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All Journal Jurnal Delima Harapan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kesehatan Tambusai JIFI (Jurnal Ilmiah Farmasi Imelda) Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Media Farmasi Indonesia International Journal of Medicine and Health Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Sciences of Pharmacy Duta Pharma Journal Jurnal Kesehatan Amanah Proceeding of International Conference Health, Science And Technology (ICOHETECH) Indonesian Research Journal on Education Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Inovasi Jurnal Pengabdian Masyarakat (IJPM) Jurnal Pengabdian Masyarakat dan Riset Pendidikan Journal of Innovative and Creativity Jurnal Pengabdian Kepada Masyarakat Citra Delima Jurnal Pengabdian Ilmu Kesehatan
Niken Luthfiyanti
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Safety of Rivaroxaban For Prophylaxis Vein Thrombosis Post Total Hip and Knee Replacement Luthfiyanti, Niken; Jayak Pratama, Kharisma; Noviana, Noviana
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4193

Abstract

Orthopaedic surgery such as surgery on the pelvis and knee bones has a high risk of developing Deep Vein Thromoembolism (DVT), especially in patients with hypercoagulability. Venous thromboembolism is the main cause of morbidity and mortality in orthopedic patients that can be prevented using thromboprophylaxis, but on the other hand is related to the risk of bleeding side effects. The study aimed to evaluate the safety of oral Rivaroxaban prophylaxis in patients after Total Hip and Knee Replacement. This research applied cross sectional technique. Retrospective data were taken from the medical records of Dr. Moewardi Surakarta, period January 2023- July 2024. The data taken are secondary data from the patient's medical record by recording clinical symptoms that appear. Rivaroxaban safety evaluation includes the incidence rate of bleeding as well as the factors that influence the occurrence of bleeding. A total of 38 patients met the inclusion criteria of the study. Bleeding occurred in 4 cases (10.5%). Factors that affect the incidence of bleeding renal failure (p = 0.001). Monitoring of Rivaroxaban side effects is indispensable. Pharmaceuticals can play an important role in monitoring and preventing the occurrence of bleeding by paying attention to risk factors, especially kidney failure.
UJI AKTIVITAS ANTIBAKTERI SEDIAAN MASKER GEL EKSTRAK DAUN TAPAK DARA (Catharanthus roseus (L) G. Don) TERHADAP BAKTERI Staphylococcus aureus Agustina, Isnaini; Wardani, Tatiana Siska; Luthfiyanti, Niken
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 2 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i2.1864

Abstract

Gel masks are semi-solid preparations that serve as skincare products with benefits, such as addressing various skin problems. This study aims to conduct a physical quality test on gel masks containing tapak dara leaf extract, determine the antibacterial activity of tapak dara leaf extract and evaluate the antibacterial activity of the tapak dara leaf extract gel mask against Staphylococcus aureus ATCC 25923 bacteria. This study uses both qualitative and quantitative analysis with experimental methods. The extraction of virgin leaves is carried out using the maceration method with a 70% ethanol solvent. The extracts and preparations are made into three concentrations: 10%, 20%, and 30%. The physical quality testing of tapak dara leaf gel masks includes organoleptic evaluation, homogeneity, pH, dispersion, and drying time. The results of one-way ANOVA for pH (sig. = 0.815), dispersion (sig. = 0.695), and drying time (sig. = 0.251) showed that the significance values were greater than 0.05. Tapak dara leaf extract demonstrates antibacterial activity against Staphylococcus aureus bacteria, with inhibitory zone diameters of 3.5 mm, 7.87 mm, and 9.85 mm. The gel mask preparation of virgin palm leaf extract exhibits antibacterial activity against Staphylococcus aureus bacteria, with inhibition zone diameters of 3.67 mm, 4.77 mm, and 7.4 mm. The results of one-way ANOVA on the activity of virgin palm leaf extract against Staphylococcus aureus bacteria showed a significance value less than 0.05.
Evaluation of Quality of Life in Breast Cancer Patients: A Cross-Sectional Comparative Study between Targeted Therapy and Conventional Chemotherapy Pratama, Kharisma Jayak; Luthfiyanti, Niken
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404453

