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puguh santoso, puguh
Akper Dharma Husada Kediri
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Skrining Fitokimia Dan Efek Antikoagulan Eliksir Dari Ekstrak Buah Mengkudu (Morinda citrifolia L.) Pada Tikus Putih Santoso, Puguh; Putri, Noviana; Wibawa, Agung Ari Chandra
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i3.13154

Abstract

The increasing prevalence of thrombosis as a manifestation of hemostatic dysfunction has prompted the search for safer and more accessible alternative anticoagulant agents. Morinda citrifolia L. (noni fruit) contains various bioactive compounds suspected to modulate blood coagulation pathways. This study aimed to evaluate the anticoagulant effectiveness of an elixir formulated from ethanolic extract of noni fruit on the bleeding time of male white rats (Rattus norvegicus). A post-test only randomized group design was employed, consisting of four treatment groups: negative control (aquadest), positive control (acetosal 80 mg), elixir at 40 mg/kgBW, and elixir at 80 mg/kgBW. The extract was prepared by ethanol maceration and then formulated into elixirs, followed by physical quality testing. Anticoagulant activity was assessed by measuring tail bleeding time. Results indicated that the elixir at 80 mg/kgBW significantly prolonged the bleeding time compared to other groups. Phytochemical screening revealed the presence of flavonoids, tannins, alkaloids, and steroids as dominant constituents. The findings demonstrate that the noni fruit elixir possesses anticoagulant activity, with the higher dose yielding the most pronounced effect. This study concludes that Morinda citrifolia has strong potential to be developed as a natural anticoagulant in pharmaceutical applications.
LOGISTIC REGRESSION MODELLING WITH VARIABLE SELECTION AND BEST MODEL EVALUATION IN THE ANALYSIS OF VARIABLES INFLUENCING TODDLER NUTRITIONAL STATUS Pujianto, Tutut; Santoso, Puguh; Anggraeni, Enggar
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12 No 2 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i2.1076

Abstract

Background: Nutritional status is one of the measures used to evaluate the adequacy of nutrition in toddlers. Many factors can affect the nutritional status of toddlers, including breastfeeding, infectious diseases, and the clean water facilities used. Considering the importance of the toddler period, high-quality analysis is needed to produce accurate outputs. One analysis that can be used to predict the role of causal factors on the resulting outcomes is ordinal logistic regression analysis, which can be obtained from logit and probit models. Objective: To determine whether a logit or probit model will be used in the analysis, simulation in its application needs to be carried out.. Method: This research uses baseline data from Pelem Village, Pare District, Kediri Regency in 2023. The selection of the best model is based on the model fitting parameter values, goodness of fit, and pseudo R square. Result : From the simulation results, it was found that the logit model produces a better model than the probit model. Furthermore, with ordinal regression analysis using the logit model, no relationship model was formed because all independent variables had p-values greater than 0.05. Conclusions: The absence of a model indicates that there is no effect of breastfeeding, infectious diseases, and clean water facilities on the nutritional status of toddlers.
Co-Authors Adrianta, Agus Agung Ari Chandra Wibawa Agustin, Ni Kadek Jessica Agustini, Ni Putu Dewi Andriese, Ni Putu Sri Ayu Sevilla Andriese Ari Candra, Agung Arieza, Ziva Baihaqi, Abyan Brian Wasita Cintya Purnama Sari, Ni Wayan Darmayanti, Gusti Ayu Putu Eka Darmayanti, Rofik Debby Juliadi Dewa Ayu Ika Pramitha Dwi Rahayu Elfi Quyumi Rahmawati Enggar Anggraeni, Enggar Erna Cahyaningsih Esmani, Neri Fajar Rinawati Fredinan Yulianda Gunawan, I Putu Windra Hengky Irawan, Hengky Heny Kristanto I Putu Tangkas Suwantara Ketut Agus Adrianta Krisnawati, Dyah Ika Kristanto , Heny Laksmi, Luh Putri Dianti Linda Paramita, Ni Kadek Madjid, Adnan Maharani, Ade Dwi Karisma Malik, Ichsan Maria Dewi, Ni Putu Megawati, Fitria Moh. Sholahuddin Muchamad Syamsulhadi, Muchamad Muhammad Agus Muljanto Nggaba, Ellenoire Rambu Kabeba Hammu Ni Luh Kade Arman Anita Dewi Ni Made Dwi Mara Widyani Nayaka Ni Nyoman Wahyu Udayani Nurita, Nurita Pariyatman, M. Harland Pridanatama, Annas Priesdiantoro, Rasid Pujo Widodo, Pujo Puspitasari, Betristasia Putra Hilmi Prayitno Putra, I Made Agus Sunadi Putri, Leoni Putri, Ni Putu Devi Nirmala Putri, Noviana Putri, Nurita Nilasari Bunga Kharisma Arifiana Putu Era Sandhi Kusuma Yuda Sandhi Kusuma Yuda, Putu Era Sari, Ni Wayan Budi setyowati, novita Sri Budiasih, Putu Eka Sucipto Sugiantari, Ni Putu Siska Sukendro, Achmed Surya Rahadi, I Wayan Vernandes Sasadara, Maria Malida Wardani, I Gusti Agung Ayu Kusuma Yunarsih Yuni A, Dinar Yunita, Astri Yuwono, Moch.