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All Journal International Journal of Public Health Science (IJPHS) MEDIA MEDIKA INDONESIANA Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Medical Journal of Indonesia Indonesian Journal of Cancer Chemoprevention Pharmascience Majalah Kedokteran Sriwijaya Sari Pediatri Biomedical Journal of Indonesia Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kedokteran dan Kesehatan Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Anestesia dan Critical Care Bioscientia Medicina : Journal of Biomedicine and Translational Research Sriwijaya Journal of Surgery Jurnal Kesehatan dan Pembangunan Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Islamic and Complementary Medicine

Theodorus Theodorus

Bagian Farmakologi Fakultas Kedokteran Universitas Sriwijaya

Author-ID : 403007

Religion Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

Published : 66 Documents Claim Missing Document

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Efektivitas Penambahan 2,5 μG Sufentanil pada 12,5 mg Bupivakain 0,5% Hiperbarik terhadap Mula dan Lama Kerja Blokade Sensorik-Motorik Anestesi Spinal pada Operasi Herniorafi Resiana Resiana; Zulkifli Zulkifli; Kusuma Harimin; Theodorus Theodorus
Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2016): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Salah satu kekurangan anestesi spinal adalah durasi blokadenya yang singkat. Berbagai cara dilakukan untuk memperpanjang durasi blokade seperti penambahan adjuvan berupa obat opioidseperti sufentanil. Penelitian ini dilakukan untuk mengetahui efektifitas penambahan sufentanil pada anestesi lokal bupivakain hiperbarik terhadap mula dan lama kerja blokade spinal. Uji klinikacak berpembanding, buta ganda telah dilakukan di Rumah Sakit Mohammad Hoesin Palembang dari bulan April sampai dengan Juli 2013. Terdapat 66 pasien yang memenuhi kriteria inklusi, yangmenjalani herniorafi dengan anestesi spinal. Pasien dibagi dalam dua kelompok, masing – masing 33 orang. Kelompok I menggunakan bupivakain 0,5% hiperbarik 2,5 ml ditambah 2,5 μg sufentanil 0,5 ml, sedangkan kelompok II bupivakain 0,5% hiperbarik 2,5 ml ditambah 0,5 ml NaCl 0,9%. Diteliti, mula kerja , lama kerja, blokade sensorik dan motorik, tinggi blokade sensorik puncak, efektivitas dan efek samping intra operatif. Analisi data menggunakan SPSS versi 20. Pada kelompok bupivakain 0,5% hiperbarik-sufentanil didapatkan mula kerja blokade sensorik danmotorik lebih cepat dan lama kerja blokade sensorik dan motorik lebih panjang daripada kelompok bupivakain 0,5% hiperbarik-NaCl 0,9% ( p<0,001), sedangkan tinggi blokade sensorik puncak ,kualitas analgesia, dan relaksasi motorik, serta efek samping sebanding. Simpulan dari penelitian ini adalah penambahan 2,5 μg sufentanil pada bupivakain 0,5% hiperbarik 2,5 ml mempercepat mula kerja dan memperpanjang lama kerja blokade sensorik dan motorik.Kata kunci: sufentanil, bupivakain, spinal anestesi, herniorafi

Evaluation of Rationality in Prescribing Metformin (Biguanide Group) at Dr. Mohammad Hoesin General Hospital Palembang Nita Parisa; Dwi Tantri Marylin; Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.471

Backgrounds. It is very important to evaluate and assess the rationality of the use of antidiabetic drugs, especially the biguanide (metformin) group to maintain the quality and quality of diabetes mellitus drug administration so that the target of diabetes mellitus control can be optimized. This study aims to evaluate the rationality of prescribing metformin oral antidiabetic at Dr. Mohammad Hoesin General Hospital Palembang. Methods. The research design is a descriptive study using secondary data from medical records in the medical records section of Dr. Moh Hoesin Hospital Palembang. The object of research is all medical records of patients with type 2 diabetes mellitus who used metformin at RSMH Palembang in the period July 1st, 2019-July 31st, 2020, with complete medical record data and without serious comorbidities. The rationality for using metformin that was assessed in this study was the frequency of use, drug dose, route of administration, duration of administration, and drug interactions. The frequency of drug use is assessed by how many times the drug is taken in one day. Results. The most age group of patients who received a prescription for metformin were 51-60 years old and 61-70 years old with a total of 17 patients (35.4%). The majority of patients were female as much as 60.4%. Drug interactions with metformin are still quite common, although the majority are synergistic and potentiating interactions. There are still 2 cases or 4.2 percent who experience antagonistic interactions. Conclusion. The rationality for using metformin in patients with type 2 diabetes mellitus is based on the criteria for the right dose (100%), the right frequency of drug administration (100%), the right time for giving the drug (100%), the right way of giving the drug (100%), and the right drug interaction. (95.8%).

