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All Journal Jurnal Kimia (Journal of Chemistry) Jurnal Ilmu Dasar Cropsaver : Journal of Plant Protection STOMATOGNATIC- Jurnal Kedokteran Gigi Chimica et Natura Acta Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research Molekul: Jurnal Ilmiah Kimia Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Makara Journal of Science YASIN: Jurnal Pendidikan dan Sosial Budaya ANWARUL: Jurnal Pendidikan dan Dakwah Bandung Conference Series: Pharmacy Molekul: Jurnal Ilmiah Kimia Semeton Mathematics Journal Hikmah: Jurnal Studi Pendidikan Agama Islam Candradimuka: Journal of Education
Rani Maharani
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Education Engineering Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Sintesis Tetrapeptida Linear (DPAP) Menggunakan Metode Sintesis Peptida Fasa Padat (SPPS) Dan Aktivitas Insektisidanya Terhadap Ulat Krop Kubis Yanti, Eka Fitri; Maharani, Rani
Indonesian Journal of Chemical Research Vol 8 No 1 (2020): Edisi Bulan Mei (Edition for May)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2020.8-eka

Abstract

Crop cabbage worm (Crocidolomia pavonana) is one of the pests that has a bad effect on the cabbage production in Indonesia. One of the efforts that has been applied to control this pest is by using bayrusil. However, the bayrusil can cause negative effects such as poisoning and environmentally polluting effects. To prevent the undesired effects, it has been developed the use of environmentally friendly insecticide and one of them is the use of insecticidal peptide. Tripsin-modulating oostatic factor (TMOF) and ist analogues is one of the peptides that has an insecticidal activity. The aim of this research is to synthesise a linear tetrapeptide (DPAP) an analogues of TMOF and to test insecticidal activities against crop cabbage worm. A DPAP has been synthesised by Solid Phase Peptide Synthesis on 2-chlorotrytil chloride resin. Fmoc strategy was applied on the synthesis and a combination DIC/Oxime was employed in the coupling reaction.The tetrapeptidyl resin was cleaved by TFA:water:EDT (90:5:5). The peptide was purified by reverse-phase column chromatography and characterized by TOF ES-MS spectroscopy. A linear peptide was biologically tested towards the C. pavonana, showing percentage of mortality values at 1000 ppm.
Phytochemistry and Biological Activities of Amomum Species Dinata, Deden Indra; Maharani, Rani; Muttaqin, Fauzan Zein; Supratman, Unang
Indonesian Journal of Chemistry Vol 24, No 6 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95402

Abstract

Amomum is a pungent and aromatic plant genus that contains 150–180 species, where Southeast Asia is the center of endemism, with Indonesia indigenous to 24 breeds. These species are used as spices and traditional medicine for the treatment of various diseases. This paper aims to provide Amomum species summarized data regarding phytochemistry and biological activities. Several studies have been carried out on the fruits, seeds, roots, rhizomes, and leaves of Amomum species from 1999 to 2024, as approximately 127 metabolites were isolated as flavonoid, diterpenoid, diarylheptanoid, monoterpenoid, sesquiterpenoid, phenylpropanoid, phenolic, and steroid groups. Besides cytotoxicity, antioxidant, and anti-inflammatory potentials; it also has an owed tendency for use as a chemical marker. The extracts and compounds obtained from the Amomum species were evaluated for biological activities, including cytotoxicity, antioxidant, anticancer, antiproliferative, anti-inflammatory, antifungal, antimicrobial, neuroprotective, platelet antiaggregation, and antidiabetic properties. Tsaoko arilon (neolignane) had antiproliferative and cytotoxic activity, with the highest reactions considered as lead compounds for further development. The findings highlighted the significance of using compounds from the Amomum genus in traditional medicine and the discovery of new medicines. Therefore, the results supported the concept of utilizing Amomum species as a potential source for producing biologically active compounds.
Sesquiterpenoids from Dysoxylum amooroides Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells Gunawan, Latifah; Mustofa, Hidayat Nurul; Naini, Al Arofatus; Harneti, Desi; Hidayat, Ace Tatang; Nurlelasari, Nurlelasari; Maharani, Rani; Mayanti, Tri; Fajriah, Sofa; Awang, Khalijah; Azmi, Mohamad Nurul; Supratman, Unang
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99121

