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All Journal Jurnal Delima Harapan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kesehatan Tambusai JIFI (Jurnal Ilmiah Farmasi Imelda) Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Media Farmasi Indonesia International Journal of Medicine and Health Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Sciences of Pharmacy Duta Pharma Journal Jurnal Kesehatan Amanah Proceeding of International Conference Health, Science And Technology (ICOHETECH) Indonesian Research Journal on Education Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Inovasi Jurnal Pengabdian Masyarakat (IJPM) Jurnal Pengabdian Masyarakat dan Riset Pendidikan Journal of Innovative and Creativity Jurnal Pengabdian Kepada Masyarakat Citra Delima Jurnal Pengabdian Ilmu Kesehatan
Niken Luthfiyanti
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Hormonal Therapy Treatment Pattern For Breast Cancer Patients At Dr. Moewardi Hospital, Surakarta Luthfiyanti, Niken; Rohmana, Vivin Marwiyati; Khusain, Muhammad Fuad Zidane
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2025: Proceeding of the 6th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/bfz6xt62

Abstract

Breast cancer is a cancer with a high prevalence and mortality rate in women. One of the main therapies for hormone receptor-positive patients isAdjuvant Endocrine Therapy (AET) in the form of tamoxifen, either alone or in combination. The study aims to determine patient characteristics and patterns of hormonal therapy use.breast cancer patients at Dr. Moewardi Regional Hospital, Surakarta. The study used a randomized controlled study design.cross sectional with technique purposive samplingThe study subjects were 64 breast cancer patients undergoing tamoxifen therapy for at least one month. Data were obtained from medical records and questionnaires, then tested using Chi-Square see the relationship between variables. The results of the study showed that the majority of patients were aged <50 years (60.9%) and were in advanced stages (III–IV) at 57.8%. The most common type of therapy was a combination of chemotherapy and hormones (51.6%), while single hormonal therapy was used in 48.4% of patients. The most frequently used chemotherapy regimen was a combination of Cyclophosphamide & Epirubicin, while the most common hormonal therapy was Tamoxifen + Zoladex. Bivariate analysis showed a significant relationship between age and type of therapy and stage and type of therapy (p<0.05).
PROFILE OF CHEMOTHERAPY TREATMENT IN BREAST CANCER PATIENTS AT MOEWARDI GENERAL HOSPITAL IN 2025 Pratama, Kharisma Jayak; Luthfiyanti, Niken; Sudarsih, Dyah Ayu
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2025: Proceeding of the 6th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/04yg4q56

Abstract

Breast cancer is one of the most common types of cancer found in women, with a prevalence that continues to increase every year. Chemotherapy is one of the main therapies in the treatment of breast cancer, both as adjuvant therapy (after surgery) and neoadjuvant therapy (before surgery). Moewardi General Hospital, as a referral hospital in Central Java Province, provides chemotherapy treatment services for breast cancer patients with various drug regimens that have been proven effective. This study aims to analyze the chemotherapy treatment profile in breast cancer patients at Moewardi General Hospital in 2025. The data used in this study included the type of chemotherapy regimen, the number of patients using it, and the side effects experienced by patients. The results showed that the combination of Paclitaxel and Epirubicin was the main regimen used, with a percentage of patients reaching 30%. Common side effects include nausea, vomiting, fatigue, and a decrease in white blood cell count. Despite challenges in managing side effects, chemotherapy treatment at Moewardi General Hospital shows promising results with a high success rate. This study is expected to serve as a reference for improving the quality of breast cancer treatment at this hospital and provide insights for the development of chemotherapy therapy in the future.
EVALUASI KETEPATAN PEMILIHAN OBAT DAN OUTCOME TERAPI PADA PASIEN DIABETES MELITUS TIPE II RAWAT JALAN DI RSUD Dr. MOEWARDI SURAKARTA Wulandari, Anggy; Luthfiyanti, Niken; S.A, Kusumaningtyas
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.28454

