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All Journal Jurnal Gizi dan Pangan Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Nexus Biomedika Nexus Kedokteran Translasional Jurnal Media Gizi Indonesia (MGI) MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Jurnal Gizi dan Kesehatan Universa Medicina Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Ilmu Gizi Indonesia Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Indonesian Journal of Medicine Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings PROFESI (Profesional Islam): Media Publikasi Penelitian INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Prosiding University Research Colloquium The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Advanced Technology and Multidiscipline (JATM)

Brian Wasita

Fakultas Kedokteran, Universitas Sebelas Maret

Author-ID : 413227

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Elevated Growol Flour Reduce Fasting Blood Glucose, HOMA-IR and Increase Insulin Level in Rat Model with Type 2 Diabetes Mellitus Nofia, Yasinta; Wasita, Brian; Susilawati, Tri Nugraha
Media Gizi Indonesia Vol. 17 No. 2 (2022): JURNAL MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v17i2.151-158

The rise of glucose levels in the blood of patients with type-2 diabetes mellitus (T2DM) is attributed to the decrease of insulin secretion and the interruption of insulin activity. Growol is a fermented product made from cassava that has the potential to lower blood glucose levels in patients with T2DM. This study was aimed to evaluate the effects of oral administration of growol flour on the levels of blood glucose, insulin, and HOMA-IR. A total of 40 male Wistar rats were divided into 5 groups i.e., negative control group, positive control group taking metformin, and 3 treatment groups taking growol flour of 3.1, 6.2, and 9.3 (g/200gBW), respectively, for 2 weeks. Blood glucose levels were measured using Enzymatic Photometric Method GOD-PAP, insulin using the ELISA kit, and HOMA-IR using the formula. The Shapiro Wilk test was used to determine the normality of the data followed by the One-Way ANOVA test and Posthoc Tukey HSD test. The Paired T-test was used to see the difference of pre- and post-treatment levels of blood glucose, insulin, and HOMA-IR. There was a decrease (p<0.05) in blood glucose levels and HOMA-IR after the administration of low, moderate, and high doses of growol flour. In contrast, the levels of insulin increased (p<0.05) after the administration of low, moderate, and high doses. In conclusion, growol flour contributes to the maintenance of T2DM by lowering the levels of fasting blood glucose levels, as well as HOMA-IR, and increasing the levels of insulin in rats.

Pengaruh Fenol dan Saponin pada Madu Hutan Apis Dorsata dan molekul docking pada penanda preeklampsia yusari; Soetrisno; Prayitno, Adi; Wasita, Brian
Journal of Advanced Technology and Multidiscipline Vol. 3 No. 2 (2024): Journal of Advanced Technology and Multidiscipline
Publisher : Faculty of Advanced Technology and Multidiscipline Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jatm.v3i2.60655

Molecular docking is an important computational method for drug design. It can be used to predict receptor binding interactions with ligans. In addition, phenol-derived compounds and Saponins are also reported to have various activities such as anti-hypertensive, anti-inflammatory and anti-apoptosis agents. The purpose of this study is to predict whether the Phenol and Saponin compounds are active as anti-inflammatory agents and also to ensure that the binding interactions are stable before and after the docking calculations. The protocol is carried out in accordance with the standards set by the LPPT-UGM Testing Laboratory. The tools, programs, and applications used in this study were Lenovo IdeaPad Flex 5 Processor, AMD Ryzen 5000 Series 5, AutoDock Tools (v1.5.6), Biovia Discovery Studio, AutodockVina, Swiss ADME, VegaZZ, Pubchem, and the and the pkCSM web server (http://biosig.unimelb.edu.au/pkcsm/). Trans-ADFH three-dimensional structure, as a test compound, and Prednisolone, as a standard compound, were downloaded from https://pubchem.ncbi.nlm.nih.gov/. The phytochemical analysis of ADFH includes phenol and saponin. Structure of PlGF 3D (IRV6) and VEGF (4KZN). Identification of ligands and proteins prepared using Pubchem results of molecular docking between preeclampsia through examination of PlGF and VEGF with phenols and saponins Identification of protein ligands using Pubchem, i.e., PlGF (IRV6) with phenol produced 2 interactions and 2 amino acid residues, while saponins produced 2 interactions and 6 residues. pharmacokinetics and toxicity using Swiss ADME, i.e., phenol and saponins are non-mutagenic to bacteria; the maximum safe dose for humans is 0.54 log mg/kg/day; it does not cause toxicity to the heart; the estimated dose for animals is 2.471 mol/kg; it does not cause allergies; it does not cause liver damage; a dose of 0.288 logμ/L can inhibit the growth of 50% of the protozoa T. Pyformis. The content of phenols and saponins in Apis Dorsata forest honey has a high docking score from the original ligand. Molecular docking on phenols and saponins identified PlGF with scores of -2.85, -2.85, and -2.85 kcal/mol, while saponins have +2.84, +2.29, and +2.29 kcal/mol values, which are stated to be better results than the original ligands. This means that phenol has a role as a standard drug that can have an effect on lowering PlGF levels for people with preeclampsia. Molecular docking on VEGF identified phenol with scores of -2.88, -2.88, and -2.88 kcal/mol, and saponins have +1.36, +3.46, and +1.36 kcal/mol values, which are stated to have better results than the original ligands. This means that saponins have a role as a standard drug that can have an effect on increasing VEGF levels for people with preeclampsia.

