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Nurfitriani Nurfitriani, Nurfitriani
Program Studi Ilmu Pemerintahan Fakultas Ilmu Sosial dan Ilmu Politik Universitas Muhammadiyah Makassar
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Journal : Veterinary Biomedical and Clinical Journal

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Effect of Jatropha(Jatropha curcas L.) Seeds Extract Induction on Liver Histopathology and SGPT levels (Serum Glutamic Piruvic Transaminase) on Rat (Rattus norvegicus) Fitria, Neny; Pratiwi, Herlina; Widodo, Edwin; Primajayanti, Angelia; Anggraini, Novia Dwi; Nurfitriani, Nurfitriani; Findi, Nadia
Veterinary Biomedical and Clinical Journal Vol. 3 No. 2 (2021)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2021.003.02.1

Abstract

Jatropha or Jatropha curcas L. is a plant of the Euphorbiaceae family with medicinal and non-medical uses, including oral contraceptives. The part of Jatropha that is often used is the seed. However, Jatropha seed also contains saponins, phorbol esters, currants, tannins which can cause organ poisoning. This study was conducted to determine the effect of Jatropha seed extract on liver histopathology and SGPT levels in Rattus Norvegicus rats, using a completely randomized design method. Experimental animals were divided into four groups, and each group consisted of five female rats. The groups were the control group without treatment and those treated with Jatropha seed extract orally at doses of 10, 50, and 100 mg/kg BW. The induction process was carried out every day for 14 days, on the 15th day, a necropsy was performed. Livers were taken for histological analysis, and blood samples were taken to measure SGPT levels. Results showed that the administration of Jatropha seed extract could increase SGPT levels. The administration of Jatropha seed extract at a dose of 100 mg/kg body weight induced the most severe damage of hepatocytes among the treatment groups.
Co-Authors Abdul jalil Abdurrahman Mansyur Achmad, Widya Karmila Sari Ade Lestari Adiman, Raja Multi Konvokesen ADINDA PRATIWI, PUTRI Ahmad Taufik Aisya, Sitti Akhmad Al Aidhi Al Fajri, Jufri ALQORNI, NISA Amellia, Ade Yuli Andi Niartiningsih Anggraini, Novia Dwi Arifahrahmi, Arifahrahmi Arifarahmi, Arifarahmi Ariyanto Ariyanto Armina, Armina Ashari, Maulana Ashari AZWIR, MAHARANI Bambang Widjajanta, Bambang Calcio, Anggun Catur Kumala Dewi Christian Adi Prasetyo Danna Solihin Dewi, Catur Kumala Dhuha, Alief Edwin Widodo Efni, Nel Eka Malfasari Eka Yudhyani Eka Yudhyani, Eka Erna Octavia, Erna Fadli, Sofiansyah Fadli Fatimawali . Febryanti, Annisa Findi, Nadia Fitria, Neny Fuadah, Hanis Gustina, Ira Haekal, Ahmad Hamrun HANDAYANI, R. SRI Haryadi, Rina Masithoh HUDA, MUHAMMAD MIFTAKHUL Hurruzia, Muhammad Fadhil Iftitah, Iftitah Indrawati, Andi Irawan, Audrey Allya Irlandes, Ciria Islahiyah, Islahiyah Jayawarsa, A.A. Ketut Juanto, Ade Julaecha, Julaecha Kaseng, Ernawati S Latif, Imam Nazarudin Lili Adi Wibowo M Hamid Malik, Nurintan Mamuaya, Gybert E. Mene Paradilla Miko Eka Putri Mila Triana Sari Mochamad Nursiyam Barkah Muhammad Hidayat Muhammad Wiharto Muhammad Zulkifli, Muhammad Nadivah, Nadivah Noval Noval Novita Sari Nur, Nurul Hidayah Nuraini Nuraini Nurbaiti Nurbaiti Nurfadhilah, Nurfadhilah Nuriatullah Nuriatullah Nurita, Suci Rahmani Nursyamsu, Nursyamsu Nurul Hidayah Nur Pebrianti, Dwi Kartika Perwitasari, Tuhu Pratiwi, Herlina Pratiwi, Putri Indah Primajayanti, Angelia PURWANTI PURWANTI Putri, Melisya R. SRI HANDAYANI Rahmawati, Helfi Ramadhani, Dwi Yunita Rendi Rendi, Rendi RIFAYANI, DESIYANTI Rignolda Djamaluddin Rizki, Safana Aulia Rohani Rohani Rusanti, Ega Sabrianti, Desy Safitri, Laila Sandy Nur Eko Wibowo Sari, Winda Purnama Seftianur, Muh Achzani Sihotang, Sifra Dosmaria Silkfan, Rara Sofyan, Syaakir Sofyan, Syathir Sri Anggraeni Sriyanto, Sesar Prabu Dwi Sukmayu, Maharani Sumarni, Rani Sunarto Sunarto Takwa, Muhammad Tina Yuli Fatmawati Titin Ruliana Trisnadiansyah, Mochamad Ridfan TRIWAHYUNI, NADIA VEVI SURYENTI PUTRI, VEVI SURYENTI Wafiah Murniati Widya Hary Cahyati Yatimantoro, Tatok Yudhi Listiawan Yuliana Yuliana Yunita, Ananda Evi Yusran, Nadilah Yusup Junaedi Zahra Zahra Zilfana, Zilfana Zulfiarini, Febriana Maya Zulfiarini, Febriana Maya