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Pengaruh Ekstrak Etanol Daun Jambu Air (Syzygium aqueum (Burm f.)Alston) terhadap Glukosa Darah, Ureum dan Kreatinin Tikus Putih (Rattus norvegicus) Joni Tandi
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i2.137

Abstract

Diabetes mellitus with complications of Diabetic Nephropathy become one of the most common cause of end-stage renal failure in the world. Impaired kidney function is measured by Glomerular Filtration Rate (GFR). Where the decline in GFR was followed by increased levels of blood glucose, urea and creatinine. This study aimed to determine whether there is the content of secondary metabolites in leaves of Sizygium aqueum leaf extract, at a dose of extract what impact the blood glucose, urea and creatinine levels of male rats and whether the water extract of guava leaves have an influence on the blood glucose, urea and creatinine white male rats. This study uses a randomized block design with six treatment groups consisting of five test animals. Group I was normal control (CMC Na suspension 0.5%). Group II negative control (streptozotocin 40 mg/kg). positive control group III (suspension glibenclamide). Group IV given guava leaf extract 100 mg/kg BW. V group awarded guava leaf extract 200 mg/kg BW. Group VI given guava leaf extract 300 mg/kg BW. Treatment was given for 28 days and measured levels of blood glucose urea and creatinine on days 0, 7, 14, 21 and 28. The results showed nefroprotektif effect on all groups and most effective extract are a group of guava leaf extract 100 mg/kg BW). Keywords: Diabetic nephropathy, urea, creatinine, Syzygium aqueum
Test of the Potential of Ethanol Extracts, Simplician Medium and Forest Umbi Juice (Eleutherine bulbosa (Factory) Urb.) against Blood Glucose Levels of Rats, and Histopatology Ratkreas Rat (Rattus norvegicus) Hypercolesterolemia Model Diabetic Joni Tandi; Tien Wahyu Handayani; Ni Wayan Ika Purwasih
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 2 (2020): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i2.229

Abstract

This study aims to examine the presence or absence of secondary metabolite compounds in ethanol extract, simplicia steeping and forest onion tuber juice, in male glucose parameters and pancreatic histopathology. Using test animals as many as 30 male white rats divided into 6 groups and each group consisted of 5 rats with group I details as normal controls, group II as negative controls given 0.5% Na-CMC suspension, group III as positive control who were given Metformin 45 mg / kg BB and IV, V, VI as the test group were given ethanol extract, simplicia extract and forest onion tuber juice with each dose of 20 g / kg BW. The results showed that there were secondary metabolites in the ethanol extract of forest onion tubers, namely flavonoids, saponins, alkaloids, steroids and tannins, giving ethanol extract of forest onion bulbs had the effect of reducing blood glucose levels in white mice with a dose of 20g / kgBW with an average of 132 and ethanol extract of forest onion bulbs at a dose of 20g / kg BB with an average of 0.5 can regenerate pancreatic tissue.
Formulasi Tabir Surya Zink Oksida Dalam Sediaan Krim Dengan Variasi Konsentrasi Ekstrak Anggur Hitam (Vitis vinivera L.) Joni Tandi; Kurnia Gatot Novrianto
Jurnal Sains dan Kesehatan Vol. 1 No. 7 (2017): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i7.72

Abstract

Senyawa tabir surya yang umum digunakan adalah bahan sintesis, akan tetapi kadangkala bahan sintesis ini dapat menjadi berbahaya bila terserap ke dalam aliran darah. Untuk menghindari dampak negatif tersebut dapat digunakan tanaman obat tradisional, salah satunya anggur hitam. Telah dilakukan penelitian dengan tujuan untuk mengetahui seberapa besar efektivitas nilai SPF tabir surya yang diberikan oleh ekstrak anggur hitam sebagai factor pelindung sinar matahari terhadap kulit. Penelitian ini dilakukan dengan cara mengekstrak anggur hitam dengan metode maserasi bertingkat untuk menarik komponen kimia sebagai senyawa tabir surya. Ekstrak dibuat dalam empat konsentrasi kemudian diukur serapannya menggunakan spektrofotometer UV-Vis pada panjang gelombang 280 nm sampai 400 nm, selanjutnya dihitung SPF. Hasil penelitian menunjukkan dari semua konsentrasi ekstrak anggur hitam memberikan nilai SPF yaitu pada konsentrasi 0% 2,33, konsentrasi 0,4% 2,38, konsentrasi 0,8% 2,48 dan konsentrasi 1,2% 2,53. Dari hasil ini dapat disimpulkan bahwa ekstrak anggur hitam mempunyai efek tabir surya karena nilai SPF yang diperoleh masuk dalam range syarat tabir surya yaitu 2 sampai 60.
Uji Efek Ekstrak Etanol Daun Sukun (Artocarpus altilis (Parkinson Ex F.A.Zorn) Terhadap Penurunan Kadar Glukosa Darah, Kolesterol Total Dan Gambaran Histopatologi Pankreas Tikus Putih Jantan (Rattus norvegicus) Hiperkolesterolemia-Diabetes Joni Tandi; Moh Rizky; Rio Mariani; Fajar Alan
Jurnal Sains dan Kesehatan Vol. 1 No. 8 (2017): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i8.73

