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All Journal Indonesian Journal of Pharmaceutical Science and Technology PROSIDING SEMINAR KIMIA MPI (Media Pharmaceutica Indonesiana) Indonesian Journal of Chemistry JCRS (Journal of Community Research and Service) Bivalen: Chemical Studies Journal Proceeding of Mulawarman Pharmaceuticals Conferences Sevanam: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Panacea Journal of Pharmaceuticals and Natural Sciences Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Lizma Febrina
Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Secondary Metabolite Profiles and Antibacterial Activity of Mitragyna speciosa Leaf Extracts According to Vein Color Variation Febrina, Lizma; Hikmawan, Baso Didik; Adyma, M. Diva
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.39

Abstract

Empirically, the three distinct color variants of M. speciosa leaves (red, white, and green) vein are widely utilized and reported to possess varying therapeutic properties. This difference in efficacy is hypothesized to be a direct consequence of variances in their respective secondary metabolite profiles. Given the limited research comprehensively characterizing these metabolites and assessing the comparative antibacterial activity of the three variants, this study aimed to identify the secondary metabolite groups present in the red, white, and green vein leaves and determine their antibacterial activity against Salmonella typhi and Staphylococcus aureus. The methodology involved maceration extraction using 96% ethanol, followed by phytochemical screening and antibacterial testing via the agar well diffusion method across concentrations of 5%, 10%, 20%, and 40%. The negative control (96% ethanol) and positive control (chloramphenicol) were simultaneously utilized. The results confirmed that all three vein samples contained major secondary metabolite groups, including alkaloids, flavonoids, phenolics, saponins, and tannins. Differential antibacterial activity was noted: the red vein extract showed the highest efficacy against S. typhi, achieving an inhibition zone of 4.68mm at 10%, while the green vein extract was most effective against S. aureus, with an inhibition zone of 5.00 mm at 10%. These findings definitively demonstrate a difference in antibacterial potency across the M. speciosa vein variants, collectively affirming their significant potential for development as antibacterial active agents.
Alkaloid Profiling of Kadamba (Mitragyna speciosa Korth. Havil.) Leaves through Chromatographic Separation and UV-Vis Spectrophotometery Analysis Arifuddin, M.; Azmi, Fatur Rahman; Iswahyudi, Iswahyudi; Bone, Mahfuzun; Farrah, Harra Ismi; Arifian, Hanggara; Almeida, Maria; Rusman, Arman; Samsul, Erwin; Riki, Riki; Rija'i, Hifdzur Rashif; Hikmawan, Baso Didik; Junaidin, Junaidin; Febrina, Lizma; Rusli, Rolan; Ibrahim, Arsyik; Ahmad, Islamudin; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.44

Abstract

Mitragyna speciosa Korth. berasal dari famili Rubiaceae yang banyak tumbuh di daratan negara-negara Asia Tenggara. Tumbuhan ini selain disebut Kratom, khususnya di daerah Kalimantan Timur dikenal juga dengan nama "Kadamba". Mitragyna speciosa Korth. belongs to the Rubiaceae family and is widely found in the mainland of Southeast Asian countries. This plant, known as Kratom, is also referred to as "Kadamba" in East Kalimantan. Kadamba has been used for generations as a traditional medicine and contains predominantly alkaloid compounds, which generally function as analgesics, antitussives, antidiarrheals, adrenergic agents, antimalarials, antibacterials, and antinociceptives. The aim of this research is to determine the isolation and identification methods for alkaloid compounds in Kadamba leaves. In this study, extraction was performed using methanol solvent, followed by fractionation using Vacuum Liquid Chromatography (VLC) and Column Chromatography (CC) with gradient eluents: 100% hexane, n-hexane : Ethyl Acetate (5:1, 1:1, 1:5), 100% Ethyl Acetate, Ethyl Acetate : Methanol (1:1, 1:5), and 100% Methanol. The compounds were then identified using Thin Layer Chromatography (TLC). The isolation process used preparative Thin Layer Chromatography (PTLC) with eluent n-hexane: ethyl acetate: 25% ammonia (6.5:3:0.5 v/v/v), and the spots were observed under UV light at 245 nm and 366 nm. The visible spots were sprayed with Dragendorff's reagent to identify the alkaloid compounds. The results showed that the UV-Vis spectrophotometric characterization of isolate B6-b had two peaks at wavelengths of 288 nm and 294 nm.
Edukasi Beyond Use Date (BUD) kepada Masyarakat di Puskesmas Lempake Samarinda Samsul, Erwin; Sari, Indah Dewi; Pasaribu, Handayani; Mus, Nurul Muhlisa; Hikmawan, Baso Didik; Arifuddin, M.; Rusman, Arman; Riki, Riki; Bone, Mahfuzun; Herman, Herman; Junaidin, Junaidin; Febrina, Lizma; Ibrahim, Arsyik; Rijai, Hifdzur Rashif; Ahmad, Islamudin; Almeida, Maria; Rijai, Laode; Arifian, Hanggara
Sevanam: Jurnal Pengabdian Masyarakat Vol 5 No 1 (2026): Maret
Publisher : Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/sevanam.v5i3.5684