Abstract

Diabetes melitus (DM) adalah penyakit gangguan metabolik yang ditandai oleh kenaikan glukosa darah akibat penurunan sekresi insulin oleh sel beta pankreas dan atau resistensi insulin.  Tujuan dari kerasionalan penggunaan terapi obat pada pasien Diabetes Melitus yaitu untuk tercapainya keberhasilan pengobatan dan juga harus memperhatikan pemantauan terapi dari obat tersebut. Keberhasilan terapi pengobatan dapat diukur dari beberapa parameter diantaranya Gula Darah Sewaktu (GDS), Gula Darah Puasa (GDP), Gula Darah 2 jam Prospandial (GD2PP) dan Hemoglobin Glikosilat (HbA1C). Penelitian ini bertujuan untuk mengetahui penggunaan obat antidiabetes, outcome atau keberhasilan pengobatan DM Tipe II serta hubungan antara ketepatan pemilihan obat dan outcome terapi pada pasien DM Tipe II.  Jenis penelitian ini adalah non-eksperimental observasional dengan rancangan retrospektif. Jumlah sampel dalam penelitian ini adalah 99 responden. Alat ukur yang digunakan pada penelitian ini berupa data Rekam Medis kemudian dianalisis dengan metode univariat dan bivariat. Hasil penelitian tentang evaluasi ketepatan pemilihan obat dan outcome terapi pada pasien diabetes melitus tipe II rawat jalan di RSUD Dr. Moewardi Surakarta menunjukkan tepat pasien 96 pasien (97%), tepat indikasi 99 pasien (100%), tepat obat 74 (74,7%), tepat dosis 98 pasien (99%).  Outcome atau keberhasilan pengobatan pasien DM Tipe II sebanyak 63 pasien (63,6%) mencapai target dan 36 pasien (36,4) tidak mencapai target. Terdapat hubungan yang signifikan pada ketepatan pemilihan obat antidiabetes dengan outcome terapi.
HUBUNGAN TINGKAT KEPATUHAN TERHADAP OUTCOME TERAPI PADA PASIEN HIPERTENSI DI RSUD DR. MOEWARDI KOTA SURAKARTA TAHUN 2023 Devitasari, Devitasari; Luthfiyanti, Niken; S.A, Kusumaningtyas
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.28465

Abstract

Hipertensi merupakan silent killer karena tidak memiliki tanda atau gejala sebelumnya, dan gejala muncul setelah penderita mengalami komplikasi pada organ-organ vital. Hipertensi atau tekanan darah tinggi adalah suatu keadaan dimana tekanan sistolik ³140mmHg atau tekanan darah diastolik ³90 mmHg pada dua kali pengukuran dengan selang waktu lima menit dalam keadaan cukup istirahat/tenang. Apabila tidak segera ditangani dapat menimbulkan berbagai komplikasi seperti serangan jantung, stroke, diabetes mellitus. Kepatuhan terhadap pengobatan merupakan faktor penting dalam outcome terapi. Oleh karena itu, pengukuran kepatuhan penggunaan obat sangat penting untuk menentukan keberhasilan pengobatan. Identifikasi faktor-faktor yang berhubungan dengan kepatuhan pengobatan hipertensi merupakan langkah pertama dalam usaha menangani permasalahan tersebut. Tujuan penelitian adalah mengetahui gambaran faktor-faktor yang mempengaruhi kepatuhan penggunaan obat pada pasien hipertensi di RSUD Dr. Moewardi Kota Surakarta Tahun 2023. Penelitian ini desain observasional deskriptif menggunakan pendekatan Cross Sectional. Pengambilan sampel menggunakan teknik accidental sampling. Alat pengumpulan data berupa kuesioner MMAS untuk kepatuhan dan data rekam medis. Analisis data diolah dengan SPSS analisis univariat dan bivariat menggunakan uji chi square. Hasil penelitian menunjukkan responden yang memiliki kepatuhan pengobatan tinggi sebanyak 43 responden (44,3%), sedang sebanyak 31 responden (32,0%) dan rendah sebanyak 23 responden (23,7%). Hasil outcome terapi tercapai sebanyak 52 responden (53,6%) dan tidak tercapai sebanyak 45 responden (46,4%). Dari hasil analisis chi square diperoleh nilai Pearson Chi Square 0,831 yang menunjukkan tidak ada terdapat hubungan antara kepatuhan pengobatan dengan outcome terapi.
EVALUASI PELAYANAN INFORMASI OBAT DAN KEPUASAN PASIEN RAWAT JALAN DI PUSKESMAS KARTASURA KABUPATEN SUKOHARJO JAWA TENGAH Oktaviani, Frida Indar; Luthfiyanti, Niken; S.A, Kusumaningtyas
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.28467

