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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan CHEMPUBLISH JOURNAL The Indonesian Biomedical Journal Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kartika Kimia Jambura Journal of Chemistry JFIOnline Jurnal Jamu Indonesia Majalah Farmasetika Jurnal Riset Kefarmasian Indonesia Journal of Community Development Indonesian Journal of Biological Pharmacy Jurnal Kesehatan JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL Jurnal Farmasi Indonesia Jurnal Ilmu Kesehatan dan Gizi Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Indonesian Journal of Jamu
Yasmiwar Susilawati
Fakultas Farmasi, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : HAYATI Journal of Biosciences

 1 
Exploring the α-Amylase Inhibitory Potential of Peronema canescens Jack: An In Vitro and In Silico Study Rahardhian, Muhammad Ryan Radix; Aryanti, Ninda; Susilawati, Yasmiwar; Sumiwi, Sri Adi; Putri, Chintiana Nindya; Ramonah, Dewi; Suharsanti, Ririn
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.712-726

Abstract

Hyperglycemia in individuals with type 2 diabetes mellitus is primarily driven by the rapid hydrolysis of starch by the enzyme α-amylase in the pancreas and the breakdown of oligosaccharides by α-glucosidase in the intestine. Peronema canescens Jack. (PC) has shown promise as a potential antidiabetic agent. This study aimed to evaluate the total flavonoid, phenolic, and α-amylase inhibitory activity of extracts and fractions derived from PC leaves using both in vitro and in silico approaches. The ethanol extract of PC leaves was fractionated through liquid-liquid extraction using n-hexane, ethyl acetate, and water as solvents. Preliminary phytochemical screening of the extracts and fractions identified the presence of alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The n-hexane fraction exhibited the highest total flavonoid content, averaging 203.37±4.38 mg QE/gram, while the ethyl acetate fraction demonstrated the highest total phenolic content, averaging 147.04±0.79 mg GAE/gram. Furthermore, the ethyl acetate fraction showed the strongest α-amylase inhibitory activity, with an average inhibition rate of 70.38±1.26%. In silico analysis, combined with GC-MS identification, suggested that three compounds, bis(2-ethylhexyl) phthalate, myristyl oleate, and 14 beta H-pregna may contribute to the observed α-amylase inhibitory activity. These findings highlight the potential of PC as a source of natural antidiabetic agents.
Co-Authors Achmad Rante Suparman, Achmad Rante Ade Zuhrotun Adrian Suparman Ahmad Muhtadi Ahmad Muhtadi Ajeng Diantini, Ajeng Ami Tjitraresmi Ami Tjitraresmi, Ami Angga Geganaputra Anis Yohana Chaerunisa Anis Yohana Chaerunisaa, Anis Yohana Anita Apriliana Anjabtsawa, Daffa Annisa Maulida Azzahra Apriani Sulu Parubak Aria Aristokrat Aryanti, Ninda Boima Ramses Situmeang Ch., Anis Yohana DIANA ALIFAH DINI HANIFA Dolih Gozali Eli Halimah Eli Halimah Eli Halimah, Eli Ellin Febrina Fahriza Ardiansyah Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Ferry Ferdiansyah Sofyan Fuji Fadhilla Sandy Gofarana Wilar HENIVIA NOVANTI Hesti Purwaningsih Hidayati, Tita Kosima Holis Abdul Holik, Holis Abdul Humaira Praswatika Dewi Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Imam Adi Wicaksono Indah Suasani Wahyuni Irma Erika Herawati Irma Melyani Puspitasari Ivan Surya Pradipta Jutti Levita Kokom, Asep Kusumastuti, Pinastya Purwakaning MEGANTARA, SANDRA Melinda Januarti MOCHAMAD RIZKY FAUZY Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono, M W Moelyono, M W Muchtaridi Muchtaridi MUFIDAH MAWADDAH Muhaimin Muhaimin Muhammad Ryan Radix Rahardhian Muhammad Ryan Radix Rahardhian Murtihapsari . Mutakin Mutakin Neli, Neli Ningrum, Sri Rahayu Widya Nita Listiani Norisca Aliza Putriana NORISCA ALIZA PUTRIANA Nugrahani, Hanny Okta Nama Putra Oktarina, Dewi Ria OKTAVIANI, DEDE JIHAN PRILLY MUTIARA SANDY Putri Churnia Arifin Putri, Chintiana Nindya Raden Maya Febriyanti Radite Yogaswara Rahayu, Fima Perdani Ramonah, Dewi Renny Amelia Ririn Suharsanti, Ririn Rochjana, Anna Uswatun Hasanah Rostinawati, Titin Rr. Kirana Andranilla Shafirany, Mareetha Zahra Silmi Auliya Zakariya Silmi Auliya Zakariya Silvia Sari Prastiwi Simorangkir, T.P.H. Simorangkir, T.P.H. Sri Adi Sumiwi Sriwidodo Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Sulistyaningsih, Widya Ayu Susilawati, Elis Syumillah Saepudin Tati Herlina TIANA MILANDA Tina Rostinawati Tira Soleha Rahmatullah Titi W Nikodemus Utami, Nadya Firdianna Utami, Nadya Firdianna Yoppi Iskandar Zakia, Syifa Zelika Mega Ramadhania Zelika Mega Ramadhania