CENTELLA ASIATICA EXTRACT EFFECT ON POSTOPERATIVE WOUND HEALING Elza Iskandar; Theodorus Theodorus; Anang Tribowo; Riani Erna; Fatimah Syakirah
International Journal of Islamic and Complementary Medicine Vol. 2 No. 2 (2021): International Journal Islamic Medicine
Publisher : International Islamic Medicine Forum

Wound healing is a complex process that is divided into four phases, namely the hemostasis, inflammation, proliferation, and tissue remodeling phase. Centella asiatica is a widely used and very popular traditional plant in the field of health for a long time. Various in vitro and in vivo studies have proven the efficacy of Centella asiatica extract in the wound healing process. This literature review uses literature search methods from Pubmed, Science Direct, and Cochrane Library with keywords Centella asiatica, wound healing, surgery. This study aims to study the effects of Centella asiatica extract on postoperative wound healing.

KARAKTERISASI PREPARAT NANOPARTIKEL KAFEIN DARI EKSTRAK KOPI ROBUSTA MENGGUNAKAN PLGA DAN PVA Rika Saputri; Muhammad Totong Kamaluddin; Theodorus Theodorus; Sonlimar Mangunsong
Oceana Biomedicina Journal Vol 5 No 2 (2022): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v5i2.87

Coffee is one of the beverages favored by the public. Coffee contains caffeine which is able to increase concentration and this ability takes place depending on the dose received by the body. The purpose of this study is to characterize caffeine nanoparticles polymerized PLGA and Pva.In the manufacture of caffeine nanoparticles using ingredients in the form of robusta coffee beans that have been dried and roasted which is then done the extraction process with digesti method, so that caffeine obtained. Then the caffeine that has been obtained is made into a formulation of polylytic nanoparticles PLGA and PVA. In the process of making nanoparticle formulations are used emulsion solvent evaporation method. The formulation of caffeine nanoparticles is characterized using PSA and the particle morphology is performed using TEM. The result of characterization using PSA obtained an average diameter of 173.8 nm, zeta potential -16.2 mV and PDI of 0.148.For morphology see spheric surface shape. So that caffeine from orbusta coffee beans can be prepared using PLGA and PVA polymers using emulsion solvent evaporation method.

ANGKA KEJADIAN KEHAMILAN SETELAH LAPAROSKOPI OPERATIF PADA INFERTILITAS AKIBAT ENDOMETRIOSIS Rafiyandi Rafiyandi; Adnan Abadi Asnawi; Awan Nurtjahyo; Theodorus Theodorus
Jurnal Ilmu Kedokteran dan Kesehatan Vol 9, No 3 (2022): Volume 9 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v9i3.6698

