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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

HIGH INTERLEUKIN-6, LOW CD4+ AND CD8+ T-LYMPHOCYTES EXPRESSIONS AS RISK FACTORS OF CERVICAL CARSINOMA INFECTED BY HUMAN PAPILLOMA VIRUS TYPE-52 Mahendra-Dewi, I G. A. S,; Suwiyoga, I K.; Joewarini, E.; Alit-Artha, and I G.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 2 (2013): IJBS Vol2 No2
Publisher : Udayana University

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Abstract

In Indonesia cervical carcinoma is the most common cancer in women and one of the leading cause of mortality. High risk human papillomavirus (HPV) is the major risk factor of cervical cancer. This study aims to know the role of IL-6, CD4+ and CD8+ T-lymphocyte for the risk of cervical carcinoma infected by HPV52. This study was a case control study, specimens of cervical carcinoma patients infected by HPV type-52 as the case group and HPV type-16 or 18 as the control group. HPV genotyping used SPF10 primer and type specific E7 primer by LiPA. Immunohistochemistry method was used to know expression of IL-6, CD4+ and CD8+ T lymphocyte. Pearson’s c2 test was applied with statistical significance was set at the 2-sided 0.05 level. The odds ratios (OR) were calculated for the risk, with 95% confidence intervals on SPSS 16.0 for windows. PCR examination was performed in 185 paraffin-embedded tissue. The risk of high IL-6 expression in cervical carcinoma infected by HPV type-52 was statistically significant 6-fold higher compare with cervical carcinoma infected by HPV type 16 (OR = 6.00 ; CI 95% = 1.13-31.99; p = 0.03; p < 0.05) and HPV type 18 (OR = 6.00 ; CI 95% = 1.13-31.99; p = 0.03; p < 0.05). The risk of low CD4+ T lymphocyte expression in cervical carcinoma infected by HPV type 52 was statistically significant 6-fold higher and 7.43-fold higher respectively compare with cervical carcinoma infected by HPV type 16 (OR = 6.00 ; CI 95% = 1.003-35.91; p = 0.04; p < 0.05) and HPV type 18 (OR = 7.43 ; CI 95% = 1.23-45.01; p = 0.02; p < 0.05). The risk of low CD8+ T lymphocyte expression in cervical carcinoma infected by HPV type 52 was statistically significant 13.5-fold higher and 11-fold higher respectively compare with cervical carcinoma infected by HPV type 16 (OR = 13.50 ; CI 95% = 1.42-128.26; p = 0.01; p < 0.05) and HPV type 18 (OR = 11.00 ; CI 95% = 1.16-103.94; p = 0.02; p < 0.05). No significance different between cases and controls group in mean-age, parity and sexual activity (p > 0.05). In conclusion, this study found that high IL-6 expression, low CD4+ and CD8+ T lymphocyte expression were the risk factors of cervical carcinoma infected by HPV type 52.
Obstetric and Gynecologic Departments, Faculty of Medicine Udayana University, Bali-Indonesia Mahendra-Dewi, I G. A. S.; Suwiyoga, and I K.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 1 (2013): IJBS Vol.7 No.1 January-June 2013
Publisher : Udayana University

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Abstract

The high risk of human papillomavirus (HPV) have already known widely and accepted as a causative agent for cervical cancer. Epidemiologically, predominant high-risk is HPV-16 and squamous cell carcinomas (SCC) is the most common histological type. HPV genotype probably correlates to histologic type. This study aims to determine how many fold is the risk of SCC on HPV-16 infection. This is a case control with SCC HPV-16 positive as the cases and SCC HPV-16 negative as the controls. Tissues diagnosed as SCC and non SCC was paraffin-embedded. SPF-10 and specific E7-primer types by LiPA were employed for genotyping of HPV-16. c2 was applied to analyze the correlation. A number of 65 SCC consisted of 33 cases and 32 controls were observed in this study. The risk of SCC on HPV-16 infection was 3.40-fold (95% CI = 1.44-8.03; p = 0.004) compare with HPV-16 negative. Controls in this study consist of 18 (27.69%) of HPV-18, 9 (13.85%) of HPV-52, and 5 (7.69%) of other HPV types. The mean-age of case group and control group infected by HPV were 52.28 ± 12.43 and 47.70 ± 8.02 year, respectively (p = 0.02). HPV-16 infection caused SCC is 3.5 more than other high risk group.
THE INCREASED INCIDENCE OF NAUSEA AND VOMITING DUE TO ANXIETY IN PACLITAXEL CARBOPLATIN CHEMOTHERAPY IN A 48 YEARS OLD FEMALE PATIENT WITH CERVICAL CANCER: A Case Report Putra, I. F. W.; Noviyani, R.; Suwiyoga, and, K.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 8 No 1 (2014): IJBS Vol8 No1
Publisher : Udayana University