Abstract

Penelitian ini bertujuan untuk mengetahui evaluasi pelayanan informasi obat dan kepuasan pasien rawat jalan terhadap pelayanan kefarmasian di Instalasi Farmasi Puskesmas Kartasura dengan menggunakan kuesioner terhadap 100 responden. Teknik analisis data dengan menggunakan metode Uji Univariat, Uji Bivariat, Uji Chi Square, metode CSI (Customer Satisfaction Index) dan metode IPA (Importance Performance Analysis). Berdasarkan hasil penelitian terkait kualitas pelayanan kesehatan di Puskesmas Kartasura dari metode gap berada pada indeks negatif yang artinya pasien belum puas dengan pelayanan yang diberikan dengan nilai gap yaitu tangible (bukti fisik) (-0.51) reliability (kehandalan) (-0.40), responsiveness (daya tanggap) (-0.43), assurance (Jaminan) (-0.41), dan empathy (kepedulian) (-0.34). Hasil analisis CSI (Customer satisfaction Index) termasuk dalam kategori sangat puas yaitu dengan nilai sebesar 84,84%. Hasil penelitian terkait sosiodemografi dan pelayanan informasi obat tidak ada hubungan dengan nilai p-value tertinggi yaitu pada karakteristik jenis kelamin (0.795). Hasil penelitian terkait sosiodemografi dan kepuasan pasien pada dimensi dirasakan pada karakteristik pekerjaan ada hubungan terkait dengan kepuasan pasien dengan nilai (0.040). Hasil penelitian di dapat tidak ada hubungan terkait pelayanan informasi obat dengan kepuasan pasien (dirasakan) dengan nilai p-value (0.263). Hasil analisis IPA menunjukkan kuadran I menjadi prioritas perbaikan meliputi tanda pengenal, fasilitas ruang tunggu dan tanggap menangani pasien terkait obat, petugas farmasi dapat menangani masalah dan memberikan solusi dengan cepat dan tepat di Puskesmas Kartasura.
HUBUNGAN KEPATUHAN PENGOBATAN TERHADAP OUTCOME KLINIS PADA PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. MOEWARDI SURAKARTA LUTHFIYANTI, NIKEN; Setyawan, Ardi
Jurnal Kesehatan Tambusai Vol. 5 No. 4 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i4.38627

Abstract

Diabetes melitus merupakan penyakit kronis yang memerlukan penggunaan obat secara terus menerus. Kepatuhan yang tinggi terhadap pengobatan akan membuahkan hasil klinis yang baik dan berperan dalam meningkatkan kualitas hidup penderita diabetes melitus. Penelitian ini bertujuan untuk mengkaji hubungan kepatuhan penggunaan obat dengan outcome klinis pada pasien diabetes melitus tipe 2 di RSUD DR. Moewardi Surakarta yang dilakukan pada periode April – Juni 2024. Penelitian ini menggunakan metode cross sectional dengan jumlah responden sebanyak 98 pasien yang memenuhi kriteria inklusi dan eksklusi. Data kepatuhan dinilai menggunakan kuesioner Modified Morisky Adherence Scale 8 (MMAS 8), dan luaran klinis dinilai dari nilai glukosa darah puasa atau sewaktu dan %HbA1C dari data rekam medis. Analisis hubungan kepatuhan dengan outcome klinis menggunakan chi-square. Hasil tingkat kepatuhan pengobatan dapat dibagi menjadi 3 kategori yaitu: kepatuhan pengobatan tinggi memiliki persentase 24,5%, kepatuhan pengobatan sedang memiliki persentase 46,9%, dan kepatuhan pengobatan rendah memiliki persentase 28,6%. Hasil klinis tercapai sebesar 37,8% dan tidak tercapai sebesar 62,2%. Terdapat hubungan antara kepatuhan minum obat dengan hasil terapi pada pasien diabetes melitus tipe 2 dengan nilai Pearson chi square sebesar 0,011. Berdasarkan data tersebut, tenaga apoteker perlu lebih menekankan kepatuhan penggunaan obat pada pasien diabetes melitus tipe 2 untuk memperoleh outcome klinis yang baik.
EFEKTIFAS EDUKASI DALAM PENCEGAHAN DIABETES MELITUS DI DESA GENENG POLOKARTO SUKOHARJO Rahmasari, Ikrima; AM, Ady Irawan; Luthfiyanti, Niken; Purwaningsih, Iswanti
Jurnal Pengabdian Kepada Masyarakat Citra Delima Vol. 1 No. 1 (2023): Jurnal Pengabdian Kepada Masyarakat Citra Delima
Publisher : Institut Citra Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33862/jp.v1i1.369