Abstract

Breast cancer is one of the most common cancers worldwide, with treatment often involving conventional therapies such as chemotherapy. Although effective, chemotherapy is often accompanied by significant side effects and reduces patients' quality of life. Targeted therapy, which targets specific molecular mechanisms in cancer cells, offers the potential to address these issues with higher efficacy and fewer side effects. This study aims to compare the quality of life of breast cancer patients receiving targeted therapy with chemotherapy. The study design used a comparative cross-sectional design involving 60 patients (30 receiving targeted therapy, 30 receiving chemotherapy) selected via consecutive sampling at RSUD Moewardi in Surakarta (January–June 2025). Data were collected using the validated Indonesian version of the EORTC QLQ-C30 questionnaire. Statistical analysis included parametric t-tests and non-parametric Mann-Whitney U tests. The study results showed that the targeted therapy group had better role functioning (p = 0.047.95% CI=0.044-0.053) and significantly lower pain (p= 0.001.95% CI=0.000-0.002) and nausea (p = 0.019.95% CI=0.016-0.021) symptoms compared to chemotherapy. Global health status did not differ significantly (p= 0.545.95% CI=0.536-0.556). Age (p = 0.012.95% CI=0.08-0.012) and stadium (p = 0.001.95% CI=0.001-0.003) significantly influenced global QoL. Targeted therapy provided advantages in functional aspects and specific symptoms, although not in global QoL. A key study limitation is its cross-sectional design, which prevents the establishment of causal relationships between the type of therapy and quality of life outcomes.
Pendampingan Program Stimulasi Ibu-Anak Cegah Stunting di Posyandu Ngadi Asih Surakarta Darah Ifalahma; Ana yuliana; Niken Luthfiyanti
Jurnal Pengabdian Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Pengabdian Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jpikes.v5i3.5863

Abstract

Integrated Health Post (Posyandu) Ngadi Asih Surakarta implements Integrated Primary Services (ILP) services targeting pregnant women, toddlers, and breastfeeding mothers in support of the zero new stunting program. So far, the implementation has been limited to weighing and measuring. Problems have been identified, including the lack of health services and health education on stunting prevention. This is due to the limited knowledge and skills of cadres. The solution is an innovative Mother-Child Stimulation Program to Prevent Stunting (Prosiacting) at the Ngadi Asih Surakarta Posyandu. The activities carried out are Prosiacting Activation and Capacity Building for cadres in the form of training in Pregnancy Exercises, Baby Massage, and Oxytocin Massage. The implementation method has 6 stages: preparation, apperception, application of science and technology, mentoring, evaluation, and termination. The results of the Mother-Child Stimulation Program Innovation to Prevent Stunting (Prosiacting) have been well implemented at the Ngadi Asih Surakarta Integrated Health Post (Posyandu). Capacity Building activities for cadres were carried out well. The knowledge and skills of cadres have increased after the training, namely Pregnancy Gymnastics skills in the good category (75%), Baby Massage skills in the good category (80%), and Oxytocin Massage skills in the good category (90%). The Mother-Child Stimulation Program to Prevent Stunting (Prosiacting) has been activated. Cadres are committed to implementing the results of the training and Prosiacting routinely once a month during the Toddler Family Development activity. With the stunting prevention stimulation skills possessed by cadres, it is hoped that cadres will be able to independently accompany pregnant women, mothers of infants and toddlers, and postpartum mothers. It is hoped that this program will be routinely implemented at the Ngadi Asih Surakarta Integrated Health Post (Posyandu) as an effort to independently prevent Stunting in the Community.
Evaluasi Kesesuaian Rekonstitusi Sediaan Steril di Bangsal Anak RS Universitas Sebelas Maret Ayu Cahyani Abidin; Hidayah Apriliawan; Niken Luthfiyanti
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Reconstitution of injectable drugs involved mixing sterile drug powders with appropriate sterile solvents prior to parenteral administration. This critical pharmacy practice was particularly vital in pediatrics where dosing errors and contamination posed significant risks. Reconstitution errors could lead to chemical instability, therapeutic failure, and serious adverse effects including toxicity or nosocomial infections. This study aimed to evaluate the appropriateness of sterile injectable drug reconstitution procedures in the Pediatric Ward of Universitas Sebelas Maret Hospital across five parameters: dosage calculation, solvent selection, solvent volume, post-reconstitution storage temperature, and Beyond Use Date (BUD) assignment. A descriptive observational study with prospective design was conducted among pediatric inpatients from December 2025 to January 2026. Seventy cases of pediatric injectable drug administrations were sampled using saturated (total) sampling technique. Primary data were collected through direct pharmacist reconstitution observations while secondary data came from medical records and sterile preparation worksheets. Compliance was benchmarked against gold standards: Pediatric Injectable Drugs 10th edition and Handbook on Injectable Drugs 17th edition. Perfect compliance (100%) was achieved for dosage, solvent selection (NaCl 0.9%, sterile water), and reconstitution volumes. However, storage temperature compliance (2-8°C for light-sensitive drugs) was only 68%, while BUD documentation aligned with post-reconstitution stability in 70% of cases, leaving 2% critical non-compliance posing patient safety risks. While reconstitution technical execution was excellent, cold chain monitoring and BUD documentation required systemic improvements through regular training, real-time temperature tracking, and stricter Standard Operating Procedures to ensure pediatric pharmacotherapy safety.
Analisis Kadar Flavonoid Total dan Aktivitas Antioksidan dari Ekstrak Etanol Serta Fraksi dari Gagang Cengkeh (Syzygium Aromaticum (L)). Intan Oktaviana Putri; Niken Luthfiyanti; Danang Raharjo
Jurnal Kesehatan Amanah Vol. 9 No. 2 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i2.989