Probabilitas kehamilan pada wanita infertil yang menderita endometriosis adalah sekitar dua kali lebih rendah daripada wanita dengan infertilitas idiopatik. Farmakoterapi untuk endometriosis tidak cukup efektif meningkatkan fertilitas, namun pembedahan dapat meningkatkan kesuburan. Penelitian ini bertujuan untuk mengetahui angka kejadian kehamilan setelah laparoskopi operatif pada infertilitas akibat endometriosis serta faktor yang mempengaruhinya. Penelitian dalam bentuk survival analysis dilakukan sejak bulan Januari sampai Juni 2017. Pada hasil penelitian, angka kejadian kehamilan adalah 23,4. Usia ≥30,5 tahun 6,061 kali lebih berisiko tidak bisa hamil setelah laparoskopi operatif dibandingkan usia < 30,5 tahun (p= 0,018). Durasi infertilitas >2,5 tahun secara signifikan lebih berisiko 18,6 kali tidak bisa hamil setelah laparoskopi operatif dibandingkan ≤ 2,5 tahun (p<0,001). Skor EFI (Endometriosis Fertility Index) ≤ 6 adalah 29,167 kali lebih berisiko tidak bisa hamil setelah laparoskopi operatif dibandingkan skor EFI >6 (p= 0,002). Uji multivariat didapatkan durasi infertilitas berpengaruh secara signifikan terhadap kejadian kehamilan setelah laparoskopi operatif pada pasien infertilitas akibat endometriosis (p= 0,028). Durasi infertilitas merupakan faktor risiko yang paling mempengaruhi angka kejadian kehamilan.

Overview of Microorganism Patterns Causing Pathological Fluor Albus at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Raden Ayu Kusuma Andini; Ferry Yusrizal; Azhari Rozali; Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.763

Background: Fluor albus, also known as leucorrhoea, vaginal discharge, or leukorrhea, is the name given to fluids that are secreted from the genitals that are not blood. Pathological fluor albus can be caused by an infection in the lower genitalia or in areas that are more proximal. This study aimed to determine the pattern of microorganisms that cause pathological fluor albus at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This study was a descriptive observational study and used primary data from a direct examination of research subjects at the obstetrics and gynecology polyclinic of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 63 research subjects participated in this study. Analysis of microorganism patterns was carried out univariately using SPSS software. Results: The majority of microorganisms that cause pathological fluor albus are Gardnerella vaginalis. Meanwhile, in non-pathological conditions of fluor albus, the majority of causative microorganisms are E. coli. Conclusion: Gardnerella vaginalis is the most common causative microorganism of pathological fluor albus disorders at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.763

Effects of Neo-Adjuvant Chemotherapy on CD8 + Serum Levels in Local Advanced Stage Breast Cancer Patients Nopriansyah Darwin; Nur Qodir; Mulawan Umar; Theodorus
Sriwijaya Journal of Surgery Vol. 3 No. 1 (2020): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v3i1.27

Introduction: CD8 + CTLs are important components of tumor specific cellular adaptive immunity in breast cancer. Chemotherapy can increase the response of cytotoxic lymphocytes and provide anti-tumor immunity. Therefore, chemotherapy can cause cell death and trigger tumor antigens that are processed by APC and activate CD8 + cells to destroy tumor cells. Evaluation of the immune system before treatment can predict chemotherapy response. The purpose of this study was to assess the effect of neo-adjuvant chemotherapy on serum CD8 + levels in patients with locally advanced breast cancer. Methods: Non-comparative clinical trials were conducted at Dr. Mohammad Hoesin Hospital Palembang from October 2017 to June 2018.The sample of this study was 30 breast cancer patients who met the inclusion criteria. All samples underwent FAC neo-adjuvant chemotherapy and data were analyzed with SPSS version 21. Results: The mean age of advanced breast cancer patients was 45.97 Â± 10,526 years with an age range of 30-66 years. Serum CD8 + levels after chemotherapy decreased significantly compared to before chemotherapy (p = 0.000). The value of serum CD8 + before chemotherapy has a sensitivity of 42.86% and specificity of 43.48% with a cut of point of 660.7 cells / mm3. Conclusion: Neo-adjuvant chemotherapy significantly decreases serum CD8 + levels in local advanced breast cancer patients.

The Relationship Between Onset Time and Outcome Patients Intra Cerebral Ganglia Basalis EC Stroke Hemorrhagic Operations at Dr. Mohammad Hoesin General Hospital Palembang Ditto Ruldifar Pribadi; Anugrah Onie; Theodorus
Sriwijaya Journal of Surgery Vol. 4 No. 2 (2021): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v4i2.64

