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Achmad Ramadhan
Fakultas Ilmu Tarbiyah dan Keguruan UIN SU Medan
Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Physics Public Health Social Sciences Other

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Effect Of Combination Administration Of Leaf Extract Star Fruit (Averrhoa Bilimbi L.) and Ginger Rhizome Red (Zingiber Officinale var. Rubrum) Until Against Creatinine In Mice (Mus Musculus) CCl4 Induced and Its Utilization As A Learning Medium Rahayu, Ratna Dwi; Ramadhan, Achmad; Sutrisnawati
Biology and Education Journal Vol. 6 No. 1 (2026): Biology and Education Journal (BaEJ)
Publisher : Universitas Islam Riau (UIR) Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/baej.2026.26707

Abstract

The combination of starfruit (Averrhoa carambola) and red ginger (Zingiber officinale var. rubrum) is important to investigate because both plants contain bioactive compounds with antioxidant potential. Starfruit contains vitamin C and phenolic compounds, while red ginger contains gingerol and other antioxidant compounds that may support physiological functions and help prevent disease. Therefore, this combination has potential as a natural antioxidant source. This study aims to understand the combined effects of starfruit leaf extract and red ginger rhizome on creatinine levels in mice that have been given CCl4 treatment. The method used is a laboratory experiment with a Completely Randomized Design (CRD) design consisting of 24 mice divided into 6 groups and 4 experimental replications. The normal control group (Kn) is a group that is only given food and water, the negative control group (K-) is given CCl4 induction, groups P1, P2, P3 and P4 are given CCl4 induction and a combination of starfruit leaf extract and red ginger rhizome with concentrations of 20%, 40%, 60% and 80%. Data were analyzed by ANOVA statistical test via SPSS version-26. The results of the study showed that the combination of starfruit leaf extract and red ginger rhizome significantly reduced creatinine levels in mice induced by CCl4, with an effective concentration of 80%. The learning media applied in this study, a flipbook e-module, met the very good category as a learning medium.
Co-Authors A. Manandri, Nikma Abd Hakim Laenggeng, Abd Hakim Abd Rauf Abd. Rasyid Syamsuri Aditya, Rivan Aini, Siti Alfarisi, Zunnu Wanis Amiruddin Kasim Amran Rede Andi Tanra Tellu Andini, Rizka Tri Angriani, Novita ANITA PURNAMA SARI Ariesty, Risda Asrini Asrini Astija Attthari, Teuku Arfa Baehaqi Bialangi, Mursito S. Burhanuddin, Alga Patricia Bustamin Bustamin D, Mutiara Daulay, Sholihatul Hamidah Dawa, Linda M Dewi Tureni Dewilis Setianingsih Dinie, Norhamizah Efendi Efendi Faisah, NUrul Faradila, Ratna Fariza, Ifat Fatmah Dhafir Fince Fince Habeahan, Rahmatilah Ainya Haerudin Haerudin Hamsi, Hamsi Hanafia, Ovi Harahap, Ananda Aditya Sari Hartono D. Mamu Hasanudin, Rezki Hasdina, Meryan Hasyim, Faiz Hayyatun Mawaddah Hijrah Hijrah Hiska, Hiska Hj. Musdalifah Nurdin Holyness Nurdin Singadimedja I Ketut Suada I Made Budiarsa I Nengah Kundera Ikran, Ikran Illah, Ininna Nur Indriana, Rinny Isnainar Isninar, Isnainar Jihan Jihan, Jihan Kisman, Dahri Krisman Krisman Laksono Trisnantoro Lilies Lilies Lilies Lilies N Tangge Lina Sri Rahayu Lubis, Nurul Amanda Khairani Mala, Nursanti A Maleko, Muh. Cilfy Manap Trianto Masriani . Masrianih Mauru, Roy Elfrado Mauruh, Renindya Marchelly Mirzan, Mirzan Misnah Misnah Mohammad Jamhari Muchlis Djirimu Mulianti, Andi Nahulae, M. Rafli Raja Gazali Najamuddin Laganing Novi, Winda Cinthia Novita, Amelia Nurhaeda, Nurhaeda Nurmin Nurmin Nurwahda, Nurwahda Payung, Lilyanti M. Pinus, Pinus Pratiwi, Elly Qirey M Putra, I Komang Adi Putri, Mutia Qonita, Ayu Rafiqa RAFIQA RAFIQA, RAFIQA Rahayu, Ratna Dwi Ramadhan, Sahri Nur Ramadhan, Suchin Ramadhanti, Yana Ramlah Ramlah Ratman Ratman Rauf, Iswadi Abd. Raya Agni Rianto, Riki Rifqi, Muhammad Hafiz Rosita Rosita Rosnita Rosnita Safitri, Bujing Saragih, Bayu Pramudia Sarni Djasa Siswahyudianto Siti Hawa Sri Wahyuni Suardi, Magfira Sutrisnawati Mardin Syech Zainal Tellu, A.Tanra Utami Dewi uunnadianti Windarsih, Yulia Wulandari, Endang Trya Yusdin Gagaramusu Yusril Ihza Mahendra Yusuf Kendek Paluin Zahman, Abdul Zasmita, Eka Zulaikhah Dwi Jayanti