Abstract

Background: Diabetes Mellitus (DM) is a metabolic syndrome due to impaired quantity and function of insulin which causes high blood glucose levels (hyperglycemia). Early prevention needs to be done for early detection of chronic diseases such as DM which have good risk factors due to unhealthy lifestyles and heredity. Early detection of DM can be done through screening by checking blood sugar levels at the time. In addition, success in preventing the onset of DM and controlling blood sugar levels in people with DM depends on people's behavior. Changes in behavior towards a healthy lifestyle in the context of correct DM prevention and control will be realized if the community has sufficient knowledge about DM and its prevention. The purpose of this activity is to add health information to the public about education on the prevention of Diabetes Mellitus. The method is carried out by lectures, discussions and questions and answers while the media uses leaflets. The education delivered increases public knowledge about diabetes risk prevention education, so that people can independently prevent the risk of diabetes mellitus which is a degenerative disease and is predicted to increase every year.
Uji Efek Tonikum Ekstrak Etanol Kombinasi Temu Putih (Curcuma zedoaria) dan Temu Hitam (Curcuma aeruginosa) terhadap Mencit Putih Jantan (Mus musculus) Afina Rachmalia Artha Aryasuta; Niken Luthfiyanti; Kharisma Jayak Pratama
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6738

Abstract

Tonic is a preparation thats can stqrengsthen the body and improve stamina. Curcuma zedoaria and Curcuma aeruginosa are known to have phytochemical compunds such as flavonoids, alkaloids, saponins, tannin, triterpenoids, curcuminoid and polyphenols that can function as stimulant and tonics. This studiy aimed to investigate tonic effects of ethanolic extracts of Curcuma zedoaria, ethanolic extract of Curcuma aeruginosa, and their combinations on male white mice (Mus musculus). Curcuma zedoaria rhizome and Curcuma aeruginosa rhizome were extracted using the maceration method for 3 days using 70% ethanol solvent which was then thickened in a waterbath. A total of 35 male mice were divided into 7 groups with different treatments, including negative control (aquadest), positive control (caffeine 100 mg/kgBB), ethanolic exctract of Curcuma zedoaria (600 mg/kgBB), ethanolic extract of Curcuma aeruginosa (600 mg/kgBB), and combination ethanolic extract of Curcuma zedoaria and Curcuma aeruginosa at dosage of 150:450 mg/kgBB, 300:300 mg/kgBB, and 450:150 mg/kgBB. Tonic effect were evaluated using natatory exhaustion and rotarod tests. The natatory exhaustion test is carried out by observing how long the mice swim, while the rotarod test is carried out by observing how long the mice stay on the rotarod apparatus. The data analyzed using ANOVA and Tukey’s test. The results of One Way Anova showed a there were significansts differensce in each groups (p<0,05) with combination of Curcuma zedoaria : Curcuma aeruginosa (150:450 mg/kgBB) yielding the best tonic effect. From the result of Tukey’s followsup test, it showed that the highers the dosae of Curcuma aeruginosa rhizome extracts the better the tonics effects giiven. This suggest that Curcuma aeruginosa has a dominant role in enhancing phsycal endurance in male white mice.
Uji Aktivitas Antioksidan dan Penentuan Nilai Sun Protection Factor (SPF) Sediaan Lip Balm Ekstrak Kayu Secang (Caesalpinia Sappan L.) Nugrahaeni Ayuningtyas; Niken Luthfiyanti; Bangkit Riska Permata
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6755