Background: Spontaneous intracerebral hemorrhage is the second most common stroke subtype defined as non-traumatic hemorrhage to the brain parenchyma, which can extend to the ventricles and into the subarachnoid space. Advances in innovations in the field of surgical intervention compared to conservative therapy are more beneficial in preventing disability in patients. The surgical methods that are often used in nontraumatic intra cerebral bleeding interventions are craniotomy and craniectomy. Many factors influence postoperative patient outcome. The level of patient awareness, the extent of the hematoma are the main predictive factors for patient outcome. Glasgow Outcome Scale is often used to measure the outcome of intracranial bleeding patient care. Methods: The study is a case series studies which was conducted by tracing 70 medical records of patients with intra-cerebral ganglia basal hemorrhage due to stroke hemorrhagic who had met the study inclusion criteria from January 2018 to December 2020 who were operated on at the Neurosurgery Installation of RSUP Dr. Mohammad Hoesin Palembang. Results: The mean ICH age in the study was 40 - 60 years (54.23 Â± 13.09), male gender were 41 samples (58.6%), mean GCS was 10.93 Â± 2.48 (3-15), pressure systolic blood 171.33 Â± 24.09 (120 - 240), diastolic blood pressure 98.8 Â± 13.46 (70 - 140), most patients ICH with a history of hypertension 68 people (97.1%), 60 people (85.7%) without a history of DM, 57.1% with craniotomy, 59 people with a bleeding volume of 30-60 cc (84.3%), surgery onset â‰¥ 8 hours (68.6%), uncal herniation (57.1%). Craniotomy and craniectomy were not significantly associated with the prognostic assessment of GOS on ICH (p value = 0.502). Uncal herniation was significantly associated with the incidence of ICH (p value = 0.000). The correlation was strong between time of onset and patient prognosis (p 0.000). Conclusion: There was a significant relationship between onset time and patient outcomes, meaning that the correlation between onset time and patient outcomes was quite strong. The longer the onset time, the more likely it is to have a bad outcome (GOS score 4-5), whereas the faster the onset time, the more likely it is to have a good outcome (GOS score 1-3).

Etlingera elatior Compounds as Anticancer Agents of Breast Cancer Through Inhibition of Progesterone Receptor: An In Silico Study Putri Mahirah Afladhanti; Haidar Ali Hamzah; Muhammad Despriansyah Romadhan; Safa Nabila Putri; Ellen Callista Angelica; Theodorus Theodorus
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp94-104

Breast cancer is the leading cause of cancer-related death in women globally. Progesterone receptor (PR) is known as the prime example of receptors amenable to targeted breast cancer drug therapy. Etlingera elatior is an herbal plant that has been renowned to have anticancer effect. This study aimed to identify the potential compounds derived from Etlingera elatior as anticancer agents of PR in breast cancer using molecular docking method. This study used fifteen compounds from Etlingera elatior along with lonaprisan as the comparative drug. The PR was downloaded from RCSB, whereas compounds and lonaprisan were from Pubchem. The drug-likeness test based on Lipinski’s rule of five was conducted using SwissADME. Toxicity analysis using admetSAR 2.0 was used to predict toxicological profile of the compounds. Compounds and lonaprisan were docked on PR using AutoDock tools 1.5.6 and AutoDock Vina 1.1.2. Molecular interactions were visualized by Discovery Studio v16. A total of nine compounds met the criteria as drugs based on drug-likeness and toxicity tests. All nine compounds except caffeic acid and vanillic acid had higher binding affinities on PR compared with lonaprisan. Ergosterol peroxide exhibited the highest binding affinity on PR with values of -9.8 kcal/mol. Moreover, ergosterol peroxide-PR interaction had thirteen hydrophobic bonds and a hydrogen bond with amino acid residues were found in the active site of PR. Most of the compounds found in Etlingera elatior have the potential to be anticancer agents of PR in breast cancer with ergosterol peroxide being the most potential compound. Further in vitro and in vivo research are needed.Keywords: breast cancer, ergosterol peroxide, Etlingera elatior, progesterone receptor, in silico.

