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All Journal VALENSI Jurnal Farmasi Udayana PHARMACON Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL ILMIAH PERSPEKTIF Majalah Obat Tradisional KOVALEN: Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Ilmiah Manuntung Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ CARADDE: Jurnal Pengabdian Kepada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research JIMR - Journal of Islamic Medicine Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Lentera Acitya Journal Of Health Majalah Farmasetika Indian Journal of Forensic Medicine & Toxicology Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Farmasi Sains dan Praktis Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Kesehatan Lentera Acitya Jurnal Pengabdian Farmasi dan Sains Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Joni Tandi, Joni
Program Studi S1 Farmasi, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
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Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes: Ethanol Extract of Some Cowpea (Vigna unguiculata (L.) Walp) Leaves: Morphometry Study of Pancreatic Islet of Diabetic Rat Model Solehah, Puput Octaviani; Tarusu, Fikhta Agnesya; Tandi, Joni; Dewi, Niluh Puspita; Ratih Lintin, Gabriella Bamba; Fitriana, Yuli; Pakaya, David
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.118 KB) | DOI: 10.22487/j24428744.2019.v5.i2.13934

Abstract

Diabetes is characterized by an increasing of blood levels and progressive changes in the structure of pancreatic islet of pancreas. Natural ingredients that contain antioxidants such as some cowpea leaves can be an alternative treatment for diabetes. This study aims to examine the effect of ethanol extract of some cowepea leaves (Vigna unguiculata (L.) Walp) on morphometry (perimeter and diameter) of pancreatic islet of diabetic rat models. The type of research is quasi-experimental with posttest group design. Samples were 30 male wistar rats, age 8 weeks, BW 250-300 grams, that induced by single dose of STZ 40 mg/kg BW. Rats were divided into 5 groups. Group A: normal control, Group B: negative control, Group C: positive control, Group D: DM rats with 100mg/Kg BW extract therapy, Group E: DM rats with 200mg/Kg BW extract therapy, Group F: DM rats with extract therapy 300mg/Kg BW. Blood sugar levels were measured on days 7, 14 and 21. Pancreatic tissue was prepared with 5μm thickness and stained with Hematoxylin Eosin. The sample was observed under 400x magnification microscope. The observation uses Image J software to measure the perimeter and diameter of the pancreatic insula. Data were analyzed by non-parametric Kruskal Wallis and post hoct Mann Whitney statistical tests. Blood glucose level was obtained on 21st day with the highest mean in group B (246.8±156.3) and lowest in group A (67.2 ±7.85), perimeter of pancreatic islet was significantly different (p=0.026), the diameter is significantly different (p =0.046). Ethanol extract of some cowpea (Vigna unguiculata (L.) Walp) leaves with dose of 300mg/kgBB helps to restore the blood and morphometry of pancreatic islet model of diabetic rats.
Potensi Rumput Laut (Eucheuma cottonii J.Agardh) Terhadap Nefropati Diabetik Tikus Putih Jantan (Rattus norvegicus): (Potency of Seaweed (Eucheuma cottonii J.Agardh) Against Nephropathy Diabetic Male White Rats (Rattus norvegicus)) Tandi, Joni; Dewi, Niluh Puspita; Wirawan, Resky Chandra; Surat, Megawati R.
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15046

Abstract

ABSTRACT This study aims to determine the effect of a multilevel dose of ethanol extract of seaweed (Eucheuma cottonii J. Agardh) on the decreasing blood glucose levels and kidney tissue regeneration of hypercholesterolemia-diabetic male white rats. 24 rats were divided into 6 groups, namely groups 1-3 (normal control, negative control, and positive control/Glibenclamide, respectively) and groups 3-6 (seaweed extract doses of 100, 200, and 400 mg/kg BW per oral, respectively). Rats were induced by high fat diet and Streptozotocin. Histopathological picture of the kidney was observed by HE staining using 400 magnifications. Data scoring of the level of kidney damage were analyzed by One Way ANOVA at a 95% confidence level and a Least Significant Difference (LSD) test was conducted. Seaweed ethanol extract at a dose of 100 mg/kg BW was effective in reducing blood glucose levels with an average value of 122.25 mg/dL and effective in regenerating the kidney tissue of male white rats with an average value of damage of 1.9. Therefore, seaweed extract has potency to be developed and further investigated as an antidiabetic agent.
The Effect of Ethanol Extract of Guava (Psidium guajava L) Leaf on Hypercholesterolemia-Diabetic White Rats Male Induced by High Fat Feed and Streptozotocin Tandi, Joni; Diana Pratiwi, Franciska; surisna, surisna; Puspita Dewi, Niluh; Magfirah, Magfirah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15533

