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All Journal Jurnal Delima Harapan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kesehatan Tambusai JIFI (Jurnal Ilmiah Farmasi Imelda) Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Media Farmasi Indonesia International Journal of Medicine and Health Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Sciences of Pharmacy Duta Pharma Journal Jurnal Kesehatan Amanah Proceeding of International Conference Health, Science And Technology (ICOHETECH) Indonesian Research Journal on Education Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Inovasi Jurnal Pengabdian Masyarakat (IJPM) Jurnal Pengabdian Masyarakat dan Riset Pendidikan Journal of Innovative and Creativity Jurnal Pengabdian Kepada Masyarakat Citra Delima Jurnal Pengabdian Ilmu Kesehatan
Niken Luthfiyanti
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Optimasi Formula Bedak Dingin Ekstrak Temu Giring (Curcuma heyneana) dengan Metode Simplex Lattice Design dan Uji Aktivitas Antioksidan Diyana Hasna Afifah; Anna Fitriawati; Niken Luthfiyanti
GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol. 4 No. 5 (2025): GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh - Oktober 20
Publisher : Program Studi Kedokteran Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jkkmm.v4i5.24153

Abstract

Rimpang temu giring memiliki sifat antioksidan dan anti-inflamasi yang kuat sebagai bahan anti-penuaan. Rimpang temu giring kaya akan kandungan senyawa seperti minyak atsiri, kurkumin, tanin, saponin, flavonoid, dan pati. Tujuan penelitan ini mengetahui aktivitas antioksidan pada ekstrak temu giring, mengetahui mutu fisik dan mengetahui aktivitas antioksidan formula optimum. Metode penelitian secara kuantitatif menggunakan SLD. Penelitian ini membuat 5 formula. Pengujian aktivitas antioksidan menggunakan DPPH. Formula yang sudah diuji mutu fisik kemudian dianalisis dan diverifikasi menggunakan uji statistik ANOVA. Hasil uji ANOVA diperoleh p-value <0,05 dan f-value >0,05. Hasil uji sediaan formula optimum bedak dingin ekstrak temu giring telah memenuhi syarat parameter uji mutu fisik yaitu uji organoleptik yaitu warna kuning, bau khas dan tekstur padat. Uji pH 5,94. Uji daya sebar 5,36cm. Uji daya lekat 04,82 detik. Uji waktu kering 16.17.61 menit. Hasil IC50 dari ekstrak 74,56 dan formula optimum 94,72 termasuk golongan antioksidan kuat.
Evaluation Of The Rationality Of Antibiotic Use In Hospitalized Adult Patients With UTI Diagnosis On Clinical Outcome At Dr. Moewardi Regional Hospital Malinda Apriliani; Kharisma Jayak Pratama; Niken Luthfiyanti
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.651

Abstract

Urinary Tract Infection (UTI) is a common infection with high antibiotic resistance due to irrational use.  To assess the rationality of antibiotics in adult inpatients with UTI at Dr. Moewardi Regional General Hospital using the Gyssens method, ATC/DDD patterns, and their relationship with clinical outcomes. A retrospective descriptive observational study of medical records of 50 acute pyelonephritis patients (population 270, Slovin sample e=10%, consecutive sampling), collected in December 2025. LPD medical records; analysis: Gyssens (qualitative Permenkes 28/2021), ATC/DDD (quantitative), Fisher's Exact (p<0.05). 64% female, 52% >60 years; ciprofloxacin 90%; rationality 46% (Gyssens category 0), 54% irrational (mainly short duration 44%); ATC/DDD: ciprofloxacin 47.2%, ceftriaxone 52.8%; outcome improved 94%; p=0.090 (not significant). Rationale was low, especially for duration, with no significant association with outcome; stewardship is recommended to prevent resistance.
Analysis Of Complication Treatment Design In Hepatitis B Patients In The Outpatient Facility Of Dr. Moewari Hospital, Surakarta Afnisyah Nurcahyati; Kharisma Jayak Pratama; Niken Luthfiyanti
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.676

Abstract

Hepatitis is an inflammation of the liver that is generally caused by a viral infection. There are five hepatitis viruses, namely Hepatitis A Virus (HAV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Hepatitis D Virus (HDV) and Hepatitis E Virus (HEV). Hepatitis B is a liver disease caused by the hepatitis B virus (HBV). HBV can cause acute or chronic liver inflammation, in a small number of cases it can progress to liver cirrhosis or liver cancer (Andriani et al., 2020). This study aims to determine the patient profile and use of hepatitis B drugs and evaluate Hepatitis B treatment in patients at the Outpatient Installation of Dr. Moewardi Regional Hospital using a non-experimental descriptive observational method with retrospective quantitative data collection. The results of the study showed that of the 99 hepatitis B patients, the majority were male (67.68%) and aged >55 years (46.5%). Most patients received antiviral therapy (60.61%), with tenofovir being the most commonly used drug (78.78%), followed by entecavir (17.17%). Evaluation of treatment suitability showed that all doses and frequencies of antiviral and hepatoprotective therapy administered were in accordance with national guidelines and MIMS references (100% compliance). Curcuma was the most frequently used hepatoprotective agent (64.64%). This indicates that the use of hepatitis B medications at Dr. Moewardi Regional Hospital is in accordance with applicable therapy standards. Based on a study of 99 hepatitis B patients, most patients received antiviral and supportive therapy according to guidelines. The use of medications, both antiviral and hepatoprotective, was appropriate in type, dose, and frequency. Patient management demonstrated rational and clinically appropriate therapy.
Predictors Of Antiretroviral Therapy Failure In HIV/AIDS Patients At Dr. Moewardi Regional Hospital, Surakarta Fachry Harbipero; Niken Luthfiyanti; Vivin Marwiyati
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.680

