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All Journal Jurnal Kedokteran Brawijaya Sari Pediatri Paediatrica Indonesiana Jurnal Aplikasi Teknologi Pangan Amerta Nutrition World Nutrition Journal Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Munasir, Zakiudin
Departemen Ilmu Kesehatan Anak Universitas Indonesia, Jakarta
Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Occurrence of Covid-19 in Children Who Have Received Live-Attenuated Dengue Vaccination Rahma Karyanti, Mulya; Alam , Anggraini; Widyahening , Indah Suci; Hadinegoro, Sri Rezeki; Munasir , Zakiudin; Sasmono , R. Tedjo; Satari , Hindra Irawan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.188

Abstract

Background: Possible cross-reactions/ false positives were reported in rapid dengue serology tests because antigenic similarities between SARS-CoV-2 and DENV. The study aims to evaluate the occurrence of COVID-19 in children who received chimeric-yellow fever tetravalent dengue vaccine. Methods: A case-control study was conducted in five districts primary healthcares in Jakarta aged 12 years and above through history of COVID-19 questionnaire. Clinical and laboratory confirmation were obtained, and blood draw was performed to measure neutralization RBD IgG SARS-CoV-2 antibody titer. The dengue vaccine group consists of subjects who have received CYD-TDV in 2011-2012 and are willing to participate. The non-dengue vaccine group were matched; all have not received dengue vaccine. Results: This study included 207 cases and 212 controls, with median age in cases 19 years (IQR 5) and control 15 years (IQR 4). Nineteen subjects in the dengue vaccine group have already been infected with COVID-19 before being given COVID-19 vaccine, compared to 11 subjects in the non-dengue vaccine group (P=0.131). The occurrence of COVID-19 in the dengue vaccine group was significantly higher (16 subjects) than the non-dengue vaccine group (4 subjects)(P=0.005) after COVID-19 vaccinations were given. Neutralization RBD IgG SARS-CoV-2 antibody titer was 71.96 U/ml (IQR 39.47) in the dengue vaccine group and 51.92 U/ml (IQR 49.03) in the non-dengue vaccine group(P=0.361). Conclusion: Our study showed that the occurrence of COVID-19 in the dengue vaccine group was higher than in the non-dengue vaccine group, which may suggest no cross reaction from dengue antibodies towards COVID-19, more studies are warranted.
Profile of Anti-Diphtheria Toxoid Immunoglobulin G among Pre-School Children in the Senen District, Jakarta, Indonesia Santi, Theresia; Jo, Juandy; Prayitno, Ari; Munasir, Zakiudin; Hegar, Badriul
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.189

Abstract

Background: Diphtheria is a re-emerging disease in Indonesia that can be prevented by vaccination. This study evaluates the anti-diphtheria toxoid immunoglobulin G levels among healthy children aged 6 – 7 years old who had not received the second booster immunization for Diphtheria, Tetanus, and Pertussis (DTP) commonly administered at 5 – 7 years old. Methods: This cross-sectional study was conducted in the Senen district of Jakarta, Indonesia. All subjects had been vaccinated with three doses of immunization for DTP during the first year of life, and subsequently classified into a group of children who received the first booster immunization of DTP at 18 – 24 months old and who had not received it yet. Antibody against Diphtheria toxoids within the sera samples was assessed by commercial Anti-Diphtheria toxoid IgG Enzyme-Linked Immunosorbent Assay and classified in four groups: no protection (< 0.01 IU/ml), uncertain (0.01 – 0.09 IU/ml), full protection (0.10 – 1 IU/ml) and long-term protection (>1 IU/ml). Results: Eighty-nine children were included in this study; only 71 subjects (79.7%) had received the first DTP booster at 18–24 months old. The specific humoral immunity against diphtheria was observed among 57 children (64%). Notably, among the 89 subjects, only two subjects not receiving the first DTP booster still had antibody protection for diphtheria (p=0.001, OR 27.5, 95% CI: 5.71 – 132.42). Conclusion: The first diphtheria booster vaccination at 18 – 24 months old is crucial to protect pre-school children against diphtheria.
Application of The JMF 10 Warning Signs for Early Detection of Primary Immunodeficiency among Children with Recurrent Infections in Indonesia Muktiarti, Dina; Hendarto, Aryono; Munasir, Zakiudin; Wulandari, Dewi; Satari, Hindra Irawan; Werdhani, Retno Asti; Wati, Ketut Dewi Kumara
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.318

