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Hubungan Kadar Enzim Transaminase Pasien COVID-19 dengan Derajat Keparahan Penyakit di RSUP Dr. M. Djamil Padang Rahmadina, Rahmadina; Herman, Deddy; Efrida, Efrida; Almurdi, Almurdi; Russilawati, Russilawati; Elvira, Dwitya
Jurnal Kesehatan Andalas Vol 13, No 1 (2024): March 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v13i1.2205

Liver injury can be caused by coronavirus disease 2019 (COVID-19), characterized by increased levels of transaminase enzymes (aspartate aminotransferase/AST and alanine aminotransferase/ALT). Objective: To determined the correlation between transaminase enzyme levels and the severity of COVID-19 in Dr. M. Djamil Central Public Hospital, Padang. Methods: This was an observational analytic study with a cross-sectional design. Data were obtained randomly from medical records of confirmed COVID-19 patients hospitalized in Dr. M. Djamil Hospital from June to August 2021, with moderate, severe, and critical severity based on Indonesian Ministry of Health criteria. Data were analyzed using the Chi-square test to examine the distribution and correlation between variables and a simple logistic regression test to assess the level of risk between variables. Results: 57,80% had abnormal AST, and 44,95% had abnormal ALT. The median AST was highest in the critical group, while the median ALT was highest in the severe group. The distribution of sex and age group were significantly different based on AST and ALT levels, and the distribution of patients with coronary heart disease was significantly different based on ALT levels. Transaminase enzyme levels had a significant correlation with the severity of COVID-19 (p-value = 0,00). Patients with critical degrees had the highest risk for abnormal AST and severe degrees had the highest risk for abnormal ALT. Conclusion: Transaminase enzymes have a significant correlation with the severity of COVID-19.Keywords: COVID-19, liver injury, transaminases, disease severity

Hubungan Kadar Enzim Transaminase Pasien COVID-19 dengan Derajat Keparahan Penyakit di RSUP Dr. M. Djamil Padang Rahmadina, Rahmadina; Herman, Deddy; Efrida, Efrida; Almurdi, Almurdi; Russilawati, Russilawati; Elvira, Dwitya
Jurnal Kesehatan Andalas Vol. 13 No. 1 (2024): March 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v13i1.2205

Liver injury can be caused by coronavirus disease 2019 (COVID-19), characterized by increased levels of transaminase enzymes (aspartate aminotransferase/AST and alanine aminotransferase/ALT). Objective: To determined the correlation between transaminase enzyme levels and the severity of COVID-19 in Dr. M. Djamil Central Public Hospital, Padang. Methods: This was an observational analytic study with a cross-sectional design. Data were obtained randomly from medical records of confirmed COVID-19 patients hospitalized in Dr. M. Djamil Hospital from June to August 2021, with moderate, severe, and critical severity based on Indonesian Ministry of Health criteria. Data were analyzed using the Chi-square test to examine the distribution and correlation between variables and a simple logistic regression test to assess the level of risk between variables. Results: 57,80% had abnormal AST, and 44,95% had abnormal ALT. The median AST was highest in the critical group, while the median ALT was highest in the severe group. The distribution of sex and age group were significantly different based on AST and ALT levels, and the distribution of patients with coronary heart disease was significantly different based on ALT levels. Transaminase enzyme levels had a significant correlation with the severity of COVID-19 (p-value = 0,00). Patients with critical degrees had the highest risk for abnormal AST and severe degrees had the highest risk for abnormal ALT. Conclusion: Transaminase enzymes have a significant correlation with the severity of COVID-19.Keywords: Â COVID-19, liver injury, transaminases, disease severity

Profil Pasien Diabetes Melitus Tipe 2 dengan Ulkus Kaki Diabetik di RSUP Dr. M. Djamil Padang Tahun 2020-2021 Jannah, Lidya Raudhatul; Elvira, Dwitya; Noer, Mustafa; Decroli, Eva; Saputra, Deddy; Linosefa, Linosefa
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 2 (2024): Juni 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i2.1114