Abstract

Penelitian ini bertujuan untuk mengetahui efek serta dosis efektif ekstrak daun sukun dalam menurunkan kadar glukosa darah, kolesterol total dan gambaran histopatologi pangkreas pada hewan uji tikus putih jantan model hiperkolesterolemia-diabetes yang diinduksi pakan tinggi lemak dan streptozotocin. Penelitian dilakukan menggunakan 35 ekor hewan uji yang dikelompokkan dalam 7 kelompok dengan perlakuan yaitu kelompok kontrol normal, kontrol negatif, kontrol positif metformin, kelompok positif sinvastatindan 3 kelompok uji dengan variasi dosis ekstrak masing-masing 100 mg/KgBB, 200 mg/KgBB, dan 400 mg/KgBB. Pengukuran kadar glukosa darah dan kadar olesterol dilakukan pada hari ke 0, 35, 42, dan 49 setelah diberi perlakuan. Data kadar glukosa darah dan kolesterol total yang diperoleh dianalisis menggunakan uji one way ANOVA pada taraf kepercayaan 95% dan dilanjutkan dengan uji Post Hoc LSD, dan data hasil skoring tingkat kerusakan pankreas dianalisis dengan uji Kruskal-Wallis dilanjutkan dengan uji Mann-Whitney untuk melihat perbedaan antar perlakuan. Hasil penelitian menunjukkan bahwa terdapat senyawa metabolit sekunder pada ekstrak etanol sukun, ekstrak daun sukun dengan dosis efektif 200 mg/kgBB memiliki efek terhadap kadar glukosa darah dan kadar kolesterol total, dosis 400 mg/kgBB regenerasi jaringan pankreas tikus.
Pola Pengobatan Penderita Schistosomiasis (Penyakit Demam Keong) Di Desa Kaduwaa Kecamatan Lore Utara Kabupaten Poso Propinsi Sulawesi Tengah Joni Tandi
Jurnal Sains dan Kesehatan Vol. 1 No. 9 (2018): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i9.74

Abstract

Telah dilakukan penelitian Pola Pengobatan Penderita Schistosomiasis (Penyakit Demam Keong) di Desa Kaduwaa Kecamatan Lore Utara Kabupaten Poso Propinsi Sulawesi Tengah. Penelitian ini bertujuan untuk menanggulangi penyakit schistosomiasis ditinjau dari kerasionalan pengobatan untuk menanggulangi penyakit schistosomiasis dan untuk mengetahui perbedaan pola pengobatan penderita schistosomiasis di Kaduwa dan Napu keseluruhan, berdasarkan persentase penggunaan obat. Data diolah dan dideskripsikan terlebih dahulu kemudian dianalisis dengan uji chi kuadrat. Hasil pengujian menunjukkan bahwa tidak terdapat perbedaan pola pengobatan penderita schistosomiasis di Kaduwaa dan Napu keseluruhan. Petunjuk teknis Pengobatan Penderita Schistosomiasis (Penyakit demam Keong), penggunaan obat praziquantel menurut petunjuk teknis yaitu 60mg/Kg BB diminum dua kali setiap 4-6 jam sehari, dan terhadap efek samping telah digunakan paracetamol dan CTM.
Test the Effect of Miana Leaf Ethanol Extract on Ureum and Creatinine Levels in Male White Rats Joni Tandi; Yustin Yustin; Rezky Yanuarty; Tien Wahyu Handayani
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1686