The Effect of Combined Extracts of Sappan Wood (Caesalpinia sappan L.) and Gotu Kola (Centella asiatica L.) in Improving Diabetic Condition in Rats Binti Maulina; Wasita, Brian; Febrinasari, Ratih Puspita
Jurnal Gizi dan Pangan Vol. 17 No. 1 (2022)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

This study aimed to determine the efficacy of combination of sappan (secang) wood and gotu kola extracts in reducing insulin resistance and Malondialdehyde (MDA) levels in diabetic rats induced by Streptozotocin (STZ) 65 mg/kg Body Weight (BW) and Nicotinamide (NA) 230 mg/kg BW. Forty-two male Sprague Dawley rats weighing ±200 g were divided into 7 groups: 1) control, 2) glibenclamide 0.45 mg/kg BW, 3) sappan wood extract (CS) 250 mg/kg BW, 4) gotu kola extract (CA) 500 mg/kg BW, 5) 1st combination of extracts of sappan wood and gotu kola (CSCA1) 125 mg/kg BW + 750 mg/kg BW, 6) 2nd combination (CSCA2) with 250 mg/kg BW + 500 mg/kg BW, and 7) 3rd combination (CSCA3) with 375 mg/kg BW + 250 mg/kg BW. The insulin resistance levels were measured using the HOMA-IR index based on fasting blood glucose and insulin. The Thiobarbituric Acid Reactive Substance (TBARs) method was used to measure MDA levels. All measurements were taken before treatment, 14 days after treatment, and 21 days after treatment. The group receiving CSCA3 showed significant reduction in insulin resistance (-3.32±0.05) and MDA levels (-2.04±0.37 nmol/ml) on Day 21 after treatment. The CSCA3 treatment did not show statistically different result compared to glibenclamide treatment (p>0.05). Hence, CSCA3 treatment was considered as the best proportion of sappan wood and gotu kola extracts mixture and the result is comparable to glibenclamide. This study shows that the combination of sappan wood and gotu kola extracts has the potential to be developed as a functional drink for people with diabetes.

Effects of Moringa oleifera extract on inflammaging markers, muscle mass, and physical endurance in geriatric mice model Budiningsih, Fatichati; Purwanto, Bambang; Wasita, Brian; Poncorini, Eti
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2052

A comprehensive approach to managing frailty is required due to the increasing number of elderly. Physical frailty, associated with inflammatory processes and a loss of muscle mass, can significantly impair health status. The aim of this study was to determine the effect of Moringa oleifera Lam. leaf extract on frailty in geriatric mice model. An experimental study was conducted using a post-test-only control group design using Mus musculus Balb/C mice aged eight weeks. The animals were divided into five groups: negative control group received intraperitoneal injections of normal saline (0.5 cc/day) for eight weeks, positive control group received D-galactose (150 mg/kg body weight (BW)/day) only, and three treatment groups treated with 150 mg/kg of D-galactose intraperitoneally for eight weeks followed by 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW of M. oleifera leaf extract orally for five weeks. At the end of the study, the blood levels of malondialdehyde (MDA), transforming growth factor-beta (TGF-β) and caspase-3, as well as caspase-3 expression in skeletal muscle, skeletal muscle mass fibrosis, and physical endurance were measured. The results showed that a dose of 400 mg/kg/day of M. oleifera leaf extract had the most significant effect on lowering MDA, TGF-β, and caspase-3 expression in skeletal muscle tissue, skeletal muscle fibrosis, and improved physical endurance compared to other groups (p<0.001). This study highlights that M. oleifera leaf extract reduced frailty in geriatric mice model-induced using D-galactose by reducing inflammaging factors, thereby improving physical endurance.