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Abstract

Nausea and vomiting was the frequently side effects in chemotherapy.Uncontrolled nausea and vomiting can cause weakened body condition, reduced appetite and drinking, dehydration, electrolyte disturbances, reduced nutritional status so the patient refused to undergo further chemotherapy. Anxiety is one of the factors that increase the risk of nausea and vomiting. We reported the case of the woman 48 years old, height 150 cm, weight 51 kg, occupation housewife, diagnosed non-keratinizing squamous cell carcinoma cervical cancer  stage-IIB and received paclitaxel carboplatin for three cycles of chemotherapy. She experienced anxiety, acute nausea vomiting on the third cycle of chemotherapy and delayed nausea and vomiting of the three cycles of chemotherapy.
Co-Authors Anak A. A. W. P. Dewi Anak Agung Gede Duwira Hadi Santosa Anak Agung Ngurah Jaya Kusuma Analysa, Analysa and I G. Alit-Artha Anom Suardika Anwar, Meirisa Afifah Nurmalia Arthawan Arthawan Aryana, Made Bagus Dwi Astawa, I Made Mulya Budiana, Nyoman Budiman, Ardelia Clara Candijaya, Gita Sirini Christyani, Fenyta Danny Aguswahyudi Darmayasa, Putu Bagus Desak Putu Oki Lestari Deviyanti, Gery Puspa Dewi, Anak A. A. W. P. E. Joewarini Evert Solomon Pangkahila Feliciano Pinto, Feliciano Ferry Santoso Fido Anggli, Fido Fransiskus C Raharja Gde Ari Putra, Orion Reffa Gede Fajar Manuaba, Ida Bagus Hadisubroto, Yona S. Hanny Aditanzil Hanny Aditanzil Harrista, Daniel Victor Heni Sunyoto I Dewa Made Sukrama I Gde Adnyana Sudibya I Gde Raka Widiana I Gde Sastra Winata I Gede Adnyana Sudibya, I Gede Adnyana I Gede M Putra I Gede Mahendra Adiguna Dira I Gede Mega Putra I Gede Putu Surya I Gusti Ayu Putri Kartika, I Gusti Ayu I Gusti Ayu Sri Mahendra Dewi I Gusti Putu Mayun Mayura I Ketut Labir I Ketut Labir I Ketut Surya Negara I Ketut Tunas I Made Darmayasa I Nyoman Gede Budiana I Nyoman H Sanjaya I NYOMAN MANTIK ASTAWA I Putu Kusuma Yudasmara, I Putu Kusuma I Wayan Artana Putra I Wayan Megadhana I Wayan Putu Sutirta Yasa I Wayan Suranadi I. F. W. Putra I. Lesmana I.W. Weta Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Ika Widi Astuti, Ika Widi Ines Kurniaty Hartono Intan Puspa Intizam, Marwa Humaira IPG Wardhiana IPG Wardhiana, IPG Janet Sumampouw Jessica Nathalia JOHANA SENSY LENI MANNA K Tangking Widarsa KADE YUDI SASPRIYANA Kadek Fajar Marta Kerans, Fransiscus Anthony Ketut S. Negara Kirana, Ni Wayan Prabasiwi Kusuma, I Komang Wira Ananta L.S. Ani Leonardo ., Leonardo Leony Lim Lidia Widianti, Lidia Luh Putu Iin Indrayani Maker Luh Seri Ani Made Bagus Dwi Aryana Mahendrata, Prayascita MANNA, JOHANA SENSY LENI Mantik AN Manuaba, Ida Bagus Gede Fajar Marta, Kadek Fajar Moestikaningsih . Mona Mariana Mona Mariana Muhammad Freddy Candra Sitepu Muliawan, Erlin Purnama N.W.A. Utami Nathalia, Jessica Negara, Ketut S. Ngurah Harry Wijaya Surya, I Gede Ni Ketut Karneli Ni Ketut Karneli Ni Ketut Supasti Dharmawan Ni Made Suciani Nyoman Bayu Mahendra Pramana, Bagus Andika Pratama, I Gede Bayu Adi Puspa, Intan Putra, I Gede M Putra, Ida Bagus Agung Widnyana Putri, Desak Agung Istri Padma Putu Adi Sujana Putra Putu Ayu Indrayathi Putu Doster Mahayasa R. Niruri Raharja, Fransiskus C Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rastiti, Ni Putu Riasa, I Nyoman Putu Rini Noviyani Riza Firman Satria Sanjaya, I Nyoman H Santoso, Ferry Sari, Jayanti Purnama Satriawan, Nyoman Gede Dikawijaya Setiawan, William Alexander Stella Kawilarang Stella Kawilarang, Stella Sugianto Sugianto Sumampouw, Janet Tjokorda Gde Agung Suwardewa Wenas, Yongki Widia, Made Yudha Ganesa Wikantyas William Alexander Setiawan Wiraputri, Anak Agung Ratih Kusumadewi Yona S. Hadisubroto Yongki Wenas Yosevangelika Hutabarat