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All Journal VALENSI Jurnal Kimia (Journal of Chemistry) Agrikultura Biotika: Jurnal Ilmiah Biologi Jurnal Ilmu Dasar Cropsaver : Journal of Plant Protection STOMATOGNATIC- Jurnal Kedokteran Gigi Chimica et Natura Acta Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research Molekul: Jurnal Ilmiah Kimia Jurnal Ilmiah Berkala Sains dan Terapan Kimia Economic Reviews Journal Makara Journal of Science YASIN: Jurnal Pendidikan dan Sosial Budaya ANWARUL: Jurnal Pendidikan dan Dakwah Bandung Conference Series: Pharmacy Molekul: Jurnal Ilmiah Kimia Semeton Mathematics Journal Hikmah: Jurnal Studi Pendidikan Agama Islam Candradimuka: Journal of Education
Rani Maharani
Departemen Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Padjadjaran
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Dammarane Triterpenoids from Aglaia eximia Miq. and Their Cytotoxic Activity Against P388 Murine Leukemia Cell Farabi, Kindi; Harneti, Desi; Nurlelasari, Nurlelasari; Maharani, Rani; Mayanti, Tri; Hidayat, Ace Tatang; Fajriah, Sofa; Naini, Al Arofatus; Sofian, Ferry Ferdiansyah; Azmi, Mohamad Nurul; Supratman, Unang
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.12796

Abstract

ABSTRACT. Triterpenoids are a large group of secondary metabolites commonly found in plants, exhibiting high diversity in both structural features and biological activities. Meliaceae family is knows as a rich source of the triterpenoid compounds. As the most extensive genus within the Meliaceae family, Aglaia is known to contain many bioactive triterpenoid compounds, including cytotoxic triterpenoids. Among the various types of triterpenoids, dammarane is frequently found in Aglaia and has demonstrated potential cytotoxic activity. This purpose of the research was to isolate and structure determination of four dammarane triterpenoids from the methanol extract of Aglaia eximia stem bark. All four compounds were successfully isolated and identified as, dammar-24-en-3a,20-diol (1), 20S,24S-epoxy-dammar-3a,25-diol (2), (E)-dammar-23-en-3a,20,25-triol (3), and (E)-25-hydroperoxydammar-23-en-3a,20-diol (4), respectively. The compounds were analyzed using a combination of spectroscopic techniques, including HRMS (high-resolution mass spectroscopy), FTIR (fourier transform infrared spectroscopy), and NMR (nuclear magnetic resonance, one and two dimensional). Cytotoxicity assays using the MTT method were applied to compounds 1-4. All isolated compounds (1-4) generated moderate cytotoxic activity against P388 murine leukemia cells with IC50 9.09, 11.03, 5.89, and 5.74 μg/mL, respectively. Preliminary structure-activity relationship (SAR) analysis suggested that the presence of hydroxyl and hydroperoxyl groups at C-25 increases cytotoxicity, whereas the cyclization in the side chain to form an epoxide ring decreases cytotoxicity. Keyword: Triterpenoids, Meliaceae, Aglaia eximia, cytotoxicity, P388 murine leukemia cells
Synthesis of Two Analogues of Xylapeptide A and Their Potency as New Antimicrobial Agent Maharani, Rani; Muchlis, Handi Nugraha; Hidayat, Ace Tatang; Al-Anshori, Jamaludin; Nurlelasari, Nurlelasari; Harneti, Desi; Mayanti, Tri; Farabi, Kindi; Supratman, Unang
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100353