Abstrak Latar Belakang: Ulkus kaki diabetik menjadi permasalahan di Indonesia karena sedikitnya tenaga kesehatan yang menggeluti ulkus kaki diabetik, sedikit pengetahuan masyarakat mengenai ulkus kaki diabetik, dan biaya penatalaksanaan yang besar. Objektif: Tujuan penelitian ini adalah untuk mengetahui profil pasien diabetes melitus tipe 2 dengan ulkus kaki diabetik di RSUP Dr.M. Djamil Padang. Metode: Penelitian ini merupakan penelitian deskriptif observatif dengan desain cross-sectional. Sampel penelitian adalah pasien dengan diagnosis ulkus kaki diabetik yang berobat di RSUP Dr.M. Djamil Padang periode 2020-2021. Pengambilan sampel menggunakan teknik total sampling dengan jumlah sebanyak 93 sampel. Data menggunakan jenis univariat dan penyajian data dalam bentuk tabel distribusi frekuensi. Hasil: Hasil penelitian menunjukkan pasien ulkus kaki diabetik paling banyak berada pada usia >55-65 tahun (41,9%), jenis kelamin perempuan (52,7%), tidak bekerja/ IRT (44,1%), tingkat pendidikan terakhir SLTA (55,9%). Derajat ulkus 5 (37,6%), lama rawatan 6-10 hari (40,9%), tekanan darah normal (43,1%). Hasil laboratorium menunjukkan keadaan anemia sedang (47,3%), hipoalbuminemia (96,8%), hiperglikemia (54,8%). Tatalaksana dengan pemberian kombinasi dua antibiotik (59,1%), terapi bedah debridemen (30,2%), kondisi pasien membaik saat dipulangkan (63,4%). Kesimpulan: Kesimpulan penelitian yaitu sebagian besar pasien ulkus kaki diabetik adalah perempuan lansia akhir dengan kondisi anemia, hipoalbuminemia, hiperglikemia. Tatalaksana yang umum diberikan adalah pemberian kombinasi dua antibiotik dan debridemen dengan luaran pasien membaik. Kata kunci: Diabetes melitus tipe 2, pasien ulkus kaki diabetik, profil Abstract Background: Diabetic foot ulcers are a problem in Indonesia because of the lack healthcare professional on diabetic foot ulcers, little public knowledge about diabetic foot ulcers, and high management costs. Objective: The purpose of this study was to determine the profile of type 2 DM patients with diabetic foot ulcers at RSUP Dr.M. Djamil Padang. Methods: This study was an observational descriptive with a cross-sectional design. The research sample was patients diagnosed with diabetic foot ulcers at RSUP Dr.M. Djamil Padang for the 2020-2021 period. The total sampling technique was used to collect a total of 93 samples. The collecting data was analyze by univariat and presented with frequency distribution tables. Results: The results of this study were the most diabetic foot ulcer patients were in the age group >55-65 years (41.9%), female (52.7%), unemployed/housewife (44.1%), and high school education (55.9%). The most ulcer grade 5 (37.6%), treatment duration was 6-10 days (40.9%) and normal blood pressure (43.1%). Laboratory results showed the conditions of moderate anemia (47.3%), hypoalbuminemia (96.8%), and hyperglycemia (54.8%). Management given was a two combination of antibiotics (59.1%), debridementt therapy (30.2%), the patient's condition improved when being discharged (63.4%). Conclusion: This study concluded that the majority of patients with diabetic foot ulcers were elderly women with anemia, hypoalbuminemia, and hyperglycemia. The most common management given was a combination of two antibiotics and debridementt, which resulted in improved patient outcomes. Patients who are at high risk are expected to be more aware of the appearance of symptoms and clinicians are expected to be able to manage patients comprehensively. Keyword : Diabetic foot ulcer patient, profile, type 2 diabetes mellitus

HIV‑1 drug‑resistance mutations and related risk factors among HIV‑1‑positive individuals receiving first-line antiretroviral therapy Elvira, Dwitya; Rahayuningsih, Sri Puji; Nadia, Rizka; Masri, Raveinal
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.57-64

