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All Journal AcTion: Aceh Nutrition Journal Media Farmasi Media Keperawatan: Politeknik Kesehatan Makassar Jurnal Comprehensive Health Care Jurnal Kolaboratif Sains Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Mandala of Health : A Scientific Journal Jurnal Pengabdian Pada Masyarakat Medical and Health Journal Journal of Public Health and Pharmacy Prosiding Seminar Nasional Pengabdian Kepada Masyarakat: Peduli Masyarakat International Journal of Business and Quality Research Linggamas: Jurnal Pengabdian Masyarakat
Wahyudin Wahyudin
Departemen Anatomi, Fakultas Kedokteran Universitas Jenderal Soedirman, Purwokerto,
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Journal : Media Farmasi

 1 
Effect Of Extract Breadfruit Leaf (Artocarpus altilis (Park.) Fosberg) Toward Tumor Necrosis Factor (TNF- α) In Obese Rat (Rattu norvegicus) With Insulin Resistance Wahyudin Wahyudin; Hasanuddin Nuru; Hendra Stevani; Salmah Arafah
Media Farmasi XXX Vol 18, No 1 (2022): MEDIA FARMASI
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v18i1.2744

Abstract

Tumor necrosis factor-α (TNF-α) contributed to the insulin resistance which leads to type 2 diabetes. The A. altilis plant has traditionally been used by the Indonesian people to treat diabetes mellitus. The purpose of this study was to determine the parameter of TNF-α level in obese mice (Rattus norvegicus). This study was used experimental laboratory with Randomized Controlled Trial (RCT) design. It’s divided into 5 groups, and each group consisted of 5 rats that have been given a 45% fat (open source) high fat diet for fattening itself. Measurement of body weight to assess obesity and examination of fasting blood sugar (GDP) were used of DR glucose test kits. Group I was negative control, group II as positive control using metformin HCl, group III using A. altilis 5%, group IV A. altilis with 10% and group V A. altilis with 15%. Treatment was carried out for 14 days in each group and TNF-α levels was assessed with ELISA test. Nonparametric test was used to see the differences between each groups with a 95% confidence level. There was a significant effect of A. altilis with 10% extract toward TNF-α levels, where the value of p = 0.018. While the administration of extracts of 5% and 15% did not show a significant effect. The administration of 10% A. altilis extract showed a significant decrease of TNF-α levels in obese mice who had hyperglycemia.Keywords: A. altilis, obesitas, TNF-α, insulin resistance
Co-Authors A Fahira Nur Ahmad Yani Alfi Muntafiah Alwi Alwi arafah, Salmah Arfi Nurul Hidayah Arfi Nurul Hidayah Bahiyah, Fiona Annisa Dewiyanti, Dewiyanti Dina Oktaviana Diyah Woro Dwi Lestari Dwi Nur Indah Sari, Dwi Nur Indah Ernawati Ernawati Fajar Wahyu Pribadi Fitranto Arjadi Fitranto Arjadi Handini, Tri Okmawati Hartina, Hartina Hasanuddin Nuru Hasnah Mutfii Hendra Stevani Hidayah, Arfi Nurul Ichsyani, Meylida Ihtiaringtyas, Suci Jajar Setiawan Joko Setyono Joko Setyono Kamriana Kamriana Kamriana, Kamriana Kusuma, Muhammad Nanang Himawan Laksitasari, Anindita Lantip Rujito Lily Kusumawati Burkon Meida Sofyana Miko Ferine Muhamad Rifqy Setyanto Muhammad Iqbal Firdaus Najmudin Nawangtantrini, Gita Nendyah Roestijawati Ning Widhi, Anriani Puspita Karunia Nining Yusnitasari Nitihapsari, Galuh Yulieta NUR'AINI, INDAH Nurachmy Sahnir Octavia Permata Sari Octavia Permata Sari, Octavia Permata Patmawati Patmawati, Patmawati Pauzi, Rizqi Yanuar Qodri Santosa Rafika Zamri Rani Afifah Nur Histiyani Ratnasari Iskandar Riski Fatah, Muhammad Rismayanti Rismayanti Rizki Amelia Sinensis Rosmin Ilham Rosmin Ilham Sallazaria Hanin Prameswari Syafiqa Ardli Sarinah Basri K Sartika, Sartika Septiya, Lia Setiawan, Ferdy Setiawati Setiawati Setyanto, Muhamad Rifqi Sofro, Zaenal Muttaqien Suardi Suardi Sudarto Sudarto Sulaiman, Ibrahim Supriyati . Susiawan, Lieza Dwianasari Syamsul, Muharti Thalib, Abdul Thianti Sylviningrum Tiara Yusan, Rizak Wisnu Budi Pramono, Wisnu Budi Yudhi Wibowo Yudhistira Tri Wardhana Yunika, Novia Zainuddin Zainuddin Zainuddin Zainuddin Zainuddin, Zainuddin