Abstract

Xylapeptide A, derived from the fungus Xylaria sp. x Sophora tonkinensis, exhibits potent and selective antimicrobial properties. Our research group has successfully synthesized xylapeptide A. In our recent work, two xylapeptide A analogues (An1 and An2) were synthesized using a combination of solid- and solution-phase synthesis methods. The linear precursors of An1 and An2 were synthesized on 2-CTC resin with the Fmoc strategy. The coupling reagents HBTU/HOBt and HATU/HOAt were employed. Subsequently, the linear precursor was cleaved from the resin using either 20% TFA or a TFE mixture, and then cyclized in solution phase with HBTU. The synthesized products were purified using semi-preparative RP-HPLC, giving the percent yields 16% for An1 and 12% for An2. Both compounds were then characterized by HR-ToF-MS, 1H- and 13C-NMR. The synthesized xylapeptide A and its analogues were evaluated against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Candida albicans. The result showed that An2, possessing arginine residue, exhibited higher activity compared to xylapeptide A and An1. This research suggests that xylapeptide A analogues hold great promise as novel antimicrobial agents.
Pengabdian Mahasiswa dalam Membangun Fondasi Moderasi Beragama Sejak Usia Dini melalui Kegiatan Baca Tulis Al-Qur’an Rani Maharani; Puji Rahayu; Selly Marita
Hikmah : Jurnal Studi Pendidikan Agama Islam Vol. 2 No. 3 (2025): Hikmah : Jurnal Studi Pendidikan Agama Islam
Publisher : Asosiasi Riset Ilmu Pendidikan Agama dan Filsafat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/hikmah.v2i3.1283

Abstract

This study departs from the urgency of early childhood religious education as the foundation for shaping religious and moderate character. The lack of Qur’an learning facilities and qualified teachers in Karang Mulya Village has hindered children aged 6–10 years in mastering Qur’anic literacy skills, even though this stage is considered a golden period of cognitive, affective, and psychomotor development. To address this issue, the research employed a qualitative descriptive method combined with a Project-Based Learning (PjBL) approach, which allowed the teaching process to be linked with practical and contextual activities. Data were collected through direct observation, structured interviews with parents and teachers, and careful documentation of student progress. The analysis was carried out through systematic steps of data reduction, presentation, and conclusion drawing. The findings reveal significant improvements in children’s ability to recognize, read, and write hijaiyah letters, although variations remain, particularly in creativity and independence. Furthermore, Qur’anic literacy activities meaningfully contributed to strengthening the understanding of religious moderation values, such as national commitment, tolerance, anti-violence, and acceptance of local culture. In conclusion, student service activities through Qur’anic literacy not only enhanced technical skills but also functioned as an effective medium for building religious moderation foundations from an early age.
Leveling Up Language Skills: Higher Students’ Perspective on Google Docs as a Tool for English learning Rani Maharani; Serlin Sepriyanti Dohare; Tharysa Rizqika Putri; Kusumawardhani, Ayuning Dyah
Candradimuka: Journal of Education Vol. 3 No. 1 (2025): Candradimuka: Journal of Education
Publisher : Pusat Penerjemah dan Penyunting Universitas Indraprasta PGRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60012/cje.v3i1.116

Abstract

The research discusses the perceptions of students using Google Docs as a collaborative tool to enhance their writing skills in English. The study employed an online survey using Google Forms, conducted on 50 students from the English education program at Indraprasta University PGRI in the 2021 academic year. The survey results indicated that most respondents found Google Docs to be very useful in collaborative writing practice. They also highlighted the importance of features such as spell checking and real-time revision in supporting the writing process. The study concludes that there is a need for more comprehensive usage guides and training to overcome technical barriers and maximize the potential of Google Docs in improving writing and collaboration skills among college students
Application of Google Earth Engine for Agriculture Drought Monitoring in East Lombok Robbaniyyah, Nuzla Af'idatur; Hidayatunnisa, Nurul; Maharani, Rani; Ulfa, Kurnia; Alfian, Muhammad Rijal
Semeton Mathematics Journal Vol 2 No 2 (2025): Oktober
Publisher : Program Studi Matematika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/semeton.v2i2.319

