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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) FITOFARMAKA: Jurnal Ilmiah Farmasi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Narra J JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Pengabdian Kefarmasian Media Farmasi Jurnal Kefarmasian Indonesia
Syamsu Nur, Syamsu
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Narra J

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Chemical fingerprinting and antioxidant properties of Glochidion philippicum Khairuddin, Khairuddin; Manggau, Marianti A.; Rante, Herlina; Hardiyanti, Widya; Latada, Nadila P.; Umar, Abdul H.; Nur, Syamsu; Wahyudin, Elly; Rahman, Latifah; Yulianty, Risfah; Nainu, Firzan
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1886

Abstract

Glochidion philippicum has been suggested to exhibit considerable pharmacological potential, yet its chemical composition and bioactivity remain inadequately explored. The aim of this study was to investigate the chemical fingerprint and antioxidant properties of G. philippicum leaf extracts using Fourier-transform infrared spectroscopy (FTIR) with chemometric analyses, and in vitro and in vivo evaluations. Four extraction methods (maceration, reflux, ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE)) were optimized with water, 70% ethanol, ethyl acetate, and n-hexane as solvents. FTIR profiles were analyzed with principal component analysis (PCA), hierarchical cluster analysis, and orthogonal partial least squares discriminant analysis. An in vitro study assessing the free radical scavenging capacity was conducted using the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) methods, while in vivo evaluations were conducted using Drosophila melanogaster to measure antioxidant enzyme activity and expression of endogenous antioxidant-related genes. FTIR profiles identified functional groups contributing to antioxidant activity. In vitro assays using ABTS and FRAP methods revealed that extracts obtained with 70% ethanol and water exhibited the highest antioxidant activity, attributed to key functional groups such as C=C (aromatic), O−H (acidic), N=O (nitro), and C−O (ester). In vivo studies showed that ethanol-based MAE extracts (MAEEO) significantly improved the survival of autoinflammatory PGRP-LBΔ mutant larvae exposed to heat-killed Escherichia coli. Real-time quantitative PCR analysis indicated this effect was dependent on endogenous antioxidant gene activation. The study highlights that G. philippicum leaf extracts as a natural source of bioactive compounds with exogenous antioxidant properties, offering potential for therapeutic applications.
Phytochemical profiling and enzyme inhibitory activity of Sterculia populifolia DC stem bark extract and fractions against elastase and tyrosinase Khairi, Nur; Nursamsiar, Nursamsiar; Utami, Novi F.; Marwati, Marwati; Nur, Syamsu; Indrisari, Maulita; Kursia, Sukriani
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.1778

Abstract

The demand for natural ingredients in cosmetic and medical applications is steadily increasing, particularly for anti-aging and skin-lightening products. Sterculia populifolia DC, a member of the Sterculia genus, is known to contain diverse bioactive compounds such as flavonoids, phenolics, and terpenoids, which may offer pharmacological benefits. The aim of this study was to evaluate the anti-aging potential of S. populifolia stem bark extract and its solvent-partitioned fractions through enzyme inhibition assays coupled with phytochemical profiling. The stem bark was extracted using 96% ethanol via maceration, followed by sequential liquid-liquid partitioning with n-hexane, ethyl acetate, n-butanol, and water. Phytochemical constituents were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The inhibitory activities of the extract and fractions against tyrosinase and elastase enzymes were evaluated using spectrophotometric assays, with kojic acid and quercetin as positive controls, respectively. IC₅₀ values were calculated to quantify enzyme inhibition potency. LC-MS/MS analysis revealed key bioactive compounds, including 4-[(E)-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol, isofraxidin, and (22E)-ergosta-4,6,8(14),22-tetraen-3-one. Among the tested samples, the ethanol extract exhibited the most potent activity, with an IC₅₀ of 93.35 µg/mL for elastase inhibition and 133.15 µg/mL for tyrosinase inhibition—classified as strong and moderate activity, respectively. Collectively, these findings demonstrate that S. populifolia stem bark extract possesses promising anti-aging and depigmenting properties, supporting its potential development as a natural bioactive ingredient in cosmetic and skincare formulations.
Co-Authors Adjara, Syafia Mustika Afsari, Mutiara Indah Ayu Agustina Aisyah, Andi Nur Aiyi Asnawi Amrullah, Akhmad Andi Ardiansyah Arifin Ariestanti, Donna Maretta Astuti Amin Awaluddin, Akbar Azizah, Suhaimi Berna Elya Biring, Frans Syukur Burhan, Asril Djamaluddin, Suci F Elly Wahyudin Endang Lukitaningsih Erma Yunita Fadilah Qonitah Fajriati, Annisa Firzan Nainu Fitriyanti Jumaetri Sami Fitriyanti Jumaetri Sami, Fitriyanti Jumaetri Forestrania, Roshamur Cahya Gemini Alam Hardiyanti, Widya Hayun Hayun Herlina Rante Indradewa, Rhian Irwana, Rina Ivone P., Velyostri Kasmawati, Henny Keyzia, Kurnia Khairi, Nur Khairuddin - Kharismatul Khasanah Kusmardi Kusmardi Latada, Nadila P. Latifah Rahman Lumi, Stefanus Agustinus Mamada, Sukamto S. Marianti A Manggau Marwati Marwati Mar’atun Jannah, Imrawati, Muzakkir Baitz, Matandung, Friska Nissa Maulita Indrisari, Maulita Megawati Megawati - Mistriyani, Mistriyani Muhammad Aswad Munawarah Munawarah, Munawarah Mus, Suwahyuni Muslimin, Lukman Novi Fajar Utami Nurjannah Nursamsiar Nursamsiar Nursamsiar Nurul Jannah paluseri, Andi Payung, Deslin Pratama, Nofran Putra Putri Indah Sayakti Rahim, Kurnia Rahman, Annisa Amirah Rahmasari, Ratika Reny Syahruni Risfah Yulianti Risfah Yulianty Rosyid, Sujud Z Rumiyati, Rumiyati Salampe, Mirnawati Sami, Fitriyanti Sami, Fitriyanti J. Sari, Rifta SEPTI WULANDARI Shelina, Vivi Sitti Rahimah, Sitti Solly Aryza Sukriani Kursia, Sukriani Tonapa, Novianti Triana Hertiani Tumigolung, Aprilia Ester Eunike Umar, Abdul H. Utami, Novi F. Wahyuddin, Nurzadrina Yusnita Rifai, Yusnita Zulbayu, L.M. Andi