Abstract

Three sesquiterpenoids, guaianediol (1), alismol (2), and spathulenol (3), were isolated from the n-hexane and ethyl acetate extracts of the stem bark of Dysoxylum amooroides. The three compounds were found in D. amooroides species for the first time. The structures of the isolated compounds were identified and established based on an extensive spectroscopic analysis involving HR-TOF-ESI-MS, IR, and NMR data, as well as a comparison with the previously reported works of literature. Compounds 1-3 were further assessed for cytotoxic effects against MCF-7 breast cancer cells. Guaianediol (1) showed inactive activity with IC50 > 100 µM, alismol (2) showed weak activity with IC50 value of 82.1 µM and spathulenol (3) showed considerable activity with an IC50 value of 15.2 µM. A brief structure-activity relationship and comparison with the previous works were also discussed to understand better the role of guaiane- and aromadendrane-type sesquiterpenoids in the biological activity perspective.
Upaya Sintesis Konjugat Kurkumin-Arginin dan Kurkumin-Alanin serta Sintesis Kurkumin-Leusin sebagai Kandidat Antibakteri Escherichia coli 10060321019, Dinah Shafira Abasi; Nety Kurniaty; Rani Maharani
Bandung Conference Series: Pharmacy Vol. 5 No. 2 (2025): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v5i2.18920

Abstract

Abstract. Curcumin is a natural compound from Curcuma longa with known antibacterial, antioxidant, and anti-inflammatory properties. However, its therapeutic use is limited due to poor water solubility and low bioavailability. One strategy to improve its biological performance is by conjugation with amino acids. This study aimed to synthesize curcumin conjugates with arginine, alanine, and leucine using Steglich esterification with DMAP and DCC. Conjugation with arginine and alanine was unsuccessful, likely due to solubility issues, steric hindrance or instability of functional groups. In contrast, the curcumin–leucine conjugate was successfully synthesized in dioxane, yielding a crude product with a 2,4% yield. High-resolution mass spectrometry (HRMS) confirmed the product with a [M–H]+ peak at m/z 580,2551, consistent with the theoretical mass of curcumin–leucine–Boc. Antibacterial activity against Escherichia coli was tested using the microdilution method, but no inhibitory effect was observed at test concentrations ≤1500 ppm. Abstrak. Kurkumin merupakan senyawa aktif alami dari Curcuma longa yang dikenal memiliki aktivitas biologis seperti antibakteri, antioksidan, dan antiinflamasi. Namun, penggunaannya secara terapeutik masih terbatas karena kelarutannya yang rendah dalam air dan bioavailabilitas yang buruk. Salah satu pendekatan untuk meningkatkan efektivitas biologisnya adalah melalui konjugasi dengan asam amino. Dalam penelitian ini, dilakukan upaya sintesis konjugat antara kurkumin dengan tiga jenis asam amino, yaitu arginin, alanin, dan leusin, menggunakan metode esterifikasi Steglich dengan katalis DMAP dan aktivator DCC. Konjugasi kurkumin–arginin dan kurkumin–alanin tidak berhasil dilakukan, diduga akibat faktor ketidaklarutan reaktan, hambatan sterik atau ketidakstabilan gugus fungsional dalam kondisi reaksi. Sementara itu, sintesis konjugat kurkumin–leusin berhasil dilakukan dalam pelarut dioksana, dan menghasilkan senyawa dalam bentuk krud dengan rendemen sebesar 2,4%. Hasil karakterisasi menggunakan spektrometer massa resolusi tinggi (HRMS) menunjukkan puncak molekul [M-H]+ pada m/z 580,2551, sesuai dengan massa teoritis konjugat kurkumin–leusin–Boc. Uji aktivitas antibakteri terhadap Escherichia coli dilakukan dengan metode mikrodilusi, namun tidak menunjukkan adanya penghambatan pada konsentrasi uji ≤1500 ppm.
Dammarane Triterpenoids from Aglaia eximia Miq. and Their Cytotoxic Activity Against P388 Murine Leukemia Cell Farabi, Kindi; Harneti, Desi; Nurlelasari, Nurlelasari; Maharani, Rani; Mayanti, Tri; Hidayat, Ace Tatang; Fajriah, Sofa; Naini, Al Arofatus; Sofian, Ferry Ferdiansyah; Azmi, Mohamad Nurul; Supratman, Unang
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.12796