Differences in Age Estimated by the Kvaal Method on Right and Left Mandibular Canines Kusumaningrum, Sulistyani; Wasita, Brian; Wujoso, Hari; Rahayu, Rachmi Fauziah; Hermansyah, Muhamad Lukman; Lawei, Tharina
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.495 KB)

Background: The radiographic method for determining the estimated age has the advantage of being non-invasive and the orthopantomogram images are digitally processed. Canines have a strong correlation with chronological age and have good resistance and large pulp space. This study aimed to determine the difference in age estimates using the Kvaal method on the right and left mandibular canines.Subjects and Method: There were 80 orthopantomogram samples from dental and oral clinic patients who had undergone orthopantomography at the Radiology Installation of Dr. Moewardi Hospital, from January 2019 to December 2020. The estimated age of right and left canines was calculated based on the Kvaal method and performed a T-test.Results: At the estimated age of the right and left mandibular canines determined by the Kvaal formula, the T-test was performed showing a mean of 38.3 years for the right mandibular canine (Mean= 38.3; SD= 6.7) and 38.2 year the left mandibular canine (Mean= 38.2; SD= 8.9), with p = 0.910. Data analysis showed that there was no difference in age estimation using the Kvaal method on the right and left mandibular canines.Conclusion: There was no difference in age estimates by the Kvaal method on the right and left mandibular canines.Keywords: Oratopantomogram, Metoday Qual, Kaninus MandibulaCorrespondence: Sulistyani Kusumaningrum. Department of Radiology Dr. Moewardi Hospital / Faculty of Medicine Universitas Sebelas Maret, Surakarta. Email: kusumasulis1@gmail.com.Indonesian Journal of Medicine (2021), 06(02): 206-211https://doi.org/10.26911/theijmed.2021.06.02.09

A 57-year-old woman with chronic hepatitis B and left hepatic nodularity unmasking intrahepatic hilar adenocarcinoma: A diagnostic case report Pramana, Triyanta Yuli; Gunawan, Timotheus A.; Prasetyo, Didik; Darmayani, Aritantri; Jati, Agus; Wasita, Brian
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art16

Metastatic breast cancer involving the biliary tract is a rare case with an incidence rate of 1.49 per 100.000 persons. Chronic hepatitis B virus (HBV) infection is associated with tumor development and migration and promotes metastasis. While hepatocellular carcinoma is the most common primary liver cancer, cholangiocarcinoma is a rarer malignancy originating from epithelial cells in various parts of the bile ducts. Intraluminal adenocarcinoma of the common hepatic duct (CHD) is an exceptionally uncommon hepatic tumor. We reported that a 57-year-old female has been complaining of abdominal pain on the upper right side for 1 year, accompanied by nausea and icterus. The patient had a history of breast cancer in 1995 and chronic hepatitis B for 20 years on Tenovofir 1x300 mg. No abnormalities were found on physical examination. However, Magnetic Resonance Cholangiopancreatography (MRCP) revealed bilateral dilatation of the intrahepatic bile duct (IHBD), common hepatic duct (CHD), ductus cysticus, and common bile duct (CBD) distal to proximal, suggesting an intraluminal mass likely due to a tumor. A plastic stent was then placed, which reduced the lesion size. Immunohistochemistry (IHC) test confirmed adenocarcinoma, in which CK-7 and mammaglobin were positive, indicating metastatic breast cancer.. A thoracic MSCT revealed multiple lytic lesions in the T1, T7, T9–T12, and L2–L3 vertebral bodies. The patient was diagnosed with intraluminal adenocarcinoma of the CHD, representing metastatic Stage I triple-negative breast cancer with biliary, pulmonary, and osseous involvement, along with chronic hepatitis B. The chemotherapy regimen included carboplatin 370 mg and paclitaxel 260 mg, continued with Taceral 500 mg 2x3 in two weeks and Zometa every 6 weeks. Post-chemotherapy MRCP evaluation showed a solid intraluminal liver lobe lesion with partial obstruction. Metastatic adenocarcinoma of the CHD caused by breast cancer is a highly unusual clinical problem. In such cases, IHC plays a vital role in identifying the primary tumor site.