Abstract

Antioxidants are substances that can inhibit oxidation caused by free radicals. Flavonoids are effective natural antioxidants due to their unique chemical structure. Both have a hydroxyl group (-OH) attached to an aromatic ring. This hydroxyl group can donate hydrogen or electrons to free radicals. Clove stems (Syzygium aromaticum (L.)) are known to possess bioactive compounds, including flavonoids like quercetin and kaempferol, which act as antioxidants in protecting cells from free radicals. Maceration is a commonly used extraction method to obtain therapeutic compounds from plants. The process involves soaking the finely or coarsely ground plant material in a solvent (liquid thinner) in a closed container. Fractionation is a method for separating chemical components in an extract based on differences in their polarity or solubility. This process uses two immiscible solvents. This study is an experimental research aimed at determining the total flavonoid content (TFC) and the IC50​ value of the antioxidant activity present in the ethanol extract and fractions of clove stems (Syzygium aromaticum (L.)) using the ABTS method. The tests utilized maceration extraction with 96% ethanol as the solvent, and liquid-liquid fractionation using N-hexane, ethyl acetate, and water as solvents, along with UV-Vis spectrophotometry analysis. The results showed that the highest flavonoid content was in the ethanol extract, with a TFC value of 51.000 mgQE/g, and the highest antioxidant activity was in the ethyl acetate fraction, with an IC50​ value of 23.716 µg/mL, indicating a strong potential as a source of natural antioxidants.
Impact of Hormonal Therapy Regimens and Adverse Drug Reactions on Quality of Life in Breast Cancer Patients at Dr. Moewardi Regional General Hospital, Surakarta Luthfiyanti, Niken; Ichsan, Burhannudin
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502555

