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Journal : Journal of Multidisciplinary Applied Natural Science

Investigation of Potential Molecular Targets of Zanthoxylum acanthopodium in Ovarian Cancer Using Network Pharmacology Assessments Wijaya, Johanna Fransiska; Chiuman, Linda; Syahputra, Hariyadi Dharmawan; Kaban, Vera Estefania; Razoki, Razoki; Ginting, Chrismis Novalinda; Iksen, Iksen
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.268

Abstract

Ovarian cancer is a serious disease that affects the ovaries, and its early detection is challenging due to vague symptoms often dismissed as minor ailments. Currently, natural sources have gained attention for their potential role in anticancer treatment. This study aimed to utilize network pharmacology to explore the potential targets and mechanisms of Zanthoxylum acanthopodium in the treatment of ovarian cancer. This study utilized the KNApSAcK and Swiss Target Prediction to identify active compounds and target genes. Additionally, ovarian cancer-specific target genes were sourced from the GEO database. To identify possible key target genes, the network interaction between protein-protein using the STRING database and visualized them in Cytoscape. Subsequent analysis using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enabled us to focus on primary therapeutic targets. Our investigation into Zanthoxylum acanthopodium revealed 10 active compounds that pass Lipinski rule of five and oral bioavailability with acceptable pharmacokinetic profiles, 88 therapeutic targets, and identified 5 hub genes: SRC, CCNB2, MMP9, PTGS2, and PTPRC, which are strongly associated with ovarian cancer progression. Pathway enrichment analysis highlighted several pathways significantly related to the pathogenesis of ovarian cancer. This study elucidates the therapeutic potential and mechanisms of action of Z. acanthopodium as a promising candidate for ovarian cancer treatment. However, further research, including both in vitro and in vivo studies, is necessary to understand its molecular mechanisms comprehensively.
Co-Authors Aprilia, Hijjatun Artanti, Elsan Fitri Bangar, Roy Indrianto Barus, Bunga Rimta Br Ginting, Astriani Natalia Br Sembiring, Novitaria Chiuman, Linda Chyntia Glori Tania Chyntia Glori Tania Denny Satria Dian Ika Perbina Meliala Dinda Sari Utami Ferendina, Imelda Firdaus Fahdi Fithri Pulungan, Ainil Friska Raulina Situmorang Gabena Indrayani Dalimunthe Ginting, Astriani Natalia Br. Ginting, Chrismis Novalinda Ginting, Junius Gian Harahap, Daimah Wirdatus Sanaun Haris Munandar Nasution Hariyadi Dharmawan Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Henni Cintya Herviani Sari Iksen, Iksen Jansen Silalahi Jessi Octavia Aritonang Karo Sekali, Elva Swandi Kasta Gurning Khairunnisa, Lia Lubis, Minda Sari lubis, muhammad fauzan Lumban Gaol, Irma Yohana Mahatir Muhammad Muhammad Fauzan Lubis Muhammad Fauzan Lubis Nasri N Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri, Nasri Nasution, Irma Suryani Ningsih, Wulan Seppia Rahmi, Alfia Raissa Fitri Razoki, Razoki Ridwanto Ridwanto Sagala, Hasel Untung Bersinar Siagian, Roy Indrianto Bangar Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Anggie Patrisia Siregar, Nurhakiki Suci, Nurul Syahputra, Hariyadi Dharmawan Tania, Chyntia Glori Wahyudi Wahyudi Waruwu, Loice Desy Krisna Yanti Wijaya, Johanna Fransiska Yulia Citra Hasibuan Yuniarti, Rafita Yusmarlisa, Siti Ziza Putri Aisyia Fauzi Zulmai Rani