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All Journal Jurnal Gizi dan Pangan Jurnal Media Gizi Indonesia (MGI) MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Universa Medicina Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Ilmu Gizi Indonesia Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Indonesian Journal of Medicine Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings PROFESI (Profesional Islam): Media Publikasi Penelitian Narra J Journal of Multidisciplinary Applied Natural Science JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Prosiding University Research Colloquium The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Advanced Technology and Multidiscipline (JATM)
Brian Wasita
Fakultas Kedokteran, Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Effects of Ambon Banana Juice on Glucose Levels and Lipid Profile in Diabetic Rats Herviana, Herviana; Indarto, Dono; Wasita, Brian
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1192.219 KB) | DOI: 10.30604/jika.v7i1.844

Abstract

Consumption of fruit juice is an alternative for diabetic patients who cannot consume fresh. Banana is one of the recommended fruits for diabetic patients because it has flavonoid content. This study aims to evaluate the effect of Ambon banana juice on fasting blood glucose (FBG), triglycerides, and total cholesterol levels in diabetic Wistar rats. The type of research is an experimental laboratory study with a pre-posttest design. The research sample was 21 male Wistar rats divided into 3 groups, T1 (control), T2 (10% fructose), and T3 (4 ml of Ambon banana juice) which were administered for 21 days. The FBG, triglycerides, and total cholesterol levels were examined using the colourimetric enzymatic method. The data were analyzed using one-way ANOVA, and post hoc tests. Ambon banana juice can improve FBG levels compared to control (p less than 0.01). Ambon banana juice can increase triglyceride levels but is significantly different from T2 (p less than 0.01). Ambon banana juice did not significantly increase total cholesterol levels compared to T2 (p less than 0.01). In conclusion, Ambon banana juice was demonstrated to decrease FBG and did not increase triglyceride and total cholesterol levels.Konsumsi jus buah merupakan alternatif bagi penderita diabetes yang tidak dapat mengkonsumsi buah segar. Pisang termasuk jenis buah yang direkomendasikan penderita diabetes, karena memiliki senyawa flavonoid. Tujuan penelitian ini untuk mengevaluasi efek jus pisang Ambon terhadap glukosa darah puasa (GDP), kadar trigliserida dan kolesterol total pada tikus diabetes. Jenis penelitian yaitu eksperimental laboratorik dengan desain pre-post test. Sampel penelitian berjumlah 21 ekor wistar jantan yang dibagi dalam 3 kelompok, T1 (kontrol), T2 (10% fruktosa), dan T3 (4ml jus pisang Ambon) yang diberikan selama 21 hari. Kadar GDP, trigliserida dan kolesterol total diukur menggunakan metode kolorimetri enzimatik. Data dianalisis menggunakan one-way ANOVA dan tes post hoc. Jus pisang ambon dapat membantu menurunkan kadar GDP dibanding kontrol (p kurang dari 0,01). Jus pisang Ambon dapat meningkatkan kadar trigliserida tetapi signifikan berbeda dibanding T2 (p kurang dari 0,01). Jus pisang ambon tidak signifikan meningkatkan kadar kolesterol total dibanding T2 (p kurang dari 0,01). Oleh karena itu, jus pisang ambon dapat membantu menurunkan kadar GDP dan tidak meningkatkan kadar trigliserida dan kolesterol total.
Propolis effectiveness on the reduction of blood glucose level and improvement of body weight in diabetic model's rat Meida, Nur Shani; Purwanto, Bambang; Wasita, Brian; Indrakila, Senyum; Soetrisno, Soetrisno
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.18617