Clinical Manifestations and Behavior Changes in Rats Treated with Jamaican Cherries Extract (Muntingia calabura) Afdhaliya, Noor Khalwati; Indarto, Dono; Wasita, Brian
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Iron deficiency anemia (IDA) in female adolescents is one of the health problems, which occupied 8th position as a cause of global disability and is the main cause of anemia in reproductive women. Iron tablet supplementation is the government program to reduce IDA prevalence in Indonesia but often results in gastrointestinal side effects. Jamaican cherries fruits contain vitamin C, iron and flavonoids, which play essential roles in iron metabolism. This study aimed to investigate the effects of Jamaican cherries fruits ethanol extract on clinical manifestations and behavior changes in female Wistar rats. This randomized controlled trial with pre-posttest control group design used 24 female Wistar rats, aged 10 -12 weeks and were randomly divided into 6 groups: N, positive control (PC: AIN-93M low iron food + elemental iron) and treatments (T1-4: AIN-93M low iron food + 0.26, 0.35, 0,5 or 0.75g/ 100g Body Weight (BW) Jamaican cherries fruits extract respectively for 28 days). Clinical manifestations, reflexes and behavior changes were observed at day 0, 14 and 28 interventions. BW data were analyzed using one way ANOVA and repeated measures ANOVA tests. All rats had normal reflexes and did not show clinical manifestations and behavior changes. The average of rat BW in T1-4 groups did not significantly differ before (p=0.896), during (p=0.884) and after treatment (p=0.775) but the average of rat BW in the T1 group increased significantly (p=0.012). In conclusion, administering Jamaican cherries fruits ethanol extracts up to 0.75g/100g BW has no toxic effects in female Wistar rats. Abstrak: Anemia defisiensi besi (ADB) pada remaja putri merupakan salah satu masalah kesehatan yang menempati posisi ke-8 sebagai penyebab disabilitas tingkat global dan penyebab utama anemia pada ibu hamil. Suplementasi tablet besi merupakan program pemerintah untuk mengurangi prevalensi ADB di Indonesia tetapi sering menimbulkan efek samping di saluran percernaan. Buah kersen mengandung vitamin C, zat besi dan flavonoids yang berperan penting dalam metabolisme besi. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak buah kersen terhadap manifestasi klinis dan perubahan perilaku tikus Wistar betina. Penelitian randomized controlled trial ini dengan pre-posttest control group design dengan menggunakan 24 ekor tikus Wistar betina umur 10 -12 minggu dan dibagi secara acak menjadi 6 kelompok: normal, kontrol posistif (KP) dan perlakuan (P1-4). Tikus di KP diberi pakan AIN-93M dengan besi rendah + besi elemental sedangkan P1-4 diberi pakan yang sama ditambah 0.26, 0.35g, 0,5g atau 0.75g/100g berat badan (BB) secara berturut-turut ekstrak buah kersen selama 28 hari. Manifestasi klinis, reflek dan perubahan perilaku tikus diamati pada hari ke-0, 14 dan 28. Data BB dianalisis menggunakan uji one way ANOVA dan uji repeated measures ANOVA. Semua tikus memiliki reflek yang normal dan tidak menunjukkan manifestasi klinis dan perubahan perilaku. Rerata BB tikus pada P1-4 tidak berbeda signifikan sebelum (p=0,896), selama (p=0,884), maupun setelah perlakuan (p=0,775) tetapi rerata BB tikus P1 meningkat secara signifikan (p=0,012). Kesimpulan, pemberian ekstrak buah kersen hingga 0,75g/100g BB tidak menyebabkan toksisistas tikus Wistar betina.