Abstract

This study aims to determine the effect of guava (Psidiium guajava L) leaf extract on hypercholesterolemia-diabetic white rats male and the effective dose for reducing cholesterol and blood glucose levels. This study is a laboratory experimental study using 30 rats divided into 6 test animals. the treatment group, each group consisted of 5 rats. Group I was normal control, group II negative control was given Na-CMC suspension, group III as positive control was given simvastatin group IV dose 150 mg / kg BW, group V dose 250 mg / kg BW and group VI dose 350 mg / kg BW. The results showed that the ethanol extract of guava leaves influenced reducing blood glucose levels of male white rats with an effective dose of 250mg / kg BW with an average reduction of 119 mg/dL and effective reducing the cholesterol levels at a dose of 150 mg /kg BW with an average reduction of 28,33 mg/dL.
Total Metabolit Sekunder dan Uji Aktivitas Antioksidan Daun Juwet (Syzygium cumini L.) dengan Spektrofotometer Uv-Vis: Total Secondary Metabolites and Test of Antioxidant Activity of Juwet Leaves (Syzygium cumini L.) with Uv-Vis Spectrophotometer Tien, Tien Wahyu Handayani; Rasmiyanti, Ni Kadek Evy; Tandi, Joni; Magfirah
KOVALEN: Jurnal Riset Kimia Vol. 9 No. 3 (2023): December Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2023.v9.i3.16672

Abstract

The aim of this research is to determine the total amount of secondary metabolites (alkaloids, flavonoids, saponins and tannins) contained in the ethanol juice of juwet leaves (Syzygium cumini L.) using the UV-Vis spectrophotometry method and to determine the antioxidant activity of the ethanol juice of juwet leaves based on IC50 value. Determination of total levels of secondary metabolites using UV-Vis spectrophotometry and antioxidant testing using the DPPH method. The results of qualitative analysis of the ethanol juice of juwet leaves contained secondary metabolite compounds, namely flavonoids, saponins, tannins and alkaloids. The average value obtained for the level of total secondary metabolites for flavonoid compounds was 0.417% w/w., saponins 0.766 w/w., tannins 0.282 w/w and alkaloids 0.384% w/w. The results of testing the antioxidant activity of juwet leaf ethanol extract and quercetin as a comparison had antioxidant activity, the average IC50 results were 14.289 ± 0.255 ppm and 102.45 ppm, therefore they were classified as moderate antioxidants.
Memberdayakan Masyarakat untuk Memerangi Hipertensi Melalui Program Edukasi Tanaman Herbal Joni Tandi; Tiara Anastasya; Lina Hardianti Rukmana
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 1 (2025): Agustus
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v8i1.2931