Abstract

Sappan wood (Caesalpinia sappan L.) is known to contain various bioactive compounds such as saponins, tannins, flavonoids, phenols, brazilin, and gallic acid. These compounds play an important role as antioxidants that can ward off free radicals and absorb UVA and UVB radiation that are harmful to the skin. Ultraviolet radiation is known to accelerate premature aging and cause tissue damage, so a topical formulation is needed that can provide protection while maintaining skin health. This study aims to determine the antioxidant activity and sunscreen ability of sappan wood extract in the form of lip balm with varying extract concentrations. Antioxidant activity was evaluated using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method, while the Sun Protection Factor (SPF) value was determined by the Mansyur method using UV-Vis spectrophotometry. Sappan wood extract was formulated into four lip balm preparations, namely F0 (control without extract), F1 (5%), F2 (10%), and F3 (15%). Physical tests including homogeneity, pH, spreadability, adhesiveness, and organoleptic were conducted to ensure the quality of the preparation. The results showed that sappanwood extract had an IC50 value of 23.62 ppm which was categorized as very strong antioxidant activity. In the lip balm formulation, the IC50 values ​​obtained were F0 = 246.76 ppm (very weak), F1 = 92.68 ppm (strong), F2 = 78.03 ppm (strong), and F3 = 63.58 ppm (strong). The SPF test showed a protection value of F0 = 2.11 (minimum), F1 = 13.64 (maximum), F2 = 14.25 (maximum), and F3 = 18.28 (ultra). Thus, lip balm made from sappanwood extract has the potential as a cosmetic preparation that not only meets physical criteria, but also provides high antioxidant activity and effective sunscreen protection.
EFFECTIVENESS OF MANALAGI MANGGO LEAF EXTRACT GEL (Mangifera indica L.) ON CUTTING WOUND HEALING IN MALE RABBITS NEW ZEALAND WHITE Luthfiyanti, Niken; Muktamaroh, Anif; Khasanah, Isna Nur
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2023: Proceeding of the 4th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v4i1.3426

Abstract

Wounds are pathological conditions that occur in skin tissue and mucous membranes of other tissues. Mango leaves (Mangifera indica L.) contain alkaloids, flavonoids, tannins and saponins which have an effect on wound healing. The purpose of this study was to determine the effectiveness of mango leaf extract gel concentration (Mangifera indica L.) on wound healing in rabbits. The test animals were divided into five treatments, namely positive control, negative control, and gel preparation with 3 variations of extract concentration, namely formula I (10%), formula II (15%), and formula III (20%). This research is an experimental study with observations for 14 days. The statistical test uses the Anova test and the Post-Hoc test. The average healing time of the positive control and negative control groups with mango leaf extract gel (Mangifera indica L.) concentrations of 10%, 15%, and 20% had a significant difference with a sig 0.000 result (P<0.05). Manalagi mango leaf extract gel (Mangifera indica L.) provides the best wound healing effect at a concentration of 20%.
Co-Authors Adliah Suci Rahmadani Afina Rachmalia Artha Aryasuta Afnisyah Nurcahyati Agustina, Isnaini Al Hajar Fuadatus Zurroh AM, Ady Irawan Amanah Saputri, Yonafara Ana Yuliana Angelina da Costa Fernandes Anna Fitriawati Anna Fitriawati Annie Rahmatillah Apriliawan, Hidayah Apriliya, Intan Ardi Setyawan Ardi Setyawan Ayu Cahyani Abidin Bagas Ardiyantoro Bangkit Riska Permata Bangkit Riska Permata Burhannudin Ichsan Danang Raharjo Darah Ifalahma devitasari, Devitasari Diyana Hasna Afifah Endang Suciati Fachry Harbipero Fransiska Luciana Putri Handayani, Yessa Octavia Hidayah Apriliawan Intan Oktaviana Putri Iza Zulfa Salsabila Jayak Pratama, Kharisma Kharisma Jayak Pratama Kharisma Jayak Pratama Kharisma Jayak Pratama Khasanah, Isna Nur Khusain, Muhammad Fuad Zidane Kristanti Prihatin Sri Rejeki, Melinia Mega Larasati, Karina Dwi Listyani, Tiara Ajeng Malinda Apriliani Meli Oktavia Muhammad Fuad Zidane Khusain Muktamaroh, Anif NOVIANA Noviana Noviana Nugrahaeni Ayuningtyas Oktafia Nur Fatimah Oktaviani, Frida Indar Pratama, Kharisma Jayak Putri Eka Prasetya Rahmasari, Ikrima Rahmatillah, Annie Rohmana, Vivin Marwiyati S.A, Kusumaningtyas Safitri, Ayu Dwi Setyaningrum, Fidya Shela Novita Devi Silvia Mawardani Siwi Artini, Kusumaningtyas Siwi, Melati Daru Sudarsih, Dyah Ayu Suharjaya, Feby Nuranawati Tiara Ajeng L Vivin Marwiyati Vivin Marwiyati Rohmana Wardani, Lydia Puspita Wardani, Tatiana Siska Wulandari, Anggy