Effects of Ambon Banana Juice on Glucose Levels and Lipid Profile in Diabetic Rats Herviana, Herviana; Indarto, Dono; Wasita, Brian
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Consumption of fruit juice is an alternative for diabetic patients who cannot consume fresh. Banana is one of the recommended fruits for diabetic patients because it has flavonoid content. This study aims to evaluate the effect of Ambon banana juice on fasting blood glucose (FBG), triglycerides, and total cholesterol levels in diabetic Wistar rats. The type of research is an experimental laboratory study with a pre-posttest design. The research sample was 21 male Wistar rats divided into 3 groups, T1 (control), T2 (10% fructose), and T3 (4 ml of Ambon banana juice) which were administered for 21 days. The FBG, triglycerides, and total cholesterol levels were examined using the colourimetric enzymatic method. The data were analyzed using one-way ANOVA, and post hoc tests. Ambon banana juice can improve FBG levels compared to control (p less than 0.01). Ambon banana juice can increase triglyceride levels but is significantly different from T2 (p less than 0.01). Ambon banana juice did not significantly increase total cholesterol levels compared to T2 (p less than 0.01). In conclusion, Ambon banana juice was demonstrated to decrease FBG and did not increase triglyceride and total cholesterol levels.Konsumsi jus buah merupakan alternatif bagi penderita diabetes yang tidak dapat mengkonsumsi buah segar. Pisang termasuk jenis buah yang direkomendasikan penderita diabetes, karena memiliki senyawa flavonoid. Tujuan penelitian ini untuk mengevaluasi efek jus pisang Ambon terhadap glukosa darah puasa (GDP), kadar trigliserida dan kolesterol total pada tikus diabetes. Jenis penelitian yaitu eksperimental laboratorik dengan desain pre-post test. Sampel penelitian berjumlah 21 ekor wistar jantan yang dibagi dalam 3 kelompok, T1 (kontrol), T2 (10% fruktosa), dan T3 (4ml jus pisang Ambon) yang diberikan selama 21 hari. Kadar GDP, trigliserida dan kolesterol total diukur menggunakan metode kolorimetri enzimatik. Data dianalisis menggunakan one-way ANOVA dan tes post hoc. Jus pisang ambon dapat membantu menurunkan kadar GDP dibanding kontrol (p kurang dari 0,01). Jus pisang Ambon dapat meningkatkan kadar trigliserida tetapi signifikan berbeda dibanding T2 (p kurang dari 0,01). Jus pisang ambon tidak signifikan meningkatkan kadar kolesterol total dibanding T2 (p kurang dari 0,01). Oleh karena itu, jus pisang ambon dapat membantu menurunkan kadar GDP dan tidak meningkatkan kadar trigliserida dan kolesterol total.

Propolis effectiveness on the reduction of blood glucose level and improvement of body weight in diabetic model's rat Meida, Nur Shani; Purwanto, Bambang; Wasita, Brian; Indrakila, Senyum; Soetrisno, Soetrisno
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.18617

Propolis is an herbal medicinal plant that contains caffeic acid phenethyl ester. This natural polyphenol compound acts as an antioxidant and can reduce blood glucose levels and increase body weight. This study aims to determine the effectiveness of Gunung Lawu propolis in lowering blood glucose levels and increasing body weight in diabetic rats. The Wistar rats were induced with STZ 45 mg/kg BW and nicotinamide 110 mg/kg BW as diabetic model rats. Research subjects were taken randomly and divided into five groups: (1) Normal, (2) DM with no propolis, (3) DM 14 days + propolis 100 mg/kg BW/day (P1), (4) DM 14 days + Propolis 200 mg/kg BW/day (P2), and (5) DM 0 day + Propolis 200 mg/kg BW/day (P3). Propolis extract was given orally once a day for 14 consecutive days (in groups 3 and 4) and 28 consecutive days (in group 5). Blood glucose levels in the treatment group (P1, P2, and P3) decreased significantly (P1: 115.28 ± 4.7 mg/dL; P2: 98.36 ± 4.8 mg/dL; and P3: 87.36 ± 4, 2 mg/dL) compared with that in the DM group (272.07 ± 3.9 mg/dL). The body weight of the treatment group (P1, P2, and P3) increased significantly (P1: 180.60 ± 5.7 g; P2: 180.60 ± 4.2 g; and P3: 208.00 ± 5.1 gr) compared with that in the DM group (160.00 ± 3.2 gr). In conclusion, Propolis is effective in reducing blood glucose levels and improving (increasing) body weight in diabetic model rats.

