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Dewi Suryani
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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Preliminary In Vitro Antiplatelet Potential of Ipomoea pes-caprae from North Lombok with Adenosine Diphosphate-Induced Platelet Aggregation Ilsa Hunaifi; Dewi Suryani; Lalu Husnul Hidayat; Muhammad Naufal Farras Ananta; Muhammad Iqbal Farobbi; Nisa Isneni Hanifa; Raisya Hasina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.229-246

Abstract

Background: Cardiovascular diseases, particularly ischemic stroke, remain a global health burden, necessitating potential candidate for further antiplatelet with fewer side effects. Objectives: This study aimed to evaluate the antiplatelet potential of ethanolic extracts from the leaves and stems of Ipomoea pes-caprae (Katang-katang) from North Lombok, Indonesia, through ADP-induced platelet aggregation. Phytochemical screening, total tannin quantification, and in vitro antiplatelet assays were conducted. Methods: The leaves and stems were macerated with 96% ethanol, followed by qualitative phytochemical tests, Folin-Ciocalteu-based tannin analysis, and platelet aggregation inhibition assays using human platelet-rich plasma. Results: The extracts contained alkaloids, flavonoids, and tannins, with higher tannin levels in leaves (4.02 ± 0.02 mgEAT/g) than stems (3.67 ± 0.17 mgEAT/g). Concentration-dependent antiplatelet activity was observed, with leaf extracts showing inhibition (85.9% at 2000 μg/mL) compared to stems (79.5%) and aspirin (77.3%). IC₅₀ values were 727.78 μg/mL (leaves) and 349.95 μg/mL (stems). Statistical analysis confirmed significant differences across concentrations (p < 0.05). Conclusion: These findings demonstrate that Ipomoea pes-caprae exhibits potent antiplatelet activity, attributed to its tannin and phytochemical content, with leaves being more effective. Although these findings suggest preliminary antiplatelet potential, further analysis is required to validate the method using aspirin IC₅₀, and subsequent in vivo and pharmacological investigations are necessary before therapeutic application can be claimed.
Co-Authors Abdallah, Zachari Ahmad Hanafi Alamanda, Baiq Irzana Putri Ali Harokan Aliza Raudatin Sahly Amanda Ayun Salsabila Ananta, Muhammad Naufal Farras Andari, Marie Yuni Andari, Marie Yuni Angelina, Varelia Ardiana Ekawanti Arif Imam Suroso Asmarwiati, Septien Bambang Heriyadi Bayu Tirta Dirja Budi Hartono Candra Eka Puspitasari Cenderadewi, Mutia Desi Marina, Ervita DEWI RAHMAWATI Dian Puspita Sari Dian Puspita Sari Diana Sari Eka Fitriana Eris, Deden Dewantara Eustachius Hagni Wardoyo Farobbi, Muhammad Iqbal Fathana, Prima Bella Gusti, Adinda Harhara, Zanira Faisal Hariandi, Rizki Harokan, Ali Hasin, Raisya Hetty Ismainar I MADE SUJANA . Ilsa Hunaifi Ilsa Hunaifi, Ilsa Imas Hari Iswanto Imran . Indah Sapta Wardani Indana Eva Ajmala Josafat, Anom Kartiwijaya, Rosadi Khairul Anwar Lalu Husnul Hidayat Lilis Suryani Maharani, Ria Miftahul Jannah MOCHAMMAD YASIR Mohamad Nur Muhamad Mardiansyah Muhammad Iqbal Farobbi Muhammad Naufal Farras Ananta Mukhlis Mulya, Shania Hafitsa Nasrul, Monalisa Neni Rohaeni Ningsih, Dewita Suryani Nintyastuti, Isna Kusuma Nisa Isneni Hanifa Novalina, Sesti Nuralyza, Imasayu Nuriah Yuliati Pendi, Hamdi Zas Puspitasari, Ema Putri, Rizky Febriyani Putu Aditya Wiguna Rahmad Fajar Sidik, Rahmad Fajar Rahman, Hadian Rahmat Junaidi Raisya Hasina Ramadhani, Shabrina Yasmin Rhomi Ardiansyah Rifana Cholidah, Rifana Rizal Syarief Rizka Amalia ROSITA, Risa RR. Ella Evrita Hestiandari Sakinah Marie Sanad Sarah Asih Faulina, Sarah Asih Sartiyah Sartiyah Sartiyah, Sartiyah Soewignyo, Dimas Adi Sugeng, Santoso Sulaiman, Helmi Sunarwidhi, Anggit Listyacahyani Tabroni Titi Pambudi Karuniawaty Umuri, Khairil Wahyu Sulistya Affarah, Wahyu Sulistya Wahyudi, Belynda Rahmalia Sanceska Wahyudi, Ira Waluyo, Untung Wasis Wasis Wicaksana, Kresna Fajri Wijaya, Christabella Natalia Yoga Pamungkas Susani Yohanes Bahari Yudha Irhasyuarna Yunita Sabrina, Yunita Zaman, Chairil