Abstract

Breast cancer remains the most common malignancy among women worldwide, and hormonal therapy is a cornerstone in the management of hormone receptor-positive cases, although its impact on adverse drug reactions (ADRs) and quality of life (QoL) remains a concern. This study aimed to evaluate the association between hormonal therapy patterns, ADRs, and QoL in breast cancer patients. An observational analytic study with a crosssectional design was conducted at Dr. Moewardi Regional General Hospital, Surakarta, from January to June 2025, involving 64 patients selected through consecutive sampling. Data were collected from medical records and structured interviews. QoL was assessed using the EORTC QLQ-C30 questionnaire, and ADRs were evaluated using the FACT-ES instrument. Bivariate and multivariate logistic regression analyses were performed. Most patients were aged <50 years (60.9%) and diagnosed at an advanced stage (57.8%). No significant associations were found between sociodemographic or clinical characteristics and type of therapy, survival duration, or ADR severity (all p>0.05). The most common ADRs were fatigue (51.6%) and hot flushes (50%). QoL assessment showed good functional status (mean = 79.65) and low symptom burden (mean = 25.06), but poor global health status (mean = 26.30). Cancer stage (p = 0.010) and type of therapy (p = 0.027) were significantly associated with QoL. Multivariate analysis confirmed that advanced-stage cancer (OR = 0.31; 95% CI: 0.14-0.68; p = 0.004) and combination therapy (OR = 0.44; 95% CI: 0.21-0.92; p = 0.024) were independent predictors of poorer QoL. These findings highlight the importance of individualized treatment strategies to optimize patient quality of life.
The Relationship Between ARV Therapy Adherence And Clinical Outcomes in HIV Patients at Dr Moewardi Hospital Putri Eka Prasetya; Niken Luthfiyanti; Vivin Marwiyati Rohmana; Angelina da Costa Fernandes; Al Hajar Fuadatus Zurroh
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/s04wca81

Abstract

Background: Human immunodeficiency virus (HIV) remains a major global public health problem with the number of people living with HIV continuing to increase, including in Indonesia. Antiretroviral therapy (ART) is the main treatment to suppress viral replication and improve immune function, however its success is highly dependent on patient adherence. Objective: This study aimed to determine the level of adherence to ART, evaluate clinical outcomes and analyze the relationship between ART adherence and clinical outcomes among HIV patients at Dr. Moewardi Hospital. Methods: This study employed a quantitative analytical design with a cross-sectional approach. A total of 83 patients (n=83) undergoing ART were included in this study. Data were collected using the Morisky Medication Adherence Scale (MMAS-8) and medical records. Data analysis was performed using univariate and bivariate methods. Results: The majority of patients demonstrated high adherence to ART (60.2%), followed by moderate adherence (34.9%) and low adherence (4.8%). Most patients achieved favorable clinical outcome with 89.2% having undetectable viral load and 10.8% having detectable viral load. CD4 levels were categorized as good (51.8%), very good (33.7%) and poor (14.5%). Bivariate analysis showed a significant relationship between ARV adherence and CD4 outcomes (p = 0.007) as well as viral load outcomes (p < 0.000). Conclusion: There is a significant relationship between ART adherence and clinical outcomes in HIV patients. Higher adherence is associated with improved CD4 levels and viral load suppression.
Relationship of Medication Adherence to Clinical Outcome in Patients Type 2 Diabetes with Modified Morisky Adherence Scale 8 (MMAS 8) Niken Luthfiyanti; Ardi Setyawan; Kharisma Jayak Pratama
International Journal of Medicine and Health Vol. 3 No. 4 (2024): Desember : International Journal of Medicine and Health (IJMH)
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v3i4.4547

Abstract

Diabetes melitus is a chronic condition desease that requires continued use of medication. High adherence to treatment will produce good clinical results and play a role in improving the quality of life of diabetes melitus sufferers. The following research aims to assess the relationship between adherence to medication use and clinical outcomes for patients with type 2 diabetes mellitus at RSUD DR. Moewardi Surakarta which was conducted in the period April – June 2024. This research used a cross sectional method with a total of 98 patients as respondents who met the inclusion and exclusion criteria. Adherence data was assessed using the Modified Morisky Adherence Scale 8 (MMAS 8) questionnaire, and clinical outcomes were assessed from fasting or fasting blood glucose values ​​and %HbA1C from medical record data. Analysis of the relationship between adherence and clinical outcomes using chi-square. The results of the level of treatment compliance can be divided into 3 categories, namely: high treatment compliance has a percentage of 24.5%, moderate treatment compliance has a percentage of 46.9%, and low treatment compliance has a percentage of 28.6%. Clinical outcomes were achieved by 38.8% and not achieved by 62.2%. There is a relationship between adherence medication and therapeutic outcomes in type 2 diabetes melitus patients with a Pearson chi square value of 0.011. Based on these data, pharmacist professionals need to place greater emphasis on adherence with medication use in type 2 diabetes mellitus patients to obtain good clinical outcomes.
A Pola Pengobatan dan Efek Samping Terapi Hormonal pada Pasien Kanker Payudara di RSUD Dr. Moewardi Surakarta Niken Luthfiyanti; Vivin Marwiyati Rohmana; Muhammad Fuad Zidane Khusain
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.137