Abstract

Propolis is an herbal medicinal plant that contains caffeic acid phenethyl ester. This natural polyphenol compound acts as an antioxidant and can reduce blood glucose levels and increase body weight. This study aims to determine the effectiveness of Gunung Lawu propolis in lowering blood glucose levels and increasing body weight in diabetic rats. The Wistar rats were induced with STZ 45 mg/kg BW and nicotinamide 110 mg/kg BW as diabetic model rats. Research subjects were taken randomly and divided into five groups: (1) Normal, (2) DM with no propolis, (3) DM 14 days + propolis 100 mg/kg BW/day (P1), (4) DM 14 days + Propolis 200 mg/kg BW/day (P2), and (5) DM 0 day + Propolis 200 mg/kg BW/day (P3). Propolis extract was given orally once a day for 14 consecutive days (in groups 3 and 4) and 28 consecutive days (in group 5). Blood glucose levels in the treatment group (P1, P2, and P3) decreased significantly (P1: 115.28 ± 4.7 mg/dL; P2: 98.36 ± 4.8 mg/dL; and P3: 87.36 ± 4, 2 mg/dL) compared with that in the DM group (272.07 ± 3.9 mg/dL). The body weight of the treatment group (P1, P2, and P3) increased significantly (P1: 180.60 ± 5.7 g; P2: 180.60 ± 4.2 g; and P3: 208.00 ± 5.1 gr) compared with that in the DM group (160.00 ± 3.2 gr). In conclusion, Propolis is effective in reducing blood glucose levels and improving (increasing) body weight in diabetic model rats.
Pengaruh Penyimpanan Nasi Gelatinsasi Terhadap Berat Badan dan Asam Propianat Pada Obesitas Harsono, Tri; Indarto, Dono; Wasita, Brian
Prosiding University Research Colloquium Proceeding of The 11th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang. Obesitas merupakan masalah baik di negara maju maupun negara berkembang dan selalu meningkat prevalensinya setiap tahun. Dampak obesitas berkaitan erat dengan penyakit metabolisme dan kardiovaskuler. Nasi gelatinisasi yang disimpan panas dan dingin menyebabkan retrogradasi dan oksidasi karbohidrat sehingga dapat meningkatkan jumlah pati resisten dan menurunkan IG (Indeks Glikemik) serta terbentuknya asam lemak rantai pendek (asetat, propianat, butirat). Pati resisten berperan dalam menurunkan kadar glukosa darah, sedangkan asam propianat berperan dalam sekresi hormon glucagon, GLP-1 dan PYY sehingga menekan nafsu makan dan menurunkan berat badan. Tujuan. Menganalisis pengaruh metode dan lama penyimpanan nasi gelatinisasi terhadap berat badan dan asam propianat pada obesitas. Metode. Desain penelitian adalah eksperimental pre-post controlled grup design dengan 65 responden obesitas dibagi dalam 5 kelompok perlakuan secara acak (Kontrol, P1, P2, P3, dan P4). Instrumen penelitian pengukuran komposisi tubuh dengan BIA (Biompedence Analysis) pre-post test, kadar asam propianat dengan VPA-GCMS (Volatil Fatty Acid - Gas Cromatography Mass Spectrometry) post test, dan food recall. Analisa statistik dengan Saphiro Wilk dan Paired t test atau Wilcoxon. Hasil. Metode dan lama penyimpanan nasi gelatinisasi berbeda nyata terhadap berat badan (p = 0,007 < 0,05) pada penyimpanan dingin 4 0C selama 48 jam (P4), sedangkan kadar asam propianat signifikan pada perlakuan (P4) yaitu (p = 0,000 < 0,05) sebanyak 0,26 mMol. Kesimpulan. Nasi gelatinisasi yang disimpan dingin pada suhu 4 0C (refrigerator) selama 48 jam dapat menurunkan berat badan dan meningkatkan asam propianat.
Potential of avocado oil (Persea americana) in improving triglyceride and High Density Lipoprotein (HDL) levels in rats (Rattus novergicus) model of dyslipidaemia due to high fat diet Sari, Eka Puspita; Wasita, Brian; Muthmainah, Muthmainah
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 4, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(4).296-305