Co-Authors Abrar Arbhiwa Tanguirsyaf Siregar Abu Bakar Lutfi Adenan Abadi Adenan Abadi admin Adnan Abadi Asnawi Adnan Abadi, Adnan Afifa Ramadanti Agustina Br. Haloho Agustinus William Agustria Z. Saleh Amarel, Fahma Alfarizqy Amir Fauzi Amirah Novaliani Anak Agung Gede Sugianthara Anang Tribowo Andriani, R.A. Linda Andriansyah, Yulius Andrina, Hana Anugrah Onie Awan Nurtjahyo Awan Nurtjahyo Azhar Susanto Azhari Azhari Azhari Rozali B, Firmansyah Benedictus Wicaksono Widodo Bernolian, N Bernolian, N Billy Sujatmiko D Saputra, Akbar N D.Y. Riyanto, D.Y. Dahler Bahrun Daniatiek, Soneta Dastamuar, Shalita Debby Handayani Harahap Debby Handayati Harahap Devy Octarina Ditto Ruldifar Pribadi Doni Kurniawan Dwi Tantri Marylin Ellen Callista Angelica Elvi Widiastuti Elza Iskandar, Elza Evi Lusiana F, Amir Fahma Alfarizqy Amarel Fakhrudit, Emir Fatimah Syakirah Fauzit, Amir Fedriyansyah Fedriyansyah Ferdi, Roni Ferry Yusrizal Firmansyah Basir Fita Asfianti Forbes, Darlin Gita Dwi Prasasty H.M. Nazir H.M. Nazir Haidar Ali Hamzah Harahap, Debby Handayani Heriansyah, Jhon Hidayat, Syarief Taufik Hilmawan, Bagus HM Nazir Hz Ika Kartika Indira, Tissa Ismail Bastomi, Ismail Julius Anzar Kamaluddin Kamaluddin Kamaluddin, MT Kamaluddin, MT Khrismawan Khrismawan Kiagus Ahmad Imanuddin Kms Yusuf Effendi Kms Yusuf Effendy Kusuma Harimin Leni Wijaya, Leni Lestari, Mayang Indah Lorenza, Geofanny Lutfi, Abu Bakar M Kamaluddin M. T. Kamaluddin Mahacakri, Eke P Mahadika, Febrinata Manan, Heriyadi Marta Hendry, Marta Martadiansyah, Abarham Maulani, H Maulani, H Maulani, Henni Mgs. Irsan Saleh, Mgs. Irsan Mgs. M. Irsan Saleh Muhammad Despriansyah Romadhan Muhammad Hafidh Komar Muhammad Irsan Saleh Muhammad Totong Kamaluddin Mulawan Umar Muzakkie Muzakkie, Muzakkie Nadhif, Aufa Muhammad Nita Parisa Nopriansyah Darwin Novianesari, Putri H Novianty, Novianty Nugraha, M Daffa Nugroho, Achmadi S Nur Qodir Nurul Islamy Nuswil Bernolian Octarina, Bertha Oktariana, Desi Pangemanan, W T Pangemanan, W T Pangemanan, Wim T PATIYUS AGUSTIANSYAH, PATIYUS Puspita, Yusni Putri Mahirah Afladhanti Putri Mirani Raden Ayu Kusuma Andini Rafiyandi Rafiyandi Rahima Rahima Renny Apliza Nasution Resiana Resiana Riani Erna Rika Saputri Rini Purnamasari Risa Vera Rizal Sanif Rizani Amran Rogatianus Bagus Pratignyo Rose Mafiana Rostika Flora Rostika Flora Rusydi, Syakroni D Sabrina, Tia Safa Nabila Putri Sahab, Abdullah Saleh, Masagus Irsan Salni Sari Octarina Piko Sastradinata, Irawan Shaleh, Agustria Z Silvana, Rista Silvia Triratna Siti Rusdiana Puspa Dewi Sonlimar mangunsong Stevanny, Bella Sudarto Sudarto Sujatmiko, Billy Sulbahri, Robby P. Suriani Rosida Sutomo Tanzil Syarif Husin Syarif Husin Tahany, Hanifah Tanzil, Sutomo Tindar, Mirzah Tissa Indira Usman, Fatimah Veronita Veronita Veronita, Veronita Wahyu Pranata, Wahyu Pranata Yohanes Febrianto Yulia Iriani, Yulia Yuliana Yuliana Yundari, Yundari Yusuf, Kemas Zainal, Rizal Zanaria, Rima Zulkifli Zulkifli

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