Background Acquired immunodeficiency syndrome (AIDS) remains a global health issue. Antiretroviral therapy (ART) controls HIV progression, but widespread use had led to drug resistance mutations (DRMs) such as M184V and K103N, compromising treatment efficacy. This study assessed the prevalence of these mutations and identified associated risk factors in patients with first-line nucleoside reverse transcriptase inhibitor (NRTI)-based ART. Methods A cross-sectional study was conducted involving 80 HIV patients aged > 18 years who had been on NRTI and non-NRTI (NNRTI) therapy for >6 months. Data included sociodemographic characteristics, ART adherence, opportunistic infections, viral load, CD4 count, treatment duration, ART regimen, and presence of M184V and/or K103N mutations. Genetic analysis was performed and statistical associations were assessed using simple and multivariate logistic regression. Results M184V and/or K103N mutations were detected in 8 patients (10%), significantly associated with poor ART adherence (p<0.01), detectable viral load (p<0.01) and male gender (p=0.048), but not with age (p=0.653), body mass index (p=0.661), opportunistic infections (p=0.938), CD4 count (p=0.265), and treatment duration (p=0.365). Multivariate logistic regression analysis showed that poor ART adherence was associated with a decreased risk of mutations compared to good adherence (OR = 0.73, 95% CI:0.012-0.427) and male patients had a 10-fold higher risk compared to females (OR = 10.03, 95% CI:1.033-97.350). Conclusion This study demonstrated that male gender was significantly associated with an increased risk of mutations, while poor ART adherence showed an unexpected inverse association. Strengthening adherence support programs remains essential to preventing drug resistance mutations and ensuring treatment efficacy.

Efficacy of Hematopoietic Stem Cell Transplantation with CCR5Δ32 Homozygous Donors in Achieving Sustained HIV-1 Remission: A Systematic Literature Review Paishal Mizan; Raveinal; Dwitya Elvira
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1305

Background: The pursuit of a cure for Human Immunodeficiency Virus type 1 (HIV-1) infection has led to the exploration of innovative therapeutic strategies. Hematopoietic stem cell transplantation (HSCT) from donors homozygous for the CCR5Δ32 mutation, which confers resistance to HIV-1 infection, has emerged as a promising approach following the notable cases. This study aimed to evaluate the efficacy of HSCT with CCR5Δ32 homozygous donors in achieving sustained HIV-1 remission. Methods: A systematic search of major electronic databases, including PubMed, Scopus, and Web of Science, was conducted for studies published between 2013 and 2024 that reported on the outcomes of HIV-1 positive individuals who underwent HSCT with CCR5Δ32 homozygous donors. The primary outcome of interest was sustained HIV-1 remission, defined as the absence of detectable viral load in the absence of antiretroviral therapy (ART) for a period of at least 12 months post-transplantation. Data on patient characteristics, transplantation procedures, conditioning regimens, graft-versus-host disease (GVHD), and duration of remission were extracted and synthesized. Results: Five case studies met the inclusion criteria. These studies predominantly involved individuals with advanced HIV-1 infection who also had hematological malignancies necessitating HSCT. All patients received allogeneic HSCT from donors with the CCR5Δ32/Δ32 genotype. Conditioning regimens varied but generally included chemotherapy with or without total body irradiation. Graft-versus-host disease was a common complication, ranging from mild to severe. Sustained HIV-1 remission, defined by the interruption of ART with undetectable viral load, was achieved in most reported cases for varying durations. Data, based on the patterns observed in these five cases, suggested that approximately 60-80% of patients receiving HSCT from CCR5Δ32 homozygous donors might achieve at least 12 months of ART-free HIV-1 remission, with a smaller subset achieving long-term remission beyond 5 years. Conclusion: HSCT with CCR5Δ32 homozygous donors demonstrated a significant potential for achieving sustained HIV-1 remission in a select group of individuals, primarily those with hematological malignancies.

EDUKASI COVID-19 DAN VAKSINASI BAGI MASYARAKAT DI KAMPUNG BATU BUSUAK KECAMATAN PAUH KOTA PADANG Saptino Miro; Roza Kurniati; Dwitya Elvira; Arina Widya Murni; Raveinal Raveinal; Alexander Kam
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 5 No. 1 (2022)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v5i1.398

Infectious diseases are still a major health issue that requires serious treatment. The covid-19 is now one of the significant infectious diseases worldwide marked by rapid contagion and global spread. The world health organization (who) has defined covid-19 as a global pandemic and the government has set public health emergencies in Indonesia, obliging countermeasures. The covid-19 countermeasures should continue massively with several strategies. In addition to promotive strategies and the application of health protocols, another effective strategy is needed to break off the chain of disease transmission through vaccination efforts. The purpose of the activity is to do the education about covid-19 and the covid-19 vaccination of the people in Kampung Batu Busuak, Kelurahan Limau Manis, Kecamatan Pauh, Padang. The implementation of this activity includes the counseling of covid-19 and the covid-19 vaccination on Saturday, November 13th, 2021. Before counseling, the Questionnaire was issued to assess a public knowledge level on covid-19 and a covid-19 vaccination. From a questionnaire on covid-19 and covid-19 vaccination, the total of people who have already been vaccinated twice is 22 people and 4 with the covid-19 vaccine once. Therefore, still needed counseling about covid-19 and covid-19 vaccination to enhance awareness of the society towards the importance of covid-19 vaccination.