Abstract

Hipertensi merupakan masalah kesehatan yang signifikan di Sulawesi Tengah, dengan prevalensi mencapai 34,11% pada orang dewasa. Masyarakat RT09 Kelurahan Lambara menghadapi kendala dalam penanganan hipertensi, termasuk rendahnya pemahaman tentang penyakit dan pemanfaatan tanaman obat. Program pengabdian masyarakat ini bertujuan meningkatkan pemahaman warga tentang pemanfaatan tanaman obat untuk mengatasi hipertensi. Metode yang digunakan adalah participatory learning melalui ceramah interaktif dan diskusi dua arah, melibatkan 20 warga sebagai peserta. Evaluasi dilakukan menggunakan pre-test dan post-test untuk mengukur peningkatan pengetahuan. Hasil menunjukkan peningkatan signifikan dalam pemahaman peserta, dimana rata-rata pengetahuan meningkat dari 15% menjadi 96,67%. Secara spesifik, pemahaman tentang hipertensi meningkat dari 25% menjadi 100%, pengetahuan tentang tanaman obat dari 10% menjadi 95%, dan pemahaman cara kerja tanaman obat dari 10% menjadi 95%. Dapat disimpulkan bahwa program edukasi ini berhasil meningkatkan pengetahuan masyarakat tentang pemanfaatan tanaman obat untuk mengatasi hipertensi, yang dibuktikan dengan peningkatan signifikan pada semua aspek yang dievaluasi.
Efek Ekstrak Etanol Daun Pepaya Terhadap Histopatologi Ginjal Tikus Putih Yang Diinduksi Streptozotocin Yanuarty, Rezky; Tamunu, Jeine Sweet Natasya; Tandi, Joni; Dewi, Niluh Puspita
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia Special Issue for 18th Mulawarman Pharmaceu
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.469

Abstract

Ginjal merupakan organ yang mempunyai kemampuan menyaring darah dengan membuang limbah alami seperti urea. Limbah alami yang diperluas bisa menyebabkan kerusakan ginjal. Penelitian ini bertujuan untuk menentukan kandungan metabolits pilihan alkaloids, flavonoids, saponins, dan tanins dalam konsentrat etanol daun pepaya, dan untuk menentukan dampak dan porsi konsentrat yang layak pada melawan sel silinder ginjal pada tikus yang digerakkan oleh streptozotocin. Hewan pengerat diisolasi ke dalam 6 kelompok yang terdiri dari control tipikal, control negatif, control positif, perlakuan lepas tandan dengan dosis 100, 200, 300mg/kg BB. Penelitian selama 28 hari. Studi ini mencatat perkembangan yang terjadi pada sel tubullus ginjal tikus putih jantan yang dipicu oleh streptozotocin sebagai tingkat kerusakans dengan nilai yangs ditentukan sebagai persentase (%) pada setiap bagian tubullus yang rusak atau rusak. Hasil penelitian menunjukkans bahwa daun pepaya secara terpisah mengandung metabolits opsional alkaloids, flavonoids, saponins dan tanins. Pemberian konsentrat etanol daun pepaya dalam porsi 300mg/kg BB secara preventif bisa mempengaruhi sel silinder ginjals pada tikus yang diinduksis STZ, dengan nilais bahaya tipikal 0,4 dari batas 4.
Uji Aktivitas Antioksidan Formula Minyak Herbal Dengan Metode 1,1-Diphenyl-2-picrylhidrazil (DPPH) Wulandari, Ayu; Nurhikmah, Nurhikmah; Tandi, Joni
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia Special Issue for 18th Mulawarman Pharmaceu
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.470

Abstract

Penelitian ini bertujuan untuk mengetahui stabilitas fisik serta aktivitas antioksidan formula minyak herbal pelita mas dengan menggunakan Metode 1,1-diphenyl-2- picrylidrazil (DPPH). Penelitian ini merupakan penelitian eksperiment laboratorium dengan rancangan untuk mengetahui nilai aktivitas antioksidan dengan menggunakan metode 1.1-Diphenyl-2-picrylhidrazil (DPPH) dan mengetahui stabilitas dari formula minyak herbal pelita mas. Analisis data menggunakan One Way Anova pada program SPSS. Hasil penelitian menunjukkan bahwa stabilitas formula minyak herbal seperti organoleptik, viskositas, kejernihan dan pH memenuhi syarat mutu sediaan minyak. Hasil pengujian aktivitas antioksidan formula minyak dan kuarsetin diperoleh nilai IC50 sebesar 101,328 ppm dan 4,623 ppm dimana formula minyak herbal pelita mas tergolongan antioksidan sedang dan kuarsetin tergolong antioksidan kuat. Hasil uji analisis statistik yaitu uji normalitas dan uji homogenitas menyatakan bahwa data terdistribusi normal dan homogen. Hasil uji One Way Anova diperoleh nilai sig. 0.000 (<0,05) hal ini menunjukkan perbedaan yang signifikan antara formula minyak herbal dengan kuarsetin.
Formulation, Evaluation And Antibactery Activity Test Of Gastroretentive Mukoadhesive Granul Matrix Earthworm Extract (Lumbricus rubellus) Magfirah, Magfirah; Alaydrus, Syafika; Tandi, Joni; Utami, Indah Kurnia; Dewi, Niluh Puspita
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.503