Abstract

Antiretroviral (ARV) therapy failure remains a significant issue in HIV/AIDS control as it contributes to disease progression and drug resistance. This study aims to analyze predictors of ARV therapy failure based on demographic and clinical characteristics of HIV/AIDS patients. This study used a retrospective quantitative descriptive analytical design with medical records of HIV outpatients at Dr. Moewardi Regional General Hospital from November 2024 to November 2025 as the data source. The study population was all HIV patients receiving ARV therapy, with a sample of 100 patients selected using accidental sampling. The research instrument was a medical record-based observation sheet, covering demographic, clinical, CD4, viral load, and clinical stage characteristics. Data analysis was performed univariately and bivariately using the Chi-square test with a significance level of p<0.05. The results showed that the majority of patients were male, productive age, married, had secondary or higher education, had a normal BMI, were in the early clinical stage, and did not experience opportunistic infections or side effects of therapy. No significant associations were found between demographic and clinical variables and CD4 count, viral load, or clinical stage. In conclusion, the immunological, virological, and clinical status of HIV patients is multifactorial and is not solely determined by the demographic and clinical characteristics studied.
The Effect Of Pill Box Use On Medication Adherence Among Type 2 Diabetes Mellitus Patients Participating In Prolanis At Sangkrah Community Health Center, Surakarta Iza Zulfa Salsabila; Niken Luthfiyanti; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 5 No. 3 (2026): Vol. 5 No. 3 SEPTEMBER 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i3.1149

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease with an increasing prevalence worldwide. According to the WHO, approximately 422 million people were living with diabetes in 2023. In Indonesia, the number of diabetes cases continues to increase, making medication adherence essential to achieve successful therapeutic outcomes. One strategy to improve medication adherence is the use of a pill box as a medication reminder. To determine the effect of pill box use on medication adherence and therapeutic outcomes among patients with type 2 diabetes mellitus enrolled in the Chronic Disease Management Program (PROLANIS) at Sangkrah Primary Health Center, Surakarta. This study employed a quasi-experimental pretest–posttest control group design involving 60 respondents, consisting of 30 participants in the control group and 30 in the intervention group. Medication adherence was assessed using the 8-item MMAS-8 and the Pill Count method, while therapeutic outcomes were evaluated based on HbA1c levels. Data were analyzed using univariate analysis, the Chi-square test, and the Wilcoxon Signed-Rank Test with a significance level of p < 0.05. The Wilcoxon Signed-Rank Test showed that pill box use significantly improved medication adherence based on both the MMAS-8 and Pill Count methods (p < 0.001). The proportion of adherent patients measured by Pill Count was higher in the intervention group (93.3%) than in the control group (70.0%). Bivariate analysis indicated that HbA1c, family support, and healthcare provider support were significantly associated with medication adherence (p < 0.05), whereas age, sex, education, occupation, duration of diabetes, comorbidities, and prescribing patterns were not significantly associated (p > 0.05). Therefore, a pill box can be recommended as a simple and effective medication reminder to help patients take their medications regularly and support successful therapeutic outcomes. The use of a pill box significantly improved medication adherence among patients with type 2 diabetes mellitus.
Hubungan Medication Beliefs dengan Kualitas Hidup Pasien Diabetes Melitus Tipe II di RSUD Dr. Moewardi Surakarta Fransiska Luciana Putri; Niken Luthfiyanti; Annie Rahmatillah
An-Najat Vol. 4 No. 3 (2026): Agustus: An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v4i3.3905