Abstract

ABSTRACT. Triterpenoids are a large group of secondary metabolites commonly found in plants, exhibiting high diversity in both structural features and biological activities. Meliaceae family is knows as a rich source of the triterpenoid compounds. As the most extensive genus within the Meliaceae family, Aglaia is known to contain many bioactive triterpenoid compounds, including cytotoxic triterpenoids. Among the various types of triterpenoids, dammarane is frequently found in Aglaia and has demonstrated potential cytotoxic activity. This purpose of the research was to isolate and structure determination of four dammarane triterpenoids from the methanol extract of Aglaia eximia stem bark. All four compounds were successfully isolated and identified as, dammar-24-en-3a,20-diol (1), 20S,24S-epoxy-dammar-3a,25-diol (2), (E)-dammar-23-en-3a,20,25-triol (3), and (E)-25-hydroperoxydammar-23-en-3a,20-diol (4), respectively. The compounds were analyzed using a combination of spectroscopic techniques, including HRMS (high-resolution mass spectroscopy), FTIR (fourier transform infrared spectroscopy), and NMR (nuclear magnetic resonance, one and two dimensional). Cytotoxicity assays using the MTT method were applied to compounds 1-4. All isolated compounds (1-4) generated moderate cytotoxic activity against P388 murine leukemia cells with IC50 9.09, 11.03, 5.89, and 5.74 μg/mL, respectively. Preliminary structure-activity relationship (SAR) analysis suggested that the presence of hydroxyl and hydroperoxyl groups at C-25 increases cytotoxicity, whereas the cyclization in the side chain to form an epoxide ring decreases cytotoxicity. Keyword: Triterpenoids, Meliaceae, Aglaia eximia, cytotoxicity, P388 murine leukemia cells
Synthesis of Two Analogues of Xylapeptide A and Their Potency as New Antimicrobial Agent Maharani, Rani; Muchlis, Handi Nugraha; Hidayat, Ace Tatang; Al-Anshori, Jamaludin; Nurlelasari, Nurlelasari; Harneti, Desi; Mayanti, Tri; Farabi, Kindi; Supratman, Unang
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100353

Abstract

Xylapeptide A, derived from the fungus Xylaria sp. x Sophora tonkinensis, exhibits potent and selective antimicrobial properties. Our research group has successfully synthesized xylapeptide A. In our recent work, two xylapeptide A analogues (An1 and An2) were synthesized using a combination of solid- and solution-phase synthesis methods. The linear precursors of An1 and An2 were synthesized on 2-CTC resin with the Fmoc strategy. The coupling reagents HBTU/HOBt and HATU/HOAt were employed. Subsequently, the linear precursor was cleaved from the resin using either 20% TFA or a TFE mixture, and then cyclized in solution phase with HBTU. The synthesized products were purified using semi-preparative RP-HPLC, giving the percent yields 16% for An1 and 12% for An2. Both compounds were then characterized by HR-ToF-MS, 1H- and 13C-NMR. The synthesized xylapeptide A and its analogues were evaluated against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Candida albicans. The result showed that An2, possessing arginine residue, exhibited higher activity compared to xylapeptide A and An1. This research suggests that xylapeptide A analogues hold great promise as novel antimicrobial agents.
Pengabdian Mahasiswa dalam Membangun Fondasi Moderasi Beragama Sejak Usia Dini melalui Kegiatan Baca Tulis Al-Qur’an Rani Maharani; Puji Rahayu; Selly Marita
Hikmah : Jurnal Studi Pendidikan Agama Islam Vol. 2 No. 3 (2025): Hikmah : Jurnal Studi Pendidikan Agama Islam
Publisher : Asosiasi Riset Ilmu Pendidikan Agama dan Filsafat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/hikmah.v2i3.1283

Abstract

This study departs from the urgency of early childhood religious education as the foundation for shaping religious and moderate character. The lack of Qur’an learning facilities and qualified teachers in Karang Mulya Village has hindered children aged 6–10 years in mastering Qur’anic literacy skills, even though this stage is considered a golden period of cognitive, affective, and psychomotor development. To address this issue, the research employed a qualitative descriptive method combined with a Project-Based Learning (PjBL) approach, which allowed the teaching process to be linked with practical and contextual activities. Data were collected through direct observation, structured interviews with parents and teachers, and careful documentation of student progress. The analysis was carried out through systematic steps of data reduction, presentation, and conclusion drawing. The findings reveal significant improvements in children’s ability to recognize, read, and write hijaiyah letters, although variations remain, particularly in creativity and independence. Furthermore, Qur’anic literacy activities meaningfully contributed to strengthening the understanding of religious moderation values, such as national commitment, tolerance, anti-violence, and acceptance of local culture. In conclusion, student service activities through Qur’anic literacy not only enhanced technical skills but also functioned as an effective medium for building religious moderation foundations from an early age.
Leveling Up Language Skills: Higher Students’ Perspective on Google Docs as a Tool for English learning Rani Maharani; Serlin Sepriyanti Dohare; Tharysa Rizqika Putri; Kusumawardhani, Ayuning Dyah
Candradimuka: Journal of Education Vol. 3 No. 1 (2025): Candradimuka: Journal of Education
Publisher : Pusat Penerjemah dan Penyunting Universitas Indraprasta PGRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60012/cje.v3i1.116