Abstract

Background: Earthworm extract (Lumbricus rubellus) has antimicrobial activity because it produces high levels of the lumbricine compound but is easily denatured in the stomach so that its solubility and biological activity change. Therefore its Application can be developed in the form of gastrorentetif mucoadhesive preparation. Objectives: The purpose of this study was to optimize and evaluate the antibacterial activity of gastroretentive mucoadhesive preparation matrix of earthworm extract (Lumbricus rubellus). Material and Methods: The matrix utilized a preparatory technique of applying wet granulation mucoadhesive polymers such as chitosan, HPMC, and sodium CMC with concentrations determined based on simple lattice design resulting in 7 granule formulas. The granule formulas obtained were then evaluated including flow time and dwell angle tests, particle size distribution tests, compressibility tests, dissolution tests, and antibacterial activity tests. Results: The results showed that the flow rate on the F3 granule formulation met the requirements of flow rate >10 g/s, a consequence of measuring the angle of repose in the F1-F5 formula had good flowability which was below 30o, in contrast to F6 and F7 which had an angle of repose of 30-40o favorable to flowability. The F1-F7 formula was mostly preserved in mesh number 20 sieve with a size of 426-850 ?m, according to the results of particle size distribution utilizing the multistage sieve method, the compressibility index of the F1-F7 granule formula was 10% and the measurement results at the 30 minute showed that the average dissolution of the F1-F3 granules was 97.77%, 97.77%, and 101.22% respectively while the F4-F7 granule formulas did not show slow drug release because at the 30th minute the drug released ranged and the antibacterial activity test of Formula 1-Formula 7 granules is respectively 6 mm, 5.5 mm, 8 mm, 3.5 mm, 4.7 mm, 2.1 mm and 3.3 mm. Conclusions: The results of the evaluation of the characteristics of earthworm extract mucoadhesive gastroretentive granule preparation demonstrated that the preparation met the requirements for granule preparation and exhibited antibacterial properties. Among the seven formulas tested, formula 3 had the highest efficacy of antibacterial activity.
Standardization of Non-specific Parameters of Honey from Farmed Bees in Tojo Una Una Islamiati, Utami; Parobe, Alda Iglesias; Yanuarty, Rezky; Tandi, Joni
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7602

Abstract

Honey is a normally sweet arrangement delivered by bumble bees from nectar sources. In the use of honey as an herbal ingredient, however, not all honey in Indonesia has been standardised, so it is necessary to confirm the quality of honey that meets the reference standards set by the government, namely SNI. The purpose of this study was to determine the quality of honey in Tojo Una-una Regency from three different sub- districts: Ampana Tete, Ampana Kota, and Ratolindo, based on standardization using non-specific test parameters. This study used pure honey and honey extract using 96% ethanol solvent. The tests based on non-specific parameters in the form of moisture content were performed by gravimetry, ash content by dry ashing, acidity by titration, and reducing sugar by UV-Vis spectrophotometry, while metal contamination by atomic absorption spectrophotometry, all tests were repeated 3 times. Statistical test results showed that there were significant differences in the quality of honey from three different locations. The results of the research on pure honey and honey extract from Ampana Tete meet the SNI requirements except for the water content test of pure honey which does not meet the SNI.
Determination of Secondary Metabolite Levels in Ethanol Extract of Clove leaves (Syzygium aromaticum L.) Using LC-HRMS Methods Tuldjanah, Muthmainah; Sasdila, Sasdila; Yanuarty, Rezky; Wulandari, Ayu; Tandi, Joni
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7975