Abstract

In tropical regions such as East Lombok Regency, where food production is highly dependent on rainfall, drought poses a major threat to the agricultural sector. This study aims to monitor drought patterns over time using Google Earth Engine (GEE). Vegetation indices, including the Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI), and Normalized Difference Drought Index (NDDI), were derived from Landsat 8 satellite imagery. The analysis revealed that during the dry season, particularly in August and September, the southern region—especially Jerowaru Sub-district—experienced severe drought conditions. The western parts, including Sambelia, Pringgabaya, and Suela Sub-districts, were also significantly affected, with the most impacted areas being rain-fed rice fields, corn plantations, and mixed horticultural crops. Temporal trend analysis indicated an increasing drought intensity in the later years of observation. The resulting information can support decision-making in drought risk mitigation and sustainable water resource management. By integrating satellite-based drought assessment with agricultural planning, this approach can strengthen food security and promote adaptive agricultural practices in drought-prone regions such as East Lombok Regency.
Pengaruh Citra Merek, Promosi, dan Online Customer Review Terhadap Keputusan Pembelian Konsumen pada Shopee di Kota Bekasi Maharani, Rani; Dananjaya, Irwandaru
Economic Reviews Journal Vol. 4 No. 4 (2025): Economic Reviews Journal
Publisher : Masyarakat Ekonomi Syariah Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56709/mrj.v4i4.1005

Abstract

The advancement of information technology has driven rapid development across various fields, including traditional, digital, and fundamental research methods. This study aims to analyze the effect of brand image, promotion, and online customer reviews on consumer purchase decisions on Shopee in Bekasi City, both partially and simultaneously. Primary data were collected from 200 respondents using a questionnaire with purposive sampling, and analyzed using SPSS through validity and reliability tests, normality, multicollinearity, heteroscedasticity, multiple linear regression, t-test, F-test, and coefficient of determination (R²). The results show that brand image (t = 6.141; p < 0.001) and online customer review (t = 10.195; p < 0.001) have a significant partial effect on purchase decisions, while promotion also shows a significant partial effect (t = 5.289; p < 0.001). Simultaneously, these three independent variables significantly influence purchase decisions with F = 110.198; p < 0.001 and adjusted R² = 0.622, indicating that 62.2% of the variation in purchase decisions can be explained by these variables. These findings confirm that brand image, promotion, and customer reviews play a crucial role in enhancing consumer confidence and purchase decisions on Shopee in Bekasi City.
Instrumen Penilaian Hasil Belajar pada Kompetensi Pengetahuan Rani Maharani; Salsa Rojana Urfa; Siti Ropidoh
YASIN Vol 3 No 4 (2023): YASIN: Jurnal Pendidikan dan Sosial Budaya
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/yasin.v3i4.1306

Abstract

The accuracy of the assessments carried out by schools, especially those related to class assessments, expresses the desire for student learning outcomes. For a teacher, the use of assessment tools is very important during the evaluation process. Starting from the assessment of the selection instrument, the preparation instrument, the review instrument, the implementation of the assessment, the analysis of the results of the assessment, and the follow-up program on the results of the assessment. This article uses the library research method, namely by collecting data related to the title of the research discussion. In this study the data collected from several sources were used, including scientific journals, research results in the form of theses, and the internet. Competence is often used to indicate one's qualifications or abilities. Knowledge assessment can be called cognitive assessment, which is a process for obtaining and using knowledge possessed by students in experiencing a process of change in learning, which consists of: recognizing, remembering, creating, and understanding material. given by their teacher during learning. The main purpose of this cognitive assessment is to find out the target in measuring the level of mastery of students about the competencies that have been achieved in the knowledge aspect. Knowledge assessment is carried out using various assessment techniques The techniques commonly used are written tests, oral tests, and assignments. The learning outcomes are when a person has learned to experience a change in behavior in that person, for example from those who do not know to know, and from those who do not understand to understand. Assessment is very necessary in learning process. Assessment instruments are very important in measuring student learning outcomes. Teachers use assessment tools, which include assessment of selection instruments, preparation instruments, study instruments, implementation of assessments, analysis of assessment results, and follow-up of assessment results. Competence refers to basic knowledge, skills and values that are reflected in a person's habits of thought and action. Common assessment techniques include written tests, oral tests, and assignments.
Pengembangan Media Pembelajaran Articulate Storyline Menggunakan Model Think Pair Share di Kelas IV SDN Karang Tengah 07 Ina Magdalena; Yusuf Fadillah; Rani Maharani; Muhammad Ariq; Gilang Kusuma N
ANWARUL Vol 2 No 1 (2022): ANWARUL: Jurnal Pendidikan dan Dakwah
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (805.74 KB) | DOI: 10.58578/anwarul.v2i1.206

