Bambang Purwanto Berek, Maria Imakulata Bhisma Murti Brian Wasita Cahyo Seftyono Danang Pujo Broto Daniyar, Pamogsa Ratri Adha Daryanto Daryanto Dono Indarto Edy Legowo, Edy Ellyas, Intan Suraya Eti Poncorini Pamungkasari Faidillah Kurniawan Fiola Indah Putri Pratama Firmanurulita, Fadhila Forestry, Silmi Furqon Hidayatullah, Furqon Gontara, Satria Yudi Gunawati, Arista Hangga Kusuma, Hangga Hari Hanggoro, Hari Herry Widyastono, Herry Hidayatullah, M.Furqon Ian Alfian Riyanto, Ian Alfian Indriyani, Nur Afifah Istiqomah, Isnanda Putri Nur Joko Nurkamto Juego, Bonn Kardiyanto, Deddy Whinata Khoirul Huda Kiyatno Kiyatno Kristiana, Irma Lelono, Sarjoko M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Mariyanto, Muhammad Maryanto, Muhammad Muazarroh, Salma Muchsin Doewes Muhammad Furqon Hidayatullah Muhammad Hisyam Muthmainah Muthmainah Nenot'ek, Frislin Paskaliner Yonatan NINGRUM, TYAS SARI RATNA Noer Rachma Nugroho, Kristanto Adi Prasetya, Hanung Pratama, Andika Priya Rachman, M Erika Rahardjo, Setyo Sri Rahelli, Yeti Restian Gigih sejati, Restian Gigih Retnaningtyas, Triya Ayu Risya Cilmiaty, Risya Rokhayah, Fajar Rokhayah, Fajar Rony Syaifullah, Rony Sadullah, Akhmad Safitri, Lina Eta Sapja Anantanyu, Sapja Sapta Kunta Purnama Saptaningtyas, Haryani Sholikah, Mutiana Agustin Sima Asmara Dewa Marya Mahardika Putri Slamet Riyadi Soetrisno Soetrisno Sugiyanto - Sumaryanto Sumaryanto, Sumaryanto Suminah Sunardi Sunardi Suprayogi, Dody Susilo, Fahmi Eko Syetiawinanda, Amriansyah Tonang Dwi Ardyanto Triasmono, Haris Kukuh Utomo, Tri Aprilijanto Vania Martha Yunita Vitri Widyaningsih Widayat, Tulus Windiartha, Abdy Windiartha, Abdy Wulandari, Cahyani Wulansari, Dasih Ayu Yoga Yuniadi Yudanto Yudanto Yuyun Ari Wibowo Zaidah, Lailatuz Zalaff, Katsran Zulkarnain, Alfian Noha