Abstract

Introduction: Limited awareness and diagnostic resources contribute to delayed recognition of primary immunodeficiency (PID). The Jeffrey Modell Foundation (JMF) 10 warning signs have been widely used for screening. However, their diagnostic performance has not been validated in Indonesia. Objective: To evaluate the diagnostic performance of the JMF 10 warning signs for early detection of PID among children with recurrent infections in Indonesia. Methods: This multicentre cross-sectional study was conducted across 10 hospitals in Jakarta involving 254 children aged 0–18 years who met the severe, persistent, unusual, and recurrent (SPUR) infection criteria. The diagnosis of PID was established based on clinical diagnosis by the European Society for Immunodeficiencies (ESID) Registry Working Definitions. Analysis was performed to determine the sensitivity, specificity, predictive values, and accuracy of the JMF 10 warning signs. Results: Diagnostic performance for PID improved with the number of warning signs, with overall accuracy increasing from 15% (1 sign) to 86.2% (≥5 signs). A total score of ≥3 signs was associated with higher occurrence of PID (PR 2.63; 95% CI 1.23–5.60; p = 0.008), providing an optimal balance of 75.7% sensitivity and 48.9% specificity. The two most specific indicators were recurrent severe sinus infections (99.5%) and ear infections (95%). All PID subjects required IV antibiotics. Conclusion: The JMF warning signs remain a valuable clinical screening tool for early detection of PID among Indonesian children. A threshold of three or more warning signs provides reasonable accuracy for screening and referral of PID in resource-limited settings.
Co-Authors Abdul Latief Abhijeet J Bhanegaonkar Afifa Fahriyani Agus Firmansyah Agus Firmansyah Ahmad Suryawan Alam , Anggraini Alan R Tumbelaka Alan R. Tumbelaka Alan Roland Tumbelaka Aman B Pulungan Amy Diana Ruth Anang Endaryanto Anggraini Alam Anggraini Alam, Anggraini Anita Halim Antonius H. Pudjiadi Ari Prayitno Ari Prayitno, Ari Arini Setiawati Arwin A.P. Akib Arwin A.P. Akib Arwin Akib Arwin AP Akib Arwin AP Akib Arwin AP Akib Aryono Hendarto Astrid W Sulistomo Ayijati Khairina Badriul Hegar Badriul Hegar Bambang Supriyatno Bambang Tridjaja AAP, Bambang Tridjaja Batubara, Jose Bernie Endyarni Medise Bertha Soegiarto Brastho Bramantyo Budi Setiabudiawan Budiman Bela Caroline Mulawi Cissy B Kartasasmita Cissy B. Kartasasmita Citra Estetika Corry S Matondang Corry S. Matondang Darus, Febriansyah Dewi Kartika Suryani Dewi Wulandari Diana Aulia Dina Muktiarti, Dina Djajadiman Gatot Dominicus Husada Dwi Prasetyo Dwi Prasetyo Eka Laksmi Hidayati, Eka Laksmi Ellen P. Gandaputra EM Dadi Suyoko EM Dadi Suyoko Endang Windiastuti Erfi Prafiantini Erica G Horodniceanu Evy Yunihastuti Ferry Damardjati S.P. Ganda Ilmana Ganung Harsono Gatot Irawan Sarosa Gatot Irawan Sarosa, Gatot Irawan Graham RR H.F. Wulandari Hanifah Oswari Harahap, Alida Roswita Hardiono D. Pusponegoro Hartono Gunardi HEM Dadi Suyoko Hindra I. Satari Hindra I. Satari, Hindra I. I Boediman I gusti Lanang Sidhiarta Ilmi, Ibnu Malkan Bakhrul Imral Chair Indah S. Widyahening Irene Irene Irma Rochima Puspita Ismoedijanto Ivo Novita Sah Bandar Johannes Hudyono Juandy Jo Julfina Bisanto Kartjito, Melissa Stephanie Katrin Roosita Kemas Firman Ketut Dewi Kumara Wati Kinesya, Edwin Knol, Klaas Kusnandi Rusmil Lenny S. Budi Levina Chandra Khoe Lily Irsa Maddepunggeng, Martira Marc F Botteman Maria Abdulsalam Martira Maddepunggeng Mei Neni Sitaremi Mei Neni Sitaresmi Melissa Gandi Melva Louisa Mia Kumiati Miesien Miesien Molly D. Oktarina Mulya Rahma Karyanti, Mulya Rahma Mulya Safri Mulya Safri Mulyadi Mulyadi Munar Lubis Naela Fadhila Nahrawi Nahrawi Nastiti Kaswandani Ni Putu Sudewi Ni Putu Sudewi Nia Kuniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nita Ratna Dewanti Novie Amelia Chozie Partini Pudjiastuti Trihono Patria Vittarina Sarisetyaningtyas Patrick Detzel Piprim Basarah Yanuarso, Piprim Basarah Pramita Gayatri, Pramita Pustika Amalia Wahidiyat Putri Maharani Tristanita Marsubrin Qatrah D. Seprida Raihan Raihan Raihan Raihan, Raihan Ratih D Palupi Ratih Dewi Palupi Ray Wagiu Basrowi Retno Asti Werdhani Rimbawan Rimbawan Rina A.C. Saragih, Rina A.C. Rinawati Rohsiswatmo Rini Sekartini Rita Evalina Rosalina Dewi Roeslani, Rosalina Dewi Rulina Suradi Rulina Suradi Rulina Suradi Saptawati Bardosono Sasmono , R. Tedjo Sasmono, R. Tedjo Setyo Handryastuti Siti D. Wisnuwardhani Siti Munawaroh Sjawitri P Siregar Sjawitri P Siregar Sjawitri P Siregar Sjawitri P. Siregar Soedjatmiko Soedjatmiko Soedjatmiko SRI LESTARI Sri Rejeki H Hadinegoro. Sri Rezeki Hadinegoro Sri Rezeki Hadinegoro Sri Rezeki Hadinegoro, Sri Rezeki Sri Rezeki S. Hadinegoro, Sri Rezeki S. Sri S Nasar Sri Sudaryati Nasar Sudung O Pardede, Sudung O Sudung O. Pardede, Sudung O. Sumadiono Sumadiono Sundjaya, Tonny Supriyadi Bektiwibowo Syawitri P Siregar Taralan Tambunan Taralan Tambunan Tetty Yuniati Theresia Santi, Theresia Tina W. Wisesa Titi Sularyo Titis Prawitasari, Titis Tjhin Wiguna Tuty Mariana Wardhana Wardhana Wing Yu Tang Xiang Ji Yaulia Yanrismet Yuditiya Purwosunu Yuliarti, Klara Yvan Vandenplas