Abstract

This study aims to determine the content of secondary metabolites in miana leaf ethanol extract, and to determine the effective dose of miana leaf ethanol extract in reducing urea and creatinine levels in male white rats. This study used 30 rats divided into 6 treatment groups, each group consisting of 5 test animals, namely normal group, negative control, positive control, dose of 150 mg/kg BW, dose 200 mg/kg BW, and dose 250 mg/kg. kg body weight. The data obtained will then be tested for normality and homogeneity to find out the data is normally distributed and homogeneous. If the data is normally distributed and homogeneous, then it is continued using One Way Anova statistical analysis at a 95% confidence level and further LSD test is carried out. If the data obtained is not normal and homogeneous, then it is analyzed using non-parametric statistics Kruskal-Wallis test and continued with Mann Whitney further test to determine the difference between all treatments. The results showed that the ethanolic extract of miana leaves contained secondary metabolites of alkaloids, flavonoids, saponins,and tannins; miana leaf ethanol extract has an effect on reducing urea and creatinine; Miana leaf ethanol extract at a dose of 250 mg/kg BW was an effective dose in reducing urea and creatinine with an average decrease of 18.8 mg/dl and 0.64 mg/dl.
Uji Ekstrak Alkohol Daun Mengkudu (Morinda Citrifolia L) terhadap Konsentrasi Kreatinin dan Ureum Tikus Putih Jantan (Rattus Norvegicus) Nefropati Diabetes Tandi, Joni; Yana Novika R; Debora Rislianti Lakiu; Magfirah; Niluh Puspita Dewi
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.241

Abstract

Diabetic nephropathy is one of the microvascular complications of diabetes mellitus (DM). One of the clinical signs of diabetic nephropathy is an increase in urea and creatinine levels. The use of medicinal plants containing antioxidants is one of the therapeutic strategies to prevent complications of DM. The noni plant (Morinda citrifolia L), especially the leaves, contains active substances that have the potential as antioxidants to be used as supportive therapy for DM. This study aims to identify the content of active substances in noni leaf extract and determine the potential of noni leaf extract to reduce creatinine, and urea levels in diabetic nephropathy rats. Noni leaf extract was obtained by maceration using 96% ethanol, and animal models of diabetic nephropathy were obtained by induction of streptozotocin 40 mg/kg BW. The test animals were divided into six groups, namely normal control, negative control, positive control, treatment 1, 2, and 3, each given extract doses of 250, 500, and 750 mg/kg BW. The results indicated the presence of flavonoids, alkaloids, steroids, saponins, and tannins in the noni leaf extract. Giving noni leaf extract can reduce, urea and creatinine levels significantly compared to negative controls. In conclusion, noni leaf extract can potentially prevent complications of diabetic nephropathy with an effective dose of 250 mg/kg BW.
POTENSI ANTIDIABETIK EKSTRAK ETANOL DAUN MATOA(Pometia pinnata) PADA TIKUS PUTIH JANTAN Tandi, Joni; Afriani S; Nadira; Handayani KR; Wirawan W; Afrizal; Tien Wahyu Handayani
Jurnal Ilmiah Manuntung Vol 8 No 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.521

Abstract

Diabetes Mellitus is a metabolic disease characterized by high blood glucose levels which is commonly called hyperglycemia due to lack of insulin secretion. One of the matoa plants (Pometia pinnata) that has been used as a traditional medicine is matoa leaves which are efficacious as diabetes mellitus. The purpose of this study was to determine the secondary metabolite compounds in the ethanol extract of matoa leaves, as well as to determine the potential dose of ethanolic extract of matoa leaves which was effective in reducing blood glucose levels and on the histopathological description of the pancreas of male white rats induced by Streptozotocin. This study used a laboratory experimental method, divided into 6 treatment groups, each group consisting of 5 rats, namely normal control, negative control, positive control, treatment groups with doses of 100, 200, and 300 mg/kg body weight. Data were analyzed using One Way ANOVA statistical test at 95% confidence level followed by LSD test to see differences between treatments. The results showed that the ethanolic extract of matoa leaves contained secondary metabolites of alkaloids, flavonoids, saponins, tannins, and steroids. at a dose of 300 mg/kg BW showed effective results in reducing blood glucose levels with an average decrease of 99.6 mg/dL and the ethanol extract of matoa leaves had the potential to regenerate pancreatic cells in streptozotocin-induced male white rats of 0. 6±0.54
PENGARUH PEMBERIAN SEDIAAN NANOPARTIKEL EKSTRAK ETANOL BIJI PINANG TERHADAP KADAR SGOT DAN SGPT TIKUS TERINFEKSI Schistosoma japonicum Ovan Nugroho Pegia; David Pakaya; Joni Tandi
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 7 No. 1 (2022): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v7i1.607

