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Journal : INDONESIAN JOURNAL OF PHARMACY

OPTIMIZATION OF FLOATING TABLET CONTAINING ASPIRIN USING SIMPLEX LATTICE DESIGN Siswanto, Agus
Indonesian Journal of Pharmacy Vol 31 No 1, 2020 In Press
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp%p

Abstract

Aspirin is an effective analgesic which is also used as an antiplatelet therapy for stroke prophylaxis. Aspirin in floating tablet formulations is used to improve the bioavailability. The aim of this study was to determine the optimum composition of floating tablets of aspirin by simplex lattice design (Design Expert 7.1.5). The tablets were prepared by direct compression technique, using polimers (Methocel K4M CR, Ethocel) and sodium bicarbonate (gas-generating agent) as independent variables. The optimum formula was determined based on numeric method with flow rate of tablet mass, floating lag time, C60, and Td as independent variables. The results indicated that the optimum composition of the matrix was Methocel K4M CR 16.94 %, NaHCO3 15.18 %, and Ethocel 17.88 %. It was observed that independent factors had significant contribution on all dependent variables.
Co-Authors Abdul Choliq Hidayat Abdul Manan Abdul Rahim Abdul Rosyid Abidin, Dodo Zaenal Achmad Fudholi Achmad Fudholi ACHMAD FUDHOLI Adithya Wahyu Pratama, Adithya Wahyu Aftoni Sutanto Ahmad Husain Asdie Akhir Riana Handayani, Akhir Riana Akhmad Kharis Nugroho Albait, Nur Aldiansyah, m. Amrullah, Bagaskara Falah Anjar Mahardian Kusuma Arvita, Yulia Ashad, Bayu Adrian Baedhowi, Abdul Latif Baehaqi, Mudofar Beny Dodit Ari Wibowo, Dodit Ari Dwi Hartanti Dwi Rahayuningsih E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Emelia, Shinta Endang Prihastuty, Endang Erfan Subiyanta, Erfan Errissya Rasywir eva rosmawati Eva Rosmawati Evi Sofia Fachruddin Fatimah Malini Lubis Fauziati, Ana Feranika, Ayu Feriyadin, Feriyadin Fiastuti Witjaksono Gustina Nurkhayatun, Gustina Hady, Sultan Hariadi Hariawan Hermawan, M. Reza Herti Yani, Herti Hery Sonawan Hidayat, Abdul Choliq Imam Baihaqi Imam Subekti Indri Hapsari Indri Hapsari Iskandar Soedirman, Iskandar Iskandar Sudirman Jasmir, Jasmir Junial Heri Kuntjoro Harimurti Machrus Ali Megantara, Marcelino A. Moeslich Hasanmihardja Mucharomah, Nurul Maghfiroh MUHAMMAD FURQONI Mutiara Poetri Nurtanti, Mutiara Poetri Nasrun, Martina W. Nunuk Aries Nurulita PAMUSO, MARLIN Paramitha, Cindy Pareza Alam Jusia, Pareza Alam Pebrianto, Feri Prayogo, Lito Pri Iswati Utami Purnomo, Luthfan Budi Rasywir, Errisya Reza Pramitha Habsari, Reza Pramitha Rizana Fauzi, Rizana Rizki Okprastowo rohadin, rohadin Rosalina, Mia Rosario, Maria rosmawati, eva Rosyadi, Marwan RR. Ella Evrita Hestiandari Rudi Putranto Rustiawan, Indra S.Kom.,M.Pd, Arifudin Setiawan, Zunan Siregar, Arief Kurniawan Siti Helmyati Siti Setiati Sofiansyah, Muhammad Edi Sudibyo Martono Sudibyo Martono SUDIBYO MARTONO Suhendro Suwarto, Suhendro Suparman Suparman Suparman Suparman Suryadi, Dikky Sutanto , Aftoni Sutoyo, Mochammad Arief Hermawan Suyanti Suyanti Suyanti Suzanna Immanuel Tohasan, Achmad W. Djoko Yudisworo Wachyu Hari Haji Wardani, Muhammad Wasiran, Wasiran Wibawa, Arief Wibowo, Indi Deli Fiallo Widya Cahya Ariswati, Widya Cahya Yafi, Zidni Reynard Yekti Mulyani, Yekti Yovi Pratama Yuli Asmi Rahman Yuni Ernawati, Yuni yusni ulfiani zulaikha Yusni Ulfiani Zulaikha zulaikha, yusni ulfiani