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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Klinik Indonesia JPSriwijaya Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Surya Medika Syntax Literate: Jurnal Ilmiah Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat (Mediteg) Jurnal Abdi Insani Pelita Masyarakat Borneo Journal Of Pharmascientech Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Khazanah: Jurnal Mahasiswa Majalah Cendekia Mengabdi Carmin: Journal of Community Service Camellia Borneo Journal of Pharmacy Journal of Pharmascience
Helmina Wati
Program Studi Pendidikan Profesi Apoteker, Universitas Borneo Lestari, Banjarbaru
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Comparison Of HbA1c Levels in Type II Diabetes Mellitus Patients Receiving A Combination of Oral Hypoglycemic Drugs and Insulin Degludec-Aspart Versus Insulin Degludec-Aspart Monotherapy Helmina Wati; Syahrizal Ramadhani; Esty Restiana Rusida; Muhammad Raffyqurrahman
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.22242

Abstract

Diabetes melitus tipe II merupakan penyakit kelebihan glukosa yang disebabkan oleh menurunnya kinerja insulin dalam tubuh. Kriteria utama dalam manajemen glukosa darah adalah kadar HbA1c. Penelitian ini bertujuan mengevaluasi perbedaan kadar HbA1c pada pasien diabetes melitus tipe II yang mendapatkan terapi kombinasi obat hipoglikemik oral dan insulin degludec-aspart dibandingkan dengan pasien yang menerima monoterapi insulin degludec-aspart. Metode yang digunakan dalam penelitian yaitu cross-sectional secara retrospektif pada bulan Januari-Desember 2023 dengan jumlah sampel sebanyak 66 pasien yang dibagi menjadi 2 kelompok. Nilai HbA1c yang diperoleh dari bulan pertama hingga bulan ketiga dianalisis secara statistik menggunakan independent sample t-test dengan uji SPSS versi 21. Hasil penelitian menunjukkan penurunan kadar HbA1c pada kombinasi terapi obat hipoglikemik oral + insulin degludec-aspart sebelum dan sesudah dengan selisih nilai ± SD sebesar (1,565 ± 1,10)% dan penurunan nilai HbA1c ± SD pada monoterapi insulin degludec-aspart sebelum dan sesudah dengan selisih nilai (1,05 ± 0,74)% dengan nilai p (<0,05). Kesimpulan penelitian ini adalah terdapat perbedaan penurunan nilai HbA1c pada kedua kelompok dengan nilai p (<0,05). Hal ini menunjukkan bahwa penggunaan kombinasi oral lebih efektif daripada monoterapi.  Kata Kunci: Diabetes Mellitus Tipe II, HbA1c, Insulin Degludec-Aspart, Obat Hipoglikemik Oral, Kombinasi Terapi. Type II diabetes mellitus is a condition marked by hyperglycemia due to reduced effectiveness of insulin within the body.The main criterion in blood glucose management is HbA1c level. The objective of this research was to assess the difference in HbA1c levels between type 2 diabetes patients treated with a combination of oral hypoglycemic agents and insulin degludec-aspart versus insulin degludec-aspart alone. This research method uses a retrospective cross-sectional research design in January-December 2023 with a total sample of 66 patients divided into 2 groups. HbA1c values collected from the first to the third month were analyzed using the independent sample t-test in SPSS version 21. The Medical Research Ethics Commission of Ulin Banjarmasin Regional General Hospital South Kalimantan has approved this study. HbA1c levels in the combination of oral hypoglycemic drug therapy and insulin degludec-aspart pre- and post- with a difference in ± SD value of (1.565 ± 1.10)% decrease and a decrease in HbA1c ± SD value in insulin degludec-aspart mono-therapy pre- and post- with a difference in value (1.05 ± 0.74)% with a p-value (<0.05).This study concludes that the reduction in HbA1c levels between the two groups differs significantly, as indicated by a p-value of less than 0.05. This implies that the use of oral combination is more effective than mono-therapy.
Knowledge and Antibiotic Adherence in Acute Respiratory Infection Patients at Karang Intan 1 Clinic Safrina Aprianti; Helmina Wati; Evy Dharmayati
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 4 No 2 (2025): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v4i2.29482