Abstract

ABSTRACT There are still some people who do not understand the difference between the expiration date (Expired Date/ED) and the drug usage limit (Beyond Use Date/BUD). BUD is the time limit for drug use after compounding or after the primary packaging is opened. This activity aims to increase public knowledge, understanding, and awareness regarding the importance of paying attention to the safe limit for drug use or Beyond Use Date (BUD), so that people can use drugs wisely, safely, and responsibly. The activity implementation method includes counseling, material presentation, distribution of leaflets or brochures, and filling out pre-tests and post-tests. The number of participants who took part in this activity was 26 people. The results of the health promotion activity at the Lempake Community Health Center, Samarinda City showed that the average knowledge of participants about Beyond Use Date before providing education was 31.92%, and increased to 88.08% after being given information. Thus, it can be concluded that this activity was successful in increasing public knowledge regarding Beyond Use Date in the Lempake Community Health Center area, Samarinda City.. Key words: Beyond Use date (BUD), Expired date (ED), Lempake Health Center Samarinda City
NMR-Based Metabolic Profiling and Anticancer Activity of Nephelium ramboutan-ake and Nephelium lappaceum Flesh Febrina, Lizma; Rusli, Rolan; Samsul, Erwin; Rijai, Laode; Ahmad, Islamudin; Rusman, Arman; Hikmawan, Baso Didik; Rija'i, Hifdzur Rashif; Almeida, Maria
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104162

Abstract

In this research, 1H-NMR-based metabolomics assessed the metabolite profiles of two Nephelium species flesh, specifically Nephelium ramboutan-ake and Nephelium lappaceum. Our research findings indicate that the metabolite profile of N. ramboutan-ake is qualitatively identical, although numerically distinct from that of N. lappaceum. The PLSDA data indicate that N. ramboutan-ake possesses elevated concentrations of acetic acid, malic acid, GABA, and succinic acid compared to N. lappaceum. In N. lappaceum, alanine and glucose serve as the distinguishing metabolites. Additionally, the anticancer efficacy of two Nephelium samples was assessed. As a result, the anticancer properties of N. ramboutan-ake were superior to those of N. lappaceum. PLS analysis indicated that GABA exhibited the most positive connection with the anticancer activity of Nephelium samples. These results indicate that the higher GABA concentrations of N. ramboutan-ake have a beneficial effect on its anticancer activity.
Co-Authors Abdul Rahim Abdul Rahim Adam M. Ramadhan Adyma, M. Diva Agus Setiawaty Almeida, Maria Anggreini, Putri Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Arsyik Ibrahim Aryanti Aryanti Azmi, Fatur Rahman Baso Didik Hikmawan Bela Apriliana Ningsih Bone, Mahfuzun Desten Prima Devitamara Ayu DEWI RAHMAWATI Dian Dwi Cahyadi Dida Fitri Lanisthi Dwi Elfira Kurniati Ema Via Mawadah Erwin Samsul Fahrul Rozi Fairul Muflihah Farah, Harra Ismi Farrah, Harra Ismi Fatimah Az-Zhahra Febrina Mahmudah Femy Linggi Allo Hadi Kuncoro Helmi Helmi Herman Herman Ibrahim, Arsyik Ika Wardani Indri Verrananda M Islamudin Ahmad Islamudin Ahmad ISWAHYUDI ISWAHYUDI Jaka Fadraersada Junaidin, Junaidin Kiki Argananta Laksono Trisnantoro Laode Rijai Laode Rijai Lusi Setiowati M. Arifuddin, M. M. Rizky Zakaria B.A. Marwah Ulfah Syurgana Mega Rizky Novitasari MUHAMMAD AMIR MASRUHIM Muhammad Azril Rizqullah Muhammad Faisal Muhammad Nasir Mus, Nurul Muhlisa Myra Puspha Hardina Nila Ayuanji Halilah Nisa Naspiah Nisa Naspiah Novita Eka Kartab Putri Nurul Annisa Nurvidya Sistha Azzahra Pasaribu, Handayani Rahmadani, Agung Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki RIKI RIKI, RIKI Risna Agustina Rita Anani Rizka Amelia Saleh Rizqullah, Muhammad Azril Rolan Rusli Rusli, Rolan Rusman, Arman Sari, Indah Dewi Septiana Dewi Setyowati, Widiastuti Agustina Eko Sinthary, Venna Siti Inayah Supriatno Suryani, Natasya Deva Tri Ratnasari VICTORIA YULITA FITRIANI Vina Maulidya Wahyu Armadiyanti Welinda Ayu Yuli Permatasari