Profil Pasien Luka Bakar dengan Syok Hipovolemik di RSUP Dr. M. Djamil Padang Tahun 2019-2021 Addina, Azka; Saputra, Deddy; Manela, Citra; Fortuna, Fory; Elvira, Dwitya; Putra, Syandrez Prima
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 2 (2025): Juni 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i2.1304

Latar Belakang: Syok hipovolemik adalah suatu keadaan gawat darurat pada luka bakar yang meningkatkan risiko kematian. Pemahaman tentang karakteristik pasien luka bakar dengan syok hipovolemik sangat penting untuk mempercepat penegakan diagnosis dan menurunkan risiko mortalitas. Objektif: Penelitian ini bertujuan untuk menilai karakteristik pasien luka bakar yang mengalami syok hipovolemik. Metode: Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional. Teknik pengambilan sampel menggunakan total sampling. Variabel yang diteliti adalah usia, jenis kelamin, penyebab, derajat luka, luas luka, komorbid, dan fasilitas kesehatan asal. Data penelitian diambil dari data sekunder rekam medis di Instalasi Rekam Medis RSUP Dr. M. Djamil Padang tahun 2019-2021. Analisis data dilakukan menggunakan analisis univariat yang dilakukan pada setiap variabel penelitian. Hasil: Sebanyak 30 pasien luka bakar dengan syok hipovolemik diikutsertakan ke dalam penelitian. Kasus terbanyak ditemukan pada kelompok usia 36-45 tahun, laki-laki, luka bakar api, derajat full thickness, luas luka 20-39% dan 40-59% TBSA, komorbid penyakit paru, serta rujukan dari rumah sakit tipe C. Kesimpulan: Risiko kejadian syok hipovolemik perlu diwaspadai pada kasus luka bakar usia dewasa akhir, luka bakar pada laki-laki, luka bakar akibat api, luka bakar dengan derajat full thickness serta luka bakar mayor, dan pada kasus dengan komorbid paru.

Kualitas Hidup Pasien Lupus Eritematosus Sistemik Berdasarkan LupusQoL di RSUP Dr. M. Djamil Padang Ramadanti, Zilhadia Mona; Julizar; Elvira, Dwitya; Abdiana; Liza, Rini Gusya; Suharti, Netti
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 2 (2025): Juni 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i2.1409

Latar Belakang: Lupus Eritematosus Sistemik (LES) merupakan penyakit autoimun sistemik kronis yang membutuhkan pengobatan jangka panjang. Penyakit LES dapat memengaruhi hampir semua aspek kehidupan pasien yang akan berdampak terhadap kualitas hidup. Objektif: Untuk melihat gambaran kualitas hidup pasien LES di RSUP Dr. M. Djamil Padang berdasarkan LupusQoL. Metode: Desain penelitian ini menggunakan cross-sectional study. Responden penelitian berjumlah 55 pasien LES di Poliklinik Khusus Alergi Imunologi dan Reumatologi Ilmu Penyakit Dalam RSUP Dr. M. Djamil Padang yang diambil secara consecutive sampling. Data diperoleh secara primer dari wawancara terpimpin menggunakan kuesioner LupusQoL dan sekunder berasal dari rekam medis pasien. Hasil: Pada pasien LES, wanita umur 18–40 tahun, pendidikan SMA, IRT, sudah menikah, telah menderita LES ≥ 1 tahun, keterlibatan organ tersering mukokutan, terdapat komorbid, diberikan terapi kombinasi glukokortikoid dan HCQ, dan memiliki derajat aktivitas ringan. Kualitas hidup baik (83,6%) pada pasien LES. Berdasarkan aspek-aspek pada LupusQoL diperoleh frekuensi kualitas hidup sebagian besar pasien LES adalah baik. Nilai rerata tertinggi terdapat pada aspek hubungan intim 85,2 ± 32,4 diikuti oleh citra diri 85,1 ± 22,4 sedangkan rerata terendah terdapat pada aspek ketergantungan pada orang lain 58,9 ± 34,2 diikuti oleh kelelahan 65,2 ± 26,2. Kesimpulan: Kualitas hidup pasien LES secara umum adalah baik. Aspek dengan rerata terendah seperti ketergantungan pada orang lain dan kelelahan harus lebih diperhatikan oleh para dokter maupun keluarga pasien untuk menciptakan kualitas hidup pasien yang lebih baik.