Abstract

Breast cancer is one of the most prevalent malignancies in women and remains a leading cause of cancer-related mortality. One of the main treatment modalities for hormone receptor–positive breast cancer is Adjuvant Endocrine Therapy (AET), particularly tamoxifen, either as monotherapy or in combination. This study aimed to evaluate patient characteristics, treatment patterns of hormonal and chemotherapy regimens, as well as adverse drug reactions (ADRs) among breast cancer patients at Dr. Moewardi General Hospital, Surakarta. This study employed a cross-sectional design with purposive sampling. A total of 64 breast cancer patients who had received tamoxifen therapy for at least one month were included. Data were collected from medical records and questionnaires, and analyzed using the Chi-Square test to determine associations between variables. The results showed that most patients were <50 years old (60.9%) and diagnosed at advanced stages (III–IV, 57.8%). The most frequent treatment was a combination of chemotherapy and hormonal therapy (51.6%), while hormonal therapy alone was administered in 48.4% of patients. The most commonly prescribed chemotherapy regimen was Cyclophosphamide & Epirubicin, whereas the most frequent hormonal regimen was Tamoxifen + Zoladex. Bivariate analysis indicated significant associations between age and treatment type, as well as between cancer stage and treatment type (p<0,05). However, no significant associations were found between age, stage, or type of therapy and ADRs (p>0.05). The most commonly reported adverse effects were fatigue, hot flushes, nausea, and bone/joint pain, with a small proportion reporting endometrial cancer.
Co-Authors Adliah Suci Rahmadani Afina Rachmalia Artha Aryasuta Afnisyah Nurcahyati Agustina, Isnaini Al Hajar Fuadatus Zurroh AM, Ady Irawan Amanah Saputri, Yonafara Ana Yuliana Angelina da Costa Fernandes Anna Fitriawati Anna Fitriawati Annie Rahmatillah Apriliawan, Hidayah Apriliya, Intan Ardi Setyawan Ardi Setyawan Ayu Cahyani Abidin Bagas Ardiyantoro Bangkit Riska Permata Bangkit Riska Permata Burhannudin Ichsan Danang Raharjo Darah Ifalahma devitasari, Devitasari Diyana Hasna Afifah Endang Suciati Fachry Harbipero Fransiska Luciana Putri Handayani, Yessa Octavia Hidayah Apriliawan Intan Oktaviana Putri Iza Zulfa Salsabila Jayak Pratama, Kharisma Kharisma Jayak Pratama Kharisma Jayak Pratama Kharisma Jayak Pratama Khasanah, Isna Nur Khusain, Muhammad Fuad Zidane Kristanti Prihatin Sri Rejeki, Melinia Mega Larasati, Karina Dwi Listyani, Tiara Ajeng Malinda Apriliani Meli Oktavia Muhammad Fuad Zidane Khusain Muktamaroh, Anif NOVIANA Noviana Noviana Nugrahaeni Ayuningtyas Oktafia Nur Fatimah Oktaviani, Frida Indar Pratama, Kharisma Jayak Putri Eka Prasetya Rahmasari, Ikrima Rahmatillah, Annie Rohmana, Vivin Marwiyati S.A, Kusumaningtyas Safitri, Ayu Dwi Setyaningrum, Fidya Shela Novita Devi Silvia Mawardani Siwi Artini, Kusumaningtyas Siwi, Melati Daru Sudarsih, Dyah Ayu Suharjaya, Feby Nuranawati Tiara Ajeng L Vivin Marwiyati Vivin Marwiyati Rohmana Wardani, Lydia Puspita Wardani, Tatiana Siska Wulandari, Anggy