Abstract

Hati menjadi tempat deposit dan berkembangnya telur Schistosoma japonicum (S.japonicum). Infeksi tersebut dapat memicu kerusakan hati yang diidentifikasimelalui pemeriksaan serum glutamic oxaloacetic transaminase (SGOT) dan serumglutamic pyruvic transaminase (SGPT). Biji pinang secara empiris memilikikemampuan mengobati infeksi S. japonicum. Penelitian ini bertujuan untukmengetahui efek sediaan nanopartikel ekstrak etanol biji pinang terhadap kadarSGOT dan SGPT pada model tikus terinfeksi S. japonicum. Pada penelitianmenggunakan 27 ekor tikus wistar jantan berusia 8 minggu dengan berat badan250-300 gram. Tikus dibuat menjadi model terinfeksi schistosoma dengan induksiserkaria. Tikus dibagi menjadi 9 kelompok; kontrol sehat (K1), kontrol negatif(K2), kontrol positif (K3), terapi ekstrak etanol biji pinang dosis 30 mg/kgBB(K4), terapi ekstrak etanol biji pinang dosis 60 mg/kgBB (K5), terapi ekstraketanol biji pinang dosis 120 mg/kgBB (K6),terapi sediaan nanopartikel ekstrak bijipinang dosis 30 mg/kgBB (K7), terapi sediaan nanopartikel ekstrak biji pinangdosis 60 mg/kgBB (K8), terapi sediaan nanopartikel ekstrak biji pinang dosis 120mg/kgBB (K9). Uji statistik menggunakan Saphiro wilk. Hasil penelitiandidapatkan sediaan nanopartiel ekstrak etanol biji pinang dosis 30, 60 dan 120mg/kgBB mampu memperbaiki rerata kadar SGPT dan SGOT pada tikus terinfeksiS. japonicum setelah 3 hari terapi.
Uji Efektivitas Antihiperglikemia Daun Kelor (Moringa Oleifera Lam.) dan Gambaran Histopatologi Pankreas Tikus Putih Jantan (Rattus Norvegicus) yang Diinduksi Streptozotocin Tandi, Joni; Yanti Palinggi, Ida; Tonapa Rammang, Seblin; Wahyu Handayani, Tien
Jurnal Jamu Indonesia Vol. 4 No. 2 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v4i2.131