Abstract

Background: Elevated levels of Dyslipidaemia pose a significant threat to cardiovascular health. Fortunately, the abundance of polyunsaturated and monounsaturated fatty acids (PUFA and MUFA) present in avocado oil offers a promising avenue for individuals with Dyslipidaemia to improve their lipid profile levels.Objectives: The objective of this research is to ascertain the potential of avocado oil in improving triglyceride and HDL levels.Methods: A pre-post test control group design was employed, utilizing male Wistar rats aged 8 weeks with a body weight ranging from 150-200 g. The mice were segregated into six groups: N, K-, K+, P1, P2, and P3. Throughout the trial, solely group N abstained from ingesting avocado oil or HC. Conversely, all other groups were administered HC and subsequently, K+ was prescribed simvastatin while P1, P2 and P3 received avocado oil for a duration of 28 days. The data was subjected to statistical analysis using SPSS vr.25. The statistical significance threshold was set at p<0.05.Results: Mean changes in levels (mg/dL) for TG -29.67 (P1), -48.99 (P2), -56.78 (P3) and for HDL 41.75 (P1), 46.35 (P2). There was a significant difference in TG and HDL levels between P1, P2, P3 when compared with K- (p<0.05).Conclusion: Avocado oil exhibits efficacy in lowering TG levels and elevating HDL levels, rendering it a viable option for daily consumption.
Modulation of AR-FGF-2-TGF beta Axis by Cosmos caudatus Suppresses Prostatic Epithelial Proliferation in a BPH Rat Model: A Comparative Study with Finasteride Sahara, Nita; Mudigdo, Ambar; Wasita, Brian; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Cilmiaty, Risya
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.370

Abstract

Benign prostatic hyperplasia (BPH) progression is critically influenced by the androgen receptor (AR), Fibroblast growth factor-2 (FGF-2), and transforming growth factor-β (TGF-β) signaling axis. Although finasteride (FIN) is the standard therapeutic agent, its use is limited by adverse effects. This study evaluated the efficacy of Cosmos caudatus (CC) extract, administered alone or in combination with FIN, in modulating the AR–FGF-2–TGF-β axis in a testosterone-induced BPH rat model. Rats were divided into five groups (n = 6): Normal (N), BPH control (KN), FIN (KP; 0.44 mg/kg), CC extract (P1; 250 mg/kg), and combination (P2; CC 250 mg/kg + FIN 0.44 mg/kg). Prostatic AR, FGF-2, and TGF-β expression was analyzed using immunohistochemistry (IHC) with H-score quantification. Both KP and P1 significantly reduced AR (KP: 112 ± 15; P1: 105 ± 12 vs KN: 195 ± 18, p < 0.05) and FGF-2 (KP: 98 ± 14; P1: 92 ± 11 vs KN: 180 ± 20, p < 0.05), approaching normal values (AR N: 90 ± 10; FGF-2 N: 85 ± 9). In contrast, combination therapy (P2) failed to suppress AR (188 ± 17, p = 0.936) and FGF-2 (175 ± 19, p = 0.870) and induced a significant increase in TGF-β (P2: 145 ± 16 vs KN: 110 ± 12, p < 0.05). All treatment groups showed reduced epithelial thickness and prostate index (p < 0.05). These findings indicate that CC extract alone exerts therapeutic effects comparable to FIN by modulating the AR–FGF-2 axis, whereas combining it with FIN disrupts pathway regulation and promotes a pro-fibrotic response. The study supports the potential of CC extract as an effective alternative for BPH management without pharmacologic complications.
Vitamin D and Magnesium Combination Lowers High-Sensitivity C-Reactive Protein, Interleukin-12, Renin, and Carotid Vessel in Diabetic Rats Rahayu, Rachmi Fauziah; Zahrah, Fathimah Afifah; Anugrah, Tessa Septian; Yudhani, Ratih Dewi; Yueniwati, Yuyun; Irawan, Amelia Tjandra; Kusumaningrum, Sulistyani; Fauzi, Adam; Wasita, Brian; Wiyono, Nanang; Muthaminah, Muthaminah; Sholikah, Tri Agusti; Wardhani, Lusi Oka; Suyatmi, Suyatmi; Yarso, Kristanto Yuli; Pesik, Riza Novierta; Siswanto, Febby Gunawan
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4061