Abstract

This research is develop an Articulate Storyline learning media using Think Pair Share model was valid and practical. this research was Research and Development. The development procedure uses the ADDIE model consisting of analysis, design, development, implementation, and evaluation. the instrument used was a validity questionnaire and a practicality questionnaire. Data collection techniques used qualitative and quantitative techniques. The results of this study are in the form of learning media produced from the Articulate Storyline application which has an attractive appearance for elementary school students. Based on the results of media validator get 76.5% a very valid category. material validator get 91% a very valid category, linguists validator get 100% a very valid category. The practicality of the teacher's response at SDN Karang tengah 7 get 91.6% a very practical category and the practicality level at SDN Karang tengah 10 get 95.8% a very practical category. The practicality of the students' responses at SDN Karang tengah 7 get 91% a very practical category and the practicality level at SDN Karang tengah 10 get 93.8% a very practical category. It can be concluded that the Articulate Storyline learning media is valid and practical.
Co-Authors 10060321019, Dinah Shafira Abasi Ace Tatang Hidayat Achmad Zainuddin Achmad Zainuddin Adhitthana Wiguna Agus Safari Agus Safari Al Arofatus Naini Al Arofatus Naini Anastasya Firdausi Andi Rahim Aprilia Permata Sari Ari Tri Wanodyo Handayani Ayu Andini Azmi, Mohamad Nurul Celcius Waranmaselembun Dadan Sumiarsa Danar Dono Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati, Darwati Deden Indra Dinata, Deden Indra Desak Made Malini Desi Harnet Desi Harneti Desi Harneti Putri Huspa Dessy Yulyani Kurnia Dewa Gede Katja Dina Puspitasari Dini Oktaviani DUDI RUNADI Dwi Maulidani Fadhlan Eka Fitri Yanti, Eka Fitri Erina Hilmayanti Erina Hilmayanti Euis Julaeha Euis Julaeha Evan Hadrian Fahmi Faturahman Fajar Fauzi Abdullah Fajar Fauzi Abdullah Farabi, Kindi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Ghina Izdihar Gilang Kusuma N Gunawan Gunawan Gunawan, Latifah Hedi Paramita Herdanu Rizqullah Hersa Milawati Hidayatunnisa, Nurul Hikmat Kasmara Hilmayanti, Erina Ika Wiani Ina Magdalena Intan Rahmayanti Iqbal Wahyu Mustaqim Irwandaru Dananjaya Jamaludin Al-Anshori Khalijah Awang Khalijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kiswaluyo . Kusumawardhani, Ayuning Dyah Lindung Tri Puspasari Madihah Madihah Melanie Melanie Mohamad Nurul Azmi Mohamad Nurul Azmi Muchlis, Handi Nugraha Muhamad Naufal Muhamad Nurul Azmi Muhamad Nurul Azmi Muhammad Ariq Muhammad Hanafi Muhammad Hanafi Muhammad Luthfi Muhammad Naufal, Muhammad Muhammad Rijal Alfian Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Muttaqin, Fauzan Zein Nadya Thufaila Nafiah, Mohamad Azlan Naini, Al Arofatus Nety Kurniaty Nur Muhammad Miftah Nurlelasari Nurlelasari Nuruzzahra Ammatillah Paramita, Hedi Puji Rahayu Purnama Purnama Purnama Purnama R. Arif Malik Ramadhan Revan Hardiawan Rika Meliansyah Risyandi Anwar Robbaniyyah, Nuzla Af'idatur Safri Ishmayana Salsa Rojana Urfa Samuel San Parulian Selly Marita Serlin Sepriyanti Dohare Shabarni Gaffar Shiono, Yoshihito Siska Elisahbet Sinaga Siti Ropidoh Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Supriatno Salam Taufiqqurahman, Taufiqqurahman Tharysa Rizqika Putri Tiara Prima Amalya Tri Mayanti Tri Mayanti Tri Mayanti Ulfa, Kurnia Unang Supratman Vita Novianti Wawan Hermawan Wawan Hermawan Winda Sukmawati Winda Sukmawati Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yusuf Fadillah Yusuf Hidayat Yusuf Hidayat Yusup Hidayat Yusup Hidayat