Efficacy of Hematopoietic Stem Cell Transplantation with CCR5Δ32 Homozygous Donors in Achieving Sustained HIV-1 Remission: A Systematic Literature Review Paishal Mizan; Raveinal; Dwitya Elvira
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1305

Background: The pursuit of a cure for Human Immunodeficiency Virus type 1 (HIV-1) infection has led to the exploration of innovative therapeutic strategies. Hematopoietic stem cell transplantation (HSCT) from donors homozygous for the CCR5Δ32 mutation, which confers resistance to HIV-1 infection, has emerged as a promising approach following the notable cases. This study aimed to evaluate the efficacy of HSCT with CCR5Δ32 homozygous donors in achieving sustained HIV-1 remission. Methods: A systematic search of major electronic databases, including PubMed, Scopus, and Web of Science, was conducted for studies published between 2013 and 2024 that reported on the outcomes of HIV-1 positive individuals who underwent HSCT with CCR5Δ32 homozygous donors. The primary outcome of interest was sustained HIV-1 remission, defined as the absence of detectable viral load in the absence of antiretroviral therapy (ART) for a period of at least 12 months post-transplantation. Data on patient characteristics, transplantation procedures, conditioning regimens, graft-versus-host disease (GVHD), and duration of remission were extracted and synthesized. Results: Five case studies met the inclusion criteria. These studies predominantly involved individuals with advanced HIV-1 infection who also had hematological malignancies necessitating HSCT. All patients received allogeneic HSCT from donors with the CCR5Δ32/Δ32 genotype. Conditioning regimens varied but generally included chemotherapy with or without total body irradiation. Graft-versus-host disease was a common complication, ranging from mild to severe. Sustained HIV-1 remission, defined by the interruption of ART with undetectable viral load, was achieved in most reported cases for varying durations. Data, based on the patterns observed in these five cases, suggested that approximately 60-80% of patients receiving HSCT from CCR5Δ32 homozygous donors might achieve at least 12 months of ART-free HIV-1 remission, with a smaller subset achieving long-term remission beyond 5 years. Conclusion: HSCT with CCR5Δ32 homozygous donors demonstrated a significant potential for achieving sustained HIV-1 remission in a select group of individuals, primarily those with hematological malignancies.

Crohn’s Disease with Comorbidites of Syndrome of Inappropriate Anti Diuretic Hormone (SIADH) caused by Pulmonary Tuberculosis Steven, Rios; Miro, Saptino; ., Arnelis; Yoga, Vesri; Viotra, Deka; Elvira, Dwitya; ., Wahyudi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202588-92

Crohn's disease is an inflammatory condition of the intestines characterized by lesions that can affect the entire digestive tract from the mouth to the anus. Globally, the prevalence of inflammatory bowel disease has increased over the past 20 years, rising from 3.32 million cases in 1990 to 4.9 million cases in 2019. Previously, the management of Crohn’s disease followed the step-up therapy approach; however, this method led to higher recurrence rates. The current approach utilizes top-down therapy, as research data indicate that the remission rate is 57% with top-down therapy compared to 25% with step-up therapy. Syndrome of Inappropriate Antidiuretic Hormone (SIADH) can be caused by pulmonary tuberculosis. A 44-year-old male patient was diagnosed with Crohn’s disease based on a colonoscopy examination, which suggested chronic active colitis with mild activity and crypt distortion consistent with Crohn’s disease. An esophagogastroduodenoscopy (EGD) revealed chronic gastritis, while a histopathological examination of the colon confirmed findings consistent with Crohn’s disease. The diagnosis of pulmonary tuberculosis was established using a rapid molecular test (TCM) with positive results. Hyponatremia with hypoosmolar euvolemia was diagnosed based on serum sodium levels of 128 mmol/L, serum osmolality of 269 mosmol/L, urine osmolality of 288 mosmol/L, and urine sodium of 73 mosmol/L. Treatment included 5-ASA and anti-tuberculosis medications. Crohn’s disease increases morbidity rates and is not limited to developing countries. It is caused by immune system dysregulation, which can predispose patients to secondary infections such as tuberculosis. Pulmonary tuberculosis, in turn, can lead to SIADH.Keywords: Crohn’s disease, pulmonary tuberculosis, SIADHTop of Form

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