Abstract

BACKGROUND: Diabetes mellitus induces oxidative stress, inflammation, and endothelial dysfunction, accelerating atherosclerosis development marked by elevated high-sensitivity C-reactive protein (hs-CRP) and interleukin-12 (IL-12). Diabetes often causes significant vascular changes, which can be represented by carotid tunica intima thickening and elevated renin level. Metformin, which remains as the standard therapy, has limited vascular effects. Vitamin D and magnesium exhibit vasoprotective and anti-inflammatory properties; however, their combined effects on diabetic vascular injury remain unclear. This study evaluated the effects of vitamin D and magnesium combination on serum hs-CRP, IL-12, renin, and carotid tunica intima thickness in diabetic rats.METHODS: Wistar rats were diabetic-induced by 45 mg/kg streptozotocin and 110 mg/kg nicotinamide. Following the induction, the rats were subsequently assigned to receive no treatment, metformin, or a combination of vitamin D and magnesium. Healthy rats were also included as control. Blood sample was collected after 21 days of treatment. Serum hs-CRP, IL-12, and renin were measured using enzyme-linked immunosorbent assay (ELISA), while the carotid tunica intima thickness was assessed by Doppler ultrasound.RESULTS: Diabetic rats showed significant increases hs-CRP, IL-12, renin level, and intima thickness (p<0.001) compared to control. Both metformin and combination of Vitamin D and magnesium reduced these parameters, with combination of Vitamin D and magnesium showing the greatest improvement. Carotid intima thickness in the combination of Vitamin D and magnesium group was comparable to normal controls, indicating marked vascular protection.CONCLUSION: Vitamin D and magnesium combination provided superior glycemic, anti-inflammatory, and vascular protective effects compared to metformin alone. This adjunctive strategy might have potential in preventing vascular complications in diabetes.KEYWORDS: diabetes mellitus, oxidative stress, endothelial dysfunction, hs-CRP, IL-12, atherosclerosis
Mahkota Dewa (Phaleria macrocarpa) Fruit Extract Decrease Malondialdehyde, Tumor Necrosis Factor-α, and Caspase 3 Levels May Improve Infertility in Endometriosis Mice Brahmana, Ivanna Beru; Soetrisno, Soetrisno; Purwanto, Bambang; Pamungkasari, Eti Poncorini; Wasita, Brian; Budihastuti, Uki Retno; Pangestu, Mulyoto; Cempaka, Rita; Lestariningsih, Sri; Wulandari, Eka Tri; Maesaroh, Siti
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.2736