Pengaruh Penyimpanan Nasi Gelatinsasi Terhadap Berat Badan dan Asam Propianat Pada Obesitas Harsono, Tri; Indarto, Dono; Wasita, Brian
Prosiding University Research Colloquium Proceeding of The 11th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Latar Belakang. Obesitas merupakan masalah baik di negara maju maupun negara berkembang dan selalu meningkat prevalensinya setiap tahun. Dampak obesitas berkaitan erat dengan penyakit metabolisme dan kardiovaskuler. Nasi gelatinisasi yang disimpan panas dan dingin menyebabkan retrogradasi dan oksidasi karbohidrat sehingga dapat meningkatkan jumlah pati resisten dan menurunkan IG (Indeks Glikemik) serta terbentuknya asam lemak rantai pendek (asetat, propianat, butirat). Pati resisten berperan dalam menurunkan kadar glukosa darah, sedangkan asam propianat berperan dalam sekresi hormon glucagon, GLP-1 dan PYY sehingga menekan nafsu makan dan menurunkan berat badan. Tujuan. Menganalisis pengaruh metode dan lama penyimpanan nasi gelatinisasi terhadap berat badan dan asam propianat pada obesitas. Metode. Desain penelitian adalah eksperimental pre-post controlled grup design dengan 65 responden obesitas dibagi dalam 5 kelompok perlakuan secara acak (Kontrol, P1, P2, P3, dan P4). Instrumen penelitian pengukuran komposisi tubuh dengan BIA (Biompedence Analysis) pre-post test, kadar asam propianat dengan VPA-GCMS (Volatil Fatty Acid - Gas Cromatography Mass Spectrometry) post test, dan food recall. Analisa statistik dengan Saphiro Wilk dan Paired t test atau Wilcoxon. Hasil. Metode dan lama penyimpanan nasi gelatinisasi berbeda nyata terhadap berat badan (p = 0,007 < 0,05) pada penyimpanan dingin 4 0C selama 48 jam (P4), sedangkan kadar asam propianat signifikan pada perlakuan (P4) yaitu (p = 0,000 < 0,05) sebanyak 0,26 mMol. Kesimpulan. Nasi gelatinisasi yang disimpan dingin pada suhu 4 0C (refrigerator) selama 48 jam dapat menurunkan berat badan dan meningkatkan asam propianat.

Co-Authors Adi Magna, Adi Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Amarduan, Tince Bety Amilia Yuni Damayanti Ana Rima Ari Probandari Asrial, An A. Bambang Purwanto Binti Maulina Budiningsih, Fatichati Budiyanti Wiboworini Cindikya Saftiari Dewi Cr. Siti Utari Cr. SitiUtari Darmayani, Aritantri David Perdana Dentiko Wasis Aulia Dewi Okta Anggraini Diana Nurrohima Didik Prasetyo Diffah Hanim Dono Indarto Dyonisa Nasirochmi Pakha Eka Puspita Sari Ellistasari, Endra Yustin ernawati, ammik Eti Poncorini Pamungkasari Fadila, F Fakurazi, Shariza Gardjito, Fajar Baskoro Gunawan, Timotheus A. Hari Wujoso Harsono Salimo Hermansyah, Muhamad Lukman Herviana, Herviana Ida Nurwati Idulhaq, Mujaddid Irma Suryani Jati, Agus Kariosentono, ⁠⁠Harijono Kusumaningrum, Sulistyani Laqif, Abdurrahman LAWEI, THARINA Marintan, Elita Muchamad Syamsulhadi, Muchamad Muhammad Riza Mulianto, ⁠Nurrachmat Muthmainah Muthmainah Muthmainah Nanang Wiyono Nofia, Yasinta Novan Adi Setyawan Nur Shani Meida Nursulistyo, Fajar Paramasari Dirgahayu Paulus Kusnanto Pesik, Riza N. Poncorini, Eti Primisawitri, Pratiwi Prasetya Pudjiastuti, Anggit puguh santoso, puguh Rachmi Fauziah Rahayu Rahayu, Rachmi F. Rahmah Rahmah Ratih Puspita Febrinasari Reviono Reviono Risya Cilmiaty, Risya Riza Deviana Riza Novierta Pesik Rizma, Amalina Sabariyah, Lely Santi, Nur Saputra, Rhyan Darma Senyum Indrakila Setianto, Budi Y. Soestrisno, Soestrisno Soetrisno Soetrisno Soetrisno Suyatmi Suyatmi Tamaulina Br Sembiring Taufiqurrahman, Surya Tedjo Danudjo Tonang Dwi Ardyanto Tri Harsono Tri Nugraha Susilawati Triyanta Yuli Pramana Umi Mahmudah Vitri Widyaningsih Wardhani, Lusi O. Wayanshakty, Janur Widhiati, Suci Wulandari, Eka T. Wulansari, Indry Yarsa, Kristanto Y. Yudhani, Ratih D. Yudhani, Ratih Dewi Yudhistira, Muhammad Yurizar Yundari, Yundari yusari Yusup Subagio Yusup Subagio Sutanto Zahidah, Fairuz Zaidah, Lailatuz

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