Abstract

Acute Respiratory Infection (ARI) is a bacterial infection affecting the respiratory tract, from the nasal cavity to the lungs, and contributes to nearly 4 million deaths globally each year. Knowledge refers to the information acquired and retained by individuals, while compliance indicates the extent to which patients adhere to medication instructions provided by healthcare professionals. This study aimed to assess the level of knowledge regarding antibiotics and patients’ compliance with antibiotic use. A prospective observational quantitative approach was employed from January to April 2025 at the Karang Intan 1 Health Center. The study used a cross-sectional design and included 80 ARI patients selected through total sampling. Data were collected using structured questionnaires over a two-month period. Results showed that the most frequently used antibiotic was cefadroxil, a first-generation cephalosporin, used by 52 respondents (65%). The knowledge assessment revealed that 76 respondents (95%) had good knowledge, while 4 respondents (5%) had poor knowledge. In terms of compliance, 65 respondents (81.25%) were compliant, 10 respondents (12.5%) were fairly compliant, and 5 respondents (6.25%) were less compliant. Statistical analysis using the Chi-square test demonstrated a significant relationship between knowledge level and antibiotic compliance (p < 0.000). This indicates that higher knowledge levels are associated with better compliance in antibiotic use among ARI patients at Karang Intan 1 Health Center
Co-Authors AA Sudharmawan, AA Abdul Karim Abdurahman Abdurrahman Abdurrahman, Faizah Aditya Noviadi Aesty Rahayu Afra, Fairuz Yaumil Ahmad Rusadi Arrahimi - Universitas Lambung Mangkurat) Ahmad Rusadi Arrahimi - Universitas Lambung Mangkurat) Akbar, Depy Oktapian Annisa, Rezka Aprilia Rahmadina As-Syahri, Hidayatullah Astuti, Karunita Astuti, Karunita Ika Ayulia Dwi Sandi, Dita Baiq Nurdiana Ulfa Dharmawan, Robby Difa Intannia Dita A. D. Sandi Djoko Wahyono Effendi, Ibrahim Rully Eka Fitri Susiani Eny Hastuti Evy Dharmayati Fatimah Nursandi Fatimah Nursandi Fitria Mahmudah Fitriyanti, Fitriyanti Guntur Kurniawan Gusti Rizaldi Haiqal, Ade Hayati, Farida Iedliany, Faradilla Ifan Anom Bintoro Aji Ikhwan Rizki, Muhammad Izma, Hayatun Jamaludin, Wahyudin Bin Kartini Kartini Kumala, Dinna Fitria Kurniawan, Guntur Liling Triyasmono Lisa - Andina Lisa Andina Muhamad Hepriatna Muhammad Arsyad Muhammad Ikhwan Rizki Muhammad Raffyqurrahman Muhammad Ramadhan Muhammad Reza Pahlevi Novian Adhipurna Nugroho, Agung Nurhaliza , Siti Nurul - Mardiati Nurul Mardiati Nurul Mardiati Nurul Mardiati Pinus Jumaryatno Prihandini, Yustin Ari Raffyqurrahman, Muhammad Rahmadina, Aprilia Rahmatullah, Satrio Wibowo Rahmi Hidayati Rahmi Muthia Rinto Widyanto Rusida, Esty Restiana Safrina Aprianti Saputra, Mochammad Maulidie Alfianoor Saputri, Revita Sari Wahyunita Selvi Amadia Setiawan, Finna Silviana, Mega Sitarina Widyarini Siti Khadijah Sri Mulyani Sri Wahyuni, Ririn Susiani, Eka Fitri Syahfari, Indra Syahizal Ramadhani Syahrizal Ramadhani Tiara Aninditha Untung Santoso Untung Santoso Vebruati Vebruati Vina Salviana Darvina Soedarwo Vina Salviana Darvina Soedarwo Vina Salviana Darvina Soedarwo Wahyudi Wahyudi Wahyudi Wahyudi Wardani, Muhammad Rizky Wulan Ageng Sujatmiko Yanie, A. Yaumi - Musfirah Yaumi Musfirah Yusmein Uyun Yustin Ari Prihandini Yustin Ari Prihandini Zanirah, Gina Rizki