Abstract

BACKGROUND: Endometriosis, which often causes infertility, is characterized by a complex interplay between oxidative stress, inflammatory response, and apoptosis. Currently, the most effective therapy used for endometriosis is hormonal treatments, however it has many common side effects. Therefore, it is necessary to explore alternative treatments for endometriosis, including herbal ingredients. Phaleria macrocarpa fruit contains flavonoids with strong antioxidant and anti-inflammatory properties which have potency to improve fertility in endometriosis cases. However, assessments of whether P. macrocarpa might have any effect on oxidative stress, inflammatory response, and apoptosis in relation to endometriosis are still limited. This study was conducted to identify the effect of P. macrocarpa fruit ethanol extract (PMFEE) in improving infertility by assessing oxidative stress, inflammatory response, and apoptosis parameters in endometriosis mice model.METHODS: Female Balb/C mice were endometriosis-induced, and treated either with 6.5 µg/day Letrozole, 7.5 mg/kgBW/day PMFEE, or 15 mg/kgBW/day PMFEE for 14 days. Heatlhy mice were also included as control. Mice were necropsied, then the uterus and fat tissue around the uterus was collected. Malondialdehyde (MDA) as oxidative stress marker, tumor necrosis factor (TNF)-α as inflammatory marker, and Caspase-3 as apoptosis marker were assessed using enzyme-linked immunosorbent assay (ELISA).RESULTS: In uterus, MDA and TNF-α levels were significantly different among all groups (p<0.05). PMFEE both at 7.5 and 15 mg/kgBW/day lowered MDA and TNF-α compared to the healthy mice and mice receiving Letrozol. Meanwhile, Caspase-3 levels were quite indifferent among groups, showing that PMFEE was able to maintain the Caspase-3 levels in the endometriosis-induced mice.CONCLUSION: PMFEE reduces the MDA and TNF-α, also maintains Caspase-3 levels in the uterus of endometriosis-induced mice, suggesting it might have potential to improve fertility in endometriosis mice.KEYWORDS: Phaleria macrocarpa, endometriosis, infertility, MDA, TNF-α, Caspase-3
Co-Authors Adam Fauzi Adi Magna, Adi Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Amarduan, Tince Bety Ambar Mudigdo Amilia Yuni Damayanti Ana Rima Anugrah, Tessa Septian Asrial, An A. Bambang Purwanto Binti Maulina Brahmana, Ivanna Beru Budiningsih, Fatichati Budiyanti Wiboworini Cindikya Saftiari Dewi Cr. Siti Utari Cr. SitiUtari Darmayani, Aritantri David Perdana Dentiko Wasis Aulia Dewi Okta Anggraini Didik Prasetyo Diffah Hanim Dono Indarto Eka Puspita Sari Eka Tri Wulandari, Eka Tri ernawati, ammik Eti Poncorini Pamungkasari Fadila, F Gardjito, Fajar Baskoro Gunawan, Timotheus A. Hari Wujoso Harsono Salimo Hermansyah, Muhamad Lukman Herviana, Herviana Ida Nurwati Idulhaq, Mujaddid Irawan, Amelia Tjandra Jati, Agus Kusumaningrum, Sulistyani Laqif, Abdurrahman LAWEI, THARINA Marintan, Elita Muhammad Riza MULYOTO PANGESTU Muthaminah, Muthaminah Muthmainah Muthmainah Muthmainah Nanang Wiyono Nofia, Yasinta Nur Shani Meida Nursulistyo, Fajar Paramasari Dirgahayu Paulus Kusnanto Pesik, Riza N. Poncorini, Eti Pudjiastuti, Anggit Rachmi Fauziah Rahayu Rahayu, Rachmi F. Rahmah Rahmah Ratih Dewi Yudhani Ratih Puspita Febrinasari Reviono Reviono Risya Cilmiaty, Risya Rita Cempaka Riza Deviana Riza Novierta Pesik Sabariyah, Lely Sahara, Nita Santi, Nur Saputra, Rhyan Darma Senyum Indrakila Setianto, Budi Y. Sholikah, Tri Agusti Siswanto, Febby Gunawan Siti Maesaroh Soestrisno, Soestrisno Soetrisno Soetrisno Soetrisno Sri Lestariningsih Suyatmi Suyatmi Tamaulina Br Sembiring Taufiqurrahman, Surya Tedjo Danudjo Tonang Dwi Ardyanto Tri Harsono Tri Nugraha Susilawati Triyanta Yuli Pramana Uki Retno Budihastuti Umi Mahmudah Vitri Widyaningsih Wardhani, Lusi O. Wardhani, Lusi Oka Wayanshakty, Janur Wulandari, Eka T. Wulansari, Indry Yarsa, Kristanto Y. Yarso, Kristanto Yuli Yudhani, Ratih D. Yundari, Yundari yusari Yusup Subagio Yusup Subagio Sutanto Yuyun Yueniwati Zahidah, Fairuz Zahrah, Fathimah Afifah Zaidah, Lailatuz