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All Journal Jurnal Kedokteran Brawijaya Sari Pediatri Paediatrica Indonesiana Amerta Nutrition World Nutrition Journal Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Zakiudin Munasir
Departemen Ilmu Kesehatan Anak Universitas Indonesia, Jakarta
Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Profile of Anti-Diphtheria Toxoid Immunoglobulin G among Pre-School Children in the Senen District, Jakarta, Indonesia Santi, Theresia; Jo, Juandy; Prayitno, Ari; Munasir, Zakiudin; Hegar, Badriul
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.189

Abstract

Background: Diphtheria is a re-emerging disease in Indonesia that can be prevented by vaccination. This study evaluates the anti-diphtheria toxoid immunoglobulin G levels among healthy children aged 6 – 7 years old who had not received the second booster immunization for Diphtheria, Tetanus, and Pertussis (DTP) commonly administered at 5 – 7 years old. Methods: This cross-sectional study was conducted in the Senen district of Jakarta, Indonesia. All subjects had been vaccinated with three doses of immunization for DTP during the first year of life, and subsequently classified into a group of children who received the first booster immunization of DTP at 18 – 24 months old and who had not received it yet. Antibody against Diphtheria toxoids within the sera samples was assessed by commercial Anti-Diphtheria toxoid IgG Enzyme-Linked Immunosorbent Assay and classified in four groups: no protection (< 0.01 IU/ml), uncertain (0.01 – 0.09 IU/ml), full protection (0.10 – 1 IU/ml) and long-term protection (>1 IU/ml). Results: Eighty-nine children were included in this study; only 71 subjects (79.7%) had received the first DTP booster at 18–24 months old. The specific humoral immunity against diphtheria was observed among 57 children (64%). Notably, among the 89 subjects, only two subjects not receiving the first DTP booster still had antibody protection for diphtheria (p=0.001, OR 27.5, 95% CI: 5.71 – 132.42). Conclusion: The first diphtheria booster vaccination at 18 – 24 months old is crucial to protect pre-school children against diphtheria.
Co-Authors Abhijeet J Bhanegaonkar Agus Firmansyah Ahmad Suryawan Alan R Tumbelaka Alan R. Tumbelaka Alan Roland Tumbelaka Aman B Pulungan Amy Diana Ruth Anang Endaryanto Anggraini Alam, Anggraini Antonius H. Pudjiadi Ari Prayitno, Ari Arini Setiawati Arwin A.P. Akib Arwin A.P. Akib Arwin AP Akib Arwin AP Akib Aryono Hendarto Astrid W Sulistomo Badriul Hegar Badriul Hegar Bambang Supriyatno Bambang Tridjaja AAP, Bambang Tridjaja Bernie Endyarni Medise Bertha Soegiarto Budi Setiabudiawan Caroline Mulawi Cissy B. Kartasasmita Citra Estetika Corry S Matondang Corry S. Matondang Darus, Febriansyah Dewi Kartika Suryani Diana Aulia Dina Muktiarti, Dina Djajadiman Gatot Dominicus Husada Dwi Prasetyo Ellen P. Gandaputra EM Dadi Suyoko Endang Windiastuti Erfi Prafiantini Erica G Horodniceanu Fatima Safira Alatas, Fatima Safira Ferry Damardjati S.P. Ganda Ilmana Ganung Harsono Gatot Irawan Sarosa, Gatot Irawan Graham RR Hanifah Oswari Harahap, Alida Roswita Hardiono D. Pusponegoro Hartono Gunardi HEM Dadi Suyoko Hindra I. Satari Hindra I. Satari, Hindra I. Hindra Irawan Satari Hindra Irawan Satari Hindra Irawan Satari, Hindra Irawan I Boediman I gusti Lanang Sidhiarta Imral Chair Indah S. Widyahening Irene Irene Irma Rochima Puspita Ismoedijanto Ivo Novita Sah Bandar Johannes Hudyono Jose RL Batubara Juandy Jo Julfina Bisanto Kartjito, Melissa Stephanie Kemas Firman Ketut Dewi Kumara Wati Kinesya, Edwin Knol, Klaas Kusnandi Rusmil Levina Chandra Khoe Lily Irsa Maddepunggeng, Martira Marc F Botteman Maria Abdulsalam Mei Neni Sitaresmi Melissa Gandi Melva Louisa Mia Kumiati Miesien Miesien Molly D. Oktarina Mulya Rahma Karyanti, Mulya Rahma Mulya Safri Mulya Safri Mulyadi Mulyadi Munar Lubis Nastiti Kaswandani Ni Putu Sudewi Nia Kuniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nita Ratna Dewanti Novie Amelia Chozie Patria Vittarina Sarisetyaningtyas Patrick Detzel Piprim Basarah Yanuarso, Piprim Basarah Qatrah D. Seprida Raihan Raihan, Raihan Ratih D Palupi Ratih Dewi Palupi Ray Wagiu Basrowi Retno Asti Werdhani Rina A.C. Saragih, Rina A.C. Rinawati Rohsiswatmo Rini Sekartini Rita Evalina Rulina Suradi Rulina Suradi Saptawati Bardosono Sasmono, R. Tedjo Setyo Handryastuti, Setyo Siti D. Wisnuwardhani Sjawitri P Siregar Sjawitri P Siregar Sjawitri P Siregar Sjawitri P. Siregar Soedjatmiko Soedjatmiko Sondang Sidabutar SRI LESTARI Sri Rezeki Hadinegoro Sri Rezeki Hadinegoro, Sri Rezeki Sri Rezeki S. Hadinegoro, Sri Rezeki S. Sri S Nasar Sudung O Pardede, Sudung O Sudung O. Pardede, Sudung O. Sumadiono Sumadiono Sundjaya, Tonny Syawitri P Siregar Taralan Tambunan Taralan Tambunan Theresia Santi, Theresia Tina W. Wisesa Titis Prawitasari, Titis Wardhana Wardhana Wing Yu Tang Xiang Ji Yvan Vandenplas