Abstract

The use of plants as raw materials for medicinal purposes has become increasingly prevalent due to the diverse secondary metabolites they can produce. Clove leaves (Syzigium aromaticum L.) are known for their antimicrobial, antioxidant, anti-inflammatory, analgesic, anticancer, anesthetic, aphrodisiac, and antipyretic properties. This study aims to determine the levels of secondary metabolites in clove leaves using the LC-HRMS method. The results showed that the ethanol extract of clove leaves contained 34 compounds, with the compounds (-)-Caryophyllene oxide and Miquelianin having the highest chromatogram peaks at 9.714195% and 8.712299% of the compound composition, respectively.
Co-Authors Afriani S Afrizal Agustinus Widodo Alaydrus, Syafika Alfia Dewi Anita Purwantari Asrifa Asrifa Astuti, Dewi Qurrotul Ayu Martina Ayu Wulandari Ayu Wulandari AYU WULANDARI Azwaajum Mutahharah Basilingan, Aprince Bella Melinda Cinda Pradita Sudar Claresta, Jong A. Darmayanti David Pakaya David Pakaya Debora Rislianti Lakiu Dewi Astuti Dhitania Ivana Harliwong Dian S. Waruwu Diana Pratiwi, Franciska Erdy Prasetyo Fahruddin Fahruddin Faisal Rahmat Nugraha Fajar Alan Feiverin Tibe Ficanata Adhiguna Toding Gabriella Bamba Ratih Lintin Gusti Ayu Gusti Ayu, Gusti Handayani KR Handayani, Tien Wahyu Handayani, Tien Wahyuni Hastuti L I Made Dipayana Ida Yanti Palinggi Irwan Irwan Islamiati, Utami Jong A. Claresta Kiki Rizki Handayani Kurnia Gatot Novrianto L, Wahyudin H Lakiu, Debora Rislianti Lexy Kareba Lidongi, Putri Marcelita Lina Hardianti Rukmana M, Yulan Magfira Magfira Magfirah Magfirah, Magfirah Magfiroh Magfiroh Maria Kanan Mariyani Marsella, Mimi Marzela Dewi Meike Rachmawati Moh Rizky Moh. Roem Muhammad Agus Muljanto Muthi’ah H Z Na'i, Alpina Nadila Nadila Nadira Nani Astria Ni Made Irma Mariani Ni Putu Intan Riani Ni Putu Setiawati Ni Wayan Ika Purwasih Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Niswatulfahriyati Niswatulfahriyati Novalia Merue Nur Azizah Nur Ikhwan Nurhikmah Nurhikmah Nurmadinah Nurmadinah Nurul Ulzmi Ovan Nugroho Pegia Parobe, Alda Iglesias Pasang, Sisilia Baan Puspita Dewi, Niluh Putu Intan R, Yana Novika Rahmawati D Rasmiyanti, Ni Kadek Evy Recky Patala Rezky Yanuarty Rio Mariani Risna Yanti Rivani Tampang Rizaldy Lalu Ronaldy Nobertson Ruterlin, Valen Salsabila, Unik Hanifah Sasdila, Sasdila Seblin Tonapa Rammang Solehah, Puput Octaviani Sri Mulyani Sri Mulyani Sri Mulyani Sri Mulyani Sabang Sririzqi Muthmainnah Stely Gracia Bengkati Suarsana, I Made Agus Surat, Megawati R. surisna, surisna Syafika Alaydrus Tamunu, Jeine Sweet Natasya Tarusu, Fikhta Agnesya Tiara Anastasya Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien, Tien Wahyu Handayani Tonapa Rammang, Seblin Towulu, Dessy Gracelia Tuldjanah, Muthmainah Utami Islamiati Utami, Indah Kurnia Valen Ruterlin Veronika Veronika Viani Anggi Vidya Christin Wahyu Handayani, Tien Wahyu Nur Afandi WAYAN WAYAN Wayan Wirawan Wirawan W Wirawan, Resky Chandra Yana Novika R Yanti Palinggi, Ida Yanuarty, Rezky Yasinta Rakanita Yuli Fitriana Yuliet Yuliet Yulistien Yusuf Yunlis Silintowe Kenta Yusriadi Yusriadi Yustin Yustin Zulfaidah