Abstract

Penelitian ini bertujuan untuk menguji efek penurunan kadar glukosa darah dan gambaran histopatologi pankreas dari daun kelor pada tikus putih jantan, serta senyawa metabolit sekunder pada ekstrak fraksi n-heksan, fraksi etil asetat dan fraksi etanol-air. Pengujian menggunakan 35 ekor tikus dibagi menjadi tujuh kelompok dengan perlakuan yaitu kelompok kontrol normal, kontrol negatif, kontrol positif metformin, kontrol positif simvastatin, dan kelompok uji (fraksi n-heksan, fraksi etil asetat dan fraksi etanol air) dengan dosis 300 mg/kg BB. Pengukuran kadar glukosa darah dilakukan pada hari ke-0, 35, 42 dan 49 setelah diberi perlakuan. Hasil penelitian menunjukkan bahwa terdapat senyawa metabolit sekunder fraksi etil asetat dan etanol air yaitu alkaloid, flavonoid, saponin, tannin dan steroid. Fraksi n-heksan hanya terdapat saponin. Fraksi etanol air ekstrak daun kelor pada dosis 300 mg/kg BB yang memiliki efek penurunan kadar glukosa darah sebesar 114,6 (mg/dL) dan nilai kerusakan pancreas rata-rata 2. Lebih baik dibandingkan dengan fraksi n-heksan dan etil asetat.
Co-Authors Afriani S Afrizal Agustinus Widodo Ahmad, Mirnawati Alaydrus, Syafika Alaydus, Syafika Andini, Tuti Allawiah Anggi, Viani Anita Purwantari Aril, Moh Arynesta, Teddy Asrifa Asrifa Astria, Nani Astuti, Dewi Qurrotul Ayu Martina AYU WULANDARI Ayu Wulandari Azwaajum Mutahharah Basilingan, Aprince Bella Melinda Bengkati, Stely Gracia Cinda Pradita Sudar Claresta, Jong A. Darmayanti David Pakaya David Pakaya Debora Rislianti Lakiu Dewi Astuti Dewi, Alfia Dian S. Waruwu Diana Pratiwi, Franciska Dipayana, I Made Erdy Prasetyo Fahri, Mohammad Fahruddin Fahruddin Faisal Rahmat Nugraha Fajar Alan Fatma, Nurul Feiverin Tibe Gabriella Bamba Ratih Lintin Gintu, Tri Juniver Gusti Ayu Gusti Ayu, Gusti Handayani KR Handayani, Tien W. Handayani, Tien Wahyu Handayani, Tien Wahyuni Harliwong, Dhitania Ivana Hastuti L Ida Yanti Palinggi Insani, Nabila Nurul Intan, Putu Irwan Irwan Islamiati, Utami Jong A. Claresta Kiki Rizki Handayani Kurnia Gatot Novrianto L, Wahyudin H Lakiu, Debora Rislianti Lexy Kareba Lidongi, Putri Marcelita Lina Hardianti Rukmana M, Yulan Magfira Magfirah Magfirah, Magfirah Magfiroh Magfiroh Maria Kanan Mariyani Mariyani, Mariyani Marsella, Mimi Marzela Dewi Meike Rachmawati Merue, Novalia Moh Rizky Moh. Roem Muhammad Agus Muljanto Muthi’ah H Z Muthmainah Tuldjanah Muthmainnah, Sririzqi Na'i, Alpina Nadila Nadila Nadila, Nadila Nadira Nani Astria Ni Made Irma Mariani Ni Putu Setiawati Ni Wayan Ika Purwasih Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Niswatulfahriyati Niswatulfahriyati Nur Azizah Nur Ikhwan Nurhikmah Nurhikmah Nurmadinah Nurmadinah Nurul Ulzmi Ovan Nugroho Pegia Parobe, Alda Iglesias Pasang, Sisilia Baan Polakitan, Grace Lovita Polibaon, Tresya J. Puspita Dewi, Niluh Putri, Debby Aulia R, Yana Novika Rahmawati D Rahmawati Salsa Dinurrosifa Rajadenda, Afwa Al Rasmiyanti, Ni Kadek Evy Recky Patala Rezky Yanuarty Riani, Ni P. I. Riani, Ni Putu Intan Rio Mariani Risna Yanti Rizaldy Lalu Ronaldy Nobertson Rusdi, Grasela Ruterlin, Valen Safitri, Nabila Umi Salsabila, Unik Hanifah Sasdila, Sasdila Seblin Tonapa Rammang Sene, Ikhsan Hi. Amir Solehah, Puput Octaviani Sri Mulyani Sri Mulyani Sri Mulyani Sri Mulyani Sabang Suarsana, I Made Agus Sujati, Ni Wayan Surat, Megawati R. surisna, surisna Syafika Alaydrus Tampang, Rivani Tamunu, Jeine Sweet Natasya Tandy, Putri Adam Tarusu, Fikhta Agnesya Tiara Anastasya Ticoh, Febriyani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien, Tien Wahyu Handayani Toding, Ficanata Adhiguna Tonapa Rammang, Seblin Towulu, Dessy Gracelia Tuldjanah, Muthmainah Uigianto, Imelda Utami, Indah Kurnia Valen Ruterlin Veronika Veronika Viani Anggi Vidya Christin Vivi Gretia Triposa Wahyu Handayani, Tien Wahyu Nur Afandi WAYAN WAYAN Wirawan W Wirawan, Resky Chandra wirawan, Wayan Yana Novika R Yanti Palinggi, Ida Yanuarty, Rezky Yasinta Rakanita Yuli Fitriana Yuliet Yuliet Yulistien Yusuf Yunlis Silintowe Kenta Yusriadi Yusriadi Yustin Yustin Zulfaidah