Abstract

The research discusses the perceptions of students using Google Docs as a collaborative tool to enhance their writing skills in English. The study employed an online survey using Google Forms, conducted on 50 students from the English education program at Indraprasta University PGRI in the 2021 academic year. The survey results indicated that most respondents found Google Docs to be very useful in collaborative writing practice. They also highlighted the importance of features such as spell checking and real-time revision in supporting the writing process. The study concludes that there is a need for more comprehensive usage guides and training to overcome technical barriers and maximize the potential of Google Docs in improving writing and collaboration skills among college students
Application of Google Earth Engine for Agriculture Drought Monitoring in East Lombok Robbaniyyah, Nuzla Af'idatur; Hidayatunnisa, Nurul; Maharani, Rani; Ulfa, Kurnia; Alfian, Muhammad Rijal
Semeton Mathematics Journal Vol 2 No 2 (2025): Oktober
Publisher : Program Studi Matematika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/semeton.v2i2.319

Abstract

In tropical regions such as East Lombok Regency, where food production is highly dependent on rainfall, drought poses a major threat to the agricultural sector. This study aims to monitor drought patterns over time using Google Earth Engine (GEE). Vegetation indices, including the Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI), and Normalized Difference Drought Index (NDDI), were derived from Landsat 8 satellite imagery. The analysis revealed that during the dry season, particularly in August and September, the southern region—especially Jerowaru Sub-district—experienced severe drought conditions. The western parts, including Sambelia, Pringgabaya, and Suela Sub-districts, were also significantly affected, with the most impacted areas being rain-fed rice fields, corn plantations, and mixed horticultural crops. Temporal trend analysis indicated an increasing drought intensity in the later years of observation. The resulting information can support decision-making in drought risk mitigation and sustainable water resource management. By integrating satellite-based drought assessment with agricultural planning, this approach can strengthen food security and promote adaptive agricultural practices in drought-prone regions such as East Lombok Regency.
Co-Authors 10060321019, Dinah Shafira Abasi Ace Tatang Hidayat Achmad Zainuddin Adhitthana Wiguna Ari Tri Wanodyo Handayani Ariq, Muhammad Ayu Andini Azmi, Mohamad Nurul Dadan Sumiarsa Danar Dono Darwati Darwati Darwati, Darwati Deden Indra Dinata, Deden Indra Desi Harnet Desi Harneti Putri Huspa Dina Puspitasari DUDI RUNADI Dwi Maulidani Fadhlan Eka Fitri Yanti, Eka Fitri Euis Julaeha Fadillah, Yusuf Fahmi Faturahman Fajar Fauzi Abdullah Fajar Fauzi Abdullah Farabi, Kindi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Gunawan, Latifah Hedi Paramita Hidayatunnisa, Nurul Hilmayanti, Erina Ika Wiani Jamaludin Al-Anshori Khalijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Kiswaluyo . Kusumawardhani, Ayuning Dyah Lindung Tri Puspasari Lindung Tri Puspasari Magdalena, Ina Muchlis, Handi Nugraha Muhamad Naufal Muhammad Hanafi Muhammad Luthfi Muhammad Naufal, Muhammad Muhammad Rijal Alfian Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Muttaqin, Fauzan Zein N, Gilang Kusuma Nadya Thufaila Nafiah, Mohamad Azlan Naini, Al Arofatus Nety Kurniaty Nurlelasari Nurlelasari Paramita, Hedi Puji Rahayu Purnama Purnama Revan Hardiawan Rika Meliansyah RIKA MELIANSYAH Robbaniyyah, Nuzla Af'idatur Ropidoh, Siti Safri Ishmayana Safri Ishmayana Selly Marita Serlin Sepriyanti Dohare Shiono, Yoshihito Siska Elisahbet Sinaga Sofa Fajriah Sofa Fajriah Taufiqqurahman, Taufiqqurahman Tharysa Rizqika Putri Tiara Prima Amalya Tri Mayanti Ulfa, Kurnia Unang Supratman Urfa, Salsa Rojana Wawan Hermawan Yoshihito Shiono Yoshihito Shiono Yusuf Hidayat Yusuf Hidayat Yusup Hidayat