Abstract

Diabetes Melitus Tipe II merupakan penyakit kronis yang memerlukan terapi jangka panjang, sehingga keyakinan pasien terhadap pengobatan (medication beliefs) dapat berperan dalam keberhasilan pengelolaan penyakit dan kualitas hidup. Penelitian ini bertujuan untuk mengetahui hubungan antara medication beliefs dengan kualitas hidup pasien Diabetes Melitus Tipe II di RSUD Dr. Moewardi Surakarta. Penelitian menggunakan desain observasional kuantitatif dengan pendekatan cross-sectional. Sebanyak 96 pasien Diabetes Melitus Tipe II rawat jalan dipilih menggunakan teknik purposive sampling. Data medication beliefs diperoleh menggunakan Beliefs about Medicines Questionnaire (BMQ), sedangkan kualitas hidup diukur menggunakan Diabetes Quality of Life (DQOL). Data dianalisis secara univariat dan bivariat menggunakan uji Pearson Chi-Square. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki medication beliefs positif, yaitu sebanyak 89 responden (92,7%). Sebanyak 50 responden berada pada kategori kualitas hidup baik dan 46 responden berada pada kategori kualitas hidup sedang. Pada responden dengan medication beliefs positif, 49 responden memiliki kualitas hidup baik dan 40 responden memiliki kualitas hidup sedang, sedangkan seluruh responden dengan medication beliefs negatif berada pada kategori kualitas hidup sedang. Hasil uji Pearson Chi-Square menunjukkan terdapat hubungan yang signifikan antara medication beliefs dengan kualitas hidup pasien Diabetes Melitus Tipe II (p=0,021). Dapat disimpulkan bahwa pasien dengan keyakinan yang lebih positif terhadap pengobatan cenderung memiliki kualitas hidup yang lebih baik. Oleh karena itu, edukasi dan komunikasi mengenai kebutuhan, manfaat, serta kekhawatiran terhadap penggunaan obat perlu diperkuat sebagai bagian dari pelayanan pasien Diabetes Melitus Tipe II.
Pengaruh Adverse Drug Reactions (ADRs) Kemoterapi Terhadap Kualitas Hidup Pasien Kanker Serviks di RSUD Dr. Moewardi Surakarta Adliah Suci Rahmadani; Niken Luthfiyanti; Bagas Ardiyantoro
An-Najat Vol. 4 No. 3 (2026): Agustus: An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v4i3.3986

Abstract

Cervical cancer is one of the cancers with a high incidence rate among women. Chemotherapy, as the main treatment, can cause Adverse Drug Reactions (ADRs), which can affect the patient’s quality of life. This study aimed to determine patient characteristics, the incidence of chemotherapy side effects (ADRs), and quality of life, as well as to analyze the influence of chemotherapy side effects (ADRs) on the quality of life of cervical cancer patients at Dr. Moewardi Hospital Surakarta. This was an analytic observational study with a cross-sectional approach. The study sample consisted of 66 patients selected through total sampling. ADR incidence was assessed using the Naranjo Algorithm, severity was graded according to the CTCAE criteria, and quality of life was measured with the EORTC QLQ-C30 questionnaire. Data analysis was performed using univariate and bivariate methods. The majority of patients were aged 41–60 years, had an elementary school education, were housewives, were married, were in stage III, underwent paclitaxel-carboplatin combination chemotherapy, and most experienced ADRs categorized as "probable." A total of 71.2% of patients had a moderate quality of life. Pearson Chi-square test results showed no significant effect of chemotherapy ADRs on the quality of life in cervical cancer patients (p=0.327). Chemotherapy side effects (ADRs) did not significantly impact the quality of life of cervical cancer patients at Dr. Moewardi Hospital Surakarta. The patient's quality of life can be influenced by factors beyond the variables studied, such as family and social support, level of spirituality, Subjective Well-Being (SWB), psychological conditions, levels of anxiety or depression, and economic status.
Co-Authors Adliah Suci Rahmadani Afina Rachmalia Artha Aryasuta Afnisyah Nurcahyati Agustina, Isnaini Al Hajar Fuadatus Zurroh AM, Ady Irawan Amanah Saputri, Yonafara Ana Yuliana Angelina da Costa Fernandes Anna Fitriawati Anna Fitriawati Annie Rahmatillah Apriliawan, Hidayah Apriliya, Intan Ardi Setyawan Ardi Setyawan Ayu Cahyani Abidin Bagas Ardiyantoro Bangkit Riska Permata Bangkit Riska Permata Burhannudin Ichsan Danang Raharjo Darah Ifalahma devitasari, Devitasari Diyana Hasna Afifah Endang Suciati Fachry Harbipero Fransiska Luciana Putri Handayani, Yessa Octavia Hidayah Apriliawan Intan Oktaviana Putri Iza Zulfa Salsabila Jayak Pratama, Kharisma Kharisma Jayak Pratama Kharisma Jayak Pratama Kharisma Jayak Pratama Khasanah, Isna Nur Khusain, Muhammad Fuad Zidane Kristanti Prihatin Sri Rejeki, Melinia Mega Larasati, Karina Dwi Listyani, Tiara Ajeng Malinda Apriliani Meli Oktavia Muhammad Fuad Zidane Khusain Muktamaroh, Anif NOVIANA Noviana Noviana Nugrahaeni Ayuningtyas Oktafia Nur Fatimah Oktaviani, Frida Indar Pratama, Kharisma Jayak Putri Eka Prasetya Rahmasari, Ikrima Rahmatillah, Annie Rohmana, Vivin Marwiyati S.A, Kusumaningtyas Safitri, Ayu Dwi Setyaningrum, Fidya Shela Novita Devi Silvia Mawardani Siwi Artini, Kusumaningtyas Siwi, Melati Daru Sudarsih, Dyah Ayu Suharjaya, Feby Nuranawati Tiara Ajeng L Vivin Marwiyati Vivin Marwiyati Rohmana Wardani, Lydia Puspita Wardani, Tatiana Siska Wulandari, Anggy